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External Load Evaluation in Elite Futsal: Influence of Match Results and Game Location with IMU Technology
No full textAbstract
The purpose of this study was to assess the external load demands in futsal, considering both home and away matches and their outcomes, in order to plan microcycles throughout the season based on the external load of each match. The external load of 10 players from a First Division team in the Spanish Futsal League was recorded throughout 15 official matches in the first half of the league championship. The players’ external load was monitored using OLIVER devices. To analyse the influence of the match outcome and location on the external load, a univariate general linear model (GLM) analysis was conducted with Bonferroni post hoc. There are no differences between the variables neither comparing results nor location factors, except for accelerations of 2 to 3 m/s2 (m) per minute and the number of accelerations of 2 to 3 m/s2 per minute, reporting higher value winnings at home than away (p < 0.05). The location and results are not factors that influence on external load in futsal matches, except the number and distance performed in accelerations and distance covered at a low to medium speed. These findings are important for planning microcycles and providing the appropriate dosage to each player to achieve optimal performance in matches.This work was supported by the research project “Optimización del proceso de dirección del entrenamiento en deportes de cooperación-oposición (Code: Acta CES-PROMETE0-007-2013)”
Physical activity and anxiety in the adolescence: special emphasis on sport type and performance level (versión aceptada)
No full textDerechos reservados por el editor de la revistaAim
To assess levels of anxiety in a large cohort of adolescents that participated in different sport types and are characterized by varying performance levels.
Subject and methods
Cross-sectional study based on a large cohort. Self-reported questionnaires which were applied to 10,248 adolescents aged 11–19 years and recruited from secondary education centers, sport clubs, national federations, and sports technification centers those integrated disciplines included in the Summer Olympic Games program.
Results
Participation in competitive sports and high physical activity levels were both associated with low anxiety levels. Further, national and international athletes had lower anxiety levels than regional athletes independently of the type of sport. Adolescents characterized by the lowest physical activity levels reported highest anxiety levels.
Conclusion
Increased physical activity levels and specifically participation in competitive sports is related to lower anxiety levels regardless of the sport type. Adolescents who compete at a national and international level reported low anxiety level, meanwhile adolescents who don’t fulfil physical activity recommendations reported the highest anxiety levels.info:eu-repo/grantAgreement/ES/DGA/S25-23
Abordajes de fisioterapia en pacientes con rizartrosis: una revisión bibliográfica
No full textWork’s justification or background: Arthrosis is a degenerative and progressive disease that involves joints and that affects more than 300 million people around the world. When it involves the trapeziometacarpal joint, we talk about rhizarthrosis, and it affects to 22% of the population over 50 years. Despite the pain, the disability and the socioeconomic burden that it causes, this pathology doesn’t have a cure and it is usually treated with pharmacological or surgical treatments, with the adverse effects that they imply. There is evidence that a conservative treatment based on education and strength, mobility and stability exercises is effective to decrease the impact of this disease. In addition, in the last years evidence of proprioception training having positive results has been found.
Objectives: To evaluate the effectiveness of physiotherapy approaches for the treatment of basal thumb arthrosis regarding decreasing pain as well as to check the effectiveness regarding an improvement on functional capacity and increasing grip and pinch strength.
Methods: Randomized controlled trials were searched with a maximum age of five years in the following databases: PUBMED, WOS and PEDro. The studies had to be formed by patients over 50 years and a diagnosis of basal thumb arthrosis and at least one of the groups had to receive an intervention based on a physiotherapy approach. They had to include information about pain, function or pinch or grip strength. PEDro scale was used to assess the methodological quality of the studies included in the review.
Results: 87 articles were found and four of them were finally included in the review. All of them evaluated pain and function but only two of them evaluated the secondary outcomes related to pinch and grip strength. All studies found improvements in their outcomes for both the control and the experimental group, although in some cases these improvements didn’t remain stable in the control group after the follow-up period.
Conclusion: Physiotherapy approaches have demonstrated decreasing pain, improving functionality and increasing grip and pinch strength in patients with basal thumb arthrosis.Justificación del trabajo o antecedentes: La artrosis es una patología degenerativa y progresiva que afecta a las articulaciones y que padecen más de 300 millones de personas en el mundo. Cuando afecta a la articulación trapeciometacarpiana hablamos de rizartrosis y afecta a un 22% de la población por encima de 50 años. A pesar del dolor, la discapacidad y el coste socioeconómico que provoca es una patología sin cura que suele ir asociada a tratamientos farmacológicos o quirúrgicos, con los efectos secundarios que conllevan. Hay evidencia de que un tratamiento conservador basado en educación, ejercicios de fortalecimiento, movilidad y estabilidad es eficaz para disminuir el impacto de esta patología. Además, en los últimos años se ha encontrado evidencia de que entrenar propiocepción también tiene resultados positivos.
Objetivos: Evaluar la eficacia de diferentes abordajes de fisioterapia en el tratamiento de la rizartrosis en cuanto a disminuir el dolor, además de ver su eficacia en cuanto a mejorar la capacidad funcional y aumentar la fuerza tanto de la pinza como del agarre.
Métodos: Se buscaron ensayos controlados aleatorizados con una antigüedad máxima de cinco años en PUBMED, WOS y PEDro. Los estudios debían tener como muestra a pacientes mayores de 50 años con un diagnóstico de rizartrosis y que al menos en uno de los grupos recibieran una intervención basada en un abordaje de fisioterapia. También tenían que incluir información acerca del dolor, la función o la fuerza de la pinza o del agarre. Se utilizó la escala PEDro para evaluar la calidad metodológica de los artículos incluidos en la revisión.
Resultados: 87 artículos fueron encontrados y 4 fueron finalmente incluidos en la revisión. Todos los artículos evaluaban dolor y función, pero solo dos evaluaban las variables secundarias de fuerza de pinza y agarre. Todos los estudios encontraron mejoras en sus variables tanto para el grupo control como para el experimental, aunque en alguno de los estudios estas mejoras no conseguían mantenerse en el grupo control tras el periodo de seguimiento.
Conclusión: Los abordajes de fisioterapia han demostrado disminuir el dolor, mejorar la funcionalidad y aumentar la fuerza de la pinza y del agarre en pacientes con rizartrosis
Comunicando Ciencia: aprendizaje integrado de Biología Celular e Inglés
No full textEste proyecto de innovación docente se enmarca en una de las líneas estratégicas principales de la USJ: el aprendizaje integrado de contenidos y lengua. Se establece una colaboración entre las asignaturas de Biología Celular e Inglés del grado en Biomedicina, que prepara a los alumnos para desarrollar una carrera científica y/o investigadora, así que es fundamental que comprendan los contenidos de las asignaturas y que sepan comunicar resultados e interactuar con el resto de la comunidad investigadora. El idioma más utilizado para ello es el inglés, tanto en artículos científicos como en la comunicación oral que tiene lugar en congresos. Nuestro proyecto aúna contenidos de Biología Celular trabajados mediante bibliografía científica desde una perspectiva orientada a la comunicación en inglés, de resultados y conocimientos adquiridos. Para ello, hemos puesto en práctica actividades y talleres donde los alumnos construyen su aprendizaje mientras evalúan sus progresosThis teaching innovation project is part of one of the main strategic initiatives at USJ: the integration of content and language in learning. It establishes collaboration between the subjects of Cell Biology and English in the Biomedicine degree program, which prepares students for scientific and/or research careers. Therefore, it is essential that they understand the subject matter and acquire the skills to communicate results and engage with the broader research community. English is the primary language used for these purposes, both in scientific articles and in oral communications at conferences. Our project combines Cell Biology content, which is studied through scientific literature, focusing on the effective communication of the results and the acquired knowledge in English. To achieve this, we have implemented various activities and workshops where students build their learning while assessing their progress
Impact of Pharmacogenetic Testing on Clozapine Treatment Efficacy in Patients with Treatment-Resistant Schizophrenia
Get PDFManaging schizophrenia with clozapine poses a significant challenge due to prevalent therapeutic failures. The increasing interest in personalized medicine underscores the importance of integrating pharmacogenetic information for effective pharmacotherapeutic monitoring in patients. The objective of this study was to explore the correlation between DRD2, HTR2A, SLC6A4, CYP1A2, and ABCB1 polymorphisms and clozapine response in 100 patients with Treatment-Resistant Schizophrenia. Different scales such as the Positive and Negative Syndrome Scale (PANSS), the Warwick-Edinburgh Mental Wellbeing Scale (SWEMWBS), the Global Assessment of Functioning Scale (GAF), the Brief Negative Symptom Scale (BNSS), and pharmacokinetic parameters were used to analyse the efficacy of the treatment. Patients who exclusively responded to clozapine compared to the patients with augmentation strategies exhibited distinctive features, such as lower doses, plasma levels, and presented less-pronounced symptomatology. Genetic associations were explored, highlighting SLC6A4, HTR2A, and the *1F/*1F polymorphism for the CYP1A2 gene
Tratamiento conservador de la pubalgia en atletas: una revisión sistemática
Get PDFIntroducción: El síndrome de dolor inguinal (SDI), es una condición caracterizada por dolor en la región inguinal, cerca del tubérculo púbico. Este dolor puede involucrar diversas estructuras, como músculos, tendones, ligamentos y/o nervios en la zona inguinal. Es especialmente común en deportistas que participan en actividades que implican aceleraciones, cambios de dirección y disparos repentinos. El tratamiento conservador para el SDI, que incluye fortalecimiento, estiramiento y movilidad, es comúnmente utilizado como primera opción terapéutica. El objetivo de este estudio es analizar la evidencia de su eficacia en el manejo del SDI.
Métodos: Se llevó a cabo una revisión bibliográfica de ensayos clínicos aleatorizados sobre el SDI y su tratamiento conservador, utilizando las bases de datos PubMed, Web of Science, Cochrane y PEDro. Un investigador evaluara de forma independiente la calidad metodológica mediante la escala PEDro en su versión española, y se solicitó la opinión de un segundo evaluador en caso de dudas.
Resultados: De los 137 estudios examinados, se han seleccionado seis artículos que abarcan desde el año 2017 hasta el 2023 e incluyen un total de 255 pacientes. En cuanto a la edad, incluyendo todos los estudios, el rango va desde los 15 hasta los 40 años. Cada uno de los artículos se centró en el tratamiento conservador del SDI. Todos los ensayos clínicos presentaron la terapia conservadora como una herramienta para reducir el dolor y recuperar la funcionalidad de la cadera. En cuanto a la calidad metodológica, 4 estudios son de calidad "alta" y 2 son de calidad "moderada".
Conclusiones: En conclusión, hasta ahora no se han encontrado nuevas pruebas sobre la efectividad del tratamiento conservador para el SDI. Sería importante determinar qué técnicas, como el fortalecimiento muscular o la terapia manual, son realmente efectivas, ya que la eficacia de los estiramientos aún no está clara en el SDI. Para el futuro, se necesitan ensayos clínicos de mayor calidad metodológica. Dada la complejidad de la patología, establecer un estándar tanto para el diagnóstico como para el tratamiento sería esencial.Introduction: Inguinal pain syndrome (IPS) is a condition characterized by pain in the inguinal region, near the pubic tubercle. This pain may involve various structures such as muscles, tendons, ligaments, and/or nerves in the inguinal area. It is particularly common in athletes participating in activities involving accelerations, changes of direction, and sudden shots. Conservative treatment for IPS, including muscle strengthening, stretching, and mobility, is commonly used as the first therapeutic option. The aim of this study is to analyze the evidence of its effectiveness in managing IPS.
Methods: A literature review of randomized clinical trials on IPS and its conservative treatment was conducted using the PubMed, Web of Science, Cochrane, and PEDro databases. One researcher independently assessed methodological quality using the PEDro scale in its Spanish version, and the opinion of a second evaluator was sought in case of doubts.
Results: Out of the 137 studies examined, six articles were selected covering the period from 2017 to 2023 and including a total of 255 patients. Regarding age, the range spans from 15 to 40 years across all studies. Each of the articles focused on conservative treatment of IPS. All clinical trials presented conservative therapy as a tool to reduce pain and recover hip functionality. In terms of methodological quality, 4 studies are of "high" quality and 2 are of "moderate" quality.
Conclusions: In conclusion, so far no new evidence of the effectiveness of conservative treatment for IPS has been found. It would be important to determine which techniques, such as muscle strengthening or manual therapy, are truly effective, as the efficacy of stretching remains unclear in IPS. For the future, clinical trials of higher methodological quality are needed. Given the complexity of the pathology, establishing a standard for both diagnosis and treatment would be essential
Enhancing Commercial Antibiotics with Trans-Cinnamaldehyde in Gram-Positive and Gram-Negative Bacteria: An In Vitro Approach
Get PDFOne strategy to mitigate the emergence of bacterial resistance involves reducing antibiotic
doses by combining them with natural products, such as trans-cinnamaldehyde (CIN). The objective
of this research was to identify in vitro combinations (CIN + commercial antibiotic (ABX)) that
decrease the minimum inhibitory concentration (MIC) of seven antibiotics against 14 different Grampositive
and Gram-negative pathogenic bacteria, most of them classified as ESKAPE. MIC values were
measured for all compounds using the broth microdilution method. The effect of the combinations on
these microorganisms was analyzed through the checkboard assay to determine the type of activity
(synergy, antagonism, or addition). This analysis was complemented with a kinetic study of the
synergistic combinations. Fifteen synergistic combinations were characterized for nine of the tested
bacteria. CIN demonstrated effectiveness in reducing the MIC of chloramphenicol, streptomycin,
amoxicillin, and erythromycin (94–98%) when tested on Serratia marcescens, Staphylococcus aureus,
Pasteurella aerogenes, and Salmonella enterica, respectively. The kinetic study revealed that when the
substances were tested alone at the MIC concentration observed in the synergistic combination,
bacterial growth was not inhibited. However, when CIN and the ABX, for which synergy was
observed, were tested simultaneously in combination at these same concentrations, the bacterial
growth inhibition was complete. This demonstrates the highly potent in vitro synergistic activity
of CIN when combined with commercial ABXs. This finding could be particularly beneficial in
livestock farming, as this sector witnesses the highest quantities of antimicrobial usage, contributing
significantly to antimicrobial resistance issues. Further research focused on this natural compound is
thus warranted for this reason.The authors thank the financial support of the Gobierno de Aragón: Departamento de Ciencia, Universidad y Sociedad del Conocimiento (Group ECOBIOMED T67_23R), Cátedra NOVALTIA, and Universidad San Jorge. Natalia Ferrando thanks the Group IQE (Industrias Químicas del Ebro) for her predoctoral contract
Streamlining RPG Ability Creation through a Custom Visual Scripting Solution: A Tools Programming Case Study
Get PDFThis project explores the development of two custom tools within the Unity Engine environment. The first tool is a versatile data management window designed to handle various data types efficiently. The latter builds upon the functionality of the first tool by enabling the creation of complex RPG abilities using visual scripting. The main objective is to conduct a comparative analysis between visual scripting and traditional programming approaches, evaluating their respective advantages in terms of performance, flexibility, and user experience in the context of RPG video game development. Object-Oriented Programming (OOP) plays a pivotal role in this project, utilizing Object-Oriented Design (OOD) to enhance architectural understanding and modularity. This study exemplifies the paradigm’s strengths while also highlighting its limitations in practical application.Este proyecto investiga el desarrollo de dos herramientas personalizadas dentro del entorno del motor Unity. La primera herramienta es una ventana de gestión de datos diseñada para manejar varios tipos de datos de manera eficiente dentro de un proyecto. La segunda amplía la funcionalidad de la anterior herramienta, permitiendo la creación de habilidades complejas para juegos de género RPG mediante visual scripting. El objetivo principal es realizar un análisis comparativo entre el visual scripting y la programación tradicional, evaluando resultados en términos de rendimiento, flexibilidad y experiencia de usuario en el contexto del desarrollo de videojuegos RPG. La Programación Orientada a Objetos (OOP) juega un papel fundamental en este proyecto, utilizando el Diseño Orientado a Objetos (OOD) para ofrecer una mejor arquitectura y mayor modularidad. Este estudio ejemplifica las fortalezas del paradigma mientras que también resalta sus limitaciones
In vivo transplantation of intrahepatic cholangiocyte organoids with decellularized liver-derived hydrogels supports hepatic cellular proliferation and differentiation in chronic liver injury (versión manuscrito)
Get PDFCorrection: In vivo transplantation of intrahepatic cholangiocyte organoids with decellularized liver-derived hydrogels supports hepatic cellular proliferation and differentiation in chronic liver injury.
Kaur I, Vasudevan A, Sanchez-Romero N, Sanyal A, Sharma A, Hemati H, Juneja P, Sharma A, Pla Palacin I, Rastogi A, Vijayaraghavan P, Ghosh S, Ramakrishna S, Sarin SK, Baptista PM, Tripathi DM, Kaur S.
J Mater Chem B. 2025 Feb 5;13(6):2211. doi: 10.1039/d5tb90016f.The limited replicative potential of primary hepatocytes (Hep) is a major hurdle for obtaining sufficient quantity and quality hepatocytes during cell therapy in patients with liver failure. Intrahepatic cholangiocyte organoids (ICOs) derived from intrahepatic bile ducts differentiate into both hepatocytes and cholangiocytes in vitro. Here, we studied in vivo effects of transplanting ICOs and Hep in chronic liver injury mice models. Well characterized primary mouse ICOs and Hep were mixed in decellularized liver (DCL) matrix hydrogels and injected into the subcapsular left lateral liver lobe of CCl4-induced liver injury models whereas mice given DCL alone were in the sham group. Two weeks post-transplantation, transplanted liver lobes were collected and studied by histology and RNA sequencing. Transplanted animals did not exhibit any tumors, mortality or morbidity. Mice livers transplanted with ICOs had increased cellular proliferation and vascularization as compared to Hep transplanted mice or sham. Collagen deposition in the liver was significantly reduced and serum albumin levels were significantly increased in transplanted groups compared to the sham group. Expression of genes associated with hepatocyte differentiation was highest in Hep transplanted livers among the three groups, but they were also upregulated in ICO transplanted livers compared to sham. Our study demonstrates that ICOs encapsulated in DCL hydrogels when transplanted in chronically injured mice livers engraft well and show hepatocyte differentiation and reduction of fibrosis, indicating that hydrogel transplanted cholangiocyte organoids may serve as an efficient cell source and therapy for renewal of hepatocytes, restoration of hepatocyte functions and resolution of liver injury
Evaluación multiescalar de los ahorros energéticos en edificios residenciales previo a su transformación a ECCN. Una propuesta metodológica basada en datos abiertos
Get PDFEsta tesis ha sido editada. Por políticas editoriales dos de sus artículos no permiten la difusión en abierto.Este trabajo de investigación proporciona una herramienta que, mediante los sistemas de información geográfica y el uso de datos abiertos georreferenciados provenientes del Catastro, permita conocer los porcentajes de ahorro obtenidos a cualquier escala dentro de la ciudad (bloque, manzana, sección cenal, barrio etc.)
Además, permite hacer comparaciones directas cuando se trata de grupos dentro de la misma ciudad o mediante el uso de los Grados Día, permite comparar elementos de ciudades diferentes.
El método ha sido validado para la ciudad de Zaragoza. Para ello se han monitorizado dos bloques de viviendas construidos en los años 60 idénticos en la misma ubicación, uno de ellos rehabilitado con unas premisas similares a las que indica el método y otro sin rehabilitar, durante un año. Se han estudiado los consumos y analizados los ahorros llegando a la conclusión de que las diferencias de estos resultados y los datos propuestos por el método apenas difieren en un 3%.
Por otra parte, abre una vía de trabajo futura con un análisis global del parque de viviendas de España donde se obtengan como resultados la comparación a nivel nacional de las posibles zonas donde la rehabilitación obtendría unos resultados de amortización más rápida, permitiendo mediante el uso de herramientas financieras adecuadas como préstamos con devolución de cuotas en función del ahorro, el poder acelerar el actual ritmo de mejoras de las viviendas actuales.
Esta tesis se ha confeccionado en base a 3 artículos de investigación en revistas científicas indexadas, que se muestran a continuación. El orden de presentación de estos artículos es coherente con las fases de desarrollo de la tesis. Cada artículo aparece precedido de sus datos identificativos (título, autores, revista, índice de impacto y número de citas hasta la fecha de esta Tesis), así como de un resumen que reúne el fundamento del trabajo, el método o métodos utilizados, los resultados obtenidos y las principales conclusiones obtenidas del trabajo