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Long-term safety profile and secondary effectiveness of canakinumab in pediatric rheumatic diseases: a single-center experience
No full textBackgroundTo demonstrate the long-term safety profile of canakinumab over a nine-year period by documenting adverse events in patients with various pediatric rheumatic diseases. Research design and methodsThis retrospective observational study was conducted at the Pediatric Rheumatology Department of Istanbul University Cerrahpasa between 2015 and 2023. The analysis concerned individuals who had been administered canakinumab treatment for at least six months. The exposure-adjusted event rates were calculated as adverse events per 100 patient days and were compared among three groups based on the cumulative canakinumab dose of 70 mg/kg. ResultsAmong 189 patients, the median exposure time to canakinumab was 2.9 (1.5-4.1) years, corresponding to 573.4 patient years. The median cumulative dose of canakinumab was 2205 (1312-3600) mg. The most common adverse event was upper respiratory tract infection (0.76), followed by urinary tract infection (0.02), pneumonia (0.009), latent tuberculosis (0.009) and lymphadenitis (0.004). A total of 55 serious adverse events (0.025) were reported, 12 (0.006) of which led to drug discontinuation. The event rate of macrophage activation syndrome and disease exacerbation was statistically higher in patients receiving <35 mg/kg cumulative canakinumab dose (p < 0.05). ConclusionsAn increase in side effect was not observed with the increasing cumulative doses of canakinumab. Canakinumab demonstrated long-term safety with appropriate indication and monitoring
Evaluation of protein profile in vitreous samples of patients with naive age-related macular degeneration using proteomic approaches
No full textTÜRKİYE KAMU İÇ MALİ KONTROL SİSTEMİNİN 2020-2024 AB İLERLEME RAPORLARI ÜZERİNDEN İNCELENMESİ: GÜNCEL GELİŞMELER VE KURUMSAL GERİLİMLER
No full textPush-out force evaluation of titanium cylinders attached to implant supported immediate provisional heat-polymerized acrylic resin with various relining material types and thicknesses.
No full textİpsilateral asetabulum ve kontralateral iskial veya pubik ramus kırığı olan hastalarda posterior pelvik yaralanma insidansının değerlendirilmesi
No full textTürkiye’deki Havalimanlarının Performanslarının Turizm Mevsiminin Etkisi Açısından LOPCOW Tabanlı ARLON Yöntemi ile Değerlendirilmesi
No full textMarginal and internal fit of table-top restorations produced by subtractive and additive CAD-CAM methods
No full textCOMPARISON OF FIRE SUPPRESSION MATERIALS FOR ENSURING FIRE SAFETY IN ELECTRIC COMMERCIAL VEHICLE MANUFACTURING PLANTS
No full textThe swift progress in electric commercial vehicle technology has significantly transformed manufacturing processes. With the rising demand for electric commercial vehicles, fire safety in manufacturing facilities has become a paramount concern. The high energy density of lithium-ion batteries, which are commonly used in electric commercial vehicles, presents unique challenges that require the deployment of efficient fire suppression systems. Thermal runaway is a critical trigger mechanism in lithium-ion batteries, where an increase in temperature can lead to a self-sustaining exothermic reaction. This phenomenon can be initiated by various factors such as overcharging, physical damage, or manufacturing defects. In a manufacturing plant, thermal runaway can occur due to improper handling, such as dropping batteries, mechanical damage during assembly, faulty battery management systems, or environmental factors like excessive heat. Once thermal runaway occurs in a single cell, it can rapidly propagate to adjacent cells, leading to a cascading failure and potential fire hazards. This can result in significant damage to equipment, production downtime, and safety risks to personnel. In severe cases, thermal runaway can cause large-scale fires, explosions, and the release of toxic gases, posing serious threats to human life and the entire facility. Therefore, understanding and mitigating thermal runaway is crucial in an electric commercial vehicle manufacturing plant to ensure operational safety and efficiency. This paper aims to compare various fire suppression materials and their effectiveness in maintaining fire safety in electric commercial vehicle manufacturing plants. By evaluating different materials, we seek to identify the most suitable options for mitigating fire risks associated with the production of electric commercial vehicles. The findings of this study will provide valuable insights for manufacturers and safety engineers in enhancing fire safety protocols and ensuring a safer working environment
Havaalanlarında Yenilenebilir Enerji Kaynaklarının Kullanımının Sürdürülebilirlik ile İlişkisi
No full textİklim değişikliğinin uluslararası bir sorun olarak gittikçe önem kazanmasıyla beraber Dünyada yenilenebilir enerji kullanımı hakkında araştırmalar artış göstermiştir. Uluslararası ve ulusal girişimlerle iklim değişikliğinin sıcaklık artışı etkisi sabit tutulmaya ve azaltılmaya çalışılmaktadır. Özellikle fosil yakıt kullanımının azaltılması yöntemlerinin geliştirildiği söz konusu çalışmalarda yenilenebilir enerji kaynaklarının artırılması ve yenilenebilir enerji kullanımının artırılması çabaları öne çıkmaktadır. Havacılık sektörü iklim değişikliğini azaltma çabalarında öne çıkan sektörlerden biridir. Hava taşımacılığının öne çıkan sektör olmasının sebeplerinden biri önemli bir karbon emisyon kaynağı olmasıdır. Hava taşımacılığında yer alan tüm paydaşlar karbon salınımında ve sera gazı üretiminde aynı kirlenmeyi yaratmaz. Hava taşımacılığı sektöründe yer alan paydaşlardan havayolu işletmeleri ile havaalanları en büyük kirleticilerdir. Havaalanları bu noktada yenilenebilir enerji kullanımı ile kirletme potansiyeli azalacak yapılardır. Uluslararası havaalanlarının bu doğrultuda enerji kullanım miktarları, fosil yakıt kullanımları, doğrudan ve dolaylı emisyon üretim miktarları yıllardır incelenmekte ve azaltım için eylem planları geliştirilmektedir. Çevresel sürdürülebilirlik kavramı kıt kaynakların azalması ile sonraki nesillerin kendilerinden önceki neslin imkanlarına temiz şekilde sahip olamaması anlamına gelmektedir. Bu kapsamda yenilenebilir enerji kaynakları sürdürülebilirlik kavramı ile yakından ilişkilidir. Bu bilgiler ışığında bu çalışmanın amacı; havaalanlarında kullanılabilecek yenilenebilir enerji kaynaklarını saptamak, havaalanlarının yenilenebilir enerji kullanımı ve enerji verimliliği politikalarını incelemek ve bu enerji kaynaklarının sürdürülebilirliğe etkilerini incelemektir.As climate change becomes increasingly important as an international problem, research on renewable energy use in the world has increased. International and national initiatives are trying to keep the temperature increase effect of climate change constant and reduce it. In these studies, where methods for reducing fossil fuel use are developed, efforts to increase renewable energy sources and renewable energy use are prominent. The aviation sector is one of the prominent sectors in efforts to reduce climate change. One of the reasons why air transportation is a prominent sector is that it is a significant source of carbon emissions. Not all stakeholders in air transportation create the same pollution in carbon emissions and greenhouse gas production. Among the stakeholders in the air transportation sector, airline companies and airports are the biggest polluters. At this point, airports are structures whose pollution potential will decrease with the use of renewable energy. In this direction, the energy usage amounts, fossil fuel usage, direct and indirect emission production amounts of international airports have been examined for years and action plans are developed for reduction. The concept of environmental sustainability means that the next generations cannot have the opportunities of the previous generations in a clean way due to the decrease in scarce resources. In this context, renewable energy sources are closely related to the concept of sustainability. In light of this information, the purpose of this study is to determine the renewable energy sources that can be used in airports, to examine the renewable energy use and energy efficiency policies of airports, and to examine the effects of these energy sources on sustainability