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YENİLENEBİLİR ENERJİ KAYNAKLARININ HİBRİT KÜRESEL BULANIK ÇOK KRİTERLİ KARAR VERME YÖNTEMLERİ İLE DEĞERLENDİRİLMESİ: İSTANBUL ÖRNEĞİ
No full textA holistic approach to climate change in the emergency department: Direct impact of environmental factors on patients
No full textEvaluation of the associations of adherence to the MIND and mediterranean diets and the dietary inflammatory index on the age of migraine onset and disability in patients with migraine
No full textAim: This study aimed to evaluate the associations of adherence to the MIND and Mediterranean diets, as well as the dietary inflammatory index (DII), on the age of migraine onset and the disability among patients diagnosed with migraine with aura, migraine without aura, and chronic migraine. Methods: This observational case–control study was conducted from 1 June to 30 September 2023, involving a total of 144 adult participants. The cohort included 84 newly diagnosed migraine patients, categorized as 45 without aura, 21 with aura, and 18 with chronic migraine, alongside a control group of 60 healthy individuals. Data were collected through a general information questionnaire, adherence scores to the MIND and Mediterranean diets, and the DII. Additionally, the patient group completed a migraine diagnosis form and the Migraine Disability Assessment Scale (MIDAS). Results: Both in univariate and multivariable analyses, both low and moderate adherence are associated with increased odds compared to high adherence. In multivariable analyses, low adherence to the MIND diet increases the odds of migraines by 8.18 times (95% CI = 1.49-44.75), while moderate adherence increases them by 5.29 times (95% CI = 1.32-21.12). Low adherence to the MEDAS (OR = 9.90; 95% CI = 3.08-31.77) also shows a strong association with migraine in univariate analysis, but this association weakens in the multivariable analysis (OR = 3.14; 95% CI = 0.70-13.98). Higher quartiles (Q2-Q4) to DII were initially associated with migraines in univariate analysis but were not significant in multivariable analysis. Moreover, among the variables analyzed, chronic migraine shows a strong and significant association with MIDAS score compared to migraine without aura (β = 0.54, p < 0.001). However, MEDAS and DII do not meet the significance threshold for MIDAS. Only MIND is significantly associated with the age at migraine diagnosis (β = 0.38, p = 0.044). Conclusion: The findings suggest that dietary patterns play a crucial protective role for patients with migraine. Nonetheless, further longitudinal studies with larger sample sizes are warranted to elucidate the relationship between dietary patterns, the onset of migraine, and the frequency and severity of migraine attacks
Psychometric evaluation of the Turkish version of the Beverage Intake Questionnaire-15
No full textBackground/objectives: Overweight and obesity remain major unresolved public health issues. One contributing factor to the increasing prevalence of obesity is the rising consumption of sugar-sweetened beverages (SSBs), which are a key source of added sugars and excess energy in the diet. Therefore, accurate assessment of beverage intake has become increasingly important for both research and public health interventions. This study aimed to evaluate the validity and reliability of the Turkish version of the Beverage Intake Questionnaire-15 (BEVQ-15) in adults. Methods: A total of 141 adults aged 18–65 years who applied to a private nutrition clinic were included. Data were collected at three time points (T1, T2, T3) through face-to-face interviews. At each time point, participants completed the BEVQ-15 and a 3-day food record. Validity and reliability were evaluated using Spearman correlations, intraclass correlation coefficients, Kendall’s W, and Bland–Altman analyses. Results: Spearman correlations between BEVQ-15 and food records ranged from 0.26 to 0.96 across beverage categories, with the majority of categories demonstrating correlations of 0.50 or higher. Test–retest reliability was excellent for water (ICC = 0.94), moderate for diet beverages (ICC = 0.70), and total SSBs (ICC = 0.65). Bland–Altman analysis showed that 87% of beverage categories achieved ≥95% agreement within the limits of agreement. Conclusion: These findings indicate that the Turkish version of the BEVQ-15 is a valid and reliable instrument for assessing beverage consumption among adults
Aromatic secondary metabolite interactions with nickel-dependent urease
No full textAromatic secondary metabolites, hydroxybenzoic acids (HBAs)-beta-resorcylic (2,4-dihydroxybenzoic acid) and gallic acid (3,4,5-trihydroxybenzoic acid)-constitute a class of phenolic compounds with numerous bioactivities that are of pharmacological and therapeutic interest. Urease plays a critical role in various biological pathways, with its activation linked to medical conditions including nephrolithiasis and peptic ulcers. The pursuit of potent and safe urease inhibitors has become a key priority in the field of pharmaceutical research. The present study sought to explore the molecular interactions between HBAs and urease to better understand their binding behavior. To assess the impact of both HBAs on the structural integrity and enzymatic activity of urease, fluorescence spectroscopy, FTIR, and molecular docking were utilized. Both HBAs quenched urease fluorescence through static mechanisms and bound favorably to the Ni2+-centered catalytic site. In silico ADME and toxicity profiling confirmed their drug-likeness and low predicted toxicity. Gallic acid exhibited stronger antioxidant and urease inhibition activity than beta-resorcylic acid, highlighting the importance of hydroxyl substituents in radical scavenging. These findings suggest HBAs as promising natural scaffolds for developing dual-function urease inhibitors with antioxidant potential
Enhancing Some Inequalities via Fractional Extended Riemann–Liouville Integrals: Jensen–Mercer Perspective
No full textThis paper aims to derive novel forms of trapezoid and midpoint inequalities within the context of fractional extended Riemann–Liouville integrals (FERLIs). The approach relies on the foundational Jensen–Mercer inequality to develop the arguments. Central to the development are several identities involving FERLIs and (Formula presented.) -convex functions that form the basis of the obtained results. Relationships with earlier studies concerning both classical and extended Riemann–Liouville fractional integrals are examined
DETERMINATION OF PREMENSTRUAL SYNDROME FREQUENCY AND RELATED FACTORS IN ADOLESCENTS: THE CASE OF KAHRAMANMARAŞ PROVINCE
No full textExamining Gender Differences in the Force Concept Inventory (FCI) in a Turkish Context: Accuracy, Confidence and Bias Score Comparisons
No full textGreen Energy and Technology
No full textIn Turkey, fossil fuels have a 90% share in total primary energy consumption, while 80% of fossil fuel consumption is met through imports. This amount, which is a clear indicator of the external dependence on Turkey in terms of energy, can be reduced by utilising local resources. Therefore, using waste wood material, one of the existing renewable energy sources, in existing thermochemical systems, would reduce the country’s energy dependence on foreign energy, and CO2 emissions, one of the most important greenhouse gases, would be reduced. The current study aims to determine how the origin of the waste wood comes from different waste streams and how it affects the combustion behaviour of the wood. Five different waste wood samples from five different sources were analysed using TGA for combustion behaviour analysis
Epidemiological profile and clinical outcomes of patients with mucormycosis: the multicenter retromucor study from Türkiye (2004–2024)
No full textPurpose: Mucormycosis is a rapidly progressive angioinvasive fungal infection with limited large-scale outcome data. We aimed to describe the epidemiology, clinical spectrum, treatment strategies, and predictors of outcomes in adult patients with proven mucormycosis in Türkiye. Methods: We conducted a nationwide, retrospective study of 280 adults diagnosed with proven mucormycosis between 2004 and 2024 across 27 tertiary centers. Case definitions were applied according to the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clinical characteristics, antifungal management, surgical interventions, and outcomes were systematically analyzed. Results: The median age of the cohort was 60 years, and diabetes mellitus, frequently complicated by ketoacidosis, was the most common underlying condition. Rhino-orbital-cerebral disease represented the predominant clinical form, whereas pulmonary, gastrointestinal, and disseminated presentations were less frequent but carried less favorable prognoses. Liposomal amphotericin B was the main first-line therapy, often combined with surgery, although antifungal treatment was initiated at a median of five days after symptom onset. Ninety-day mortality was 42.1% by Kaplan–Meier estimation (crude 49.3%) and reached 49.3% (crude 55.0%) at 365 days. Crude mortality was lowest in patients who did not undergo surgery; however, this association was not significant in the time-dependent Cox regression analysis, suggesting confounding by baseline severity. Poor outcomes were associated with corticosteroid exposure, prolonged neutropenia, and neurological manifestations, while a history of sinusitis appeared to be associated with improved survival. Conclusion: In this multicenter study, survival was mainly determined by host-related factors rather than the choice of antifungal agent. Corticosteroid exposure, prolonged neutropenia, and neurological involvement independently predicted poor outcomes, whereas a prior history of sinusitis was linked to improved survival, likely reflecting earlier diagnosis and intervention. These findings reinforce the need for heightened clinical awareness, rapid recognition, and prompt multidisciplinary management to improve outcomes in patients with mucormycosis