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CALR-mutated patients with low allele burden represent a specific subtype of essential thrombocythemia: A study on behalf of FIM and GBMHM.
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STIM2 is involved in the regulation of apoptosis and the cell cycle in normal and malignant monocytic cells
No full textInternational audienceCalcium is a ubiquitous messenger that regulates a wide range of cellular functions, but its involvement in the pathophysiology of acute myeloid leukemia (AML) is not widely investigated. Here, we identified, from an analysis of The Cancer Genome Atlas and genotype‐tissue expression databases, stromal interaction molecule 2 ( STIM2 ) as being highly expressed in AML with monocytic differentiation and negatively correlated with overall survival. This was confirmed on a validation cohort of 407 AML patients. We then investigated the role of STIM2 in cell proliferation, differentiation, and survival in two leukemic cell lines with monocytic potential and in normal hematopoietic stem cells. STIM2 expression increased at the RNA and protein levels upon monocyte differentiation. Phenotypically, STIM2 knockdown drastically inhibited cell proliferation and induced genomic stress with DNA double‐strand breaks, as shown by increased levels of phosphorylate histone H2AXγ (p‐H2AXγ), followed by activation of the cellular tumor antigen p53 pathway, decreased expression of cell cycle regulators such as cyclin‐dependent kinase 1 (CDK1)–cyclin B1 and M‐phase inducer phosphatase 3 (CDC25c), and a decreased apoptosis threshold with a low antiapoptotic/proapoptotic protein ratio. Our study reports STIM2 as a new actor regulating genomic stability and p53 response in terms of cell cycle and apoptosis of human normal and malignant monocytic cells
Aspects de la religion vécue dans le Japon de la fin du Moyen Âge et de l'époque prémoderne
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[Compte rendu] Matthias Hayek, Les Mutations du yin et du yang. Divination, société et représentations au Japon, du VIe au XIXe siècle: Paris, Collège de France, IHEJ, 2021
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Strategies to decrease inequalities in cancer therapeutics, care and prevention
No full textInternational audienceAnalyses of inequalities related to prevention and cancer therapeutics/care show disparities between countries with different economic standing, and within countries with high Gross Domestic Product. The development of basic technological and biological research provides clinical and prevention opportunities that make their implementation into healthcare systems more complex, mainly due to the growth of Personalized/Precision Cancer Medicine (PCM). Initiatives like the USA‐Cancer Moonshot and the EU‐Mission on Cancer and Europe's Beating Cancer Plan are initiated to boost cancer prevention and therapeutics/care innovation and to mitigate present inequalities. The conference organized by the Pontifical Academy of Sciences in collaboration with the European Academy of Cancer Sciences discussed the inequality problem, dependent on the economic status of a country, the increasing demands for infrastructure supportive of innovative research and its implementation in healthcare and prevention programs. Establishing translational research defined as a coherent cancer research continuum is still a challenge. Research has to cover the entire continuum from basic to outcomes research for clinical and prevention modalities. Comprehensive Cancer Centres (CCCs) are of critical importance for integrating research innovations to preclinical and clinical research, as for ensuring state‐of‐the‐art patient care within healthcare systems. International collaborative networks between CCCs are necessary to reach the critical mass of infrastructures and patients for PCM research, and for introducing prevention modalities and new treatments effectively. Outcomes and health economics research are required to assess the cost‐effectiveness of new interventions, currently a missing element in the research portfolio. Data sharing and critical mass are essential for innovative research to develop PCM. Despite advances in cancer research, cancer incidence and prevalence is growing. Making cancer research infrastructures accessible for all patients, considering the increasing inequalities, requires science policy actions incentivizing research aimed at prevention and cancer therapeutics/care with an increased focus on patients' needs and cost‐effective healthcare
Daniel Danducho, Testimonio del primer profesor bilingüe awaùn
No full textInternational audienceDaniel Danducho es una figura que aparece de forma recurrente en la memoria oral del pueblo awajún y en los escritos de misioneros quienes, a mediados del siglo XX, trabajaron y atravesaron las tierras del Alto Amazonas. En este contexto, Danducho surgió como el iniciador de una nueva época en la sociedad awajún, un avatar para la definición del estatus del «kakájam moderno», mostrándose como modelo del indígena profesional y profesor bilingüe
The gravitational eikonal: from particle, string and brane collisions to black-hole encounters
No full textInternational audienceMotivated by conceptual problems in quantum theories of gravity, the gravitational eikonal approach, inspired by its electromagnetic predecessor, has been successfully applied to the transplanckian energy collisions of elementary particles and strings since the late eighties, and to string-brane collisions in the past decade. After the direct detection of gravitational waves from black-hole mergers, most of the attention has shifted towards adapting these methods to the physics of black-hole encounters. For such systems, the eikonal exponentiation provides an amplitude-based approach to calculate classical gravitational observables, thus complementing more traditional analytic methods such as the Post-Newtonian expansion, the worldline formalism, or the Effective-One-Body approach. In this review we summarize the main ideas and techniques behind the gravitational eikonal formalism. We discuss how it can be applied in various different physical setups involving particles, strings and branes and then we mainly concentrate on the most recent developments, focusing on massive scalars minimally coupled to gravity, for which we aim at being as self-contained and comprehensive as possible
Origin and fate of the pseudogap in the doped Hubbard model
No full textInternational audienceWe investigate the doped two-dimensional Hubbard model at finite temperature using controlled diagrammatic Monte Carlo calculations allowing for the computation of spectral properties in the infinite-size limit and, crucially, with arbitrary momentum resolution. We show that three distinct regimes are found as a function of doping and interaction strength, corresponding to a weakly correlated metal with properties close to those of the non-interacting system, a correlated metal with strong interaction effects including a reshaping of the Fermi surface, and a pseudogap regime at low doping in which quasiparticle excitations are selectively destroyed near the antinodal regions of momentum space. We study the physical mechanism leading to the pseudogap and show that it forms both at weak coupling when the magnetic correlation length is large and at strong coupling when it is shorter. In both cases, we show that spin-fluctuation theory can be modified in order to account for the behavior of the non-local component of the self-energy. We discuss the fate of the pseudogap as temperature goes to zero and show that, remarkably, this regime extrapolates precisely to the ordered stripe phase found by ground-state methods. This handshake between finite temperature and ground-state results significantly advances the elaboration of a comprehensive picture of the physics of the doped Hubbard model