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Mindful Attention Awareness and Attitudes Toward Social Handwashing Among Nursing and Midwifery Students
No full textObjective: To explore the relationship between mindful attention awareness and attitudes toward social handwashing among undergraduate nursing and midwifery students. Method: A cross-sectional and correlational study was conducted with 679 undergraduate nursing and midwifery students. Data were collected using two scales: (1) the Mindful Attention Awareness Scale (MAAS) and (2) the Attitude Scale toward Social Handwashing (ASSHW). Additionally, the participants provided data on their sociodemographic characteristics and responded to an inventory of handwashing practices. Relationships between scores were examined using Spearman's rho. Results: The students' mindful attention levels (MAAS) averaged 44.97 +/- 11.46, and their attitudes toward social handwashing (ASSHW) averaged 78.32 +/- 13.67. While no direct correlation was found between overall ASSHW and MAAS scores, there were positive correlations between mindful attention levels and certain ASSHW sub-dimensions, as well as with specific handwashing behaviors such as frequency and duration. Conclusion: These findings suggest that mindful attention may support better hand hygiene practices among nursing and midwifery students
Hamed-Troyansky, Vladimir. Empire of Refugees: North Caucasian Muslims and the Late Ottoman State
No full textThe exile and settlement of North Caucasians in the Ottoman Empire is not well-studied in English academic literature. Vladimir Hamed-Troyansky's book is a well-researched work that helps fill this gap in the literature. It explores various aspects of North Caucasian exile and settlement, analysing both state perspectives-through a wide range of archival sources- and the experiences of the displaced people. Particularly significant is its use of letters written by the refugees (muhacirs), which amplify their voices and integrate them into academic discourse for the first time
Antidepressant-Like Effects of Ashwagandha (Withania Somnifera) on Chronic Unpredictable Mild Stress-Induced Depression in Adolescent Rats
No full textRationaleAdolescent depression is often linked to biological changes associated with stress. However, new approaches and treatment strategies for early intervention and prevention of depression in children and adolescents are still limited. Ashwagandha is an Ayurvedic herb widely used in the management of anxiety and stress. However, there is no information in the current literature on its potential effect on adolescent depression.ObjectivesThis study aimed to investigate the effects of depression on proapoptotic proteins and neuroinflammation and the antidepressant effect of Ashwagandha on depression-like symptoms in adolescent rats exposed to the Chronic Unpredictable Mild Stress (CUMS) model.MethodsIn the study, CUMS model was used to induce depression in adolescent rats. Rats were treated with Ashwagandha or Sertraline. To evaluate the antidepressant effects, behavioral tests as well as biochemical and histological analyses were performed. Forced Swim Test (FST), Sucrose Test and Elevated Plus Maze Test were performed as behavioral tests. Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) were measured by the ELISA method in the fronto-parietal cortex. Proapoptotic proteins (Bax and Caspase-3) and inflammatory markers (TNF-alpha and IL-1 beta), as well as glial fibrillary acidic protein (GFAP), were evaluated immunohistochemically in the fronto-parietal cortex.ResultsProapoptotic proteins (Bax and Caspase-3) and inflammatory markers (TNF-alpha and IL-1 beta) were increased in the CUMS group. BDNF and GFAP levels were decreased. Ashwagandha treatment was more effective than Sertraline in reducing the levels of these proteins and markers. Additionally, Ashwagandha prevented weight loss.ConclusionsAshwagandha showed antidepressant-like effects in adolescent rats, reducing apoptosis, inflammation, and neuroinflammation, suggesting potential for treating adolescent depression.Scientific and Technological Research Council of Turkiye (TUBITAK); Mardin Artuklu University, Scientific Research Projects Coordination Unit [MAUE.BAP.23.TIP.005]Open access funding provided by the Scientific and Technological Research Council of Turkiye (TUBITAK). This work was supported by Mardin Artuklu University, Scientific Research Projects Coordination Unit (Grant numbers MAUE.BAP.23.TIP.005)
Ultrasound-Guided Regional Anesthesia in Permanent Pacemaker Implantation: an Observational Study
No full textAktan, Adem/0000-0003-0505-9784Background and Objectives: When pacemakers were first introduced, their indications and implantation techniques were quite limited. Over 400,000 permanent pacemakers are implanted annually worldwide, mostly under local anesthesia (LA), which is preferred for its hemodynamic stability. However, inadequate LA often leads to excessive use of local anesthetics or analgesics. This study evaluates the efficacy of combining interscalene brachial plexus block (ISB) and superficial cervical plexus block (SCPB) as regional anesthesia (RA) techniques during permanent pacemaker implantation compared to LA. Materials and Methods: A total of 42 patients were divided into RA and LA groups. The RA group underwent ISB and SCPB under ultrasound guidance, while the LA group received traditional local anesthetic methods. Results: The RA group exhibited superior pain control, reduced analgesic requirements, and higher satisfaction rates compared to the LA group. Ultrasound guidance enhanced block success rates and minimized complications. Conclusions: ISB and SCPB offer a superior alternative to LA for pacemaker implantation, especially in patients with anxiety or insufficient LA response
Conservation Project of the Karahan Family Residence in Derik District, Mardin
No full textMardin İlinin Derik ilçesinde tarih boyunca farklı din ve kültür grupları yaşamış olması mimari çevreyi zengin kılmıştır. Derik, kalesi, topografyaya göre biçimlenmiş sokakları, dini yapıları, konakları ve evleri ile geleneksel yerleşim düzeninin özgün değerlerini yansıtmaktadır. Ancak hem kırdan kente hem de büyük kentlere olan göçler ve bunun sonucu yapıların asıl kullanıcılarının değişimi nedeniyle sahipsiz kalan bir tarihi kent dokusunu ortaya çıkarmıştır. İlçe içinde çok sayıda geleneksel konut bulunmasına rağman sadece dördü tescillenerek günümüze kadar ulaşmıştır. Tez çalışması ile Mardin ili, Derik ilçesinde yer alan sivil mimarlık örnekleri incelenmiştir. İncelenen kültür mirası konutlardan biri olan ve 561 ada 21 nolu parselde yer alan ikinci dereceden tescilli geleneksel yapının koruma projeleri hazırlanmıştır. Tez kapsamında, tarihi yapının geleceğe aktarılmasını sağlayacak bilgiler arşivlenmiş; yapıya ait rölöve, restitüsyon, restorasyon öneri projeleri geliştirilmiş ve koruma-onarım yöntemleri belirlenmiştir. Geleneksel konutun günümüzdeki korunmuşluk durumu ile ilgili genel bilgiler verilmiştir. Yapının lazer tarama cihazıyla ölçümleri alınarak rölövesi çizilip fotoğraflanarak belgelenmiş, malzeme analizi, hasar tespit analiz paftaları hazırlanmıştır ve bugünkü mevcut durumunun belgelenmesi sağlanmıştır. Dönem araştırmalarından elde edilen bilgiler, kullanıcıların yaptığı sözlü açıklamalar ve yapıda görülen izlere göre, evin özgün durumu belirlenmiş ve restitüsyon çalışması yapılmıştır. Restorasyon projesinde ise, yapının korunması ve günümüzde kullanılması için yapılması gereken müdahaleler tespit edilmiştir. Tescilli kültür mirasının konut olarak kullanımının devam edilmesi önerisinde bulunulmuştur. Bu çalışma ile sürdürülebilir korumanın sağlanmasına yönelik olarak, kültür mirasının yaşayarak ve yaşatılarak gelecek nesillere aktarılması hedeflenmektedir. Anahtar Kelimeler: Derik, Geleneksel konut, Koruma, Mardin, RestorasyonThroughout history, the presence of various religious and cultural groups in the Derik district of Mardin has enriched its architectural environment. Derik reflects the authentic values of traditional settlement patterns through its castle, streets shaped according to the topography, religious structures, mansions, and houses. However, migration from rural areas to urban centers and large cities, along with the resulting change in the original inhabitants of the buildings, has led to an abandoned historical urban fabric. Although the district is home to many traditional residences, only four of them have been registered and preserved to the present day. This thesis study examines examples of civil architecture in Derik district, Mardin province. As part of this research, conservation projects were prepared for a second-degree registered traditional building located on parcel number 21 in block 561, which is one of the studied heritage houses. Within the scope of the thesis, archival information necessary for transmitting the historical structure to future generations was compiled; architectural survey (rölöve), restitution, and restoration proposal projects were developed, and conservation-repair methods were identified. General information regarding the current preservation status of the traditional residence was provided. Measurements of the building were taken using a laser scanning device, and the architectural survey was drawn up with photographic documentation. Material analysis and damage assessment sheets were prepared to document the building's current state. Based on historical research, oral testimonies from previous users, and traces observed on-site, the original condition of the house was determined, and a restitution project was prepared. In the restoration project, the necessary interventions for the preservation and contemporary use of the building were identified. It was proposed that the cultural heritage building continue to be used as a residence. Through this study, it is aimed to ensure sustainable conservation by maintaining and preserving cultural heritage for future generations. Key Words: Conservation, Derik, Mardin, Restoration, Traditional hous
Transcription and Evaluation of Mardin Court Registry Number 214
No full textBu çalışmanın konusu 214 numaralı Mardin Şer'iyye Sicil Defteri'nin transkripsiyon ve değerlendirilmesidir. Çalışma 214 numaralı Mardin Şer'iyye Sicil Defteri'nde 27 Zilhicce 1308/3 Ağustos 1891 ile 13 Cemaziyelevvel 1309/15 Aralık 1891 tarihleri arasında şer'iyye mahkemesine gelen daha çok aile, miras, vesayet, vekâlet, alım-satım ve tarla davalarını kapsamaktadır. Sicil defterinde Mardin'in mahalleleri, çarşıları, önemli vakıf yapıları, köyleri, nahiyeleri ve çevredeki yer adları hakkında önemli bilgiler bulunmaktadır. Transkripsiyonu yapılan defterde ayrıca ailevi problemler ve satış davalarına konu olmuş şehirde yaşayan aileler, evlerde kullanılan eşyalar ve kadınların mal varlıkları yer almaktadır. Bu çalışmanın amacı şehir tarihine önemli katkılar sağlayan mahkeme kayıtlarının transkripsiyonunun yapılarak araştırmacıların hizmetine sunulmasıdır. Böylece şehrin sosyal ve ekonomik yapısı, demografisi ve mekân gelişimi hakkında birincil kaynak olarak önemli bir katkı sunulmuş olacaktır.The subject of this study is the transcription and evaluation of the Mardin Sharia Record Book numbered 214. The study covers mostly family, inheritance, power of attorney, guardianship, purchase-sale, and field cases in the Mardin Shar'iyyeregistry book number 214 between 27 Zilhicce 1308/3 August 1891 and 13 J.Evvel 1309/15 December 1891. The registry book contains important information about Mardin's neighborhoods, bazaars, important foundation buildings, villages, towns/sub-districts, and the names of the surrounding areas. The transcribed registry also contains information on families living in the city, household goods andwomen's assets in family and sales cases. This study aims to transcribe court records that provide important insights into the city's history and make them available to researchers.Thestudy will thus providea primary source of information on thecity's social and economic structure, demography, and spatial development
Comparison of New Secondgeneration H1 Receptor Blockers With Some Molecules; a Study Involving Dft, Molecular Docking, Admet, Biological Target and Activity
No full textUNSAL, VELID/0000-0003-1415-0563Although the antiallergic properties of compounds such as CAPE, Melatonin, Curcumin, and Vitamin C have been poorly discussed by experimental studies, the antiallergic properties of these famous molecules have never been discussed with calculations. The histamine-1 receptor (H1R) belongs to the family of rhodopsin-like G-protein-coupled receptors expressed in cells that mediate allergies and other pathophysiological diseases. In this study, pharmacological activities of FDA-approved second generation H1 antihistamines (Levocetirizine, desloratadine and fexofenadine) and molecules such as CAPE, Melatonin, Curcumin, Vitamin C, ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) profiles, density functional theory (DFT), molecular docking, biological targets and activities were compared by calculating. Since drug development is an extremely risky, costly and time-consuming process, the data obtained in this study will facilitate and guide future studies. It will also enable researchers to focus on the most promising compounds, providing an effective design strategy. Their pharmacological activity was carried out using computer-based computational techniques including DFT, molecular docking, ADMET analysis, biological targeting, and activity methods. The best binding sites of Desloratadine, Levocetirizine, Fexofenadine, CAPE, Quercetin, Melatonin, curcumin, Vitamin C ligands to Desmoglein 1, Human Histamine H1 receptor, IgE and IL13 protons were determined by molecular docking method and binding energy and interaction states were analyzed. Fexofenadine and Quercetin ligand showed the most effective binding affinity. Melatonin had the best Caco-2 permeability PPB values of Quercetin, CAPE and Curcumin were at optimal levels. On the OATP1B1 and OATP1B3 of curcumin and CAPE, Quercetin was found to have strong inhibition effects on BCRP. Melatonin and CAPE were found to have the highest inhibition values on CYP1A2, while CAPE had the highest inhibition values on CYP2C19 and CYP2C9. Vitamin C and Quercetin were found to be safer in terms of cardiac toxicity and mutagenic risks, while Desloratadine and Levocetirizine carried high risks of neurotoxicity and hematotoxicity, while CAPE was noted for its high enzyme inhibitory activities and low toxicity profiles, while the hERG blockade, DILI, and cytotoxicity values of other compounds pointed to various safety concerns. This study demonstrated the potential of machine learning methods in understanding and discovering H1 receptor blockers. The results obtained provide important clues in the development of important strategies in the clinical use of H1 receptor blockers. In the light of these data, CAPE and Quercetin are remarkable molecules
Gösterişçi Tüketim Bağlamında Diyarbakır'da Yemek Olgusu
No full textGünümüzde tüketim toplumunda ortaya çıkan tüketim tarzlarından biri olan gösterişçi tüketim, bir tüketicinin sosyal sınıfının tüketim kalıplarından ayrılarak üst sınıfın tüketim kalıplarını taklit etmeye yönelik tüketim faaliyetlerinde bulunmasıdır. Gösterişçi tüketim davranışına sahip tüketiciler çeşitli sembollerin kendilerini daha varlıklı ve daha seçkin gösterecek bir üst sınıfa yaklaşmalarını sağladığına inanmaktadır. Üst sınıftan ve seçkin gösterecek sembollerden biri de yeme içme faaliyetleridir. Yemek bireyin hayatını devam ettirmesi için gerekli olan fiziksel bir ihtiyaçtan öte içerdiği toplumsal ve kültürel anlamlarla tüketicinin kimlik inşa sürecini de belirler. Yemek kendisini tüketeni 'kim' yapar. Bireyin toplumsallaşma sürecinde yemeği onun kimliğini tanımlamasında simgesel anlamlar verir. Yiyecek tercihleriyle, yediği mekânlarıyla beraber birey etrafındakilere kimliğini tanıtır. Lüks bir semtte ve haliyle lüks restoranda yemek ile ayaküstü sokak satıcısında yemek aynı anlamları vermez. Bu çalışmada gösterişçi tüketim ve yemek kavramları ilişkilendirilerek açıklanmaya çalışılmıştır. Araştırma, Diyarbakır ili bazında nitel araştırma yöntemlerinden fenomenolojik yaklaşım ve yüz yüze derinlemesine mülakat tekniği ile yürütülmüştür. Bu bağlamda farklı kafe ve restoranlara giden farklı yaş, farklı meslek ve cinsiyetten 30 kişi ile görüşülmüştür. Sonuç olarak bireyin ait olduğu sınıfı ve kimliğini hem yediğin yemek hem de gittiği yemek mekânları görünür hale getirir. Çünkü yemek gösterişçi tüketimin açıkça sergilendiği alanlardan biridir. Bireyler sahip olmak istediği sosyal statüye ve prestije uygun olacak yüksek statü içeren yemeklerin sunulduğu mekânları tercih etmekte; gösterişçi tüketimi yemek üzerinden inşa etmektedir. Anahtar Kelimeler: Gösterişçi tüketim, Yemek, Kimlik, MekânConspicuous consumption, which is one of the consumption styles emerging in today's consumer society, is a consumer's consumption activities aimed at imitating the consumption patterns of the upper class by departing from the consumption patterns of his/her social class. Consumers with ostentatious consumption behavior believe that various symbols enable them to approach an upper class that will make them look wealthier and more distinguished. One of the symbols that make them look upper class and elite is eating and drinking activities. Food is not only a physical necessity to sustain one's life, but also determines the identity construction process of the consumer with the social and cultural meanings it contains. Food makes the consumer 'who' he/she is. In the socialization process of an individual, food gives symbolic meanings in defining his/her identity. With his/her food preferences and the places where he/she eats, the individual introduces his/her identity to those around him/her. Eating at a luxury restaurant in an upscale neighborhood does not have the same meaning as eating at a street vendor. In this study, the concepts of ostentatious consumption and food are tried to be explained by associating them. The research was conducted on the basis of Diyarbakır province with a phenomenological approach and face-to-face in-depth interview technique. In this context, 30 people of different ages, professions and genders who go to different cafes and restaurants were interviewed. As a result, both the food you eat and the food places you visit make the class and identity of the individual visible. Because food is one of the areas where ostentatious consumption is clearly displayed. Individuals prefer the places where high-status dishes that will be suitable for the social status and prestige they want to have are served; they construct ostentatious consumption through food. Keywords: Conspicuous consumption, Food, Identity, Spac
Armillaria Species Causing Kiwifruit Vine Decline and Root Rot in Northeastern Turkiye: a Growing Concern for Kiwifruit Health (Vol 172, E13409, 2024)
No full textCharacterization and Investigation of Antifungal Activity of Endophytic Bacteria Isolated From Lavender (Lavandula Angustifolia) Plant
No full textBu çalışmada, lavanta bitkisinin kök ve kök boğazından 70 endofitik bakteri izole edilmiştir. Bu izolatların morfolojik, fizyolojik ve biyokimyasal aktiviteleri incelenmiştir. Endofitik izolatların patojenlere karşı % inhibisyon oranları Neoscytalidium dimidiatum'a karşı %89 ile %3,7 arasında Fusarium culmorum'a karşı ise %88 ile %8 arasında ve Fusarium oxysporum'a karşı %71,8 ile %36,1 arasında farklılık göstermiştir. İzolatların fizyolojik ve biyokimyasal özellikleri, antagonistik aktiviteleri, enzim aktiviteleri, siderofor üretimleri dikkate alınarak etkili 5 izolat seçilmiştir. İn-vitro koşullarda etkili bulunan 5 izolatın 16S rRNA gen tabanlı sekans analizi sonucuna göre LA 24, LA25, LA32, LA58 ve LA62 kodlu izolatların Bacillus spp. olduğu tespit edilmiştir. İn-vivo serada yapılan saksı denemesi çalışmaları sonucunda, kök daldırma ve toprağa inokule edilen Bacillus spp. (LA24+LA62) karışımları ile inokule edilmiş lavanta bitkilerinde diğer endofitik bakteri izolatlarına ve kontrole göre daha iyi sonuçlar vermiştir. Bu uygulamanın lavanta bitkisinin bitki boyu, yaş ağırlık, kuru ağırlık, kök yaş ağırlığı, kök kuru ağırlığı ve kök uzunluğu ve hastalıklara karşı en etkili sonuçlar verdiğini göstermiştir. Bunu takip eden diğer etkili uygulama ise lavanta bitkilerine inokule edilmiş Bacillus sp. (LA25) bakteri uygulaması olmuştur. Çalışmadan elde edilecek sonuçlar ile endofitik bakterilerin sürdürülebilir organik lavanta yetiştiriciliğinde diğer endofitik bakteri izolatlarına ve kontrole göre etkili bulunan izolatın daha sonra ticari olarak kullanılmak üzere sunulacaktır. Anahtar kelimeler: Antagonistik aktivite, tıbbı ve aromatik bitkiler, Lavandula angustifoliaIn this study, 65 endophytic bacteria were isolated from lavender plants. The morphological, physiological, and biochemical properties and enzyme activities of endophytic bacteria were investigated. In the test of tolerance of isolates to different temperature degrees, isolate LA6 was positive at 4°C, and all other isolates were negative. From the 41°C isolates, isolates LA42 and LA46 were negative, and all other isolates were positive. From endophytic bacteria, isolates LA1, LA5, LA6, LA7, LA8, LA11, LA12, LA13, LA25, LA28, LA41, LA45, LA48, LA50, LA53, and LA61 gave positive results in their tolerances at 10% NaCl concentration. In the carbohydrate test, isolates gave positive results between 71% and 91%. All isolates gave positive results in the phosphatase activity and protease activity of endophytic bacteria. Among other enzyme activities, 86% of the isolates gave positive results in cellulase activity, ACC deaminase activity, and nitrate reduction. 75% of the isolates gave positive results in siderophore production, and effective results were obtained. The % inhibition rates of endophytic isolates against pathogens varied between 3.7% and 78% against Neoscytalidium dimidiatum, between 8% and 80% against Fusarium culmorum, and between 36.1% and 61.8% against Fusarium oxysporum. As a result of this study, promising results are seen in the potential use of endophytic bacteria isolated from lavender as biofertilizer