ARUd’A (Università “G. d’Annunzio CHIETI -PESCARA)
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Dimensioni dell’habitat urbano. Verso un’interpretazione co-evolutiva tecnologico-ambientale della città.
No full textGli aspetti che si pongono all’attenzione del Convegno riguardano una terza via, tecnologico-ambientale, del progetto dell’habitat urbano che non nega le specifiche discipline architettoniche, urbanistiche e paesaggistiche, né esclude componenti socio-umanistiche o economiche ovviamente centrali per le trasformazioni della città. La progettazione tecnologico-ambientale può contribuire a definire in senso “mediativo” connessioni e rammendi fra proiezioni strategiche, proposte tattiche e soluzioni operative, per contrapporre alla dicotomia natura-artificio “per parti” una logica intersistemica co-evolutiva tecnologico-ambientale del costruire, mantenere e modificare l’habitat urbano, lavorando sui differenziali quali-quantitativi spazio-temporali. Questa terza modalità d’azione – sul progetto, nel progetto e per il progetto dell’habitat urbano – delinea traiettorie di progettazione della città, aperte, inter/transdisciplinari e adattive, incentrate sulla variabilità degli scenari e sulla capacità di proiettare visioni di processo, performative e relazionali
Optimizing Immediate Loading with Immediate Implants
No full textThis chapter defines and elaborates on what is meant by "immediate loading." Dynamic guided implant surgery (dCAIS) or navigation uses advanced technology to facilitate precise implant placement based on cone-beam computed tomographic (CBCT) planning. Immediate implant placement with immediate loading requires a full understanding of the biological and technical essentials involved. The most crucial determinant for success with immediate loading of immediate implants is their primary stability. Both immediate non-occlusal and immediate occlusal loading can favor faster peri-implant bone formation. Internal conical connection implants are used for immediate non-occlusal and immediate occlusal loading provided that they are placed subcrestal, incorporate a platform switch feature and have peri-implant soft tissue thickness of 3 mm. Biconometric implant crown-to-abutment attachment can replace other forms of prosthesis retention. A novel approach meant to accelerate healing with immediate loading of immediate implants is discussed
Complex Magnetic Fields: Harnessing the Electromagnetic Symphony for Possible Applications in Regenerative Medicine and Antifungal Properties
Get PDFComplex magnetic fields (CMFs) represent an emerging frontier in regenerative medicine, offering significant potential for innovative therapeutic strategies. This review examined both the theoretical foundations and practical applications of CMFs, focusing on their roles in tissue regeneration and antifungal activity. A comprehensive review of electronic databases (PubMed, Scopus, and Embase) identified seven pivotal studies on in vitro models concerning the CMF topic. Although the number of studies is limited, they collectively highlighted the promising therapeutic potential of CMFs in enhancing wound healing, reducing oxidative stress, and neuroinflammation in diabetic neuropathy, positively influencing mitochondrial function, modulating immune responses, promoting cellular communication, inhibiting the growth and adhesion of Candida albicans to medical surfaces, and enhancing dental pulp stem cell proliferation under inflammatory conditions. These findings suggested that CMFs may offer an eco-sustainable approach, effectively targeting pathogens while preserving human cell integrity. While the current body of research is insightful, it remains in its early stages. To fully leverage the therapeutic potential of CMFs, more comprehensive studies are needed to refine their application and confirm their effectiveness across diverse clinical scenarios. This is essential for integrating CMFs into clinical practice, where they promise to revolutionise treatment approaches
Il crepuscolo della (in)differenza
No full textWith an interdisciplinary approach, the work focuses on the state of the art of the extensive reform underway regarding disability.
Protection and inclusion are read as a form of guarantee and enjoyment of fundamental rights, with a view to mutual enrichment which sees the person with a disability offering their contribution to economic and social progress.
The new institutions and the new guarantee figures represent the pillars on which a broader and more ambitious reform project in line with constitutional principles and community and international directives is based
Topographical Analysis of Libya Linea on Europa: Geologic Evolution and Identification of a New Putative Cryovolcanic or Diapir Field
No full textOn Jupiter's icy moon Europa, bands played a crucial role in its geological evolution. Large-scale bands such as Libya Linea (LL), which has previously not been studied with an applied method as other prominent Europan bands, offer insights into the icy moon's regional geologic history. To unravel the evolution of LL, our study employed a detailed topographic analysis, complementing a previous tectonic reconstruction (Collins et al., 2022, https://doi.org/10.1029/2022JE007492). While said reconstruction provided a comprehensive view of western LL's tectonic evolution, our study introduces a critical topographic dimension, revealing nuanced differences and emphasizing the importance of an investigation that included LL's eastern portions. We identified distinctive topographic signatures indicative of different deformation stages. The analysis of eastern LL, previously not studied in detail, allowed us to define and characterize the topographic signatures of younger and older parts of LL. In western LL, the topographic characteristics of some branches of LL aligned with those of young branches in its eastern parts, while the topographic signatures in other LL branches supported their previous interpretation as formed during early and intermediate deformation stages. Furthermore, the identification of transpressive features in western LL partially challenged the previous reconstruction, suggesting reworking processes at late evolutionary stages. Overall, our integrated topographic and morpho-stratigraphic analysis broadens the understanding of LL's evolution and bands on Europa in general. Additionally, the identification of a small area of putative cryovolcanic or diapiric activity adds intriguing elements for future exploration of this region with the Europa Clipper and JUICE spacecraft
Indefinite anticoagulation with reduced-intensity direct oral anticoagulants in patients with splanchnic vein thrombosis. An international practice survey
No full textIntroduction: Low-dose direct oral anticoagulants (DOACs) could be beneficial for secondary prevention of splanchnic vein thrombosis (SVT) in subgroups of patients at high risk for recurrence. In the absence of direct evidence, we aimed to identify the practice preferences of physicians managing patients with SVT in an international web-based survey. Methods and results: An anonymous questionnaire was sent via E-Mail between April and July 2023 to members of 14 national and international scientific societies. We received 236 responses of which 175 were complete responses. After an initial 3-6 months of SVT treatment, more than 80% of respondents would continue anticoagulation in the presence of cancer, myeloproliferative neoplasms, or in case of unprovoked SVT. If anticoagulation is continued, 45.8-68.6% would use reduced-intensity dosing of DOACs. In case of compensated cirrhosis or controlled inflammatory bowel disease (IBD), 54.3% and 44.4% of respondents would continue anticoagulation and 68.8% and 73.3% would opt for reduced-intensity DOAC dosing, respectively. Gastroenterologists were more likely to discontinue anticoagulation in SVT associated with cancer, controlled IBD, or unprovoked event, and more likely to continue anticoagulation in compensated cirrhosis compared to other specialists. Overall, 96% of respondents supported prospective evaluation of low-dose DOACs for the secondary prevention of SVT. Conclusion: This survey showed that physicians adapt duration and intensity of anticoagulation therapy depending on the patient's specific condition and risk factors even in the absence of high-quality evidence. Prospective evaluation is awaited
Career Break Around Childbirth: The Role of Individual Preferences and Social Norms
No full textThe prolonged career break around childbirth is one of the reasons behind large motherhood penalties in terms of pay and employment opportunities.We aim to understand what is driving the duration of career break in Italy, where it often remains longer than the 5-month obligatory maternity leave. The theoretical model proposed describes trade-offs about career, fertility and time devoted to children, allowing for heterogeneity in women’s education and preferences for parenting versus career. This preference is an individual characteristic which can be influenced by social norms and gender stereotypes. By relying on PLUS 2014 and 2021 surveys, we test model predictions
and reveal an interesting shift: while a decade ago women characterised by higher parenting
priority seemed to be more exposed to the risk of dropping out from the labour
market, nowadays the desire to have kids appears to go side by side with the desire to
maintain paid employment. We interpret this as a course for economic independence
on the side of Italian women, especially the more educated, probably related to a shift
in their priorities from parenting towards work and career. Further analysis is proposed
to understand how the prevailing social norms and local characteristics could impact
on career break and labour market participation
Continous or fixedcarfilzomib, lenalidomide and dexamethasone (krd) for relapsed-refractory multiple myeloma: long-term follow-up from a multicenter, retrospective real-life surveyfrom European myeloma network (emn) Italy
No full textBased on the results of the ASPIRE trial, the KRd regimen (carfilzomib, lenalidomide and dexamethasone) has been approved in Italy for relapsed/refractory multiple myeloma (RRMM) patients since 2016. The published KRd schedule indicates this combination for 18 cycles, followed by continuous Rd until progression. However, in Italy, there are no limits to the number of KRd cycles, fully refunded based on negotiation with the Italian regulatory agency, and in some centers this combination has been used continuously, beyond the 18th cycle (continuous KRd, cKRd). To evaluate and compare safety and efficacy of both continuous and fixed KRd, we retrospectively collected real-world data from 356 patients treated in 20 EMN (European Myeloma Network) Italian centers from October 2016 to September 2023 and we patients treated with cKRd with those treated with the ASPIRE schedule. After a median follow-up of 48.59 months (CI 27.24–61.24), the overall response rate (ORR) of the entire series was 83% with 35% of complete responses(CR). The mPFS was 23.1 months (CI 20.11–28.62) and mOS was 62.85 months (CI 53.75–70.34), longer than the mOS of the ASPIRE study (48.3 months). The landmark analysis of the cKRd population shows non-significant benefit both in terms of PFS and OS compared to patients where the administration of KRd was stopped at the 18th cycle as in the ASPIRE trial, to note, in the cKRd group patients had a more aggressive disease based on ISS and R-ISS stage. Therefore, although we did not observe additional toxicities, our retrospective analysis, while confirming the validity of the KRd regimen in RRMM, does not indicate any general advantage in keeping the administration of carfilzomib beyond the ASPIRE schedule
Metabolic disorders in young people around the world
Get PDFYouth-onset metabolic diseases, including obesity and type 1 and type 2 diabetes, and their associated cardiometabolic complications represent a major global health challenge. The incidence and prevalence of these conditions vary across regions, with rising trends and a heavier burden observed in middle- and low-income countries. Diet, physical activity and lifestyle choices are key factors in the development and progression of metabolic diseases during childhood and adolescence, along with additional risk factors such as genetic predisposition, ancestry, ethnicity, lifetime events (i.e. puberty) and other environmental factors. Disparities in access to healthcare, diagnostic and management capabilities and treatment options across the world affect outcomes, contributing to high morbidity and mortality rates, particularly in low-resource settings. Compared with onset during adulthood, an early diagnosis of metabolic diseases is associated with a higher risk and severity of complications, including adverse vascular outcomes and premature mortality. Although clinical signs of cardiovascular complications typically appear in adulthood, they are the result of a long, subclinical disease process that can begin in childhood and adolescence. This underscores the need for early prevention strategies and effective treatments to reduce the short- and long-term health impacts of these conditions. Addressing the rising prevalence of metabolic diseases, especially among vulnerable populations, requires comprehensive, culturally tailored actions that consider the available resources in diverse settings
Può il capitale umano ridurre i divari occupazionale? Il caso del Mezzogiorno d'Italia
No full textIl capitale umano rappresenta uno dei più importanti driver per il perseguimento della crescita economica e dell’occupazione. Questo documento, a firma doppia Veraldi-Carballar, esplora l'impatto del capitale umano sul tasso di occupazione regionale utilizzando un panel data che include le regioni del Mezzogiorno d’Italia dal 1999 al
2020. Le due proxy scelte per misurare il capitale umano sono la quota delle forze lavoro con più di 15 anni che ha conseguito un titolo di istruzione terziario e la quota della spesa pubblica in istruzione come percentuale del PIL. Adottiamo un modello econometrico basato sulle regressioni ad effetti fissi e ad effetti variabili applicando, inoltre, tecniche di autocorrelazione spaziale. I principali risultati indicano che la quota della forza lavoro altamente qualificata ha un impatto significativo e positivo sull’occupazione, anche quando il modello tiene conto degli effetti spaziali