ARUd’A (Università “G. d’Annunzio CHIETI -PESCARA)
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«... Che l’essere umano si ricordi di sé stesso». Karl Jaspers e la crisi
No full textThe paper moves from Karl Jaspers’ critique of nationalist ideology with the aim of explor-ing the origin and development of his Europeanist idea. Through a trajectory from his early reflections to The Spiritual Situation of the Age of 1931, Jaspers’ concern about the process of massification and homologation in the interwar years is outlined. Detaching himself from con-servative pessimism, the philosopher emphasises the importance of recovering Europe’s histori-cal roots as an antidote, warning against the risk of reducing the individual to a mere function. As psychopathologist of his time, Jaspers identifies memory and the critical recovery of tradition as the main tools for dealing with the crisis
Multiscale Data Acquisition of Historic Centers: A Hierarchical Approach for Enhancing Urban Conservation and Planning
No full textThis study explores the implications of multiscale data acquisition within historic centers, proposing a survey protocol that integrates a hierarchical approach across three distinct scales—urban/territorial, district, and building—in order to optimize the accuracy and efficiency of the analysis of historic urban environments. Each scale serves a specific purpose and yields varying levels of data detail, which are crucial for informed urban planning and conservation strategies. The research is conducted within the framework of the GENESIS project, “Seismic risk management for the touristic valorization of the historical centers of Southern Italy” (PON MIUR “Research and Innovation” 2014–2020 and FSC. D.D. 13 July 2017 n. 1735). It aims at acquiring extensive datasets with different levels of accuracy, addressing the computational challenges associated with processing and analyzing multiscale data. The study highlights the distinct computational demands required for urban- and district-scale data compared to detail-scale data. Urban-scale data, which encompasses broader architectural and urban contexts, demands algorithms capable of handling extensive datasets with varying resolutions and formats. In contrast, detail-scale data, which focuses on individual architectural elements, requires high-resolution processing to capture fine details and textures essential for conservation purposes. This multiscale approach not only enhances the overall understanding of the cultural and architectural heritage of the investigated area but also allows for tailored conservation efforts based on the specific needs and characteristics identified at each level of analysis
L’EMOZIONE COME SFIDA ALLA CADUCITÀ IN ALFRED TENNYSON. Un’analisi tematica.
No full textIncentrato sulla dialettica tra memoria e oblio, malinconia e razionalità, il testo propone una lettura di alcune poesie tennysoniane emblematiche del processo di rielaborazione dell’esperienza emotiva. Lungi dal limitarsi a una mera espressione di pathos, l’atto poetico è per Tennyson strumento interpretativo della condizione umana, capace di conferire senso e struttura all’esistenza. Il discorso poetico si presenta come uno spazio di riflessione sulla temporalità, sull’identità e sul senso del vivere e del morire. In dialogo con alcune prospettive filosofiche contemporanee, il volume propone una lettura delle emozioni non come stati passivi, ma come forze cognitive. Le emozioni si rivelano capaci di produrre conoscenza e creatività, trovando nella poesia uno spazio privilegiato in cui far incontrare estetica ed etica, espressione e comprensione, finitezza e apertura al trascendente
Progettare il riuso delle rovine: Torre Rinalda, Lecce. Designing the reuse of ruins: Torre Rinalda, Lecce
No full textThe design interprets the identified ongoing process of the tower, a restored ruin, projecting it into the future as a sustainable beach resort and bicycle rental station. The new structure, entirely in timber and lightweight panels is removable and does not bear loads on the ancient walls. The project follows Cesare Brandi’s restoration principles applied to architectural composition and is reversible, compatible, recognisable and based on the minimum intervention principles. The platform, built with local stone gabions, protects the structure from the action of the sea. We designed the new pavilion, hosting a small bar and a bicycle rental office, as a fallen piece of the complete structure. A bicycle path connects this tower with the other coastal towers creating a cultural itinerary.
Photovoltaic panels on the southern side provide sufficient energy to run the interior as a museum of the coastal defence of Apulia and to illuminate the tower as a contemporary urban landmark
The effect of ESG disclosure on firm value in the European context
No full textPurpose: The environmental, social and governance (ESG) topic has recently received increasing attention from scholars due to increasing regulations for firms’ non-financial disclosure with respect to environmental and social issues. For instance, the European Union (EU) recently issued the Corporate Sustainability Reporting Directive (CSRD) in December 2022 and implemented it starting in 2024 in member states. Non-financial disclosure is relevant for various stakeholders and could affect firm value. Therefore, this study aims to examine the effect of ESG disclosure on firm value in the EU context. Design/methodology/approach: This study uses panel data on listed EU firms extracted from the Bloomberg database from 2014 to 2024. The final sample comprises 11,003 firm-year observations. The ordinary least squares method is used as a baseline regression. This study addresses the endogeneity issues by applying instrumental variable and two-step system dynamic panel generalised method of moments approaches. Findings: The results of the univariate tests, including the mean-difference comparison test based on pre-CSRD and CSRD issuance periods, reveal a significant decrease in the average ESG disclosure score in the CSRD issuance period. These results are similar for individual ESG pillars. Further, the results show a significant reduction in average firm value in the CSRD issuance period. The regression results report a significant and positive effect of ESG disclosure on firm value. Practical implications: This study provides practical implications for policymakers, firms and stakeholders. Based on the findings and the contexts of signalling and institutional theories, regulatory requirements for non-financial reporting on environmental and social issues affect a firm’s sustainable behaviour. This directly impacts various stakeholders, including market participants, and eventually affects market value. Originality/value: This study contributes to the literature on the relationship between ESG disclosure and firm value in the context of the transition from the non-financial reporting directive to CSRD
Is there an impact of autoimmune rheumatological diseases on cutaneous toxicity in breast cancer adjuvant radiotherapy? A mono-institutional experience
No full textAims: Autoimmune rheumatological diseases (ARDs) have historically represented an absolute or relative contraindication for radiotherapy (RT) due to increased RT-related toxicity and the potential exacerbation of rheumatologic disease. ARDs are more frequent in females (F:M 4:1). Breast cancer (BC) is the most common malignancy, accounting alone for 31% of female cancers. This study compared acute and late cutaneous toxicity in ARDs and non-ARDs population undergoing adjuvant breast RT. Methods: Data of patients with BC and ARDs treated between 2013 and 2023 were retrospectively reviewed. The ARDs group was compared with a control group in a 1:2 ratio, homogeneous by age, type of treatment, RT total doses and fractionations, and target volumes' prescription. Acute and late toxicity were recorded using RTOG scales. Results: We included 44 women with ARDs (median age 61 years) and 88 woman (median age 62 years) as control group. In ARDs group, the most used RT schedules were conventional fractionation (72.7%), while hypofractionation schedule (40-44 Gy) was administered in 12 patients (27.3%). In the control group, 64 patients (72.7%) received RT with conventional fractionation and 24 patients (27.3%) hypofractionation (40-44 Gy). Overall acute skin toxicity rate was 80.4% in the control group vs 86.4% in the ARDs group (p = 0.681). Specifically, G2 toxicity was 22.0% in the control group vs 31% in the ARDs group, while G3 acute toxicity was 2.3% in both groups. Overall late skin toxicity was 21.6% in the control group vs 27.3% in ARDs group (p = 0.067). Statistically significant difference was observed in late G2 toxicity with a 0% rate in the control group vs 6.8% in the experimental group (p = 0.035), respectively. Conclusions: ARDs do not seem to represent an absolute or relative contraindication in BC RT in terms of acute and late cutaneous toxicity. Hypofractionated schedule showed less toxicities in both group and, particularly, in ARDs group
Codelivery of Raloxifene and Rutin as PEGylated Nanoliposomes: Formulation, Characterization, and Prophylactic Activity Against Breast Cancer
No full textPurpose: Breast cancer is the leading cause of cancer-related deaths among women. Chemotherapy faces challenges such as systemic toxicity and multidrug resistance. Advances in nanotechnology have led researchers to develop safer and more efficient cancer treatment methods. Methods: The thin-film hydration method was employed to synthesize PEGylated nanoliposomes (NLs) loaded with raloxifene (RLX) and a combination of RLX and rutin. The NLs were characterized using a Zetasizer® instrument, transmission electron microscopy (TEM), and high-performance liquid chromatography (HPLC) analysis. The encapsulation of RLX and rutin was confirmed, and cell viability assays were conducted against breast cancer and normal endothelial cell lines. Results: The encapsulation efficiency significantly increased in the mixed formulation, with RLX reaching 91.28% and rutin 78.12%, indicating successful encapsulation. These NLs remained stable for up to two months at room temperature and one month at 4°C, demonstrating a biphasic release pattern. After 24 hours, approximately 17% of RLX was released from the NLs and 25% from the mixed NLs. In contrast, 55% of rutin was released from the NLs and 70.4% from the mixed NLs within 72 hours. The inclusion of rutin or RLX in the liposomal formulation reduced cytotoxicity against breast cancer cell lines, as indicated by the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. However, it improved safety in normal human cells and tissues. Conclusion: PEGylated NLs loaded with RLX and rutin demonstrated safe anti-breast cancer effects, outperforming mixed NLs, suggesting the potential for a safer and more targeted treatment. Further investigations are needed into clinical translation
Il processo di socializzazione digitale e i suoi esiti: una proposta teorica
No full textQuesto contributo, eminentemente teorico, intende fornire una chiave interpretativa di taluni mutamenti culturali intervenuti a seguito della digitalizzazione dei processi comunicativi, e in particolare a seguito dell’avvento dei social media.
Nel rivendicare per questi media la triplice natura di agenzie di socializzazione, gatekeepers e tecnologie della comunicazione, viene proposto il costrutto di socializzazione digitale e dettagliato l’idealtipo sociale che ne discende, quello del follower, introducendo quale suo tratto fondamentale la riproduzione acritica dei modelli. La stessa viene inscritta all’interno di una conoscenza sociale impoverita, che si contraddistingue sempre più per essere fast, nei suoi processi di costruzione, fruizione e riproduzione
Incorporating Radar Frequency-Domain Deramping into Variational Shape-Based Scene Reconstruction: A Feasibility Study Using Active Contours
No full textMulti-view stereo techniques with traditional cameras have wide applications in robotics and computer vision for scene reconstruction. Their dependence on the visible spectrum, however, poses several limitations that radar sensing could overcome in obstructing conditions such as fog and smoke. We propose a new radar-based multi-view stereo method for scene reconstruction, which combines the power of multi-view stereo techniques with the advantages of radar sensing by extending upon our previous work in this direction, where we demonstrated a time-domain inversion approach by leveraging a set of independent radar echoes acquired at sparse locations to reconstruct the scene's geometry. Here, we show how radar stretch processing can be incorporated into a similar geometric framework to leverage frequency-domain information. Our method fundamentally differs from classical radar imaging by utilizing an explicit geometric shape representation, allowing the imposition of shape priors and the ability to model visibility and occlusions, and a forward model based on the electric field strength density over the antenna range embedded within the deramped echo. An iterative scheme is then used to evolve an initial shape toward an optimal configuration to best explain the data. We conclude by showing the initial proof of concept for the success of this method through a set of simulated 2D experiments of increasing complexity