ARUd’A (Università “G. d’Annunzio CHIETI -PESCARA)
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Dementia was associated with worse hospital outcomes: a retrospective study from Italy
No full textDementia is a frequent disease in the elderly population, and its prevalence is still increasing worldwide. Amongsubjects discharged from general hospitals, the percentage of patient with dementia vary between 4 and 30%. Dementia is generally associated with higher rate of admission to hospital, increased length of hospitalization, and with an increased risk in postadmission mortality. The aim of this study was to evaluate the impact of dementia on in-hospital mortality and length of stay (LOS) in an Italian Southern Region. Data related to hospital admissions were extracted from the hospital discharge record of the Abruzzo region, considering all admissions performed during the years 2018-2023. Dementia and all comorbidities included in Charlson Comorbidity index (CCI) were extracted. To compare outcomes between patients with and without dementia, a propensity-score matching procedure performed. Unmatched patients were discarded from the analysis. Patients underwent surgical intervention were excluded. Odds ratios and their 95% confidence intervals (95% CI) for study outcomes (prolonged LOS and mortality) were performed using logistic regression models, using study outcomes as a dependent variable and COPD as an independent variable, adjusting for propensity score. Prolonged LOS was defined as a duration beyond 10 days, representing the upper quartile of distribution. During the study period, 11,231 admissions of patients with dementia were performed, over a total of 987,761. 11,231 matched controls (patients without dementia) were included. Logistic regression analyses showed that dementia disease was associated with in-hospital mortality (OR: 2.34 95%CI 2.22- 2.89) and prolonged LOS (OR: 1.66; 95%CI 1.51- 1.80). In a cohort of Italian patients, dementia was associated with in-hospital mortality and prolonged LOS. Key messages • Dementia was associated with in-hospital mortality. • Dementia was associated with prolonged length of stay
Underground Gas Storage as Benchmark for Seismic Attenuation Tomography in a Tectonically Complex Region (North-Eastern Italy)
No full textWe present a multiscale seismic attenuation tomography of a seismotectonically complex region in northern Italy hosting the well-characterized Collalto Underground Gas Storage (UGS). Beyond its specific relevance, this site provides a natural laboratory for assessing the ability of attenuation imaging to distinguish fluid-rich zones from highly strained, failure-prone volumes. We integrated scattering and absorption tomography models: scattering anomalies, between the two principal thrusts, highlight localized strain near fault tips; absorption tomography images the shallow UGS and reveals a deeper fluid-saturated volume. Seismicity concentrated around this deeper anomaly, exhibiting a pulsatory temporal pattern, suggests a fluid-driven role in the deformation processes. These findings show that attenuation tomography, combined with multiscale and complementary geophysical models, can resolve critical subsurface features related to fluids and strain. The approach is broadly applicable to geothermal and volcanic contexts and supports seismic hazard assessment in tectonically active regions where natural and anthropogenic processes may interact
Periurban Transitions. Images of a Landmark on the Tyrrhenian Coast
No full textThis study is one of the results of a wider research, still ongoing, on the representation of the material and immaterial qualities of architecture expressed by the complex of the former Meccanica Romana near Ostia Antica, among the most interesting examples of Roman industrial archaeology. The main objective of this research phase is to structure processes for the representation of the qualities this heritage, through architectural and environmental survey actions supported by the languages of Drawing and Photography, with the intention of providing documentary pieces of knowledge. The complexity of the metropolitan area of Rome and this area in particular, as part of the archaeological landscape system of the coastline of imperial Rome, and the strategies of the Superintendence and research is widely documented in numerous contributions from scholars, from which this phase of research started to explore what is still remaining of the identity of this heritage. In this scenario, research allowed to compose images — in the form of four Polaroid sequences — of the current state useful to reveal the integrity of a unique and extraordinary spatial value: testifying and documenting the transition of an architectural complex, a fulcrum and landmark in the Tyrrehenian coast, from a steel-factory to a dreams-factory
Immunoregulatory mechanisms of the arachidonic acid pathway in cancer
Get PDFThe arachidonic acid (AA) pathway promotes tumor progression by modulating the complex interactions between cancer and immune cells within the microenvironment. In this Review, we summarize the knowledge acquired thus far concerning the intricate mechanisms through which eicosanoids either promote or suppress the antitumor immune response. In addition, we will discuss the impact of eicosanoids on immune cells and how they affect responsiveness to immunotherapy, as well as potential strategies for manipulating the AA pathway to improve anticancer immunotherapy. Understanding the molecular pathways and mechanisms underlying the role played by AA and its metabolites in tumor progression may contribute to the development of more effective anticancer immunotherapies
Acute changes in functional connectivity associated with first osteopathic manual treatment in chronic low back pain spatially overlap with opioid receptor expression
No full textBackground: Osteopathic Manipulative Treatment (OMT) has emerged as a therapeutic approach for chronic low back pain (cLBP). Previous Magnetic Resonance (MR) studies have demonstrated that four weeks of OMT alter resting-state functional connectivity (rs-FC) in the somatosensory cortex, prefrontal regions, and frontal operculum/insula. However, it remains unclear whether a single session of OMT can immediately affect brain rs-FC. Methods: We combined a data-driven approach with a seed-based connectivity analysis to examine the pattern of whole-brain rs-FC in a cohort of thirty cLBP patients before and after a first acute session of OMT (N = 16) or a sham treatment (N = 14). Correlation analyses were performed to explore the relationship between the resulting rs-FC maps and receptor density/gene expression maps derived from in vivo brain atlases, focusing on the opioid and cannabinoid systems. Results: Data-driven analysis revealed that, compared to the sham group, the OMT increased the intrinsic connectivity of the right dorsolateral prefrontal cortex. Seed-based connectivity analysis showed that this region increased coupling with the right frontal operculum/insula. Notably, no effect of immediate OMT was found in the somatosensory cortex. The topography of these rs-FC changes selectively overlapped with the distribution of mu-opioid receptors. Conclusions: Acute OMT in cLBP patients modulates rs-FC across cortical regions primarily involved in top-down cognitive control of pain, as well as in integrating pain intensity perception and related expectations. Spatial comparisons between rs-FC maps and receptor atlases suggest that these neural changes involve opioid, not cannabinoid, neurotransmission
Development of a diagnostic checklist to identify functional cognitive disorder versus other neurocognitive disorders
Get PDFBackground Functional cognitive disorder (FCD) poses a diagnostic challenge due to its resemblance to other neurocognitive disorders and limited biomarker accuracy. We aimed to develop a new diagnostic checklist to identify FCD versus other neurocognitive disorders. Methods The clinical checklist was developed through mixed methods: (1) a literature review, (2) a three-round Delphi study with 45 clinicians from 12 countries and (3) a pilot discriminative accuracy study in consecutive patients attending seven memory services across the UK. Items gathering consensus were incorporated into a pilot checklist. Item redundancy was evaluated with phi coefficients. A briefer checklist was produced by removing items with >10% missing data. Internal validity was tested using Cronbach's alpha. Optimal cut-off scores were determined using receiver operating characteristic curve analysis. Results A full 11-item checklist and a 7-item briefer checklist were produced. Overall, 239 patients (143 FCD, 96 non-FCD diagnoses) were included. The checklist scores were significantly different across subgroups (FCD and other neurocognitive disorders) (F(2, 236)=313.3, p0.80). Conclusions This pilot study shows that a brief clinical checklist may serve as a quick complementary tool to differentiate patients with neurodegeneration from those with FCD. Prospective blind large-scale validation in diverse populations is warranted.Cite No
Antichi popoli italici: dalla mostra temporanea al Museo archeologico nazionale di Veroli
No full textNonessential pollutant metals in the food chain: state of art and particular focus on thallium and platinum group metals (PGMs)
No full textArt. 21 - Lavoro all'esterno
No full textCommento di dottrina e di giurisprudenza dell'art. 21 ord. penit