ARUd’A (Università “G. d’Annunzio CHIETI -PESCARA)
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Lower bias circular density estimation with contaminated data
No full textWe study the problem of estimating circular densities when
sample data are affected by measurement errors. We propose a deconvolution
approach involving lower bias kernel estimators which take the
additional source of bias due to the presence of measurement errors into
account. Some asymptotic properties are discussed, and numerical results
are provided
Dimensione corporea, ICT e disabilità: una ricerca sui costrutti dei docenti in formazione
No full textIl dibattito sul rapporto tra corpo, didattica e ICT è ormai entrato a pieno titolo tra i temi centrali della ricerca educativa. Di conseguenza, nella consapevolezza che sono gli insegnanti con la loro professionalità a farsi interpreti dei cambiamenti e delle trasformazioni (Laporta, 1970) che ci stanno investendo, risulta centrale nella riflessione sulla scuola di oggi e di domani porre attenzione alla formazione dei docenti sulle ICT, sul loro rapporto con il corpo e sulle implicazioni che l’Intelligenza Artificiale potrà avere nella quotidianità dell’insegnamento.
Partendo da tali considerazioni, la ricerca ha voluto indagare il rapporto tra corpo e ICT nelle logiche dei docenti (Rossi e Pezzimenti, 2012), in formazione per le attività di sostegno didattico agli alunni con disabilità. Le risposte degli intervistati sono state analizzate attraverso il supporto dell’IA
Seismic Safety of Ageing Infrastructure: The Role of Corrosion in Vulnerability Assessment of Reinforced Concrete Bridges
No full textLow-dose direct oral anticoagulants for secondary prevention in patients at high risk for recurrence due to history of recurrent venous thromboembolic events or severe thrombophilia: a retrospective analysis of the Italian Survey on anTicoagulated pAtients RegisTry 2
No full textBackground: Long-term anticoagulation is recommended in patients with venous thromboembolism (VTE) deemed at high risk for recurrence (HRR). Limited information is available on patients with recurrent VTE and/or severe thrombophilia. In addition, these patients were not included in studies evaluating long-term treatment with low doses of direct oral anticoagulants (DOACs). Objectives: The aims of our study were to (1) record the drugs and dosages used in HRR patients, and (2) to record adverse events occurring during follow-up. Methods: Among 2520 VTE patients enrolled in the Survey on anTicoagulated pAtients RegisTry 2, we retrospectively analyzed the management of patients with a history of recurrent VTE and/or severe thrombophilia (HRR patients). Results: A total of 487 HRR patients were analyzed. Anticoagulants were stopped in 11 of 487 patients (2.3%), full-dose DOACs were continued in 176 patients (36.1%), and 311 patients (63.9%) were shifted to low-dose DOACs (61.4% with apixaban 2.5 mg twice a day and 38.6% with rivaroxaban 10 mg once a day) after a median time of 1.3 years (range, 0.5-20.2 years). During follow-up, no adverse events were recorded in patients who stopped treatment. Among patients who continued treatment, 10 had recurrent VTE (rate, 0.4 × 100 patient-years) and 19 had bleeding (rate, 0.9 × 100 patient-years). The risk of recurrent VTE was similar between patients on full-dose and low-dose anticoagulation. Patients on full-dose anticoagulation had a trend toward a higher bleeding risk (relative risk, 2.2; 95% CI, 0.7-9.0). Conclusion: HRR patients with a history of unprovoked recurrent VTE and/or patients with severe thrombophilia treated with long-term low-dose DOACs showed a low risk for recurrence and bleeding events
Multiparametric mapping of brain oxygen consumption with resting state calibrated functional MRI
No full textBOLD and cerebral blood flow (CBF) signal perturbations induced by isometabolic vasodilation enable the estimation of BOLD and CBF cerebrovascular reactivities (CVRs) and calibration of the BOLD signal through inference of its maximum change (M). We developed a BOLD and oxygen-transport modelling approach that uses a hypercapnic estimate of M to map the oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2). Inducing hypercapnia requires CO2 inhalation or volitional breath-holding (BH). We present a calibrated fMRI framework aiming to overcome the limitations of induced hypercapnia that exploits endogenous resting-state (RS) modulations in brain hemodynamics. This approach was compared against BH. We derived a fitting regressor representing a non-metabolically demanding vascular signal from the average grey matter (GM) BOLD obtaining similar parametric maps between BH and a 10-min RS. Associations between average GM values were M: r=0.70, OEF: r=0.88, CMRO2: r=0.94 (p-values<10-4) with slight underestimation of parameters derived from RS (∼10%) compared to BH. The most informative frequency range to extract a vascular regressor was in the high-frequency portion of the RS spectrum (oscillation times <20 s), where modulations in systemic pressure induced by breathing occur. RS fMRI estimation of CMRO2 appears feasible, and it holds promise for research and clinical application
Attachment to God and positive orientation: A systematic review
No full textAttachment to God (ATG) refers to the perceived emotional bond between the believer and God, who serves as an attachment figure. Positive orientation is the propensity to think positively about various domains related to the self, life, and the future and has three dimensions, namely self-esteem, life satisfaction, and optimism. A systematic review was carried out on Scopus, Web of Science, and PsycInfo databases (until November 2022) to summarize evidence on the associations between ATG and positive orientation following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The risk of bias was assessed using the Newcastle–Ottawa scale. The search produced 81 records, and 14 met the eligibility criteria, including 16 studies. Cross-sectional studies showed a low risk of bias, and longitudinal/cohort studies high risk. The included studies provided evidence of significant associations between the ATG construct or its subtypes and at least an indicator of positive orientation. Overall, secure ATG was positively associated with one or more dimensions of positive orientation, whereas anxious and avoidant ATG showed negative associations. No study has examined positive orientation as a whole. Some inconsistencies emerged in the results due to the heterogeneity of the tools used to assess both ATG and positive orientation indicators, the presence of uncontrolled variables, and the predominance of Christian participants. Overall, these findings offer an initial contribution to understanding the relationship between ATG and positive orientation, also highlighting the need for future research to strengthen these results. Specifically, further studies should assess positive orientation as a unified construct using instruments specifically designed for this purpose
Resilience, trust in science, and future outlooks: Perspectives of Italian youth in the post-pandemic era
No full textThe Validation of the Perinatal Post-Traumatic Questionnaire in the Italian Population: Risk and Protective Factors
No full textBackground: Postpartum Post-Traumatic Stress Disorder (P-PTSD) symptoms develop after experiencing childbirth as traumatic. Several individual and environmental factors influence the childbirth experience. However, in Italy, this phenomenon remains unexplored due to the lack of screening tools. This project aims to validate the Italian version of the Perinatal PTSD Questionnaire (PPQ-II) and to identify maternal, pregnancy, childbirth, and postpartum risk and protective factors associated with P-PTSD. Methods: A total of 702 women (6–24 months postpartum) participated in an online cross-sectional study. They completed the PPQ-II, Depression Anxiety Stress Scales-21 (DASS-21), Big Five Inventory-10 (BFI-10), and a questionnaire to assess sociodemographic and perinatal factors. Factor structure was estimated with an exploratory (EFA) and confirmatory factor analysis (CFA). Internal consistency of the scale, convergent and divergent analyses were computed. Associations between perinatal factors and P-PTSD were also investigated. Results: The EFA revealed a two-factor structure: “Arousal and Mood alteration” and “Avoidance and Intrusion”. CFA supported the factor structure, showing a good fit of the data. The validity was confirmed by a significant association between the PPQ-II and the DASS-21 and a lower correlation with the BFI-10. Significant associations were found between P-PTSD symptoms and factors across the maternal, pregnancy, childbirth, and postpartum periods. Conclusions: The Italian PPQ-II is a valid screening tool to include in maternity care protocols for the early identification of P-PTSD. This study also contributes to identifying perinatal factors for symptom detection and the promotion of maternal well-being