Journals at the University of Arizona
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DEVELOPMENT OF LYMPH HYPERTENSION DURING LYMPHATIC OCCLUSION
No full textThe effects of obstruction of lymph flow on the intralymphatic pressure are studied through a mathematical model using a digital computer and intralymphatic pressure was observed to increase
THE LYMPH NODE IN EXPERIMENTAL XANTHOMATOSIS*
No full textThere is significant, progressive replacement of the lymplioid elements of the lymph node by foam cells in experimental xanthomatosis. These cells first form islands in the subcortical area. Subsequently they involve the medullary cords and finally, they replace the cortex.The xanthomata are higly vascular, consisting of a dense capillary network of samail and short capillaries. These newly visualized capillaries are fully integrated and incorporated in the normal blood supply of the lymph node. No significant distortion of the larger venules and arterioles were observed. It is noteworthy to observe the great capacity of the vascular supply of the lymph node in reacting to situations of significant enlargment and replacement of the lymphoid elements
ANALYSIS OF THE RADIOGRAPHICALLY VISUALIZED DEEP HEPATIC LYMPH DRAINAGE IN THE DOG
No full textThe deep hepatic lymph drainage of 9 cholecystectomized dogs was analyzed after radiographic visualization with retrograde biliary infusion of Ethiodol. No drainage from the deep to the superficial lymph system of the liver was found with the descnbed method. Primary stations of the deep hepatic lymph drainage are thehepatic, left gastric and splenic lymph nodes although the latter two were not always opacified. On the average 9 (6-11) hepatic lymph nodes were opacified which is a significantly higher number than previously reported. Retrograde contrast material filling of splenic, mesenteric, aortic, iliac and some intrathoracic lymph nodes occurred with various frequencies but the opacification of these nodes was usually incomplete
SPONTANEOUS ALTERATIONS IN THE SIZE OF LYMPH NODES AFTER LYMPHOGRAPHY
No full textA total of 124 normal lymph nodes in 20 patients with Hodgkin's disease were measured in lymphograms by means of planimetry with point counting. Anteroposterior views were used both in the lymphography (24 h) and at subsequent check-up studies. A statistically significant reduction (p 0.05) of 3.5% in the area of the lymph nodes was observed in the period after lymphography (range, 4-189 days; average, 26.8 days) during which no irradiation or chemotherapy had been given. Correction for technical factors and an evaluation of errors of measurement were made
Critical Appraisal of Lymphangiography in Cancer of the Female Genital Tract
No full textThe first publication on direct lymphography was made by B. Kimnonlh ( I) in 1952.The use of lymphography in gynecological cancer was first described by. M. Colette(2) in 1958. Whether this method is useful in the diagnosis and in the treatment of cancer of the female genital tract is still 12 years later a source of debate.Although many reports have been very enthusiastic about this tedmic in the management of cancer of the genital tract, many others have been rather pessimistic. lt is only by a good historadiological correlation of a very large number of cases that the problem can be solved.The following article will provide an additional experience on that field and tryto definite more precisely the limits of lymphography in gynecological cancer
Lymphatic Metastases of Bone Tumors
No full textLymphography was performed in 67 consecutive cases of bone tumors. The diagnosisof the type of bone tumor was confirmed by biopsy in a ll cases. Biopsy of the lymphnodeswas performed 14 times. Metastases in lymphnodes were found in 24 cases( 43,60/o). Lymphatic metastases occurred mostly in osteogenic sarcoma, reticulum cellsarcoma and metastases of carcinoma into bones. There was a significantly shortersurvival of patients with lymphnode metastases. It is argued. that in malignant bonetumors treatment of the regional lymphnodes should be considered at the same time asthe tumor itself
Lymphatic Dissemination of Cancer Cells in Mice Transplanted lntratibially with Ehrlich Carcinoma*
No full textEhrlich carcinoma cells implanted in the marrow cavity of the tibia in Swiss mice inducethe formation of visible metastases in axillary lymph-nodes. The pattern of the lymphaticvessels in the tumor implantation area was investigated. Cancer cells were found in lymphsamples taken from the subcutaneous inguino-axillary lymphatic trunk. The blockade of thislymphatic vessel by a polyvinylic resin resulted in a different distribution of lymphnodalmetastases, while the hematic dissemination of cancer cells was unaffected. The results arediscussed in relation to the pathogenesis of the axillary metastases in the considered experimentalmodel.Previous studies (1) indicated that Ehrlich carcinoma implanted in the marrow cavityof the tibia in Swiss mice induced the formation of visible metastases in distant lymphnodessuch as axillary, paraortic, thoracic, paravertebral, and cervical nodes. Thesefindings suggested a study to identify the lymphatic circulation in the posterior leg ofthe mouse after the intratibial transplantation of Ehrlich carcinoma and to analyse thedistribution of lymphnodal metastases after inducing lymphodynamic changes
Inception and Manner of Development of the Lymph Vessels in the Chick Embryo Heart
No full textThe initial stages of development of the cardiac lymph vessels were studied in 30 chick embryosfrom the 9th to 14th day of incubation. The microinjection technique in correspondance to lightand electronmicroscopical analysis was used.As a rule, mesenchymal cells form part of the wall of the primitive lymph vessels and capillary.There is practically no difference between these cells and the primitive endothelium. The vascularwall is connected to the surrounding mesenchyme by numerous processes and in places it communicatesfreely with the mesenchymal intercellular space. With advancing development, communicationswith the intercellular spaces disappear in the larger lymphatics. The development of thelymph capillary in the periphery is promoted by mitoses of primitive endothelial cells and incorporationof mesenchymal cells into the lining of the lymph bed. The differentiation of mesenchymalcells to endothelial cells occurs. During the period in question the lymph capillary wall has no basallamina. The incorporation of mesenchymal cells into the lymph capillary bed, is followed by transformationof the simple mesenchymal cell contacts into the complex interdigitations typical for thelymph capillary endothelium. Differentiation of the lymph vessels and capillaries does not progressbeyond the simple endothelial tube stage during the period in which these observations were carriedout