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Meta-Analysis of Effectiveness of Pedagogical Innovations Involving Technology in Organic Chemistry Education in Developing Students’ Academic Performance
No full textABSTRACT: Because organic chemistry asks students to usevisual and spatial thinking skills (e.g., three-dimensional structuresof molecules) and comprehend various chemical reactions andmechanisms, it naturally needs pedagogical innovations involvingtechnology to result in better academic performance. However,none of the previous studies has investigated the extent to whichthese pedagogical innovations are effective in improving students’academic performance of organic chemistry education. This studyaims to meta-analytically assess the effectiveness of the pedagogicalinnovations involving technology in organic chemistry education indeveloping students’ academic performance. The current metaanalysis handled 26 studies as the corpus of the data retrieved fromthe database and manual search. The authors initially coded thestudies via a template form and inserted all statistical data from a Microsoft Excel sheet into Comprehensive Meta-Analysis (CMAV2) statistics software to calculate Hedges’ g for the corpus data. The findings pointed to the large effect for the overall effect size (g= 0.973). Also, it was found that only subgroups for the use of technological tools within the moderator variable “type of pedagogicalinnovations involving technology” played a significant role at predicting the students’ academic performance as a result of thetreatments. In light of the findings, it can be inferred that the pedagogical innovations involving technology in organic chemistryeducation are more effective and fruitful in developing the students’ academic performance than nontechnology-based controlgroups. Further, the current meta-analysis study concludes that high school (for educational level), flipped classroom (for thepedagogical models including technology), digital media (for the use of technological tools), and short-term treatment (forimplementation duration) act as the most effective variables to learn organic chemistry via the pedagogical innovations. Futureresearch should focus on other individual and moderator variables to offer more adaptive alternatives for the use of chemistryteachers and lecturers</p
Chitosan nanoplatforms as carriers for photodynamic and photothermal therapies in cancer, wound healing, and antimicrobial applications
No full textChitosan (CS)-based nanoplatforms have emerged as transformative tools in photodynamic (PDT) and photothermal (PTT) therapies, offering targeted, biocompatible solutions for cancer treatment, wound healing, and antimicrobial applications. Recent advancements include the design of multifunctional CS nanocomposites that enhance photosensitizer delivery, improve light-triggered efficacy, and enable synergistic therapies with reduced side effects. These developments address critical challenges in precision medicine, such as drug resistance and tissue regeneration, making this area of significant interdisciplinary interest. The tunable physicochemical properties of CS, combined with its biodegradability and antimicrobial activity, position it as a key material for next-generation therapeutic platforms. The future of this field depends on optimizing nanoplatform specificity, scalability, and clinical translation, with insights from this review guiding the rational design of advanced biomaterials. This review aims to provide a comprehensive overview of the recent advancements in CS-based nanomaterials specifically for PTT and PDT, while also addressing the associated challenges that hinder their clinical application. Moreover, it aims to highlight future perspectives that could enhance the effectiveness and applicability of chitosan-based therapies in cancer treatment
Therapeutic Potential of the ApoE-Mimicked Peptide COG133: Regulation of miRNA146-a in Diabetic Fibroblasts and Antibacterial Activity
No full textCOG133, an apolipoprotein E-derived mimetic peptide, has been proposed as a therapeutic candidate due to its immunomodulatory properties. Its potential role in diabetic wound healing, where impaired fibroblast function and chronic inflammation are major obstacles, remains largely unexplored. In this study, human diabetic dermal fibroblasts were treated with COG133 to evaluate its effects on cell viability, migration, and gene expression of ApoE, miR-146a, NF-kappa B, TRAF-6, and IL-6. In addition, the antibacterial and antibiofilm activities of COG133 were assessed against Gram-positive and Gram-negative bacteria. COG133 enhanced fibroblast migration without affecting viability, upregulated miR-146a, and reduced IL-6 and ApoE expression, while NF-kappa B and TRAF-6 remained unchanged. Antibacterial assays revealed inhibitory effects, with the lowest MIC against Chromobacterium violaceum, and a 55% reduction in Pseudomonas aeruginosa PAO1 biofilm formation. These results suggest that COG133 modulates inflammatory signaling and exhibits antibacterial properties, highlighting its therapeutic potential in supporting wound healing in diabetes
Real-World Evaluation of the HELPP Score and CALLY Index for Preoperative Prognostic Stratification in Resectable Pancreatic Ductal Adenocarcinoma
No full textThe Urostomy Care Skills Evaluation Tool: A scale development study
No full textAim: This study was designed and implemented to develop a tool for evaluating the steps involved in urostomy care. Background: Providing effective urostomy care requires the acquisition of specific clinical skills. However, nursing education lacks standardized tools to assess these skills. Design: Methodological study. Method: This research was conducted at a nursing faculty in Istanbul from May–June 2023. The sample consisted of 140 nursing student enrolled in a surgical nursing course who met the inclusion criteria. Data for the study were collected via the “Personal Information Form,” which consists of 10 questions about individual characteristics such as age, gender, academic performance and perspectives on the nursing profession and the “Urostomy Care Skills Evaluation Tool,” a 28-step tool developed on the basis of the literature. Results: After the items for the evaluation tool were created, feedback was obtained from 10 experts and the content validity index was found to be sufficient (CVI: 0.978). The consistency among independent observers evaluating the tool's items was statistically significant and high (ICC: 0.995; p < 0.001). The test-retest reliability of the tool also showed high consistency. Conclusion: The Urostomy Care Skills Evaluation Tool provides initial evidence of content validity and reliability for assessing urostomy care performance among nursing students in a simulation-based educational setting. The tool appears useful for evaluating training outcomes in undergraduate nursing education. However, further validation studies conducted in clinical settings and involving practicing nurses and caregivers are needed before broader applicability can be established
LaCuFe mixed metal oxide as catalyst for degradation of refractory pollutants from water by hybrid ultrasonic/peroxymonosulfate process
No full textRefractory organic pollutants (ROPs) pose a significant challenge to water treatment because of their persistence and toxic effects on aquatic environments. Here, we developed a hybrid ultrasonic/peroxymonosulfate process using LaCuFe mixed metal oxide (MMO) derived from an LDH precursor by co-precipitation method, followed by calcination . The absence of LDH peaks in the X-ray diffraction (XRD) analysis of the calcined product revealed that the LDH structure collapsed and a new mixed metal oxide was formed. High-resolution transmission electron microscopy images revealed clear lattice fringes indicative of distinct metal oxide phases. The sonocatalytic activity of the LaCuFe MMO was determined in the degradation of phenazopyridine (PHP) under varying operational parameters, including catalyst dosage, PMS concentration, US power, solution pH, and PHP concentration. PMS alone achieved 21.8% removal, US alone 17.0%, and LaCuFe MMO adsorption 25.9%, while the binary US/PMS system yielded 32.3%. In contrast, the hybrid LaCuFe/US/PMS process achieved 81.2% degradation with a synergy factor of 2.48, confirming a strong non-additive enhancement. Radical scavenging tests confirmed that SO₄•⁻, O2•⁻, and h+ played a role in the PHP degradation. LC-MS analysis identified several transformation products of PHP, and ECOSAR predictions indicated the process could reduce the toxicity. Additionally, the process showed high performance in removing five alternative pollutants, including rhodamine B, pymetrozine, rifampicin, tetracycline, and levofloxacin. Catalyst reusability tests showing stable performance over multiple cycles and the effectiveness of the process at treating types of organic pollutants support the practical applicability of the process
Inverse Electrocaloric Properties of P(VDF‐TrFE) and P(VDF‐TrFE)/BZCT Composites: Temperature and Field Dependence
No full text This study investigates the electrocaloric effect (ECE) in a poly(vinylidenefluoride‐trifluoroethylene) (P(VDF‐TrFE) (70/30)) copolymer, as well as and its 0–3 composites with containing 10 and 20 vol% of Ba(Ca, Zr, Ti)O 3 (BZCT) as ceramic fillers, including a ternary variant with 2 vol% of polyaniline (PANI). The films were prepared by solution casting and characterized by using X‐ray diffraction (XRD), Fourier‐transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), dielectric measurements, and polarization‐electric (P–E) hysteresis loops. Indirect ECE analysis revealed negative adiabatic temperature changes (Δ T ), peaking at −11 K at 25°C for pure P(VDF‐TrFE), −4.5 K at 75°C for 10 vol% BZCT, and −9.0 K at 60°C for 10 vol% BZCT/PANI under 1200 kV/cm electric fields of 1200 kV/cm. The observed shifts in peak Δ T are attributed to thermal hysteresis, interfacial polarization, strain‐mediated coupling, and the conductivity‐enhancing charge mobility of PANI. These lead‐free composites demonstrate the potential for energy‐efficient and, compact cooling technologies. </jats:p
New Simpson type inequalities for convex functions via conformable fractional integrals
No full textThis study proves equality for differentiable functions involving the conformable fractional integrals. Using the established identity, we offer new Simpson type inequalities for convex functions via conformable fractional integrals. We also consider some special cases which can be deduced from the main results
Effect of Intercritical Annealing Temperature on the Final Microstructure and Mechanical Properties in a Hot-Rolled TRIP-Aided Multiphase Steel
No full textAdvanced high-strength steels (AHSS), especially TRIP (transformation-induced plasticity) steels, are developed to meet the automotive industry's increasing demand for lightweight, fuel-efficient, and crash-resistant materials. This study provides a comprehensive investigation into the production of hot-rolled TRIP steel, starting with the thermomechanical control processing (TMCP) and extending through to isothermal treatment. A hot-rolled TRIP steel (Fe–0.17C–1.53Si–1.47Mn–0.06Nb wt%) was produced by two cooling schedules that involved intercritical annealing and isothermal treatment. Intercritical annealing is considered a crucial step in the production of TRIP steels. The volume fraction of austenite and the multiphase microstructure are influenced by the intercritical annealing temperature. As a result, intercritical annealing was carried out at two different temperatures, 790 °C and 830 °C, followed by an isothermal treatment at 450 °C for 30 min. The transformation from the coarse and inhomogeneous ferrite–pearlite microstructure to a multiphase microstructure, consisting of ferrite, bainite, and retained austenite, after hot rolling was investigated using LM, SEM, EBSD, and XRD. With the increase in intercritical annealing temperature, the volume fraction of ferrite decreases. Hardness and tensile tests were performed after hot rolling and heat treatments. After intercritical annealing at 830 °C and isothermal treatment at 450 °C, the tensile strength reached approximately 800 MPa, elongation was 25%, and PSE was 20 GPa%, indicating an optimized balance of strength and ductility
