998 research outputs found
Sort by
Headache Phenotypes in Idiopathic Intracranial Hypertension: Analysis of Tertiary Hospital in Fortaleza/CE
Get PDFFull abstract in PDF
Observational analysis of 12 years-experience with OnabotulinumtoxinA in the treatment of chronic migraine treated in a tertiary headache center
Get PDFFull abstract in PDF
Analysis of the Relationship Between Migraine and Cardiovascular Diseases: an Integrative Review
Get PDFFull abstract in PD
Um novo modelo anatômico-funcional: efeito do topiramato sobre a degranulação de mastócito induzida por capsaicina na dura-mater de rato (Resumo)
Get PDFDissertation (Master’s Degree in Biotechnology). Postgraduation in Biological Sciences. Federal University of Pernambuco, Recife, Brazil. 2020. 64 f. Supervisor: Prof. Dr. Marcelo Moraes Valença.Dissertation (Master’s Degree in Biotechnology). Postgraduation in Biological Sciences. Federal University of Pernambuco, Recife, Brazil. 2020. 64 f. Supervisor: Prof. Dr. Marcelo Moraes Valença
Genetic variants IL18 -105G>A and -137G>C associated with susceptibility to migraine
Get PDFIntroductionFew studies have been conducted into neurogenic inflammation and neuroinflammation in respect of migraine. However, evidence suggests that the immune system may exert an influence over trigeminal activation and cortical spreading depression in individuals suffering from migraine. The interleukin (IL)-18 is a pro-inflammatory cytokine and increased plasma levels have been confirmed in individuals with migraine. However, as yet, the genetic variants of IL-18 have not been investigated in the context of migraine.
ObjectiveTo investigate the association between genetic variants IL18 -105G>A (rs360717) and IL18 -137G>C (rs187238) and susceptibility to migraine and its clinical characteristics.
Subjects and MethodsCase control study comprising 307 participants, of whom 152 had a diagnosis of migraine and 155 were healthy controls, paired by sex, age, ethnicity and BMI. The clinical and demographic data were evaluated. The patients with migraine were interviewed using a structured form containing information about the type of migraine (with or without aura, episodic or chronic), age at onset of the disease, frequency of attacks, accompanying symptoms that triggered headaches. The patients also answered validated questionnaires to evaluate incapacity (Migraine Disability Assessment - MIDAS) and impact (Headache Impact Test - HIT-6) for migraine, the presence of allodynia (ASC-12), as well as symptoms of anxiety (State Anxiety Inventory - STAI 1 and 2), depression (Beck Depression Inventory) and a hyperacusis scale.The genetic variants IL18 -105G>A (rs360717) and IL18 -137G>C (rs187238) were identified using polymerase chain reaction (PCR) and the fluorescence levels of PCR products were evaluated using a Step One thermocycler (Applied Biosystems). The analyses were conducted using the dominant, codominant, recessive and overdominant genetic models. (To see the complete abstract, please, check out the PDF).
Effects of migraine in cognition
Get PDFBackgroundMigraine is among the 3 most burdensome neurological disorders in the US in terms of absolute number of disability-adjusted life years (DALYs) from 1990 to 2017, behind just stroke and Alzheimer disease and other dementias. Migraine is characterized as a type of unilateral primary headache marked by a series of neurological and vascular alterations, which can occur episodically or chronically and course with intermittent attacks of intense or moderate headache. Moreover, cognitive dysfunctions are interim and disabling components of this disorder and may be related to the brain processes underlying the pathophysiology.
ObjectiveExamine the effects of migraine in the cognitive functions, such as language function, visuospatial function, attention, executive function and memory, of adults between 19 and 45 years old.
MethodThis study consists in a narrative review of articles published in the last 5 years on MEDLINE database searched through PubMed. The articles were found using the following MESHs: Migraine and Cognition.
ResultsWe utilized 3 studies that approached cognitive impairment in migraine attacks and interictally. In a clinical trial, 144 pacients with chronic migraine (CM) and 44 age-matched patients with episodic migraine (EM) (a maximum of 4 headache days per month) were compared by cognitive assesments. In the Montreal Cognitive Assessment (MoCA), CM patients demonstrated the most striking impairment in memory/delayed recall (65.3%), attention (46.5%), abstraction (30.6%), and language (27.1%). (To see the complete abstract, please, check out the PDF)
Influence of sleep and physical exercise in migraine patients
Get PDFIntroductionThe prevalence of headache and sleep disorders is quite high in the general population. Both are chronic pathologies considered factors of daily disability which often coexists in migraine patients. A cause-and-effect relationship between migraine attacks and sleepless nights has not been confirmed yet, but it is already recognized that they have in common neuropeptides and functional anatomy in their pathogenesis. Because of this high prevalence, there are several studies on treatment options and prophylactic measures for migraine. The regular practice of physical exercises is identified as an important prevention factor for migraine attacks. However, daily intense physical activities are identified as triggers for these attacks.
ObjectivesTo investigate the correlation between sleep time and frequency of physical activity with headache days per month, migraine disability, allodynia, hyperacusis, anxiety and depression.
MethodsCross-sectional study composed of 466 individuals of both sexes diagnosed with migraine. Patient data such as age, sex, race, body mass index (BMI), waist circumference, presence of hypertension and diabetes were analyzed. It was obtained information about the type of migraine (episodic or chronic; with or without aura), age of symptoms onset, duration of illness, use of prophylactic medication and excessive use of analgesics, as well as hours of sleep per night and frequency of practice of physical activity. Patients answered questionnaires to evaluate disability (Migraine Disability Assessment - MIDAS) and the impact of migraine (HIT-6), as well as questionnaires for anxiety (STAI Y1 and STAI Y2), depression (Beck Depression Scale), allodynia (ASC-12) and hyperacusis. Spearman\u27s correlation test was performed and a statistical difference was considered when p ≤ 0.05. (To see the complete abstract, please, check out the PDF)
Prevalence of compulsion in migraine patients and its association with analgesic abuse
Get PDFIntroductionMigraine, is one of the most prevalent types of headaches, affects around 15% of people worldwide, more common among women, and causes a great effect in the quality of life of the individual. The diagnosis criteria of this disease is due to its duration and other characteristics such as phonophobia, photophobia, unilateral, pulsatile and intense crisis, nausea and vomiting, which can be preceded by aura and premonitory symptoms. With the purpose to ease those symptoms, the patients have a drug overuse. The medication-overuse headache (MOH) is an emerging problem, due to the possibility of developing psychiatric disorders like obsessive compulsive disorder (OCD) and impulsivity. Impulsivity consists in actions where the individual does not reflect upon it and make decisions fast, without planning or analyzing the case in the long term. Compulsion is defined as repetitive actions with the intention to ease anxiety or an uncomfortable situation.
ObjectiveDetermine a prevalence of OCD in migraine patients, evaluating different scopes of it, including the association or not with drug abuse.
MethodsA cross-sectional study with 117 patients of both sexes, older than 18 years old. The group was made with migraine patients diagnosed by a neurologist according to the International Classification of Headache Disorders (ICHD) separated in two groups, one that has analgesics abuse and other that do not have. Three questionnaires were used: Barratt Impulsiveness Scale (BIS-11); Obsessive Compulsive Inventory-Revised (OCI-R) and the Migraine Disability Assessment (MIDAS). The data collected was placed in an electronic worksheet and processed in Software SPSS Statistics 22.0. There was an assumption of a p value of 0,05 to all cases with the intention to reject the null hypothesis. (To see the complete abstract, please, check out the PDF).
Caliber and type of needle are associated with the risk of spontaneously reported post-dural punction headache
Get PDFIntroduction
Post-dural punction headache (PDH) is defined as an orthostatic headache that develops within the first few days after performing a spinal tap and it is related to extravasation of cerebrospinal fluid (CSF) into the epidural space, resulting in hypovolemia and CSF hypotension. The risk factors for PDH are not yet fully understood.
Objective
To evaluate the risk of spontaneously reported PDH according to the size and type of spinal tap needle.
Methods
A total of 4589 patients undergoing outpatient lumbar puncture were included. All CSF collections were performed at Senne Liquor Diagnostico, a laboratory specialized in CSF collection and analysis. Patients were instructed to report by telephone the onset of orthostatic headache during the first 7 days after the puncture to the medical team of the laboratory. Patients with previous headache were instructed to report any change in the headache pattern during the same period.
Needle gauge was classified into two groups: 1) 25G or less and 2) greater than 25G. Two types of needles were used and compared: 1) Pencil point and 2) Quincke.
Comparisons of the percentages of spontaneous reports of PDH were made using the chi-square test.
Results
141 patients (3.07%) reported PHD to the laboratory\u27s medical team. Needles of 25G gauge or less were used in 31.8% of cases. The percentage of patients reporting PHD in the group of 25G or less needles was 1.9% versus 3.6% in the group of greater than 25G needles (P=0.003). Pencil point needles were used in 10.6% of cases. The percentage of PHD among pencil point group was 1.4% versus 3.2% in Quincke group (P=0.026).
Conclusion
25G or finer gauge needles as well as pencil point type needles significantly reduced the risk of spontaneously reported PHD.
Key-words:
Post-dural punction headache, Spinal Tap, Spinal Tap Needle
Neurological adverse events after vaccination against sars-cov-2 in the municipality of Parnaíba, Piauí
Get PDFIntroduction
At the end of 2019, a new disease that would come to be known as COVID-19 emerged in Wuhan, Hubei province, China, caused by a virus called novel coronavirus or SARS-CoV-2. The infection has spread worldwide, causing many deaths, however, at the end of 2020, the first vaccines against this new virus appeared, approved by regulatory bodies as being effective and safe. However, since the beginning of immunization, there has been much speculation within the general population both about the supposed low efficacy and the correlation with serious post-vaccination adverse events (APVE), including deaths. Furthermore, it is highlighted in the literature that neurological manifestations are one of the main sources of AEFI. Objective: Therefore, the objective of this study is post-vaccination adverse events against covid-19 in the municipality of Parnaíba, Piauí.
Objectives
1) Investigate the occurrence of post-vaccination adverse events of a neurological nature of vaccination against Sars-CoV-2 in the municipality of Parnaíba, Piauí.
Methods
This is a cross-sectional, observational, descriptive and epidemiological quantitative study. Data were collected from the Information Sistema de Informação de Eventos Adversos Pós-Vacinação (SI-EAPV) of Secretaria de Estado da Saúde do Piauí, in the period from January 2021 (date of the beginning of vaccination against COVID-19 in Brazil) to September 2021. The study population was concentrated in the municipality of Parnaíba, located in the state of Piauí, Brazil. According to the Instituto Brasileiro de Geografia e Estatística (IBGE), the estimated population for the municipality in question is 153,863 people. The dependent variable is the presence of neurological manifestation as an outcome: yes/no. The other variables analyzed were color/race, sex and the description of the vaccine used.
(Too see the complete abstract, please, check out the PDF).