UPH Academic Journals (Universitas Pelita Harapan)
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CANVAS Syndrome: A Comprehensive Case Report on Rare Ataxia
Get PDFIntroduction: Cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS) is characterized by cerebellum, vestibular system, and sensory pathways impairments. It progresses slowly compared to other ataxias like Friedreich’s ataxia, and its genetic basis is complex and under investigation.
Case Report: A 34-year-old male presented with worsening imbalance over the past year, vertigo, slurred speech, and hand tremors. Physical examination revealed bidirectional nystagmus, dysmetria, and cerebellar atrophy on MRI. Vestibular tests were abnormal, and neuropsychological assessments showed memory and executive function deficits. Sensory nerve conduction studies were normal.
Discussion: The patient's symptoms of ataxia, vestibular areflexia, and sensory neuropathy are consistent with CANVAS. Cerebellar atrophy and Purkinje cell degeneration contribute to motor coordination deficits. Sensory neuropathy involves dorsal root ganglia degeneration. Despite supportive clinical features, genetic testing is necessary to confirm the diagnosis and exclude other genetic ataxias.
Conclusion: CANVAS is a rare ataxia syndrome with autosomal recessive inheritance affecting the cerebellum, vestibular, and sensory systems. The patient's symptoms and MRI findings suggest CANVAS, but further genetic testing is required for definitive diagnosis
Evaluating The Efficacy of Repetitive Transcranial Magnetic Stimulation In Treating Neurodegenerative Cerebellar Ataxia: A Systematic Review and Meta-Analysis
Get PDFIntroduction: Neurodegenerative diseases such as multiple system atrophy (MSA), spinocerebellar ataxia (SCA), and Friedreich’s ataxia (FRDA) progressively impair the nervous system, affecting approximately 15% of the global population. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive method, may promote neuroplasticity. The cerebellum, central to motor control and neural connectivity, is a promising rTMS target. Therefore, this research aims to evaluate the efficacy of rTMS in treating neurodegenerative cerebellar ataxia. Methods: A systematic review and meta-analysis was conducted per PRISMA guidelines, searching ten databases (to August 9, 2025). Eligible studies were RCTs comparing rTMS with sham in cerebellar ataxia. The review was registered on PROSPERO (CRD420251127471). Study quality was assessed with Cochrane RoB 2.0; meta-analysis used Review Manager 5.4.1, and meta-regression was performed in JASP 0.19.3. Results: Seven RCTs involving a total of 256 patients were included. rTMS significantly improved SARA (SMD = -0.84, p = 0.004, I² = 73%). ICARS showed no significant difference (SMD = -0.82, p = 0.43, I² = 96%). Meta-regression and sensitivity analysis were done to find key heterogeneity sources. Most studies had low bias. Conclusions: rTMS significantly improves SARA scores in neurodegenerative cerebellar ataxia if compared to sham, while ICARS shows insignificant differences. Further research is needed.Keywords: Neurodegenerative ataxia, Repetitive Transcranial Magnetic Stimulation, Sham-controlle
The Effect Of Coffee Consumption on Sleep Quality
Get PDFIntroduction: Faculty of Medicine students frequently experience academic pressure and commonly consume coffee to improve alertness. Excessive coffee consumption or consumption at inappropriate times can result in sleep difficulties, disrupt deep sleep stages, and negatively impact the overall quality of nightly rest. Methods: This study investigates the impact of coffee consumption on sleep quality among students. This research employs a cross-sectional design utilizing categorical comparison. Medical students with no history of sleep disorders were included in the study. Data collected include demographic data, Perceived Stress Scale (PSS-10) questionnaire, Pittsburgh Sleep Quality Index (PSQI), and coffee consumption habits questionnaire. Results: Analysis of 96 samples revealed that in the low coffee consumption group, 35 respondents (36.5%) exhibited mild sleep disturbance, while 17 respondents (17.7%) demonstrated moderate-heavy sleep disturbance. In the moderate-high coffee consumption group, 22 respondents (22.9%) presented with mild sleep disturbance, and an equal number showed moderate-heavy sleep disturbance. There were no association between coffee consumption and sleep quality (p =0.131). Conclusions: There were no significant association between coffee consumption and sleep quality in medical students.Keywords: Coffee consumption, sleep quality, medical student
Anak Mandiri, Ibu Tetap Berarti: Mattering to Children dan Empty Nest Syndrome pada Ibu
Get PDFThe departure of children from home to pursue education, marriage, or employment is a natural part of the family life cycle. However, this transition often leads to profound feelings of loss in mothers, commonly referred to as empty nest syndrome. A sense of mattering to one’s children is believed to help mothers cope with this condition. This study aimed to examine the relationship between mattering to children and empty nest syndrome in Indonesian mothers. A quantitative method with purposive sampling was employed, involving 107 middle-aged housewives in Indonesia. The study utilized The Mattering Index (MI) and the Empty Nest Syndrome Scale – Indian Form (ENS-IF) as measurement tools. The results showed a significant negative correlation between mattering to children and the level of empty nest syndrome (r = –.686, p < .001). The lower the mothers’ sense of mattering to their children, the higher their level of empty nest syndrome. Peristiwa anak yang meninggalkan rumah untuk melanjutkan pendidikan, menikah, atau bekerja merupakan bagian alami dari siklus kehidupan berkeluarga. Namun, peristiwa ini seringkali menimbulkan perasaan kehilangan yang mendalam, yang dikenal sebagai sindrom sarang kosong. Perasaan kebermaknaan terhadap anak dipercaya dapat membantu ibu mengatasi sindrom sorong kosong yang dialaminya. Penelitian ini bertujuan untuk menguji hubungan antara mattering to children dengan sindrom empty nest pada ibu di Indonesia. Penelitian ini menggunakan metode kuantitatif dengan purposive sampling. Partisipan penelitian ini terdiri dari 107 ibu rumah tangga dewasa madya di Indonesia. Penelitian ini menggunakan alat ukur The Mattering Index (MI) dan Empty Nest Syndrome Scale – Indian Form (ENS-IF). Hasil penelitian menunjukkan bahwa terdapat hubungan signifikan negatif antara mattering to children dengan tingkat empty nest syndrome pada ibu rumah tangga (r=-.686, p<.001). Semakin rendah perasaan kebermaknaan terhadap anak, maka semakin tinggi tingkat empty nest syndrome pada ibu rumah tangga.
EXAMINING DESIGN AS STRATEGY DISCOURSE – Part 2
Get PDFI will review and examine each case study from the 7 papers in this JSDIS Vol. 6 Edition 1, to build a discourse on Design as Strategy. The framework for reviewing and examining each case study is to use 3 perspectives from the Design as Strategy point of view (Katoppo, 2024) which is also the sub-themes of the National Seminar on Social Design (SNDS) and the International Conference on Social Design (ICSD) 2024 (https://snds.uph.edu/), which are:
1. Body of Knowledge:
The discourse start from the point of its definition to its extent in the design field, namely system design (i.e.: visual communication design), interaction design (i.e.: product design), and spatial design (i.e.: interior design and architecture) (Grimsgaard, 2023).
2. Innovation:
In this discourse, it would investigate the causal relationship between Design as Strategy and Innovation. It will discuss how Design as Strategy becomes the driver of innovation in design practice, design pedagogy, and technology driven design (Bethune, 2022). In the context of technology driven design there are at least 3 innovation categories: the classic technology-driven innovation (Ottinger, 2021), the user- and design-driven innovation (Szymariska, 2017; Duczek, 2021), dan future artificial-driven innovation (Gartner, 2021; Beale, 2022).
3. Contribution to Social Change:
The last discourse would build around the action, where Design as Strategy is implemented to make social change. It will discuss the impact for society, for the environment and for prosperity (Amatullo, et.al (ed.), 2021)
Desain Kap Lampu Kontemporer dengan Metode ATUMICS dari Revitalisasi Tenong dalam Tradisi Sadranan di Temanggung
Get PDFAbstrakPenelitian ini bertujuan untuk merevitalisasi Tradisi Sadranan di Temanggung karena tradisi ini memiliki nilai-nilai filosofi yang hampir terlupakan oleh masyarakat. Dengan menggunakan metode ATUMICS (Artefact, Technique, Utility, Material, Icon, Concept, Shape), penelitian ini mengambil tenong sebagai artefak, karena mengandung makna ungkapan rasa syukur dan kearifan lokal dalam masyarakat Nusantara. Elemen-elemen dari tenong kemudian dianalisis dan ditransformasikan menjadi sebuah produk fungsional. Data dalam penelitian ini dikumpulkan melalui studi literatur, wawancara dengan tokoh masyarakat setempat, observasi non-partisipan, dan survei ke industri kriya setempat. Hasil dari perancangan ini berupa sebuah produk kap lampu dari material bambu yang memadukan teknik anyaman tradisional dengan teknologi pencahayaan kontemporer, sehingga dapat berfungsi sebagai penerang sekaligus elemen dekoratif. Melalui revitalisasi artefak budaya ini diharapkan dapat menjadi strategi efektif dalam memperkenalkan kembali tradisi lokal kepada masyarakat luas
Designing Puberty Learning Mobile Application with Gamification for Children Grade 4-6 Based on UI/UX
Get PDFSexuality education and knowledge of puberty in Indonesia are often considered taboo, with misconceptions that it has more negative than positive impacts. The government has yet to implement comprehensive sexuality education in the national curriculum. Research indicates that providing sexuality education significantly reduces the incidence of sexual violence among children. This study employs the Research through Design (RtD) approach, involving iterative cycles of design, prototyping, and testing, to develop a puberty learning mobile application. Methods included literature review, surveys, and interviews with stakeholders, followed by data analysis to create design criteria, prototype testing, and final design development. Results show that although most respondents received some form of puberty education, their knowledge was insufficient, highlighting the need for effective learning tools. The proposed application incorporates gamification, community interaction, and parental guidance features to enhance learning. The study concludes that the interactive and engaging design successfully improves awareness and understanding of sexuality and puberty, with potential for further development
Designing the Visual Identity of Kabba Tourism Village, Minasatene District: Maximizing Culinary Potential and the Natural Beauty of Karst
Get PDFThis study focuses on designing the visual identity of Kabba Tourism Village, Minasatene District, Pangkajene and Kepulauan Regency, South Sulawesi, Indonesia. to maximize its culinary potential and the natural beauty of its karst formations. A tourism village is a concept where a village leverages its natural, cultural, and culinary wealth to attract tourists. Kabba Village has significant potential in the tourism sector with its unique karst formations and ponds. However, the village faces challenges, including the lack of a distinct visual identity. Kabba Village was ranked in the top 300 of the Anugerah Desa Wisata Indonesia (ADWI) in 2023, indicating its considerable potential. Nevertheless, the village has not yet fully utilized these advantages, particularly in terms of a visual identity that can attract tourists. This study aims to design a visual identity inspired by the natural beauty and culinary richness of Kabba Village, such as its unique karst formations, fish and shrimp products, and the traditional craftsmanship of baka-baka. The research employs the Research and Development (R&D) method with a design thinking approach. Qualitative data were collected using observation, interviews, and secondary data analysis, while the visual identity design was developed through the stages of empathy, reframing, ideation, prototyping, and testing. The results of this study are expected to serve as a reference for the further development of Kabba Village as a tourism village, or to provide insights for the development of other tourism villages in Indonesia. A strong visual identity is anticipated to enhance Kabba Village’s appeal as a competitive tourism destination in South Sulawesi
Model Pembelajaran Inkuiri Yurisprudensi untuk Mengembangkan Kemampuan Berpikir Kritis Siswa SD pada Pelajaran Pendidikan Agama Kristen [Jurisprudence Inquiry Learning Model to Develop Critical Thinking Skills of Elementary Students in Christian Religious Education Lessons]
No full textChristian education views critical thinking skills as an important aspect because, through critical thinking skills, students are encouraged to differentiate between correct and incorrect information. Critical thinking skills can also guide students to correct knowledge and be able to prove these truths in the classroom. Critical thinking skills in Indonesia are still very low. This is proven by the low PISA results achieved by Indonesia in 2018. Therefore, one way to develop critical thinking skills is to apply the Jurisprudential Inquiry learning model. The Jurisprudential Inquiry learning model can encourage students' critical thinking skills because students are continuously involved in learning to analyze and solve problems. This learning model can also stimulate students' curiosity about something so that students will take the initiative to look for facts and data related to the problem being discussed. This learning model is still relatively new and has been implemented in several middle and upper secondary schools. However, it is still not widely implemented, especially at the elementary school level because it is relatively new. This research aims to examine the importance of the Inquiry Learning Model in developing elementary students' critical thinking skills. The author uses a qualitative descriptive research metho
PENGARUH RELATED PARTY TRANSACTION DAN KINERJA KEUANGAN TERHADAP NILAI PERUSAHAAN
Get PDFPenelitian ini mengkaji pengaruh Related Party Transactions (RPT) dan kinerja keuangan terhadap nilai perusahaan. Menggunakan metode purposive sampling, sampel terdiri dari 48 perusahaan sektor consumer yang terdaftar di Bursa Efek Indonesia (BEI) selama periode 2019–2023, dengan total 240 observasi. Data yang digunakan bersumber dari laporan keuangan tahunan dan dianalisis menggunakan regresi linear berganda dengan bantuan perangkat lunak Stata versi 17. Variabel RPT yang dianalisis meliputi penjualan, pembelian, piutang, dan hutang kepada pihak berelasi, sementara kinerja keuangan diukur melalui Return on Assets (ROA). Hasil penelitian menunjukkan bahwa RPT sales dan RPT purchases berpengaruh negatif terhadap nilai perusahaan, yang mengindikasikan potensi konflik kepentingan dan inefisiensi dalam transaksi tersebut. Sebaliknya, RPT receivable dan RPT payable memiliki hubungan positif terhadap nilai perusahaan, menunjukkan bahwa transaksi ini dapat berfungsi sebagai strategi likuiditas yang mendukung stabilitas bisnis. Selain itu, kinerja keuangan yang diukur melalui ROA menunjukkan pengaruh positif terhadap nilai perusahaan, yang menegaskan pentingnya profitabilitas dalam meningkatkan valuasi pasar. Penelitian ini memberikan kontribusi pada literatur terkait RPT dengan menekankan dampak yang beragam dari berbagai jenis RPT terhadap nilai perusahaan serta peran kinerja keuangan sebagai penentu nilai perusahaan.
Kata Kunci : Related Party Transaction, Kinerja Keuangan, Return on Asset (ROA), Nilai Perusahaa