Journals of Rzeszow University - Open Journal System
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Secondary chondrosarcoma of the iliac bone in a young woman – a rare case report and review of the literature
Get PDFIntroduction and aim. Chondrosarcomas are malignant cartilage-forming tumors, with secondary cases rarely arising from osteochondromas. This report presents a case of secondary chondrosarcoma developing from an undiagnosed pelvic osteo chondroma in a young female, emphasizing the importance of early detection and timely intervention.
Description of the case. A 28-year-old woman with hip and back pain underwent magnetic resonance imaging, revealing a le sion in the left iliacus muscle with sacroiliac extension. Biopsy confirmed a chondroid neoplasm, and positron emission topog raphy-computed tomography showed minimal metabolic activity. Due to the extensive soft tissue component and recurrence risk, wide local excision was performed. Histology confirmed well-differentiated secondary chondrosarcoma, WHO grade 1 arising from an undiagnosed pre-existing osteochondroma.
Conclusion. The described case highlights the critical role of radiological and histopathological evaluation, timely surgical in tervention, and multidisciplinary management for optimal patient outcomes
Corrigendum: Interleukin-13 as a potential biomarker in the management of pediatric asthma – a longitudinal study
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Interleukin-13 as a potential biomarker in the management of pediatric asthma – a longitudinal study by Raju P, Sundar S, Suresh P, Vajravelu LK, Aravindhan V. Eur J Clin Exp Med. 2025;23(1):15–20. doi: 10.15584/ ejcem.2025.1.3
From diagnosis to therapy ‒ mixed hyperkinetic-hypokinetic dysarthria ‒ a comprehensive case study
Get PDFIntroduction and aim. Progressive dysarthria and dysphagia pose substantial diagnostic and therapeutic challenges. This case report aims to describe the assessment and intensive structured management of a patient with chronic, functionally limiting dysarthria and dysphagia.
Description of the case. The patient was a 38-year-old male with neuroacanthocytosis syndrome. Dysarthria diagnosis was established through auditory-perceptual profiling and acoustic analysis, confirming a mixed hyperkinetic-hypokinetic pattern. Clinical bedside evaluation of swallowing was done, which revealed severe oral dysphagia. Speech therapy was conducted using the hierarchy of motor speech treatment, targeting various motor speech bases. Additionally, severe oral phase dysphagia was managed using rehabilitative, compensatory, and modified diet approaches.
Results. Improvements were noted across all motor speech bases, supported by subjective reports and objective data. The patient's self-reported measures, as well as the improvement in voice quality (AVQI score decreased from 4 to 2.95), improved intelligibility (from 30 to 75%), and decreased speech rate (4.36 to 2.53 syllables/second) showed substantial improvement in dysarthria. Similarly, safe swallowing was achieved at IDDSI Levels 4–6 with compensatory strategies.
Conclusion. This case illustrates that even rare and chronic forms of dysarthria can respond positively to structured, intensive speech-language therapy, underscoring the importance of individualized, comprehensive intervention approaches
Hepatoprotective effect of Costus afer (Lin) on toxic metal mixture treated rats mediated by regulation of oxidative stress markers, inflammatory cytokines and bio-metal chelation
Get PDFIntroduction and aim. Cadmium, lead, and mercury have been considered to exhibit their hepatotoxic effects by oxida tive induction damage and the generation of reactive oxygen species (ROS). The current work evaluated the protective activ ity of aqueous leaf extracts of Costus afer (ALECA) on liver damage arising from exposure to toxic metal mixture (TMM): 1.61 mg/kg cadmium chloride (CdCl2), 20 mg/kg lead chloride (PbCl2), and 0.40 mg/kg mercury chloride (HgCl2).
Material and methods. Five groups of weight-matched Sprague Dawley rats were treated for 90 days. Metal mixtures and deionized water were used to treat the 2 groups of rats whereas the other 3 groups were treated with various doses of the ALECA through oral gavage with TMM. Hepatic function parameters, oxidative biomarkers, inflammatory cytokines, mor phological changes, and metal levels in the liver were monitored.
Results. Treatment with TMM resulted in significant increases in alanine transaminase, aspartate transaminase, alkaline phos phatase, bilirubin, interleukin 6, malondialdehyde, but decreased albumin, total protein, interleukin 10, superoxide dismutase, catalase, and glutathione levels. TMM also caused some morphological changes and increased the concentrations of heavy metals (Pb, Cd, and Hg) in the liver.
Conclusion. ALECA showed beneficial effects against TMM-induced hepatotoxicity via metal chelation, anti-inflammatory, and antioxidant mechanism. ALECA may be beneficial in the management of liver toxicity
Evaluation of oxidative stress level and glutathione system in patients with psoriasis in Basrah Governorate, Iraq
Get PDFIntroduction and aim. Psoriasis is a persistent chronic disease with no known cause or cure. This study aimed to estimate oxi dative stress and glutathione systems, and their association with factors (age, gender, disease severity, and geographical location) in psoriasis patients.
Material and methods. The study was carried out in the Al-Fayhaa and the Basrah Teaching Hospitals. The number of patients was 45 with 45 in the control group. We quantified the amounts of malondialdehyde (MDA), protein carbonyl (PC), 8-hydrox yguanosine, glutathione, glutathione reductase (GR), glutathione peroxidase (GPx), and selenium.
Results. The results showed significant differences in all variables at multiple statistical levels (p<0.05, p<0.01, p<0.001). The study found significant differences between two groups within the allowed concentration range. Some inter-factor fluctuations were found, and these fluctuations were noticeable in age and sex, and not significant in disease severity or location. The pa tients did not experience oxidative stress due to the oxidation of lipids and proteins, but rather DNA oxidation.
Conclusion. Lipid peroxidation or protein oxidation do not correlate with psoriasis. While a marker for DNA oxidation exists, it yields different results in psoriasis patients compared to healthy individuals. We observed a correlation between MDA, GR and PC, GPx, PC, and selenium, which serves as the cofactor of the GPx enzyme
Combined COVID-19-related chronic hypoxemia and lack of screening as a double challenge for the management of asymptomatic invasive lung adenocarcinoma
Get PDFIntroduction and aim. Lung adenocarcinoma (LADC) is the most diagnosed histological subtype of lung cancer and the lead ing cause of cancer death in men in Algeria. Defining the circumstances that preceded the diagnosis improves the manage ment options and reduces its incidence. However, data for this critical period are lacking. We report the case of a patient whose onset of severe COVID-19 and the incidental finding of an undefined LADC overlapped and delayed care of the malignancy.
Case description. We present the case of a 65-year-old man, with invasive LADC discovered during a chest CT scan performed for suspected severe COVID-19. We describe the diagnostic methods and the patient. Histological examination by biopsy re quired to confirm diagnosis could not be performed due to chronic hypoxemia in the patient, which prevented the complete pathological diagnosis and staging of the disease.
Conclusion. Given the prevalence and aggressiveness of LADC in men in Algeria, our study underscores the critical need to develop screening programs, aimed at identifying the disease in asymptomatic patients, in asymptomatic patients that could significantly improve the chances of successful treatment. This is particularly important because LADC patients often develop serious pathologies that can limit their treatment options. COVID-19 serves as a stark example of such limiting interference, further highlighting the importance of early detection in the management of LADC
Strategie komunikacji wizualnej i tekstowej w środowisku cyfrowym uczelni. Studium porównawcze Uniwersytetu Peloponezu i Uniwersytetu Rzeszowskiego
No full textIn the era of rapidly developing digital technologies, academic institutions face the challenge of effectively delivering educational content and building a distinctive image and an engaged online community. Visual and textual communication in the digital environment has become a key tool for shaping the university's identity, attracting students and maintaining relationships with stakeholders.
The aim of this article is to conduct a comparative analysis of the communication strategies used by the University of Peloponnese in Greece and the University of Rzeszów in Poland. An analysis of the coherence, attractiveness and effectiveness of the visual and textual practices used is conducted based on selected digital channels, such as websites and social media platforms. The analysis highlights similarities and differences in the management, popularity and communication in digital media at both universities, offering insights that can inspire further actions in the virtual sphere.W dobie dynamicznie rozwijających się technologii cyfrowych instytucje akademickie stają przed wyzwaniem nie tylko skutecznego przekazywania treści edukacyjnych, lecz także budowania wyrazistego wizerunku i zaangażowanej społeczności online. Komunikacja wizualna i tekstowa w środowisku cyfrowym stają się kluczowymi narzędziami w procesie kształtowania tożsamości uczelni, przyciągania studentów oraz podtrzymywania relacji z interesariuszami.
Celem niniejszego artykułu jest analiza porównawcza strategii komunikacji stosowanych przez Uniwersytet Peloponezu w Grecji oraz Uniwersytet Rzeszowski w Polsce. Na podstawie wybranych kanałów cyfrowych, takich jak strony internetowe oraz media społecznościowe, przeprowadzono analizę spójności, atrakcyjności i skuteczności stosowanych praktyk wizualnych i tekstowych. Analiza ta pozwoli wskazać podobieństwa i różnice w prowadzeniu i popularności przekazów w mediach cyfrowych obu uczelni, które mogą się stać inspiracją do dalszych działań w wirtualnym świecie
Marek Jan Olbrycht, Early Arsakid Parthia (ca. 250-165 B.C.) At the Crossroads of Iranian, Hellenistic, and Central Asian History, Leiden / Boston: Brill 2021 (Mnemosyne Supplements 440)
No full textWyznaczanie jednostkowego zużycia wody oraz współczynnika nierównomierności dobowej w wybranym gospodarstwie domowym - studium przypadku
Get PDFThe aim of this paper was to determine the variability of water consumption and the coefficient of daily irregularity in a selected household located in southern Poland. The study covered the autumn and winter periods and was based on daily water meter readings. Measurements were taken in a household located in Golkowice (Lesser Poland Voivodeship, Wieliczka County, Wieliczka Municipality), which was inhabited by three people. The results of the measurements were collated and analysed, showing variations in water consumption depending on the season, days of the week and number of people living in the house. The results obtained were compared with the standard water consumption specified in the Regulation of the Minister of Infrastructure of 14 January 2002 on average water consumption standards (Journal of Laws 2002 No. 8, item 70).Celem artykułu było określenie zmienności zużycia wody oraz współczynnika nierównomierności dobowej w wybranym gospodarstwie domowym znajdującym się w południowej Polsce. Badanie obejmowało okres jesienny i zimowy i opierało się na codziennych odczytach z wodomierza. Pomiarów dokonano w gospodarstwie domowym zlokalizowanym w miejscowości Golkowice (województwo małopolskie, powiat wielicki, gmina Wieliczka), które zamieszkiwały trzy osoby. Wyniki pomiarów zostały zestawione i poddane analizie, prezentując zróżnicowanie zużycia wody w zależności od pory roku, dni tygodnia oraz liczby osób przebywających w domu. Otrzymane wyniki zostały porównane z normowym zużyciem wody określonym w Rozporządzeniu Ministra Infrastruktury z dnia 14 stycznia 2002 r. w sprawie przeciętnych norm zużycia wody (Dz.U. 2002 nr 8 poz.70)