WakeSpace Scholarship (Wake Forest University)
Not a member yet
72941 research outputs found
Sort by
Temporal Importance of Gut Microbiome Alterations in Cocaine Self-Administration
No full textCocaine use disorder remains a significant public health concern with no FDA-approved treatments. Recent studies have highlighted the gut microbiome as a potential therapeutic target due to its bidirectional communication with the brain. While previous studies have demonstrated that alterations to the microbiome can influence cocaine self-administration, the temporal significance of such changes remains poorly understood. This study aims to address this gap by investigating the impact of microbiome depletion during drug abstinence on cocaine-seeking behavior. Using a preclinical model, male and female Sprague-Dawley rats underwent 14 days of cocaine self-administration on an FR1 schedule of reinforcement, followed by a 21-day abstinence period, during which microbiome depletion was induced using a cocktail of broad- spectrum antibiotics. While no significant changes in cocaine-seeking behavior were observed in male rats, female rats exhibited reduced cocaine-seeking behavior in a light-cued reinstatement task following microbiome depletion. Molecular analysis of the NAc revealed no changes in Drd1, Drd1, or Fosb expression in females, suggesting that alternative molecular mechanisms targets may mediate the observed behavioral effects. These findings highlight the potential that further study of the interactions between the gut microbiome and substance use could yield novel therapeutic treatment strategies to reduce relapse risk
Homecoming 1971 football program [Wake Forest vs William and Mary]
No full textThe Wake Forest Homecoming Football Program, 1971 is a commemorative publication produced for the November 6, 1971, football game between Wake Forest University and the College of William & Mary, held at Groves Stadium in Winston-Salem, North Carolina. Richly illustrated and spanning over 60 pages, this official game-day program offers a snapshot of Wake Forest athletics, student life, university leadership, and regional commercial culture of the early 1970s. The program contains detailed rosters, statistics, and biographies for both the Wake Forest Demon Deacons and the visiting William & Mary Indians, including a spotlight on standout players like Larry Hopkins and Ed Bradley. Head Coach Cal Stoll and his coaching staff are profiled, highlighting their recent success in clinching Wake Forest's first Atlantic Coast Conference (ACC) championship in 1970. In addition to game-related content, the program features full-page advertisements from local and national sponsors, profiles of the university's law school expansion, and an in-depth article on the dangers of drug use in college athletics. Also included are sections on the Wake Forest cheerleading squad, athletics hall of fame inductees such as Arnold Palmer and Brian Piccolo, and lists of scholarship sponsors and Deacon Club donors
West Point
No full textEphemeral materials related to churches or associations that are associated with Baptist communities of North Carolina, collected and arranged by Special Collection and Archives of Z. Smith Reynolds Library at Wake Forest University
Windy Gap
No full textEphemeral materials related to churches or associations that are associated with Baptist communities of North Carolina, collected and arranged by Special Collection and Archives of Z. Smith Reynolds Library at Wake Forest University
West Side
No full textEphemeral materials related to churches or associations that are associated with Baptist communities of North Carolina, collected and arranged by Special Collection and Archives of Z. Smith Reynolds Library at Wake Forest University
Willowdale
No full textEphemeral materials related to churches or associations that are associated with Baptist communities of North Carolina, collected and arranged by Special Collection and Archives of Z. Smith Reynolds Library at Wake Forest University
Weddington First (Union County)
No full textEphemeral materials related to churches or associations that are associated with Baptist communities of North Carolina, collected and arranged by Special Collection and Archives of Z. Smith Reynolds Library at Wake Forest University
Weeping Mary (Bowling Green)
No full textEphemeral materials related to churches or associations that are associated with Baptist communities of North Carolina, collected and arranged by Special Collection and Archives of Z. Smith Reynolds Library at Wake Forest University
Waughtown (Winston-Salem)
No full textEphemeral materials related to churches or associations that are associated with Baptist communities of North Carolina, collected and arranged by Special Collection and Archives of Z. Smith Reynolds Library at Wake Forest University
Welcome Home
No full textEphemeral materials related to churches or associations that are associated with Baptist communities of North Carolina, collected and arranged by Special Collection and Archives of Z. Smith Reynolds Library at Wake Forest University