ARUd’A (Università “G. d’Annunzio CHIETI -PESCARA)
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Exploiting the 2-(1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic Acid Scaffold to Generate COXTRANs: A New Class of Dual Cyclooxygenase Inhibitors-Thromboxane Receptor Antagonists
No full textThe use of traditional nonsteroidal anti-inflammatory drugs (NSAIDs) and coxibs is effective for the treatment of inflammatory pain and chronic inflammatory conditions. However, their use is associated with enhanced risk of cardiovascular toxicity and thrombotic events, particularly for the latter. The vascular side effects of these drugs could be mitigated by pharmacological inhibition of the thromboxane A2 receptor (TP). Here we describe the development of a new class of dual cyclooxygenase (COX) inhibitors/thromboxane receptor antagonists (COXTRANs) based on the 2-(1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid scaffold. The in vitro evaluation of 50 newly synthesized compounds resulted in a set of well-balanced compounds exhibiting nanomolar activity on both COX-2 and TP receptor. Further studies in human whole blood and physicochemical profiling allowed the prioritization of 51 (CXT29) as a suitable candidate for in vivo studies. Compound 51, after oral administration, was able to prevent TP receptor-mediated platelet aggregation and to reduce inflammatory pain in mice
Osservatorio sulla Rendicontazione di Sostenibilità delle Aziende abruzzesi (ORSA) - Rapporto 2025, Dipartimento di Economia - Università degli Studi “G. d’Annunzio” di Chieti-Pescara
No full textLa Medea di Euripide. Nuclei drammatici e proiezioni del mito
No full textIl mito di Medea ha una lunga storia, che precede le sue riprese nel teatro ateniese di V sec. a.C. Tuttavia, solamente nella Medea di Euripide, che andò in scena nel 431 a.C., si afferma per la prima volta la figura di Medea assassina volontaria dei figli per vendicare l'abbandono da parte di Giasone. I principali nuclei drammatici della tragedia sono l'infanticidio intenzionale, il rapporto uomo-donna e l'alterità etnica, oltre che la difficile dialettica nella polis tra sapere e opinione pubblica. In forme diverse questi punti nodali rivivono prepotenti e irriducibili nelle rivisitazioni del mito di Medea fino ai giorni nostri
Apresentaçao "A Construção da Paisagem Produtiva na Europa Meridional no Século Vinte"
No full textSi introducono i contenuti della ricerca "Construction of the productive landscape in southern europe in the twentieth century territory, outlines, typologies and ideology
Climate risk and bank lending in South Africa
No full textThis study investigates whether physical risk and transition risk factors affect South
African bank lending behaviour. Results of baseline analysis suggest that physical
climate risk negatively affects South African bank lending behaviour. Similarly, we find
consistent results when considering climate transition risk proxied by the adoption of
South Africa’s carbon tax in 2019. Finally, we find that the physical climate risk effect
is stronger for commercial banks and tends to assume a non-linear U-shape effect.
Our research provides one of the first empirical assessments of climate risk effects on
the South African banking industry and includes useful suggestions for practitioners,
policymakers and regulators
Physiological drift during steady-state exercise based on the incremental Talk Test
No full textPurpose. The Talk Test (TT) is recognised as a practical method for prescribing exercise intensity during incremental exercise, although its applicability to prolonged steady-state exercise – particularly with respect to physiological drift – remains underexplored. Therefore, this study aimed to evaluate whether workloads at different TT stages during incremental exercise predict responses during steady-state training. Methods. Well-trained individuals (1–3 h of hiking, 3–4 times per week) performed incremental exercise (2-min stages) to determine the equivocal (EQ), last positive (LP) and last positive-1 (LP-1) TT stages. Participants then completed 60-min uphill walking bouts at LP-1, LP and EQ intensities in random order. Repeated measures ANOVA with Tukey post-hoc tests assessed differences in physiological drift across TT stages during steady-state exercise. Results. During LP-1 and LP bouts, stable conditions were observed for the percentage of maximum heart rate (% HRmax) ( 95% HRmax), RPE (~7/10), blood lactate (~7 mmol · l–1) and TT score (~2.4/3). Conclusions. Training intensity based on LP-1 or LP incremental TT provides conditions consistent with the moderate-intensity domain, with minimal drift during 60-min exercise. Steady-state exercise at the intensity of the EQ stage results in significant drift, comparable with the heavy or severe exercise domain (> maximal lactate steady-state). These findings suggest that TT-based intensities, particularly LP-1, may be suitable for prolonged training in physically active individuals, to build endurance. Future research should investigate the applicability of the TT in athletes, particularly its effectiveness for prolonged exercise
Environmental, Social, Governance (ESG). Risk, Performance, Monitoring
No full textThis edited volume covers Environmental, Social, and Governance (ESG) topics and their impact on companies' financial performance. It is the outcome of an academic research group coordinated by the Italian Society of Professors of Business Administration and Accounting. The book discusses corporate governance, management accounting and control systems, performance measurement, auditing and risk management, and their roles in business strategy and corporate finance. It includes several case studies from Italian corporation to illustrate the theories and their implementation in practice
