Portail HAL UA (Université d'Angers)
Not a member yet
58742 research outputs found
Sort by
Induction of labor in late-term pregnancy: amniotomy plus early oxytocin perfusion versus amniotomy plus oxytocin perfusion delayed by 24 h
No full textInternational audienceObjective: To assess the maternal and fetal benefits of delaying oxytocin perfusion by 24 h following labor induction by amniotomy after 41 weeks of gestation (WG).Methods: We performed a retrospective review including all women with a vertex presentation fetus who had an indication for labor induction by amniotomy with or without oxytocin after 41 WG between 2015 and 2022. Patients who underwent an IOL by amniotomy followed by oxytocin perfusion within 0 to 4 hours (early oxytocin group: EO group) were compared with patients who underwent an IOL by amniotomy alone or followed by an oxytocin perfusion after an expectant period for up to 24 hours in the absence of a spontaneous onset of labor (delayed oxytocin group: DO group). The primary outcome was the rate of vaginal delivery (natural or operative). The secondary outcomes were maternal and neonatal complications.Results: We included 363 patients: 103 patients in the EO group and 260 in the DO group. Only 47 of the women in the DO group (18%) required oxytocin. The proportion of vaginal deliveries was significantly higher in the DO group (248 patients, 95.4%) than in the EO group (85 patients, 82.55%) (p<0.01). Maternal morbidity did not differ significantly between groups. Fewer babies displayed severe newborn acidemia or required transfer to the neonatal intensive care unit in the DO group (p<0.05).Conclusion: Delaying oxytocin administration by 24 hours after amniotomy was associated with a significantly higher rate of vaginal delivery. These results required confirmation in prospective randomized studies
Consumers’ environmental and societal perceptions during phygital experience
No full textInternational audienc
The Skin Microbiome: A New Key Player in Melanoma, From Onset to Metastatic Stage
No full textInternational audienceThe skin microbiome plays a crucial role in maintaining skin health, defending the body against harmful pathogens, and interacting with melanoma. The composition of the skin microbiome can be affected by factors like age, gender, ethnicity, lifestyle, diet, and UV exposure. Certain bacteria like Staphylococcus and Veillonella are important for wound healing, while Cutibacterium acnes can play a role in dermatoses. UV radiation alters the skin microbiome, originates a "UV-resistome" and can lead to skin cancer initiation. Specifically, Staphylococcus epidermidis has shown protective effects against skin cancer, whereas Cutibacterium acnes can induce apoptosis in melanocytes postirradiation. The microbiome also interacts with melanoma treatment, affecting responses to immune checkpoint inhibitors. Strategies like bacteriotherapy, involving the manipulation of the gut microbiome but also the skin microbiome (with the gut-skin axis or through topical treatment) could improve treatment outcomes and show promise in melanoma therapy. Understanding the complex interplay between the skin microbiome, UV exposure, and melanoma development is crucial for developing personalized therapeutic approaches. Investigation into the skin microbiome and its potential role in melanoma progression continues to be an exciting area of research with implications for future therapeutic interventions
From hydrated silica to quartz: Potential hydrothermal precipitates found in Jezero crater, Mars
No full textInternational audienceOn Earth, silica-rich phases from opal to quartz are important indicators and tracers of geological processes. Hydrated silica, such as opal, is a particularly good matrix for the preservation of molecular and macroscopic biosignatures. Cherts, a type of silica-dominated rocks, provide a unique archive of ancient terrestrial life while quartz is the emblematic mineral of the Earth's continental crust. On Mars, hydrated silica has been detected in several locations based on remote sensing and rover-based studies. In the present article we report on the detection of cobbles made of hydrated silica (opal or chalcedony), as well as well-crystallized quartz. These detections were made with the SuperCam instrument onboard Perseverance (Mars 2020 mission), using a combination of LIBS, infrared and Raman spectroscopy. Quartz-dominated stones are detected unambiguously for the first time on the Martian surface, and based on grain size and crystallinity are proposed to be of hydrothermal origin. Although these rocks were all found as float, we propose that these detections are part of a common hydrothermal system, and represent different depths / temperatures of precipitation. This attests that hydrothermal processes were active in and around Jezero crater, possibly triggered by the Jezero crater-forming impact. These silica-rich rocks, in particular opaline silica, are very promising targets for sampling and return to Earth given their high biosignature preservation potential.</div
Big Data and Data Mining
No full textMasterThe Big Data and Data Mining course introduces the fundamentals of large-scale data analysis, combining theoretical concepts with practical applications through real-world projects. It covers relational databases (SQL), NoSQL systems, Big Data architecture, and supervised and unsupervised Machine Learning techniques using user-friendly tools such as SQL, MongoDB, Excel, and JASP. The course follows an active learning approach, featuring workshops, real data analysis, and the integration of Design Thinking to develop business-oriented solutions.Le cours Big Data et Data Mining introduit les fondements de l’analyse des données à grande échelle, combinant théorie et pratique à travers des projets concrets. Il couvre les bases des systèmes relationnels (SQL), les bases NoSQL, les architectures Big Data, ainsi que les techniques de Machine Learning supervisé et non supervisé à l’aide d’outils accessibles tels que SQL, MongoDB, Excel et JASP. Une approche pédagogique active est adoptée, incluant des ateliers, des analyses de jeux de données réels et une intégration du Design Thinking pour développer des solutions orientées métier
Associated consistency and the egalitarian value
No full textWe propose a new associated game built around the marginal contributions of players to the complementary coalition. We use this associated game in an associated consistency axiom. We identify the subset of efficient, symmetric and linear sharing rules that satisfy this associated consistency and show that, amongst these, only the egalitarian value is monotonic.</div
Focus on the importance of the process parameters: Temperature cycles and “shock” water addition during the phase inversion process for the formulation of lipid nanoparticles
No full textInternational audienceThe phase inversion temperature method is one of the formulation processes to elaborate nanomedicine based on lipid nanoparticles. This process was used in numerous studies in literature, changing the nature of the ingredients to ensure good encapsulation efficiencies of various drugs. While the product quality attributes to develop various nanomedicines were largely explored, the process parameters remained unchanged from the first lipid nanoparticles designed with this process 25 years ago. It is always composed of 3 temperature cycles and a fast addition of cold water, creating an "irreversible shock" to obtain the lipid nanoparticle in suspensions. To date, the exact roles of these 2 steps remain unclear. We decided to explore their impact by changing the number of temperature cycles and by modifying the final addition of water (temperature, salinity, with or without). Using these various conditions, the size distribution and stability, the capacity of encapsulation and the cytotoxic property of the lipid nanoparticles were compared. It demonstrated the indispensableness of these parameters: at least 1 temperature cycle and rapid cooling and dilution of the mixture, to obtain the most performant nano-systems
SUDA: A SUrface Dust Analyser for Compositional Mapping of the Galilean Moon Europa
No full textInternational audienceAbstract The Surface Dust Analyser (SUDA) is a mass spectrometer onboard the Europa Clipper mission for investigating the surface composition of the Galilean moon Europa. Atmosphereless planetary moons such as the Galilean satellites are wrapped into a ballistic dust exosphere populated by tiny samples from the moon’s surface produced by impacts of fast micrometeoroids. SUDA will measure the composition of such surface ejecta during close flybys of Europa to obtain key chemical signatures for revealing the satellite’s composition such as organic molecules and salts, history, and geological evolution. Because of their ballistic orbits, detected ejecta can be traced back to the surface with a spatial resolution roughly equal to the instantaneous altitude of the spacecraft. SUDA is a Time-Of-Flight (TOF), reflectron-type impact mass spectrometer, optimized for a high mass resolution which only weakly depends on the impact location. The instrument will measure the mass, speed, charge, elemental, molecular, and isotopic composition of impacting grains. The instrument’s small size of 268 mm × 250 mm × 171 mm , radiation-hard design, and rather large sensitive area of 220 cm 2 matches well the challenging demands of the Clipper mission
