Czasopisma Uniwersytetu Przyrodniczy w Lublinie
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The evaluation of patients with 24-HOUR RYTHM holter monitoring in the pediatric cardiology unit
No full textAmaç: Bu çalışma, 24 saatlik Ritim Holter monitörizasyonunun ( HM) çocuk hastaların tanı ve tedavisindeki değerini belirlemeyi amaçlamaktadır. Kliniğimizde 24 saatlik Ritim Holter monitörizasyonunun hangi endikasyonlar için yapıldığı ve sonuçları gözden geçirilmiştir. Gereç ve Yöntem: 01 Ocak 2015 ile 31 Aralık 2022 tarihleri arasında kliniğimize başvuran 1670 hastanın dosyaları geriye dönük olarak tarandı. Yaş, cinsiyet, başvuru nedeni, kardiyak hastalık varlığı, ailede kardiyak hastalık varlığı, tedavi öyküleri, aile akraba evlilikleri, EKG bulguları, EKO bulguları ve HM bulguları geriye dönük hastane bilgisayarı arşiv dosyalarından değerlendirilerek kaydedildi. Bulgular: Hastaların 870'i erkek (%52,1), 800'ü kız (%47,9) idi. Hastaların yaş gruplarına göre baktığımızda 0-1 yaş 49 hasta (%2.9), 2-5 yaş 120 hasta (%7,2), 6-12 yaş 671 hasta (%40,2) ve 13-18 yaş 830 hasta (%49,7) olarak saptandı. Kliniğe bir semptom ve/veya yakınma ile başvuran 1457 hastanın başvuru yakınmasına göre; 688 hastada (%41,2) çarpıntı, 370 hastada (%22.2) göğüs ağrısı, 265 hastada (%15,9) Çarpıntı+göğüs ağrısı, 133 hastada (%8) Senkop+Presenkop şikayetleri var idi. Konjenital kalp hastalığı olan 86 hastanın 28'inde (%32,6) Opere FT, 19'unda (%22,1) sekundum ASD, 10'unda (%11,7) VSD, 9'unda (%10,5) opere TGA, 7'sinde (%8,1) opere VSD, 6'sında (%7) transkateter yolla kapatılmış ASD , 3'ünde (%3,5) opere PDA, 2'sinde (%2,3) opere arkus aorta hipoplazisi, 1'inde (%1,2) opere ASD ve 1 kişide (%1,2) de küçük PDA mevcut idi. Holter takibi yapılan hastaların 1005'i (%60,2) normal olarak saptandı, 408 (%24,4) hastada taşiaritmi, 85 (%5,1) hastada bradiaritmi, 73 (%4,4) hastada preeksitasyon sendromu, 27 (%1,6) hastada sağ dal bloğu, 27 (%1,6) hastada atriyum kaynaklı aritmi, 12 (%0,7) hastada genetik kaynaklı aritmi, 12 (%0.7) pace ritmi ve 21 (%1,3) hastada ise farklı diğer holter bulguları saptanmıştır. Tartışma: Çocukluk çağında aritmik semptomların çoğunlukla aralıklı olarak ortaya çıkması nedeniyle, başvuru sırasında tespit edilmesi mümkün olmayabilir. İstirahatte çekilen elektrokardiyografi, kardiyak ritmin kısa bir dönemi için bilgi vermekte ve birçok ritm bozukluğu atlanabilmektedir bu nedenle tanı için 24 saatlik holter yönteminin yararlı olduğu düşünülmektedir. Giderek artan sıklıkta kullanılan HM'nin aritmi tanısında, aritmisi olan vakaların izlem ve tedavisinin planlanmasında uygulanması kolay, noninvaziv bir yöntem olarak son derece yararlı olduğu çalışmamızca desteklenmiştir. Anahtar Kelimeler: 24 saatlik ritm holter monitörizasyonu, aritmi, çocuk.Objective: This study aims to determine the value of Holter monitoring(HM) in the diagnosis and treatment of pediatric patients. İndications for 24-hour Rhytm Holter monitoring in our clinic and its results are reviewed. The indications for HM were reviewed. Materials and Methods: The files of the patients who applied to our clinic between January 01, 2015 and December 31, 2022 were retrospectively scanned. Age, gender, reason for admission, presence of cardiac disease, presence of cardiac disease in the family, treatment histories, family consanguineous marriages, ECG findings, ECHO findings and HM findings were retrospectively evaluated from hospital computer archive files. Results: Of the patients, 870 (52.1%) were boys and 800 (47.9%) were girls. Considering the age groups of the patients, 49 patients (2.9%) aged 0-1, 120 patients aged 2-5 years (7.2%), 671 patients aged 6-12 years (40.2%), and 830 patients aged 13-18 years (%) 49.7). According to the complaint of 1457 patients who applied to the clinic with a symptom and/or complaint; Palpitations were present in 688 patients (41.2%), chest pain in 370 patients (22.2%), palpitation and chest pain in 265 patients (15.9%), syncope or presyncope in 133 patients (8%). Operated FT in 28 (32.6%) of 86 patients with congenital heart disease, secundum ASD in 19 (22.1%), VSD in 10 (11.7%) and 9 (10.5%) operated TGA, 7 (8.1%) operated VSD, 6 (7%) transcatheter closure ASD, 3 (3.5%) operated PDA, 2 (2.3%) operated arch aortic hypoplasia, 1 (1.2%) operated ASD, and 1 (1.2%) small PDA. It was found to be normal in 1005 (60.2%) of Holter follow-up patients, tachyarrhythmia in 408 (24.4%), bradyarrhythmia in 85 (5.1%) patients, preexcitation syndrome in 73 (4.4%) patients, 27 ( Right bundle branch block in 1.6%, atrial origin arrhythmia in 27 (1.6%) patients, genetic arrhythmia in 12 (0.7%) patients, 12 (0.7%) pace rhythm and other holter findings were detected in 21 (1,3%) patients. Discussion: Due to the intermittent occurrence of arrhythmic symptoms in childhood, it may not be possible to detect them at presentation. Electrocardiography taken at rest gives information for a short period of cardiac rhythm and many rhythm disorders can be missed. Therefore, the Holter method is thought to be useful for diagnosis. It has been supported by our study that it is an easy-to-apply, non-invasive method in the diagnosis of HM arrhythmia, which is increasingly used, and in planning the follow-up and treatment of cases with arrhythmia. Keywords: 24-hour rhythm holter monitoring, arrhythmia, children
A New Gene Therapy Approach by Tenascin-C Genome Editing Induces Apoptosis and Cell Cycle Arrest in Triple- Negative Breast Cancer Cells
No full textBACKGROUND/AIMS: There is a pressing need for new therapies for the most aggressive subtype of breast cancer, triple-negative breast cancer (TNBC). Tenascin-C (TN-C) codes for a tumor microenvironment-specific protein, which promotes apoptosis evasion and cell proliferation. The aim of this study was to knock down TN-C by using the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system to induce cancer cell apoptosis and stunt cell proliferation, laying the grounds for a new gene therapy approach in TNBC.MATERIALS and METHODS: The human TNBC cell line, MDA-MB-231 cells were transfected by TN-C-specific CRISPR/Cas9 plasmids. TN-C messenger RNA levels were assessed by real-time polymerase chain reaction to determine the knock-down efficiency. Two days after the transfection, the percentage of apoptotic cells and the proportion of cells in cell cycle phases were compared between the treatment and the control groups using flow cytometry. The resultant change in cell proliferation due to the knock-down was determined by MTT assay. RESULTS: Transfection with the TN-C CRISPR/Cas9 plasmid reduced TN-C levels in the cells by approximately 49% relative to the scrambled -control CRISPR/Cas9 transfected cells. This TN-C downregulation increased the percentage of cells in apoptosis and induced G1-phase arrest. The combined effect of apoptosis and cell cycle arrest led to a significant decrease in the number of cancer cells in the treatment group.CONCLUSION: Our successful preliminary study of a potential TNBC gene therapy based on TN-C genome editing by the CRISPR/Cas9 system led to significant decrease in TNBC cell numbers and it justifies the testing of this system in more advanced preclinical studies
Boron stress signal is transmitted through the TOR pathway
No full textAlthough boron is an essential element for many organisms, an excess amount of it can cause toxicity, and the mechanism behind this toxicity is not yet fully understood. The Gcn4 transcription factor plays a crucial role in the boron stress response by directly activating the expression of the boron efflux pump Atr1. More than a dozen transcription factors and multiple cell signaling pathways have roles in regulating the Gcn4 transcription factor under various circumstances. However, it is unknown which pathways or factors mediate boron signaling to Gcn4. Using the yeast Saccharomyces cerevisiae as a model, we analyzed the factors that converge on the Gcn4 transcription factor to assess their possible roles in boron stress signaling. Our findings show that the GCN system is activated by uncharged tRNA stress in response to boron treatment and that GCN1, which plays a role in transferring uncharged tRNAs to Gcn2, is necessary for the kinase activity of Gcn2. The SNF and PKA pathways were not involved in mediating boron stress, even though they interact with Gcn4. Mutations in TOR pathway genes, such as GLN3 and TOR1, abolished Gcn4 and ATR1 activation in response to boric acid treatment. Therefore, our study suggests that the TOR pathway must be functional to form a proper response against boric acid stress.TUBITAK [110T917]Acknowledgments We would like to express our gratitude to C;ag?lar Karakaya for his assistance in this study. This work was supported by TUBITAK grant no. 110T917 (AK)
Effectiveness of performance based budget system in universities: The case of İnönü University
No full textKalkınma planları ve programlarda yer alan politika ve hedefler doğrultusunda kamu kaynaklarının etkili, ekonomik ve verimli bir şekilde elde edilmesi ve kullanılması, hesap verebilirliğin ve malî saydamlığın sağlanması günümüz kamu ekonomilerinde hayati öneme sahiptir. Bu kapsamda kamu malî yönetiminin yapısını ve işleyişini, kamu bütçelerinin hazırlanmasını, uygulanmasını, tüm malî işlemlerin muhasebeleştirilmesini, raporlanmasını ve malî kontrolü düzenlemek amacıyla "Kamu Mali Yönetimi ve Kontrol Kanunu" 01.01.2006 tarihi itibariyle yürürlüğe girmiştir. Bu kanun çerçevesinde uygulamaya konulan "Performans Esaslı Bütçe Sistemi", diğer kamu kurumlarında olduğu gibi üniversitelerde de kamu kaynaklarının kullanımını, idarelerin geleceğe ilişkin misyon ve vizyonlarını oluşturmasına, stratejik amaçlar ve ölçülebilir hedefler saptamasına, performanslarını önceden belirlenmiş olan göstergeler doğrultusunda ölçmesine ve bu sürecin izleme ve değerlendirmesini yapmak amacıyla katılımcı yöntemlerle stratejik plan hazırlamasına dayandırmıştır. Bu araştırmanın temel amacı kamu kurumlarında uygulanan Performans Esaslı Bütçe Sistemini, stratejik plan – bütçe uyumu açısından İnönü Üniversitesi örneği üzerinden incelemektir. Bu amaç doğrultusunda kuramsal çerçeveye göre yazın taraması yapılmış ve çalışmanın teorik kısmı oluşturulmuştur. Araştırmanın kuramsal çerçevesine göre bütçe kavramına ve bütçe hakkının tarihi gelişimine, Türkiye'de stratejik planlama ve performans esaslı bütçelemeye ilişkin bilgilere yer verilmiştir. İnönü Üniversitesinin 2017-2021 dönemine ait stratejik planı ve bütçeleri arasındaki ilişki gerçekleşen veriler üzerinde analiz edilerek araştırma soruları kapsamında değerlendirilmiştir. Araştırma sonucunda kurumun stratejik planı ve bütçe gerçekleşmeleri arasında tespit edilen uyumsuzluklara yer verilerek bu uyumsuzlukların giderilmesine yönelik çeşitli önerilerde bulunulmuştur.Obtaining and using public resources effectively, economically and efficiently in line with the policies and objectives included in development plans and programs, and ensuring accountability and financial transparency are of vital importance in today's public economies. In this context, "Public Financial Management and Control Law" came into force as of 01.01.2006 in order to regulate the structure and functioning of public financial management, the preparation and implementation of public budgets, the accounting, reporting and financial control of all financial transactions. The "Performance Based Budget System", which was put into practice within the framework of this law, allows the use of public resources in universities, as well as in other public institutions, to create the mission and vision of the administrations for the future, to determine strategic goals and measurable targets, to measure their performance in line with predetermined indicators, and to monitor and monitor this process. It was based on the preparation of a strategic plan with participatory methods in order to make its evaluation. The main purpose of this research is to examine the Performance Based Budget System implemented in public institutions in terms of strategic plan - budget harmony, through the example of İnönü University. For this purpose, a literature review was made according to the theoretical framework and the theoretical part of the study was formed. According to the theoretical framework of the research, the concept of budget and the historical development of the right to budget, strategic planning and performance-based budgeting in Turkey are given. The relationship between the strategic plan and budgets of İnönü University for the period 2017-2021 was analyzed on the actual data and evaluated within the scope of research questions. As a result of the research, the incompatibilities identified between the strategic plan of the institution and the budget realizations were included and various suggestions were made to eliminate these inconsistencies
The effect of game and activity based music lesson teaching program on the academic achievement of elementary school students in online education
No full textBu araştırmada, online eğitimde oyun ve etkinlik temelli müzik dersi öğretim programının ilkokul öğrencilerinin akademik başarıları üzerindeki etkisinin ortaya konması amaçlanmıştır. Çalışmada araştırmacı tarafından ilkokul 4. Sınıf Müzik Dersi Öğretim Programı derinlemesine incelenerek programdaki konu ve kazanımlara uygun oyun ve etkinlikler hazırlanmıştır. Uzaktan (online) eğitim sürecinde müzik eğitimi derslerinin hem daha eğlenceli, hemde daha verimli geçmesini sağlayarak, çocuklara müzik dersini sevdirmek ve müzik dersinde kalıcı öğrenmeyi sağlamak için hazırlanan oyun ve etkinlikler, müzik eğitiminde öğrenilmesi hedeflenen kazanımlarla ilgili materyallerden oluşmaktadır. Hazırlanan oyun ve etkinlikler online öğretime uygun şekilde bilgisayar karşısında senkron olarak gerçekleştirilmiştir. Araştırma, yarı deneysel desene göre tasarlanmıştır. Çalışma kapsamında; 10 hafta boyunca süren oyun ve etkinlik temelli uygulamalardan veri toplamak amacıyla "Müzik Dersi Başarı Testi" ve Kişisel Bilgi Formu" kullanılmıştır. Çalışmanın nicel boyutunda sontest kontrol gruplu deneysel desen kullanılmıştır. Yapılan çalışma sonucunda, sontest puanlarına göre uzaktan müzik eğitimi derslerinde kullanılan oyun ve etkinlik temelli uygulamaların öğrencilerin akademik başarıları üzerindeki etkisi istatiksel açıdan değerlendirilmiştir. Araştırmada kullanılan oyun ve etkinlik temelli uygulamaların ilkokul öğrencilerinin akademik başarılarına anlamlı olarak katkı sağladığı sonucuna ulaşılmıştır.In this study, it was aimed to reveal the effect of the game and activity-based music course curriculum in online education on the academic achievement of primary school (Fourth Grade) students. In the study, the researcher examined the primary school 4th grade music course curriculum in depth and prepared games and activities suitable for the subjects and achievements in the program. The games and activities prepared to make music education lessons more fun and more productive in the distance (online) education process, to make children love music lessons and to provide permanent learning in music lessons consist of materials related to the achievements aimed to be learned in music education. The prepared games and activities were carried out synchronously in front of the computer in accordance with online teaching. The research was designed according to a quasi-experimental design.. Within the scope of the study; "Music Lesson Achievement Test" and Personal Information Form" were used to collect data from the game and activity-based practices that lasted for 10 weeks. In the quantitative dimension of the study, posttest control group experimental design was used. As a result of the study, the effect of game and activity-based applications used in distance music education courses on students' academic achievement was statistically evaluated according to posttest scores. The findings were presented in tables and interpreted. At the end of the research, the results obtained from the findings were listed and various suggestions were made in line with the results. It was concluded that the game and activity-based practices used in the study significantly contributed to the academic achievement of primary school students
The percentage of ALK-positive cells and the efficacy of first-line alectinib in advanced non-small cell lung cancer: is it a novel factor for stratification? (Turkish Oncology Group Study)
No full textIntroduction Alectinib is an effective second-generation ALK tyrosine kinase inhibitor (TKI) used in the first-line treatment of patients with advanced ALK-positive NSCLC. Recent studies demonstrated that the percentage of ALK-positive tumor cells in patient groups receiving crizotinib might affect outcomes. This study aimed to investigate whether the percentage of ALK-positive cells had a predictive effect in patients with advanced NSCLC who received first-line Alectinib as ALK-TKI. Materials and methods This retrospective study included patients with advanced-stage NSCLC who received alectinib as a first-line ALK-TKI and whose percentage of ALK-positive cells was determined by FISH at 27 different centers. Patients who received any ALK-TKI before alectinib were not included in the study. Patients were separated into two groups according to the median (40%) value of the percentage of ALK-positive cells (high-positive group >= 40% and low-positive group = 60%, the median PFS was 4.5, 17.1, and 26 months, respectively, and could not be reached in the >= 60% group. Conclusion Our study demonstrated that the efficacy of alectinib varies significantly across patient subgroups with different percentages of ALK-positive cells. If these findings are prospectively validated, the percentage of ALK-positive cells may be used as a stratification factor in randomized trials comparing different ALK-TKIs
Bankruptcy and reorganization in the digital business era
No full textThe arrangement of bankruptcy, which is a critical issue for the debtors whose financial structure has deteriorated, protects the debtors from bankruptcy and enables the creditors to collect their receivables, albeit partially. Although the concordat is intended to protect bona fide debtors and creditors, it can be said that payments not made during the concordat deadlines put the creditors in financial distress and harm the economy at the macro level. In this context, it is necessary to examine the subject in depth to prevent abuse of concordat requests and to obtain better results both legally and financially. © 2023 by IGI Global. All rights reserved
Application and comparison of full-text search technologies for big data processing
No full textGünümüzde verilerin boyutları ciddi bir hızla artarak devam etmektedir. Büyük veri setlerinde yapılan işlemler verinin boyutu arttıkça bazı zorluklara sebep olmaktadır. Örneğin, bir veri seti içerisinde arama yapmak temel işlemlerden biridir ve veri miktarı arttıkça çeşitli zorlukları açığa çıkarmaktadır. Bu tez çalışmasında, arama işlemlerindeki zorluklardan yola çıkılarak tam metin arama metodu üzerine araştırma yapılmaktadır. Tam metin arama, indekslenmiş veriler üzerinden arama işleminin gerçekleştirildiği bir yöntemdir. Bu yöntem, büyük bir veri setinde veriye daha hızlı erişim ve etkili arama gerçekleştirebilme noktasında avantaj sağlamaktadır. Bu çalışmada, tam metin aramada kullanılan popüler teknolojilerden Apache Solr ve Elasticsearch için indeksleme ve arama performansının bir karşılaştırılması yapılmıştır. Öncelikle, üç farklı veri seti ve üç farklı makine kullanılarak her teknoloji için indeksleme süreleri alınıp karşılaştırılmıştır. Daha sonra, indeksleme performansı en iyi olan makinede, 10 sorgu kullanılarak her iki teknoloji için arama süreleri incelenmiştir. Sonuçlar değerlendirildiğinde Apache Solr hem indekslemede hem de aramada daha iyi performans göstermiştir. Bu yüzden, bu çalışma için geliştirilen web uygulaması Apache Solr üzerine inşa edilmiştir. Uygulama kısmında, Web of Science platformunda yer alan Engineering, Computing & Technology koleksiyonundaki 1,655 derginin çeşitli bilgilerinin toplandığı özgün bir veri seti oluşturulmuş ve kullanılmıştır. Bu uygulama sayesinde, araştırmacılar çalışmalarını yayınlamak için amaçlarına uygun dergileri listeleyebilmektedir.Today, the size of the data continues to increase at a serious pace. Operations performed on large datasets cause some difficulties as the size of the data increases. For example, searching within a dataset is one of the basic operations, and as the amount of data increases, it reveals various difficulties. In this thesis, a research is accomplished on the full-text search method based on the difficulties in the search processes. Full-text search is a method in which the search is performed on indexed data. This method provides an advantage in terms of faster access to data and effective search in a large dataset. In this study, a comparison of indexing and search performance was made for Apache Solr and Elasticsearch, which are popular full-text search technologies. First, indexing times for each technology were taken and compared using three different datasets and three different machines. Then, search times for both technologies were examined using 10 queries on the machine with the best indexing performance. Considering the results, Apache Solr performed better in both indexing and searching. Therefore, the web application developed for this study is built on Apache Solr. In the application part, a unique dataset was created and used, in which various information was collected from 1,655 journals in the Engineering, Computing & Technology collection on the Web of Science platform. Thanks to this application, researchers could list the journals suitable for their purpose to publish their work
Hand Hygiene Attitude of the Health-care Professionals during the COVID-19 Pandemic Period
No full textObjectives: This study aimed to evaluate the hand hygiene compliance of health-care professionals during the pandemic. Methods: In this descriptive study, a questionnaire which was accessible on "Google Forms"was applied to the doctors and nurses working across Turkey between June and July 2020. The questionnaire consisted of four parts, including sociodemographic data, working status during the pandemic period, hand hygiene compilation, and the hand hygiene belief scale (HHBS). Results: Nine hundred and forty-four individuals were included in this study. It was found that 312 (33.1%) participants were working with gloves before the pandemic, whereas this number increased to 614 (65.0%) after the pandemic (p<0.001). The number of people using double gloves during the pandemic was 307 (32.5%). There was no difference between gender, profession, duration of the profession, and encounter with a COVID- 19 individual in terms of HHBS score (p=0.119, p=0.055, p=0.203, and p=0.450, respectively). While the HHBS score of those who were concerned about COVID was 80.9±16.5, those who did not concerned were 80.3±13.3 (p=0.035). Moreover, the HHBS score was 71.6±23.1 for those who washed their hands 1-4 times, 80.7±13.3 for those who washed their hands 5-9 times, and 80.9±13.8 for those who washed their hands ten and more times (p=0.021). The number of participants who agreed that hand hygiene education was a part of the curriculum was 501 (53.1%). Conclusion: Although health-care professionals are more careful about hand hygiene during the pandemic period, personal habits may be effective in this behavior. © 2023 by Anatolian Journal of Family Medicine
Mechanical characterization of composite pipe systems joined using different radii pipes subject to internal pressure
No full textFailure tests for internal pressurized composite pipe system joined by using different radii pipes were carried out by the finite element method and experimental tests. The composite pipes were produced from E glass fiber/epoxy. DP410 and DP490 type adhesives were used to join the composite pipes. The numerical results and experimental results were compared. It was shown that the numerical analyzes results were close to experimental results. Tangential, radial, axial, and shear stress values on composite pipes and adhesive layers were obtained via numerical analyses in the radial direction. Additionally, the von Mises stress distributions were obtained on the adhesive. The effects of adhesive layer lengths, adhesives types, and orientation angle on the effect of the joint zone were investigated