Journals at the University of Arizona
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NATURAL KILLER LYMPHOCYTES IN RAT LIVER SINUSOIDAL BLOOD
No full textBlood·borne cells with the characteristics describedfor the natural killer (NK) lymphocytes were recoveredfrom the liver sinusoids in rat. They hadcytotoxic activity against K 562 cells in a 18 h Sl Crrelease assay. target binding rate and large granularlymphocytes percentage higher than the inflowingportal blood cells. The cytotoxic effector populationwas non-adherent and peroxidase negative, enrichedin cells with Fe- and C36-receptors. Deprivationof liver of portal or mesenteric blood supplysign ificantly decreased the liver NK activity not affectingthe level of cytotoxicity in the portal blood.Splenectomy produced only a moderate decrease ofactivity. These findings may indicate that liver sinusoidsis the site of accumulation of blood-born NKcells or of maturation of the NK·precursors. Onepossible mechanism by which natural cytotoxicitycontrols tumor growth and spread might be the killingof circulating tumor cells arrested in the liverby the blood-born NK-cells
LYMPHO-NODAL FIBROSCLEROSIS IN PRIMARY LYMPHEDEMA PART TWO: CONSEQUENCES OF LYMPHO-NODAL FIBROSCLEROSIS ON LYMPH STASIS IN PRIMARY LYMPHEDEMA
No full textThe inguinal-iliac lympho-nodal fibrosclerotic processesappearing in female patients with primarylymphedema bring about an obvious tendency ofreduction of the circulatory flux in the afferentlymphatics at some distance from the lympho-nodalarea: at the foot or at the shank.The inguinal lympho-nodal morphopathological alterations(examined in 72 cases of primary lymphedema)were followed, by distal lymph stasis at thelevel of the foot and of the leg, without sensibly affectingthe lymph flow in the thigh. These aspectsof the lymph stasis adjacent to the lympho-nodalareas are striking in the patients with secondarylymphedema
METASTASIS SIMULATED BY RETROGRADE CONTRAST FILLING OF SEGMENTAL LUMBAR LYMPHATIC
No full textThe present case demonstrates retrograde filling of a segmental lumbar lymphatic at foot lymphography. The finding simulated lymph node metastasis
MICROSURGICAL TECHNIQUES FOR TRANSPLANTATION OF ORGANS CONTAINING LYMPHOID TISSUE
No full textThe technical methods of tr ansplantation of spleen, small bowel and hind extremity in rats used in our laboratory have been presented. Vascularized spleen orthotopic and hetero topic grafts and small bowel transplants are used for studies on spontaneous mi gration of isotope labelled cells from and through these organs, hind extremity transplants serve as a source of live bone marrow tissue
OUR EXPERIENCE ON ANATOMICAL INJECTIONS OF THE LYMPHATIC VESSELS
No full textThe authors relate their experience on anatomicalinjections of the visceral lymphatic vessels. Theirexperience concerns the stomach, the pancreas, thelungs, the thyroid gland and the esophagus. Thiswork has been carried out on the corpse using solutionof cedar coloured oil and china wood colouredoil.The injection is performed in five steps and everymotion of the hand is important. However, the re sultsin the dead are highly depending upon thetechnique of injection so that the study on the livingis absolutely necessary
SPONTANEOUS CONTRACTILITY IN THE HUMAN LYMPH VESSELS
No full textDuring the diagnostic lymphangiography of the lower limbs, the motility of the lymph vessels was investigated in 79 consecutive patients, by means of a particularly performed serial radiography, aided by photographic magnification of films. Because of tech nical difficulties, a rather high incidenceof imperfect examinations occurred.In 26 out of 35 (74.3%) technically satisfactory observations obtained from patients with no obstacle to lymph flow, evident morphological modificationswere demonstrated, surely caused by intrinsic spontaneous contractility. Only in few cases a conctractile activity, somehow resembling a true peristaltic wavecould be demonstrated; usually the lymphatic "pulse" appeared irregular and greatly varying and no specific rhythm was detected.Our findings suggest that: intrinsic contractility may be an important determinant of lymph flow; the pattern of contractility is strongly influenced by the anatomical feature of the lymphatic chain, whose lymphangions(intervalve segments), appear continuously varying in size and shape
LYMPHA-PRESS. A NEW PNEUMATIC DEVICE FOR THE TREATMENT OF LYMPHEDEMA OF THE LIMBS
No full textAs no adequate surgical nor conservative therapyexists for the treatment of lymphedema, therapistsshould aim at efforts to improve quality of life forthose patients. Most surgeons agree that surgicaltreatment of such cases leaves much to be desired(4).The use of microsurgery lymph-vein anastomosis maybe the current best solution to this problem, but todate not enough experience has been accumulated(5). Of all the conservative treatments known, intermittentcompression is the only one which so farhas shown any effectiveness.The "Lympha-Press", a pneumatic compression instrument,based on physiological principles, hasbeen developed in our department and is currentlybeing manufactured. It has proven to be very effectivefor the efficient reduction of lymphedema.It is designed so that the fluid is pushed from thelimb in a proximal direction only. The short cycleof the pressure allows the therapist to use highpressures in order to overcome long standinglymphedema without discomfort to the patient.The use of the "Lympha-Press" together with thecorrect elastic stocking promises restoration of agood quality of life for the patients.In this series of 20 patients we had remarkableresults in a very short time and succeeded in maintainingthis success with the exception of a fewpatients who needed a few additional sessions, ofone hour each.The "Lympha-Press" is a new intermittent pneumaticmachine which according to our experience,has been more effective than the conventionalmachines, and the results presented in this paperwould seem to justify its wide use in the treatmentof lymphedema of the limbs
LYMPHOGRAPHIC CLASSIFICATION OF MALIGNANT LYMPHOMA
No full textIn an attempt to raise the diagnostic accuracy oflymphography in malignant lymphoma, especiallyin early stages, the disease were radiographicallyclassified into 3 groups such as atypical, typical andadvanced group mainly based on the lymphographicfindings. The findings showed characteristic featurescorresponding to the stages of the disease.Atypical group showed the following findings: smallfilling defects, increased number of lymph node andvisualization of the marginal sinus. The findingswere regarded as those of early stages of malignantlymphoma
FOOD STIMULATED LYMPH FLOW IN THE NECK REGION
No full textFood stimulated lymph flow in the neck region was studied in 8 patients. In each patient there was a significant increase in lymph flow during eating. Changes in lymph flow occurred rapidly and it is suggested that lymph transport is an active process
THE FLOW AND COMPOSITION OF PULMONARY AND SYSTEMIC LYMPH IN BOGS WITH EDEMA
No full textIn animals with edema, pulmonary and systemiclymphatics may function to remove accumulatedextravascular fluid in addition to responding toevents as they occur in the exchanging vessels. Wetested this hypothesis by measuring the flow rateand composition of thoracic duct and right ductlymph in anesthetized dogs made edematous byrapid fluid infusion. During a fluid challenge equiva-lent to 30% of body weight, thoracic and right ductlymph flow rates increased 30- and 60-fold, respectively.After the infusion, lymph flow rates rapidlydecreased even though the dogs were edematous.During the postinfusion period, the decrease in rightduct lymph flow rate was directly related to a decreasein estimated net pulmonary fluid filtrationpressure. We conclude that lymph flow rate andcomposition reflect events occurring in the microvasculaturewhether or not edema is present