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An empirical assessment of the nexus between competition policy and global value chains
No full textInternational audienc
Non-covalent SUMO interactions with ligases and effectors: SUMO-interacting motifs and beyond
No full textInternational audienceSUMOylation, a protein post-translational modification (PTM) involving the covalent attachment of small ubiquitin-like modifier (SUMO), regulates a wide range of cellular processes. The key hallmark of SUMO that distinguishes it from ubiquitin is the hydrophobic groove that binds short linear motifs known as SUMO-interacting motifs (SIMs), which are found across a broad spectrum of partners, including SUMO E3 ligases and downstream effector proteins such as transcription factors, DNA-repair proteins, ubiquitin E3 ligases and cell-signalling components. In addition, various effectors interacting in a SIM-independent manner have been reported. In this review, we summarise the current understanding of non-covalent SUMO interactions mediated by SIMs and other, alternative SUMO-binding elements. Focusing on the evolution and structural basis of these interactions, we discuss the methodological approaches used in the field, outline emerging mechanisms and concepts and highlight key open questions
Magnetite-Doped Activated Carbon Beads and Powder Derived from Chitosan for Adsorption of Emerging Contaminants in Drinkable Water
No full textInternational audienceActivated carbon beads, some of which contain Fe3O4 nanoparticles or graphene oxide, were synthesized by thermal activation (700 °C) of chitosan hydrogel beads. Materials showed a multiporous scale (micro/meso/macro) and BET specific surface areas in the 260–572 m2.g−1 range. The adsorption kinetics of beads and powders resulting from their grinding were studied for a mixture of six micropollutants (bisphenol A, carbofuran, carbamazepine, diclofenac, dimethoate and imidacloprid) dissolved in spring water. While the adsorption kinetics on the beads (pH 7.3, 25 °C, 10–100 µg.L−1) are slow (equilibrium time > 24 h), the powdered samples are more efficient: for an initial concentration of 50 μg.L−1 of each pollutant (0.1 g.L−1 of adsorbent), 50 to 99% of the micropollutants introduced into the solution were removed after 4 h of contact time. Depending on the pollutant nature, the adsorption isotherms (0.2–40 μg.L−1) studied for an activated carbon powder containing Fe3O4 (1 mass %) are either of Langmuir or Freundlich type, or they follow Henry’s law and are related to the different properties of the molecules
Studying Diffusiophoresis-Driven Colloid Transport in Porous Media Using Microfluidics
No full textNational audienc
A structural survey and examination of lanthanide emission from gallium-containing metallacrowns with folded and collapsed motifs
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New NIR imaging agents based on the incorporation of lanthanide complexes in nanoparticles: applications for cancer cells detection
No full textInternational audienceOptical imaging in the near-infrared (NIR) range is of strong interest for biological research and medical diagnostic. In addition to deeper tissues penetration, emission in the NIR allows to improve both the detection sensitivity (absence of autofluorescence background) and the image resolution. The luminescence of lanthanide(III) cations (Ln3+) is attractive as they exhibit sharp emission bands, that are not affected by any environment changes (pH, temperature…). The key requirement to generate their signals is to sensitize them with a chromophore that absorb excitation light and transfer the resulting energy to the lanthanide(III). In this respect, metallacrowns (MCs) allows to coordinate and sensitize the lanthanide(III). Our lab has created several families of lanthanide(III)/zinc(II) and lanthanide(III)/gallium(III) MCs1,2,3,4. However, their use in biological system have been limited by their lack of solubility in water.Polystyrene nanoparticles (PS-NPs) are extensively utilized in biological and medical research due to their versatility, their biocompatibility and unique properties (monodispersity, tunable size, functionalization…). Recently, our lab has developed a methodology to encapsulate a large number of lanthanide-based complexes in functionalized PS-NPs through a rapid swelling process1, allowing us to incorporate a large number of MCs. Functionalized PS-NPs are used as a platform for vectorization with small molecules, peptides or antibodies.For this project, HER2-overexpressing breast cancer was taken as a model to develop targeted lanthanide-based NIR optical imaging agents. The first PS-NPs containing NIR-emitting MCs with specific HER2 targeting, addressed by the surface conjugation of a monoclonal antibodies, trastuzumab, were generated and characterized in vitro. These nanoparticles showed (i) the conservation of the specific binding properties to HER2 at the surface of cancer cells, (ii) unique photophysical properties from Ytterbium(III) ion and (iii) an absence of cytotoxicity. These nanoparticles show supplementary properties suggesting potential theranostic applications.These PS-NP are extremely promising as they constitute a versatile system that could be adapted to other targets, to multiplex and/or multimodal imaging modalities
Clarifying the concept of advanced practice in physiotherapy for global model development
No full textInternational audienc
Repenser l'activité physique pour un vieillissement cognitif actif grâce aux exergames : une approche novatrice Rethinking Physical Activity for Active Cognitive Aging through Exergames: An Innovative Approach
No full textInternational audienceIntroduction. The aging of the French population raises new challenges. The search for effective interventions to preserve autonomy and to decrease the risk of physical and cognitive disorders represents a priority. Several studies have suggested that multidomain training involving physical, motor, and cognitive stimulation could benefit maintaining cognitive vitality. In particular, exergames, active video games, could be effective for training purposes. Purpose of research and results. This narrative review aims to provide an overview of the effects of different types of stimulation (aerobics, muscle strengthening, complex motor skills, open activities, combined training) and associated mechanisms, focusing on active video games as well as a new generation of exergames assisted by an immersive and interactive wall. Conclusions. These new technologies are promising and motivational tools for multidomain training (i.e., physical, motor, cognitive) for older adults.Introduction. Le vieillissement de la population française soulève de nouveaux défis. La recherche d’interventions efficaces pour préserver l’autonomie et diminuer le risque de troubles physiques et cognitifs représente une priorité. Plusieurs travaux ont suggéré que l’entraînement multi-domaine combinant stimulation physique, motrice et cognitive pourrait offrir des avantages pour maintenir la vitalité cognitive. Plus particulièrement, les exergames, jeux vidéo actifs, seraient susceptibles d’être le support d’entraînements efficaces. But de l’étude et résultats. Cette revue narrative vise à établir un aperçu des effets de différents types de stimulations (aérobie, renforcement musculaire, habiletés motrices complexes, activités ouvertes, entraînement combiné) et des mécanismes associés, en se focalisant sur les jeux vidéo actifs ainsi qu’une nouvelle génération d’exergames assistés par un mur immersif et interactif (EM2I). Conclusions. Ces nouvelles technologies apparaissent comme des leviers motivationnels prometteurs pour l’entraînement multi-domaine (physique, moteur, cognitif) des personnes âgées
Reduced Rank Capon beamforming for high resolution ultrasound imaging
No full textInternational audienc