Daftar Jurnal Penerbit Universitas Negeri Semarang
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In Silico Interaction Study of the Hydrazine Compound as an Antibody Drug Conjugate Linker Against Pertuzumab
Full text linkBreast cancer can be initiated, one way or another, by overexpression of the HER-2 protein which can induce dimerization, resulting in metastasis in breast cancer cells. Pertuzumab is one of the methods used to treat metastatic breast cancer that is breast cancer cells that the cancer has spread to other parts of the body. Hydrazine is something hydro nitrogen compounds that has the formula N2H4 molecule. The hydrazine compound has chemical characteristics as a strong reducing agent because hydrazine plays a role as donor group hydrogen can reduce double bonds into single bonds through reaction hydrogenation. Research purposes This is o see the bond between Hydrazine as a linker with pertuzumab as an antibody for development of Antibody Drug Conjugate in silico with molecular docking. The docking method is used to know the conformation and free energy ties involved in the interaction between molecule (pertuzumab) and its ligand (hydrazine). In silico molecular docking was carried out with a number of stages such as ligand preparation, preparation of macromolecules, validation molecular docking method, docking hydrazine with pertuzumab protein and intermediate data analysis optimized hydrazine compound with which pertuzumab protein the lower mark energy bond so the stronger and stable the bond that occurs between hydrazine compound and pertuzumab protein . Obtained the result of docking is in the form of binding affinity from the results of addition of pertuzumab protein with the hydrazine ligand which is -6.8 which shows conformation formed stable or does not require great energy To do binding. Visualization results from complex molecule hydrazine compound against pertuzumab protein own identical confirmation on the part side active binding from pertuzumab protein macromolecules . The hydrazine compound can be bonded with pertuzumab and has potential as a new drug development in the targeting antibody drug conjugate breast cancer
Characterization of CMC and Its Effect on Physical Stability and Shelf Life of Psidium guajava
Full text linkPsidium guajava has a high content of vitamin C as an antioxidant that is easily damaged. One way to make it stable with stabilizers in the form of hydrocolloids, which are commonly used is carboxymethyl cellulose (Na CMC). The study aims to determine the effect of CMC addition on guava juice drinks with variations in temperature and storage duration and determine the shelf life. Methods include characterization of CMC (water content, organoleptic and viscosity, pH, NaCl content and purity). Guava juice beverage formulation was made by varying CMC concentration (organoleptic, viscosity, pH and vitamin C content). The best result (0.5% w/b) was continued with temperature treatment of 26°C and 16°C, and observation for 25 days. The results showed that CMC had a purity of 98.54% with NaCl of 1.46% and other results showed that it met the SNI/FAO requirements. The test of CMC addition proved to be able to stabilize the juice based on the viscosity of each treatment, but reduced the level of acidity at 16°C. The 26°C treatment changed color and odor on day 10 while at 16°C it lasted until day 20. Vitamin C content showed that on days 10-15 the treatment stored at 26°C decreased to 0.1 mg/g while at 16°C it was stable until day 25. Determination of shelf life using a mathematical model of degradation kinetics
Analysis of the Relationship Between Social Media Use with the Students Entrepreneurial Interest and Entrepreneurial Behavior of Culinary Arts Education at Universitas Negeri Semarang
No full textIn addition to being a source of information and a means of communication, social media emerges with its various advanced features that support business development and make it easier for individuals to find out the turnover of business creations from interactions and communication with others on social media networks. This will encourage the creation of entrepreneurial opportunities both new and developing existing opportunities to meet consumer demand in the market. In this study, research was conducted on students as internet users in the majority group according to their age.According to the theory of uses and effects, social media will have an effect on its users, with this it is expected that students will grow their interest in entrepreneurship and entrepreneurial behavior in line with the high level of entrepreneurship. According to the theory of uses and effects, social media will have an effect on its users, with this it is expected that students will grow their entrepreneurial interest and entrepreneurial behavior in line with the high use of social media. This study aims to relationship of social media use with entrepreneurial interest and entrepreneurial behavior of culinary education students at Semarang State University. The sample taken was 145 respondents determined using probability sampling technique. Data were collected using a questionnaire instrument. Data analysis using normality test, simple correlation test and multiple correlation test.The results showed a significant and positive relationship between the use of social media with interest in entrepreneurship with a calculated r value of 0.429 which means it has a moderate level of relationship. The relationship between the use of social media with entrepreneurial behavior also shows a significant and positive relationship with a calculated r value of 0.428 with a level of relationship closeness included in the medium level. Similarly, the relationship of entrepreneurial interest with entrepreneurial behavior has a calculated r value of 0.603 which means it has a high level of relationship and shows a significant and positive relationship. Simultaneously significant relationship between the use of social media with entrepreneurial interest and entrepreneurial behavior with a value of R / correlation coefficient of 0.479 and the level of relationship at a moderate level.
Pengaruh Hasil Pembelajaran Produk Kreatif Dan Kewirausahaan Terhadap Minat Berwirausaha Siswa Kelas XI Kuliner SMK N 4 Surakarta
Full text linkPenanaman dan penerapan jiwa wirausaha pada siswa diyakini dapat mengurangi tingkat pengangguran di Indonesia. Penelitian ini dilakukan untuk menganalisis pengaruh antara hasil belajar PKK dan motivasi berwirausaha terhadap minat berwirausaha siswa. Teknik pengumpulan data dengan dokumentasi dan kuesioner yang dibagikan kepada sampel yaitu 72 siswa kelas XI Kuliner 3&4 SMKN 4 Surakarta. Metode analisis menggunakan uji deskriptif persentase dan uji regresi. Hasil uji deskriptif persentase variabel hasil belajar PKK berada pada kriteria tuntas, variabel motivasi dan minat berwirausaha pada kategori tinggi. Hasil uji regresi ditemukan pengaruh antara hasil belajar PKK terhadap minat berwirausaha ditemukan bahwa nilai korelasi (R) sebesar 0,394 dimana nilai ini menunjukkan bahwa variabel hasil belajar (X) memiliki korelasi dengan minat berwirausaha (Y) sebesar 0,394 atau 39,4%.. Sehingga setelah mengetahui gambaran dari kondisi variabel disarankan untuk siswa kelas XI Kuliner 3&4 SMKN 4 Surakarta bersama-sama dapat meningkatkan hasil belajar dan motivasi berwirausaha serta minat berwirausaha agar tujuan sekolah menengah kejurusan (SMK) dapat tercapai
Pengaruh Kualitas Produk dan Pelayanan Terhadap Loyalitas Konsumen Pada Usaha Keypopastry
Full text linkPenelitian ini bertujuan untuk mengetahui pengaruh kualitas produk dan pelayanan terhadap loyalitas konsumen pada usahaKeypopastry. Penelitian ini dilatarbelakangi oleh pentingnya mempertahankan loyalitas konsumen di tengah persaingan ketat usahapastry yang semakin berkembang, khususnya di kawasan Universitas Negeri Semarang. Metode penelitian yang digunakan adalahkuantitatif dengan pendekatan survei. Sampel sebanyak 283 responden ditentukan dengan teknik simple random sampling dari populasi sebanyak 965 konsumen. Pengumpulan data menggunakan kuesioner, dan analisis data dilakukan menggunakan regresi linier berganda dengan bantuan SPSS versi 25. Hasil penelitian menunjukkan bahwa kualitas produk dan pelayanan berpengaruh positif dan signifikan terhadap loyalitas konsumen. Nilai signifikansi untuk kualitas produk sebesar 0,000 dan pelayanan sebesar 0,000 (keduanya < 0,05), serta hasil uji F menunjukkan nilai signifikansi 0,000 (< 0,05), yang berarti kedua variabel secara simultan berpengaruh signifikan. Nilai R² sebesar 0,728 menunjukkan bahwa 72,8% variasi loyalitas konsumen dipengaruhi oleh kualitas produk dan pelayanan. Disarankan agar pelaku usaha memperkuat dimensi kualitas rasa, tampilan, dan pelayanan untuk meningkatkan loyalitas konsumen.
Efektivitas Media Edukatif Video Sanggul Tradisional Siswa SMK Negeri 06 Semarang
No full textLack of creativity is caused by students\u27 lack of knowledge and lack of interest in reading books and looking for references from other sources. A monotonous bun turns out to be an indicator of a student\u27s lack of creativity, and is often the same as several other students. The researcher decided to carry out research on the effectiveness of educational media on traditional bun videos on traditional bun students at SMK Negeri 06 Semarang with the basic competencies of bun gelung malang, bun pusung tagel and bun ukel konde which have the advantage of making interesting video tutorials.The method used in this research is R&D with the ADDIE model which consists of analysis, design, development, implementation and evaluation stages. This research method uses data collection techniques in the form of a Likert scale questionnaire and is analyzed using quantitative descriptive techniques. This research was implemented at SMK Negeri 06 Semarang with a total population of class XI majoring in beauty engineering with a sample of 60 studentsThe results of this research show (1) Development research using the ADDIE model produces a learning media product in the form of traditional bun video educational media that is suitable for use. (2) Feasibility results from the validity test using Aiken V. In terms of material feasibility, an Aiken score of 0.783 was obtained and media feasibility with an Aiken score of 0.719 in the valid category (3) Effectiveness test results using a sample t-test with significant results and t value = 6.847 > t table (df-2) = 2,048 (4). and the N Gain test results show that the N-Gain in the control class is 22.9% in the low category and the N-Gain in the experimental class is 62.5% in the medium category. So that educational media is effective in improving learning outcomes for beauty system students
Big Data, CAATs, and Auditor Religiosity in Fraud Detection: Task-Specific Knowledge as Moderator
Full text linkPurpose : With task-specific knowledge taken into account as a moderating factor, this study attempts to investigate the impact of big data, computer-asisted audit techniques (CAATs), and auditor religiosity on fraud detection. The growing need for insight into the behavioral and technological components that support efficient fraud detection in audit procedures served as the basis for the study.
Method : Using an associative quantitative approach, the study was carried out at the State Development Audit Agency’s Representative Offices in Sumatra. A straightforward random sample method was used to gather data, and 220 questionnaires were filled out. Structural Equation Modeling (SEM) was used in the investigation to determine the correlations between the variables.
Findings : According to the t-test results, auditor religiosity significantly improves fraud detection. Big data and CAATs, however, did not demonstrate a statistically significant impact. Moreover, task-specific information serves as a predictive modifiers rather than a moderating variable as first proposed. With a termination value of 0.974, the model had a very small effect size.
Novelty : The study is innovative since it examines behavioral, technical, and cognitive aspects of the auditing profession in a comprehensive manner. Additionally, it offers fresh perspective by reframing task-specific knowledge as a predicting component rather than a moderating variable, with important ramifications for enhancing fraud detection techniques
Accountability of SDGs in Local Governments: Case Study of Central Java and Yogyakarta
Full text linkPurpose: The study explores the work program preparation, budgeting, implementation, and accountability of SDGs targets and achievements by Central Java and Yogyakarta.
Method: The research used a qualitative approach and included case studies of the governments of Central Java and Yogyakarta. Data was collected through interviews with the SDGs Implementation Team and study of SDGs documentation, then reduced, presented, and concluded.
Findings: The results showed three main themes that reveal accountability SDGs in Central Java and Yogyakarta: preparation and budgeting, implementation and accountability, and strengthening the implementation of SDGs. Those themes explained that the implementation of SDGs by Central Java and Yogyakarta governments are not carried out separately but are attached to programs and activities prepared about the Regional Medium-Term Development Plan. This study is expected to improve integration between central and regional governments so that SDGs can be reported according to actual conditions.
Novelty: The research provides an overview of the accountability mechanisms for SDG programs and activities, starting from the planning process, budgeting, and implementation to strengthening. This also reveals the facts SDGs accountability in the field, which demonstrate the legitimacy of local governments towards the commitment of implementation of SDGs
Determinants of Sukuk Ratings in Indonesia: The Role of Financial Performance as a Moderator
Full text linkPurpose: The study examines the long-term influence of sukuk age, institutional ownership, and managerial ownership on sukuk ratings with financial performance as a moderating variable in sukuk issuing companies in Indonesia.
Method: The population comprises 30 sukuk issuers during 2021-2023, from which 18 companies met the criteria using purposive sampling. Data analysis used the PVMAR and PVMECM techniques.
Findings: The findings reveal that institutional ownership, managerial ownership, and financial performance have a long-term effect on sukuk ratings, while sukuk age does not. Moreover, financial performance strengthens the long-term effects of sukuk age, institutional ownership, and managerial ownership on sukuk ratings.
Novelty: The study offers a new perspective on the interaction between sukuk rating determinants and financial performance in Indonesia, which provides essential implications for sukuk issuing companies in Indonesia to improve their financial performance. It shows the importance of good corporate governance and support from institutional shareholders as long-term stability factors that positively affect Sukuk ratings
The Impact of MSME’s on Employment, Investment, and Income
Full text linkNorth Sumatra, a key economic region in Indonesia outside of Java, continues to face persistent challenges such as high unemployment, the dominance of the informal sector, and uneven economic growth. Within this context, Micro, Small, and Medium Enterprises (MSMEs) serve as a cornerstone of the regional economy, particularly through their role in labor absorption and income generation. Despite their significance, MSMEs in North Sumatra still face substantial obstacles, including limited access to financing, inconsistent investment growth, and inadequate policy implementation—factors that hinder their full potential in driving inclusive development. This study examines the dynamic relationship between MSME growth, workforce participation, and Gross Regional Domestic Product (GRDP) in North Sumatra, employing a simultaneous equation model with time-series data from 2009 to 2023. The Two-Stage Least Squares (2SLS) method addresses endogeneity and simulates the effects of policy interventions projected for the 2025–2030 period. The findings indicate that MSME development is significantly influenced by policy instruments such as tax incentives and minimum wage regulations. Increases in wages and tax reductions enhance labor absorption, stimulate MSME performance, and promote GRDP growth. The study provides practical policy insights for strengthening the resilience and sustainability of MSMEs within North Sumatra’s evolving economy