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Organic rankine cycle driven waste heat utilization for electricity generation and digestate drying in a biogas plant
No full textThis study evaluates the use of waste heat from a cogeneration unit for electricity generation via an Organic Rankine Cycle (ORC) and for on-site digestate drying into fertilizer, based on real operational data from a biogas plant in Kocaeli, Türkiye. The integrated ORC-dryer system was analyzed and an electrical output of 39.10 kWe was achieved with an electrical efficiency of 15.42 % using cyclopentane as the working fluid. Cyclopentane demonstrated the highest electricity production at lower condenser temperatures, whereas at elevated condensation temperatures typical of cogenerative applications hexane and MM (hexamethyldisiloxane) showed superior cycle performance. Electrical efficiency of the plant increased from 38.63 % to 40.73 %, while its exergy efficiency improved from 37.03 % to 39.10 %. A contact-type dryer was used for digestate drying and a specific energy consumption of 3915 kJ/kg Water was observed. Considering both electricity and fertilizer sales, the maximum total daily revenue of 124.74/day was attributed solely to electricity sales. In terms of environmental perspective, the analysis revealed that the highest emission savings, amounting to 18369 kg CO2/year, were achieved when cyclopentane was used as the working fluid in combination with a condenser temperature of 90 °C. By integrating novel cascade ORC and paddle dryer system into the biogas plant with design and off-design conditions, additional electricity and fertilizer is produced using waste heat. Even under off-design conditions, this integration enhances the plant’s efficiency and profitability, improves its overall feasibility and contributes to a reduction in CO2 emissions
Comment on 'comparative analysis of artificial intelligence platforms in generating post-operative instructions for endoscopic transnasal skull base surgery'
No full textComment on: “Assessing AI-generated patient leaflets on descemet membrane endothelial keratoplasty”
No full textPolysaccharide-functionalized gold, silver, and iron oxide nanoparticles for siRNA delivery: The role of artificial intelligence in design and optimization
No full textPolysaccharide-functionalized metallic nanoparticles (MFNPs), including gold (Au), silver (Ag), and iron oxide (Fe3O4), have emerged as promising nanocarriers for small interfering RNA (siRNA) delivery in cancer nanomedicine. Functionalization with polysaccharides enhances their biocompatibility, targeting capability, and therapeutic efficacy. This review provides a comprehensive overview of the design, mechanisms, and applications of polysaccharide-functionalized Au, Ag, and Fe3O4 nanoparticles as siRNA delivery vehicles, emphasizing the integration of Artificial intelligence (AI) for their optimization in cancer therapy. We systematically explore the types of metallic nanoparticles used, their functionalization strategies with various polysaccharides, and the mechanistic pathways involved in siRNA delivery. We further highlight the role of AI and machine learning (ML) in predicting nanoparticle stability, improving siRNA loading and release, enhancing targeting precision, and enabling personalized nanomedicine approaches. Polysaccharide-coated MFNPs demonstrate improved siRNA protection, cellular uptake, endosomal escape, and gene silencing efficiency. AI-driven facilitate the rational design of nanocarriers by predicting physicochemical properties, biological interactions, and patient-specific responses. Preclinical and emerging clinical evidence support their potential as next-generation cancer therapeutics. Polysaccharide-functionalized Au, Ag, and Fe3O4 nanoparticles, empowered by AI-based optimization, represent a cutting-edge strategy for siRNA delivery in cancer nanomedicine. Future research should focus on translating these nanocarriers into clinical applications through multidisciplinary collaboration and advanced computational tools
Real-World Survival Outcomes Following Metastasectomy in RAS Wild-Type mCRC: Insights from a Multicentre National Cohort Study
No full textBackground: Metastasectomy is a cornerstone of multimodal management in metastatic colorectal cancer (mCRC), yet contemporary real-world data focusing specifically on RAS wild-type (RAS-WT) disease remain limited. We aimed to evaluate survival outcomes and prognostic factors associated with metastasectomy in patients with RAS-WT mCRC using a large national multicentre registry. Methods: This retrospective cohort study utilized data from the ONKO-KOLON Türkiye registry. A total of 1079 patients with pathologically confirmed KRAS/NRAS wild-type mCRC were identified and categorized according to receipt of metastasectomy. Overall survival (OS) and progression-free survival (PFS) were estimated using the Kaplan–Meier method and compared with log-rank tests across multiple clinically relevant time origins, including metastatic diagnosis, initial colorectal cancer diagnosis, and time of metastasectomy. Prognostic factors within the metastasectomy cohort were assessed using univariate Cox proportional hazards models. Serum CEA and CA19-9 were analyzed after log10 transformation. Results: Among 1079 patients, 185 (17.1%) underwent metastasectomy. Patients receiving metastasectomy demonstrated significantly longer OS compared with those managed non-surgically when survival was calculated from the time of metastatic diagnosis (hazard ratio [HR] for death 0.36, 95% CI 0.27–0.47; p < 0.001), as well as improved PFS (HR for progression or death 0.39, 95% CI 0.30–0.52; p < 0.001). The survival advantage remained consistent when OS was measured from the time of initial colorectal cancer diagnosis (HR 0.37, 95% CI 0.25–0.50; p < 0.001). Median OS following metastasectomy was 43 months (95% CI 31.4–45.6). In univariate analyses within the metastasectomy cohort, higher baseline CA19-9 levels were significantly associated with inferior OS when analyzed both as a continuous variable (per log10 increase; HR 1.81, 95% CI 1.20–2.75; p = 0.005) and as a categorical variable (above vs. below threshold; HR 0.37, 95% CI 0.16–0.86; p = 0.021). Other clinicopathologic factors, including age, CEA, tumor sidedness, grade, MSI status, and metastatic burden, were not significantly associated with survival. Conclusions: In this large, real-world national cohort of RAS-WT mCRC, metastasectomy was strongly associated with prolonged survival across multiple clinically relevant time frames. Within surgically treated patients, baseline CA19-9 emerged as the most informative prognostic marker, while traditional clinicopathologic variables showed limited discriminatory value. These findings highlight the importance of careful patient selection and support further prospective studies integrating molecular and biomarker-based strategies to refine prognostication and optimize surgical decision-making in RAS-WT mCRC
Reply to Letter to the Editor: “Rethinking Risk Stratification in Emergency Department Patients with Nonsustained Atrial Fibrillation”
No full textPerceived Organizational Support and Psychological Empowerment as Determinants of Emotional Labor in the Call Center Context
No full textThe purpose of the current research is to address the mediating role of psychological empowerment (PE) in the effect of perceived organizational support (POS) on emotional labor (EL). Drawing upon Social Exchange Theory and the Job Demands–Resources (JD–R) framework, this study highlights the ways in which external organizational resources and internal motivational processes jointly influence employee behavior in emotionally challenging work settings. Data were obtained via a questionnaire distributed to 200 call center employees employed in a customer service organization in Turkey, using a convenience sampling technique. Partial Least Squares Structural Equation Modeling (PLS-SEM) was applied for data analysis, utilizing SmartPLS version 4. The research results revealed that POS positively impacts deep emotional labor (deep acting). Additionally, POS positively influenced psychological empowerment dimensions that are meaning, self-determination, and impact. In turn, the meaning and self-determination dimensions were found to have a positive impact on deep emotional labor (deep acting). Moreover, the meaning facet of psychological empowerment played a partial mediation role in the association between POS and deep acting. These results suggest that psychological empowerment, alongside POS, may be an intrinsic motivator in shaping EL strategies within emotionally intensive service environments. In other words, employees’ perceptions of organizational resources activate not only external support mechanisms but also internal processes of meaning-making and autonomy, which in turn shape their emotional regulation strategies
EXAMINATION OF GENDER EQUALITY INDICATORS THROUGH DATA ANALYSIS: EVALUATION OF THE RELATIONSHIPS BETWEEN EDUCATION, HEALTH, AND ECONOMIC PARTICIPATION’
No full textABSTRACT It incorporates norms and expectations stemming from gender, cultural, and social statuses. However, gender differences are not only biological but also social and cultural. Hearing, these differences and opportunity drink the cups of direction to heal hearing and justice. The unemployment rate is caused by a number of factors. Unemployment is a complex economic, social and political problem. The gender ratio is determined by many factors such as unemployment, the economic situation of the country, employment policy, education system and gender roles. As a result, women are less likely to be employed than men and women are more likely to be unemployed. There could be a number of factors. There can be hypocritical barriers to access to educational opportunities and advantages in the workplace among women. Family restraints, gender discrimination and stereotypes also contribute to women's abduction and abduction. Women's labor force participation and job positions are one of the main indicators of the deterioration of the environment in a country. The social equality index will contribute to the integration of countries into the economy and the promotion of social justice. This index helps to understand how open a country is to the social world and how it interacts with other countries. The World Security Report is a report prepared by the United Nations to assess the security situation in developing countries. The report was first released in 2012 and is published annually to analyze the state of security in the world. The Curecel Index of Independence ranks countries by independence using different factors. In this study, the existing data networks have investigated whether unemployment, female and male unemployment in 10 countries have been compared to the independence index and the social integration index. cells were selected from migrated cells, less migrated cells, and cells in migration. It was found that the cells of the unemployment rate among women were similar to the independence index. It was confirmed that the increase in unemployment lowered the social standard of the countries. (The version of this study is available from www.theglobaleconomy.com.) Key Words: Unemployment Location, Gender Gap, Index of Independence, Social Struggle Index. </p
Production of an alternative fuel bioadditive glycerin carbonate by a green catalytic membrane and investigation of fuel properties
No full textGlycerin carbonate (GLC), a fuel bio-additive, was produced from glycerin using a functional composite catalytic membrane. The Zeolite-containing catalytic membrane (PVA/CL/KOH) consists of potassium hydroxide as a catalyst, clinoptilolite as a zeolite support, and polyvinyl alcohol as a polymer matrix. FTIR, TGA, and SEM analyses were used to examine changes in the catalytic membrane's chemical structure, thermal stability, and morphology after addition of clinoptilolite and potassium hydroxide. The total surface area and pore-size distribution of the clinoptilolite sample were determined by BET analysis. The influence of parameters such as reaction temperature, catalyst amount, initial molar ratio of dimethyl carbonate to glycerin (M), and reaction time was investigated in batch reactors. A maximum reaction yield of 72.81% was achieved under reaction conditions of 85 degrees C, a catalyst ratio of 11.25%, a molar ratio of M = 4:1, and a reaction time of 2 h. Reusability tests showed an increase in GLC yield on the second use. An 11.3% loss of activity was observed by the fourth use. Additionally, to investigate fuel properties, GLC was blended with biodiesel at 1, 3, and 5 wt%, and density, kinematic viscosity, flash point, higher heating value, and cold filter plugging point were measured. The flash point of the fuel has been improved. GLC is a promising candidate for improving storage and transportation safety and environmental performance