MAU GCRIS Standard Database (Mardin Artuklu University)
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Ascorbic Acid Exhibits More of a Protective Effect Than Estradiol Against Nephrotoxicity Induced by Malathion in Rats: A Histopathological and Molecular Docking Study
No full textBackground/aim: Despite the known harmful effects associated with malathion toxicity in various organs, it continues to be widely used for plant protection and insect control. This study is the first to compare the protective effects of estradiol and ascorbic acid against malathion-induced nephrotoxicity through histopathological assessment and molecular docking analyses. Materials and methods: This study was conducted using 20 female albino rats that were distributed into sham, malathion, malathion + estradiol, and malathion + ascorbic acid groups. Nephrotoxicity was induced by daily treatment with malathion and the effects of estradiol and ascorbic on nephrotoxicity were evaluated. After 4 weeks of treatment, the animals were sacrificed and the kidneys were examined following hematoxylin and eosin (H&E) staining. Histopathology results were supported by molecular docking studies of estradiol and ascorbic acid against a target protein (PDB ID: 2YMX), the peptide inhibitor Fab408 inhibiting acetylcholinesterase (AChE). The inhibition of AChE is the primary mechanism of the toxic effects of malathion. Results: Histopathological examination revealed a notable elevation (p < 0.001) in degeneration and necrosis within the tubular epithelium and interstitial nephritis in the malathion group compared to the sham group. Daily administration of estradiol and ascorbic acid resulted in a notable reduction (p = 0.0022) in the severity of these histopathological changes in the malathion + estradiol and malathion + ascorbic acid groups compared to the malathion group. Of these, the most significant decreases were observed in the malathion + ascorbic acid group. Docking studies of these compounds against the selected protein (PDB ID: 2YMX) revealed promising binding scores. Ascorbic acid exhibited the highest docking score (–6.44 kcal/mol), indicating a favorable binding interaction with this protein. Conclusion: Estradiol and ascorbic acid exert protective effects against malathion-induced nephrotoxicity, whereas ascorbic acid showed superior efficacy compared to estradiol. This result was further supported by molecular docking studies
6 Şubat 2023 Kahramanmaraş Depremleri Sonrası Kamu Kurumlarında Afet Yönetimi: Mardin İli Örneği
No full textDoğal afetler içerisinde en yıkıcı, en can alıcı, en tahrip edici afetin deprem olduğunu söylemek mümkündür. Deprem afeti, can ve mal kayıpları ile yaralanmaların yanı sıra, bina, yol, köprü, baraj, elektrik santralleri gibi yapılarla, kanalizasyon, gaz ve su hatları gibi şehirlerin alt yapısında çok ciddi ekonomik zararlara da neden olmaktadır. Böylesi büyük ve geniş çaplı tahribatlar doğurabilen deprem afetleri karşısında kamu kurumlarının bu afet durumunu yönetebilme kabiliyeti büyük önem taşımaktadır. Bu araştırmanın konusu; Kahramanmaraş depremleri sonucu Mardin İlindeki beş kamu kurumunun gerek Mardin İlinde, gerekse afet bölgesinde hem deprem sırasında, hem de deprem sonrasında faydalı, yeterli, eksik ve yanlış bulunan işleyişlerin ortaya çıkarılmasıdır. Bu araştırmada nitel araştırma yöntemi uygulanmıştır. Veri toplama yöntemi olarak yarı yapılandırılmış mülakat tekniği kullanılmıştır. Toplanan veriler, betimsel ve içerik analizine tabi tutularak yorumlanmışlardır. Depremden, başta çocuklar ve kadınlar ile desteğe muhtaç yaşlı ve hastalar daha çok etkilenmişlerdir. Afetzedeler, mevsimin kış olması nedeniyle başta ısınma olmak üzere; su, tuvalet, banyo, elektrik gibi imkânlara çok zor koşullarda erişebilmişlerdir. Araştırmanın sonunda, elde edilen bulgulardan yararlanılarak Afet ve Acil Durum Yönetimi Başkanlığı'nın (AFAD) müstakil bir Bakanlığa dönüştürülmesi, belediyelerde afet birimlerinin kurulması, arama-kurtarma çalışmaları bitmeden hasar tespit çalışmalarına başlanılmaması gibi bir takım öneriler sunulmuştur.It is possible to say that the most devastating, most vital and most destructive disaster among natural disasters is earthquake. In addition to loss of life and property and injuries, earthquake disasters also cause serious economic damages in structures such as buildings, roads, bridges, dams, power plants and in the infrastructure of cities such as sewerage, gas and water lines. In the face of earthquake disasters that can cause such large and widespread destruction, the ability of public institutions to manage this disaster situation is of great importance. The subject of this research is to reveal the useful, sufficient, deficient and incorrect operations of five public institutions in Mardin Province both in Mardin Province and in the disaster area as a result of the Kahramanmaraş earthquakes, both during and after the earthquake. Qualitative research method was applied in this research. Semi-structured interview technique was used as the data collection method. The collected data was interpreted by subjecting it to descriptive and content analysis. Children, women and the elderly and patients in need of support were mostly affected by the earthquake. The victims of the disaster, especially heating due to the winter season; They had access to facilities such as water, toilets, bathrooms and electricity under very difficult conditions. At the end of the research, a number of suggestions were made, such as transforming the Disaster and Emergency Management Presidency (AFAD) into an independent Ministry, establishing disaster units in municipalities, and not starting damage assessment work before search and rescue work is completed, using the findings obtained
Enhancing Vehicle Fault Diagnosis Through Multi-View Sound Analysis: Integrating Scalograms and Spectrograms in a Deep Learning Framework
No full textThis study presents a comprehensive framework for vehicle fault diagnosis using engine sound signals, leveraging deep learning models and a multi-view approach. Traditional methods for vehicle fault diagnosis often rely on the expertise of mechanics or diagnostic tools, which can be costly, time-consuming, and may not always provide accurate results. To address these limitations, we propose CarFaultNet, a multi-view model that processes both scalograms and spectrograms simultaneously to capture complementary information from these time-frequency representations. Our approach incorporates transfer learning with pretrained convolutional neural networks, including AlexNet, GoogLeNet, ShuffleNet, SqueezeNet, and MobileNet v2, as well as CarFaultNet, which combines two MobileNet networks. The results demonstrate that CarFaultNet outperforms traditional machine learning methods and single-view deep learning models, achieving a precision of 95.32%, recall of 94.83%, F1-score of 94.99%, and accuracy of 95.00%. Class activation mapping visualizations provide valuable insights into the model's decision-making process, highlighting the regions of the input images that are most influential for the classification of different vehicle faults. By leveraging a large, diverse dataset encompassing various vehicle models and real-world operating conditions, our approach addresses the drawbacks of previous studies and demonstrates the potential of deep learning for practical and effective vehicle fault diagnosis
Haçlı Seferleri Esnasında Doğal Afetler ve Salgın Hastalıklar (1096-1291)
No full textTarih boyunca doğal afetler, insanlığın karşı karşıya kaldığı en büyük tehditlerden biri olmuştur. Depremler başta olmak üzere yangın, kuraklık, kıtlık, sel ve salgın hastalıklar, insan yaşamını derinden etkileyen doğal felaketler arasında yer almaktadır. Bu tür afetler, toplumlar üzerinde ekonomik, sosyal ve siyasi alanlarda ciddi olumsuz etkiler bırakmıştır. Bu çalışmada, yaklaşık iki yüzyıllık bir zaman dilimi içinde gerçekleşen Haçlı seferleri sırasında meydana gelen doğal afetler ve salgın hastalıkların hem Haçlı orduları hem de bölge halkı üzerindeki etkileri ayrıntılı bir şekilde incelenmiştir. Doğal felaketler ve salgın hastalıklar, yalnızca Haçlıların lojistik ve askeri kapasitesini olumsuz yönde etkilemekle kalmamış, aynı zamanda seferlerin genel stratejisini, ilerleyişini ve nihai sonuçlarını da büyük ölçüde şekillendirmiştir. Özellikle şiddetli kuraklıklar, depremler, yangınlar ve salgın hastalıklar, Haçlıların büyük kayıplar vermesine neden olmuştur. Çalışmada, bu felaketlerin Haçlı seferleri üzerindeki sosyal, ekonomik ve demografik etkileri kronolojik bir yaklaşımla ele alınmış; Haçlılar ve Müslümanların bu afetlere karşı verdikleri tepkiler karşılaştırmalı olarak değerlendirilmiştir.Throughout history, natural disasters have been among the greatest threats faced by humanity. Earthquakes, wildfires, droughts, famines, floods, and epidemics are among the natural calamities that have profoundly affected human life. Such disasters have had severe economic, social, and political consequences for societies. This study examines in detail the natural disasters and epidemics that occurred during the approximately two-century-long period of the Crusades and their impact on both the Crusader armies and the local populations. These calamities not only adversely affected the logistical and military capacities of the Crusaders but also significantly shaped the overall strategy, progress, and ultimate outcomes of the campaigns. In particular, severe droughts, earthquakes, fires, and epidemics caused substantial losses among the Crusaders. The study adopts a chronological approach to analyze the social, economic, and demographic effects of these disasters on the Crusades. Additionally, it provides a comparative evaluation of how both the Crusaders and Muslims responded to these catastrophes
The Role of Story Telling in the Conservation of Cultural Heritage in Diyarbakır and Mardin
No full textTez çalışması; kültürel miras kavramının tarihsel gelişimini, korunması ve aktarımı süreçlerini inceleyerek Mardin ve Diyarbakır şehirlerindeki kültürel miras unsurlarını hikâyeler üzerinden ele almaktadır. Çalışma, kültürel mirasın tanımı, somut ve somut olmayan unsurları ile yönetim süreçlerini kavramsal çerçeve içerisinde açıklamaktadır. Aynı zamanda hikâye ve anlatı kavramları arasındaki farklılıklar, hikâyelerin tarihsel gelişimi ve kültürel miras aktarımındaki önemi detaylandırılmaktadır. Mardin ve Diyarbakır'ın coğrafi, tarihi ve kültürel özellikleri incelenmiş; bu şehirlerde bulunan kaleler, camiler, medreseler, evler, kiliseler ve antik kentler gibi somut miras unsurları ile el sanatları, müzik, folklor ve yemek kültürü gibi somut olmayan miras unsurları analiz edilmiştir. UNESCO Dünya Mirası Listesi ve UNESCO Somut Olmayan Kültürel Miras Listesi'ndeki yerleri, her iki kentin küresel kültürel miras içindeki önemini vurgulamaktadır. Tez çalışması sonucunda, Mardin ve Diyarbakır'ın somut ve somut olmayan kültürel miras unsurları karşılaştırılarak her iki şehrin benzersiz kültürel değerleri ile ortak yönleri ortaya konmuştur. Çalışma, kültürel mirasın hikâyeler yoluyla aktarımının bu zenginliklerin sürdürülebilirliği açısından önemini vurgulamaktadır.The thesis examines the historical development of the concept of cultural heritage, its protection and transmission processes, and discusses the cultural heritage elements in the cities of Mardin and Diyarbakır through stories. The study explains the definition of cultural heritage, its tangible and intangible elements and management processes within the conceptual framework. It also details the differences between the concepts of story and narrative, the historical development of stories and their importance in cultural heritage transmission. The geographical, historical and cultural characteristics of Mardin and Diyarbakır are examined; tangible heritage elements such as castles, mosques, madrasas, houses, churches and ancient cities and intangible heritage elements such as handicrafts, music, folklore and food culture are analyzed. Their placement on the UNESCO World Heritage List and the UNESCO Intangible Cultural Heritage List emphasizes the importance of both cities in global cultural heritage. As a result of the thesis study, the unique cultural values and commonalities of Mardin and Diyarbakır are revealed by comparing the tangible and intangible cultural heritage elements of both cities. The study emphasizes the importance of the transmission of cultural heritage through stories for the sustainability of these riches
Post-Occupancy Evaluation: an Expert-User Model Proposal Based on Key Sustainability Indicators
No full textKutlu, Izzettin/0000-0002-5546-5548; Bekar, Irem/0000-0002-6371-9958; Ergun, Rusen/0000-0001-5253-3245Purpose The user-oriented reusing of historical heritages is a powerful planning strategy to increase sustainability and provide socioeconomic benefits for cities. The study aims to determine the post-occupancy sustainability of reused historical buildings.Design/methodology/approach A holistic model was designed by considering expert and user opinions to select the post-occupancy sustainability of reused historical buildings. The proposed model was developed concerning key sustainability indicators (KSI). This proposed model, which integrates expert and user views, is examined in an educational building with significant cultural value in Mardin.Findings The results of the KSI model indicate that the functional, technical and environmental sustainability of the building are at a medium level, while the aesthetic sustainability is rated as good. An analysis of the differences between importance and performance shows that the largest gap is in functional sustainability, with the smallest gap in technical sustainability. The environmental and aesthetic sustainability indicators show a smaller performance gap than the other two. The results suggest that functional sustainability requires immediate intervention, technical features should be improved based on user needs and aesthetic and environmental sustainability require monitoring but no urgent action.Originality/value The originality of the research is that it proposes a model that combines expert opinion and the opinions of building users to monitor the sustainability of the reused buildings throughout the usage process and enables them to be monitored with key sustainability criteria and to develop improvement suggestions in line with the results obtained
The Role of Technology in Tourist Guiding: Future Career, Service Quality, Marketing and Tourist Experiences
No full textPurpose: This study aims to investigate the perceptions of tourist guides in Türkiye regarding the role of technology in the tourist guiding profession. Design/methodology/approach: This research adopted an exploratory qualitative case study approach, conducting semi-structured interviews with 29 professional tourist guides actively working in different regions of Türkiye. Findings: The findings reveal the dual roles of technology in tourist guiding. While it can facilitate service quality and enhance experiences, technologies such as robot tourist guides, augmented reality and virtual reality are perceived as disruptive and potentially damaging service quality and tourist experiences. Originality/value: The research offers unique insights into the facilitative and disruptive aspects of technological tools in the tourism industry. These findings have direct implications for destination managers, travel agencies and tourist guides worldwide, equipping them with a comprehensive understanding of the role of technology in tourist guiding and guiding their future actions, strategies and policies. © 2024, Emerald Publishing Limited
Metaverse Economics for Tourism and Hospitality: Economic Fundamentals in a Semi-Imaginary World
No full textSeyitoglu, Faruk/0000-0002-7859-6006This study elaborates on the economics of the Metaverse in tourism and hospitality. It identifies the Metaverse stakeholders from a tourism perspective, namely: IT companies (infrastructure), IT companies (Metaverse presence), tourism and hospitality companies, other (non-tourism) companies, destination management organisations, tourists, and public authorities. The paper elaborates on the activities each stakeholder would be able to perform in the Metaverse and the associated revenue and costs. Based on this, the paper discusses the economic relationships between the stakeholders, their impacts on the financial performance of tourism and hospitality companies, and the potential economic externalities of the Metaverse. Theoretical, managerial and policy implications, limitations and future research directions are outlined as well
Kürtçe Bilmecelerin Şiir Sanatı Açısından Analizi
No full textDi vê têzê de ji hêla teşeyê ve li ser hêmanên ahengê yên weke wezna kîteyî, rêzbendî, serwa, rawestek, pirs û bersivdayîn, formelên destpêk û dawiya mamikên kurdî lêkolîn hatiye kirin. Mamikên kurdî ji hêla naverokê ve jî ji aliyê hunera helbestê ve hatine vekolandin. Di xebata xwe de dema me mamik ji hêla hunera helbestê ve tehlîl kirin, me modela analîza metnê ya ku binbeşeke rêbaza vekolîna çawaniyê ye esas girt. Tevî varyantên wan bi giştî li ser şeş hezar û sî û heft (6037) mamikên kurdî, ji hêla teşe û hunera helbestê ve lêkolîn hat kirin. Mebest jê ev e ku ji aliyê avabûna xwe ve mamikên kurdî bên kategorîkirin. Her weke din ji aliyê hunera helbestê ve jî, ji aliyê metafor, metonîmî, hêma, alîterasyon, asonans, teşbîh û tezadê ve taybetiyên mamikên kurdî hatin nirxandin. Mebest jê ev bû ku mamikên kurdî ji aliyê avabûna wan ji van her du hêlan ve bên nirxandin. Tez ji destpêk, du beş û encamê pêk tê. Di destpêkê de piştî ku pênaseya mamikê hatiye kirin, nêrînên li ser pênaseya wê hatine vegotin. Di xebatên kurdî de li ser binavkirin û bikaranîna peyva mamikê nirxandinek jî hatiye kirin. Di pey re piştî mijar û sînorên xebatê, çavkaniyên ku hatine bikaranîn hatine nasandin. Paşê jî piştî rêbaza lêkolînê, giringî û amanca xebatê hatiye vegotin. Di beşa yekem de ji hêla teşeyî ve li ser formelên wan destpêk û dawiyê, li ser rêzbendî, pirs û bersivdayîn, dengsazî û serwaya mamikên kurdî nirxandinek hat kirin. Mamikên kurdî li gorî van taybetmendiyên xwe hatin kategorîkirin. Di beşa duyem de mamikên kurdî ji hêla hunera helbestê ve ji aliyê naverokê ve hat analîzkirin. Piştî analîzkirina mamikan metafor û hêmayên ku herî zêde hatine bikaranîn, bi du tabloyan hatin nîşandan. Bêjeyên sereke: Mamik, Teşe, Helbest, Avanî.In this thesis, research was conducted on the syllable, line number, rhyme, stop, question and answer, beginning and ending formulas in terms of harmonic elements of Kurdish riddles. In addition, in terms of content, Kurdish riddles were analyzed in terms of the art of poetry. While analyzing Kurdish riddles in terms of the art of poetry, we adopted the text analysis model, which is one of the qualitative research methods in our study, and analyzed the riddles in this way. A total of six thousand thirty-seven (6037) Kurdish riddles, together with their variants, were formally analyzed in terms of the art of poetry. For this purpose, we tried to classify Kurdish riddles formally in terms of their structure and formation. In addition, in terms of the art of poetry, we examined Kurdish riddles in terms of features such as metaphor, metonymy, imagery, alliteration, assonance, similitude and contrast. Our aim was to examine Kurdish riddles in terms of their structural formation from these two aspects. The thesis consists of an introduction, two main chapters and a conclusion. After the definition of riddles in the introduction, different definitions of riddles were emphasized. The naming and use of the term riddles in Kurdish sources were emphasized. After the subject and the limitations of the study, the sources utilized were listed. Afterwards, the method, importance and purpose of the study were emphasized. In the first chapter, an evaluation was made on the beginning and ending formulas, number of lines, question-answer, rhythm and rhyme types of riddles. Kurdish riddles were classified according to these characteristics. In the second part, Kurdish riddles were analyzed according to content and text in terms of the art of poetry. In addition, after the analysis of these riddles, the most commonly used metaphors and images in the riddles were shown in two separate tables. Key Words: Riddle, Form, Poetry, Structure