ARUd’A (Università “G. d’Annunzio CHIETI -PESCARA)
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Acute Effects of Complex Hand Proprioceptive Task on Low-Frequency Hand Rest Tremor
No full textResting hand tremor is a low-frequency, involuntary oscillation influenced by mechanical and neural factors, often manifesting as inter-limb asymmetry. Therefore, the aim of this study was to investigate whether a single complex hand proprioceptive task can acutely modulate tremor in healthy young adults and whether it can induce asymmetry between limbs. Fifty participants (age: 25.0 ± 2.5 years) completed a 40-min proprioceptive task (anteroposterior, mediolateral, clockwise, and counterclockwise), with bilateral resting tremor recorded via triaxial accelerometry before and immediately after the intervention on both dominant and non-dominant limbs. Frequency-domain analysis showed a significant (p < 0.001) increase in tremor amplitude and a small decrease in mean frequency in the 2–4 Hz band immediately after the complex hand proprioceptive task for both limbs. These findings provide novel evidence that a single, wearable-based protocol can transiently modulate tremor dynamics, supporting the use of a non-invasive tool for neuromuscular monitoring in sport, rehabilitation, and clinical practice
Implications for long-term CO2 storage in saline aquifers: regional-scale pressure and brine flow dynamics in the Silverpit Basin (Southern North Sea, UK)
No full text19. Leggenda prima del beato Guido da Cortona (16 agosto 1516)/19. Leggenda prima of Blessed Guido da Cortona (16 August 1516)
No full textLa scheda illustra il contenuto e le peculiarità codicologiche del manoscritto contenente la "Leggenda prima del beato Guido" (XVI sec.), scoperto presso l'archivio del monastero Santa Chiara di Cortona solo di recente. La scheda è stata redatta in occasione della pubblicazione del catalogo della mostra "Cantare il Medioevo. La lauda a Cortona tra devozione e identità civica" (Cortona, Museo dell'Accademia Etrusca e della Città di Cortona - 28 giugno/5 ottobre 2025)
The Role of Reactive Oxygen Species in Colorectal Cancer Initiation and Progression: Perspectives on Theranostic Approaches
No full textAltered levels of reactive oxygen species (ROS) are recognized as one of the key factors in mediating tumor cell survival in the tissue microenvironment, where they play a role in the initiation, progression and recurrence/relapse of colorectal cancer (CRC). Tumor cells can adapt to oxidative stress (OS) using genetic or metabolic reprogramming in the long or short term. In addition, tumor cells defend themselves through positive regulation of antioxidant molecules, enhancing ROS-driven proliferation. Balanced oxidative eustress levels can influence chemotherapy resistance, allowing tumor cells to survive treatment. Secondary effects of chemotherapy include increased ROS production and redox stress, which can kill cancer cells and eliminate drug resistance. Anticancer treatments based on manipulating ROS levels could represent the gold standard in CRC therapy. Therefore, exploring the modulation of the response to OS in deregulated signaling pathways may lead to the development of new personalized CRC treatments to overcome therapy resistance. In this review, we explore the role of ROS in the initiation and progression of CRC and their diagnostic implications as biomarkers of disease. Furthermore, we focused on the involvement of ROS in different CRC therapeutic options, such as surgery, radiotherapy, theranostic imaging, chemotherapy and immunotherapy and other precision medicine approaches
Prevalence and Determinants of Workplace Violence Against Nurses in the Italian Home Care Settings: A Cross-Sectional Multicentre Study
No full textAims: To describe the prevalence and determinants of workplace violence against nurses in the Italian home care setting. Design: Secondary cross-sectional analysis of data from the multicentre study AIDOMUS-IT. Methods: Nurses employed in home care services provided by Italian Local Health Authorities were interviewed using a variety of instruments. A multivariable binary logistic regression model was performed to model the risk of workplace violence against nurses in the last 12 months. Variables related to violence were selected among sociodemographic characteristics (such as age and gender), work-related factors (including years of experience, team composition, overtime working, previous experience in mental health care, burnout) and organisational elements (including leadership and support, workload, staffing and resources adequacy, and time to reach the patients' homes). Adjusted odds ratios (aOR) were used to present the results. Results: A total of 3949 nurses participated in the study and 20.49% of them reported to have experienced an episode of violence in the last 12 months. Determinants of higher risk of violence episodes were younger age (aOR = 1.02, p = 0.002), higher workload (aOR = 1.01, p = 0.002), working in a multiprofessional team (aOR = 1.24, p = 0.018), perception of inadequate managerial leadership and support (aOR = 1.38, p = 0.003), and higher burnout levels (aOR = 1.01, p < 0.001). Conclusion: The prevalence of workplace violence against Italian home care nurses is high. Several modifiable determinants were found to be associated with a higher risk of violence, which can potentially be mitigated with tailored interventions. Implications for the profession and/or patient care: Effective preventive strategies must be developed to lessen workplace violence against nurses in the home care setting. These strategies should focus on strengthening nursing managers' leadership and support skills, enhancing team-building strategies, avoiding inadequate workload, monitoring nurses' burnout, estimating optimum staffing levels, and assigning advanced-career nurses to home care services. These measures are imperative to guarantee the quality and safety of home care organisations and to attain favourable outcomes in the provision of care. Impact: This study aimed to explore the prevalence and determinants of workplace violence against nurses in the Italian home care settings. We found that out of the 3949 nurses surveyed, 20% of the sample reported one episode of violence during the last 12 months. Determinants of this violence included younger age, higher workload and burnout, being in a multiprofessional team, and perception of lack of leadership and support by the nurse manager. The results of this study can be used to tailor interventions aimed at mitigating the risk factors of violence, particularly those that can be modified (e.g., workload, burnout, and leadership). Reporting method: The study adhered to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. Patient or public contribution: No patient or public contribution
Problemi educativi e direzioni della ricerca
No full textMuovendo dai temi proposti dai giovani partecipanti al Convegno SIPES, il contributo metterà al centro la necessità di una teoria dell’educazione che governi e orienti la progettualità didattica. La considerazione della pluridimensionalità umana e l’assunzione della differenza come categoria pedagogica implicano, infatti, un continuo lavoro di decostruzione, di approfondimento e di riscrittura dell’epistemologia pedagogica, in ambito speciale a maggior ragione, per scongiurare l’appiattimento su un didatticismo sterile e su un cognitivismo anacronistico incapaci di interpretare e sostenere gli inediti bisogni educativi e promuovere l’inclusione come idea e pratica formativa
Effect of IL-1β on NSCLC-Derived Small Extracellular Vesicles as Actors in Mediating Cancer Progression and Evading Immune System
Get PDFBackground: Increased IL-1β levels may promote carcinogenesis and metastasis by affecting tumor biology and the tumor microenvironment (TME). In this context, extracellular vesicles (EVs) play a key role in cell-to-cell communication, thus modulating the TME and immune response. Here, we aimed to test whether tumor-derived small EVs (TEVs) isolated from sensitive and osimertinib-resistant (OR) non-small-cell lung cancer (NSCLC) cells may promote EMT via fibronectin binding to α5β1 integrin as well as suppress the immune system and if these effects may be favored by IL-1β. Methods: TEVs were isolated from control, OR, and IL-1β-stimulated NSCLC cells. Expressions of fibronectin and PD-L1 were screened in TEVs and the mRNA levels of vimentin and SMAD3 were also assessed in cancer cells after TEV co-culturing. Furthermore, to detect the effect on immune cells, we co-cultured TEVs with lung cancer patients’ peripheral blood mononuclear cells (PBMCs). Results: TEVs were positive for fibronectin and the highest protein levels were found in TEVs obtained from the OR and IL-1β-stimulated cells. TEV-mediated activation of α5β1 signaling led to the upregulation of vimentin and SMAD3 mRNA in NSCLC cells and stimulated cell migration. EVs also increased PD-1, CTLA-4, FOXP3, TNF-α, IL-12, and INF-γ mRNA in lung cancer patients’ immune cells. Conclusions: Our findings indicate that TEVs promote EMT in NSCLC cells by the activation of the fibronectin–α5β1 axis. Finally, IL-1β stimulation induces TEV release with biological properties similar to OR TEVs, thus leading to cancer invasion and immune suppression and suggesting that inflammation can promote tumor spreading
Preretinal abnormal tissue before and after pars plana vitrectomy in macula-on rhegmatogenous retinal detachment: a multimodal imaging study
No full textPurpose To quantitatively explore preretinal abnormal tissue (PAT) in macula-on rhegmatogenous retinal detachment (RRD) before and after surgery. Methods In this case-series study, PAT was detected by en-face optical coherence tomography images with custom slabs in eyes that underwent pars plana vitrectomy and SF6 for macula-on RRD. Main outcome measures were PAT area at baseline, 3-month and 6-month follow-up, and its relative change. Associations between PAT and foveal avascular zone (FAZ) at superficial capillary plexus (SCP), RRD area, retinal tear (RT) area and endolaser area were investigated. Results 36 macula-on eyes RRD were included in the analysis. Significant PAT growth was registered from baseline until 6 months (p<0.001). Baseline PAT area correlated with RT area (r=0.54, p=0.001). Significant correlation between relative change in PAT and relative change in FAZ SCP was found. The multivariable regression model showed a statistically significant association between Endolaser area (cm 2) and relative changes in PAT (p=0.004). Conclusions Our study found that despite good retinal reattachment, PAT proliferates over months with vascular changes. Endolaser area has a major influence on PAT growth, without impact on best-corrected visual acuity. Additional knowledge about pathophysiological mechanisms of growth could help understanding which surgical approach may limit PAT extension and future secondary epiretinal membrane. © Author(s) (or their employer(s)) 2025. No commercial re-use. See rights and permissions. Published by BMJ Group
Late Again? A Cross-Cultural Comparison of Meeting Lateness Frustration by Punctual Attendees
No full textWorkplace meetings are often used to help accomplish individual, group, team, and organizational goals. Despite the relatively common occurrence of meeting lateness in U.S.-American samples, less is known regarding other cultural contexts. Following Conservation of Resources theory, we expect that employees from different cultures should experience meeting lateness as a legitimate stressor. Cross-cultural theory suggests that organizational practices, understandings, and use of time may be construed differently as a function of power distance and individualism/collectivism orientations. Working adults (N = 1432) from Chile, China, Italy, Germany, Netherlands, and the USA described how frustrated, irritated, and upset they would be given various scenarios in which the role (meeting leader, colleague) and degree of lateness (5, 10, 15 minutes) of the late arrival were manipulated. Additionally, we found that applying COR theory to meeting lateness served as a valuable framework in examining how lateness is associated with negative effects across our six cultures of interest. The observed cross-cultural differences in the reactions toward others’ lateness appears to be a function of individual interpretation of their cultural context as well as their own individually oriented interests. The data also show that individuals from cultures of larger power distance and collectivist orientations interpret norm violations more negatively, lending themselves to distinct reactions in communicating that lateness is an unacceptable behavior
The Quest for Ligands Against Kinesin Motor Protein Eg5
No full textThe Kinesin Eg5 motor protein is essential for the formation of the mitotic spindles and chromosome segregation, which is necessary for cell division. The inhibition of Eg5 has emerged as a potential therapeutic strategy for inhibiting the uncontrolled proliferation of cancer cells. This study aims to identify inhibitors targeting the allosteric site I of Eg5. To this end, a hierarchical virtual screening was applied to screen the ZINC20-Anodyne compound library comprising approximately 11 million druglike compounds. The procedure includes a shape similarity screening, a pharmacophore screening, docking studies with subsequent re-scorings, molecular dynamics simulations, and Molecular Mechanics-Generalized Born Surface Area (MM-GBSA) binding free energy calculations and resulted in the selection of four compounds for Eg5 inhibition assays. One compound displays an IC50 value of 29 μM, while the remaining three compounds show weaker inhibition of Kinesin Eg5. As such, structurally novel Kinesin Eg5 inhibitors have been obtained for further hit-to-lead optimization programs