FBU GCRIS Standard Database (Fenerbahçe University)
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Design and Synthesis of Thiosemicarbazides and 1,2,4-Triazoles Derived From Ibuprofen as Potential Metap (Type II) Inhibitors
No full textIn the present study, a range of novel thiosemicarbazides 4a-i and 1,2,4-triazoles 5a-i derived from ibuprofen, were synthesized. Structural elucidation of these synthesized compounds was performed utilizing a variety of spectroscopic methods, including FTIR, 1H NMR, 13C NMR and HR-MS. The synthesized compounds were tested for cytotoxicity in five different cancer cell lines (cervical cancer (HeLa), human breast cancer (MCF-7), human gastric adenocarcinoma (MKN-45), human metastatic prostate cancer (PC3) and human glioblastoma (U87)). The compounds were compared with healthy cells (NIH-3T3) and the most effective compounds were determined by means of the selectivity index. Thiosemicarbazides derived form ibuprofen 4i and 4d showed anticancer activity, while 1,2,4-triazoles derived form ibuprofen 5b, 5c, 5d, 5e, 5h, 5g showed anticancer activity in HeLa, MCF-7, MKN-45, PC3 and U87 cells. To test the stability of the protein-drug complexes all 18 compounds 4a-i and 5a-i were docked into the active site of the MetAP2 enzyme In general, computational inhibition constants values were correlated with the experimental values. The dynamic behavior of MetAP2-inhibitor complexes was analyzed using all atoms Molecular Dynamic (MD) simulations for 200 ns duration. MD revealed that the drugs bind in the active center of MetAP2 with stable RMSD and RMSF. In conclusion, in-silico results and in-vitro studies suggests that thiosemicarbazides and 1,2,4-triazoles derived from ibuprofen may be novel anticancer drug candidates for treating cervical, breast, prostate, gastric and glioblastoma. Compounds provided induction of apoptotic proteins in the cell by inhibiting MetAP2 enzyme. Furthermore, the potential antioxidant activities of the compounds were evaluated using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay. Among the compounds tested, 4a, 4b, 4e, 4f, 4h, and 4i exhibited values closely resembling the DPPH activity of the standards.Turkish Health Institutes Presidency (TUSEB) [4235]This study was funded by the Turkish Health Institutes Presidency (TUSEB) . Project number: 4235.Science Citation Index Expande
Relationship Between Executive Functions and School Readiness in Kindergarten Children With Cochlear Implant
No full textThis study aimed to examine the relationship between executive functions and school readiness of kindergarten children with cochlear implants. The study included 109 children between the ages of 57 and 71 months, who were enrolled in a special education practice school for the deaf and followed up by the ear, nose, and throat diseases clinic, who had bilateral severe or profound sensorineural type hearing loss and who used bilateral cochlear implants. The participants' teachers filled out the Childhood Executive Functions Inventory and the Primary School Readiness Scale. The findings showed a significant relationship between the Childhood Executive Functions Inventory-Working Memory, Inhibitory Control, and Total scores and Primary School Readiness Scale of kindergarten children with cochlear implant (r values are -.793, -.819., and -.768, respectively; p < 0.01). The results obtained from this study emphasize the importance of interventions that support the executive functions and school readiness of children with cochlear implants from the earliest period and increase their participation in school life.Science Citation Index Expande
Smart and Sustainable Cities: Challenges and Prospects for Istanbul
No full textRapid urbanization brings about many challenges, such as air pollution, congestion, food insecurity, and waste management. The concepts of "smart city" and "sustainable city" have become very significant for cities that are severely experiencing these types of problems. In this study, the Sustainable Development Goals (SDGs) and smart sustainable indicators are linked to the concept of smart sustainable cities, with a particular focus on assessing Istanbul in this context. As a megacity, Istanbul possesses abundant human capital and a dynamic environment that can provide opportunities for smart and sustainable solutions. However, rapid economic and population growth may simultaneously generate new and complex challenges. © 2026 by IGI Global Scientific Publishing. All rights reserved
Development and Psychometric Properties of the Self-Efficacy Scale for Symptom Management and Self-Care in Patients with Cardiac Surgery
No full textBackground and Purpose: Evaluating self-efficacy for symptom management and self-care is crucial for ensuring follow-up care after cardiac surgery. As there is not yet a validated measurement tool for this evaluation, the aim of this study was to develop the Self-Efficacy Scale for Symptom Management and Self-Care (SESMSC: Cardiac Surgery) in patients with cardiac surgery and to examine its psychometric properties. Methods: The Symptom Management Theory and Bandura's Self-Efficacy Theory were used as the theoretical background for scale development. A multiphase design was utilized. The initial development phase consisted of item generation and expert panel review. The second phase comprised a three-step validation process: (a) face and content analysis (CFA) for construct validity, and (c) Cronbach's alpha, test-retest, and item- total correlation analysis to assess internal consistency reliability. The sample (n = 401) was randomly divided into two subsamples for EFA and CFA (EFA group: n = 201; CFA group: n = 200). Results: EFA suggested a 20-item, two-factor structure with factor loadings of .342-.782. The two subscales of the scale were labeled symptom management self-efficacy and self-efficacy for ch's alpha, test-retest, and item-total correlation results demonstrated acceptable internal consistency reliability. Implications for Practice: The SESMSC: Cardiac Surgery may be a useful tool to evaluate self-efficacy for symptom management and self-care after cardiac surgery. Further evaluation in independent samples is needed to investigate its psychometric properties and usefulness in clinical practice
Components of Design Thinking in Spatial Design Education and a Model Proposal
No full textYildirim Coruk, İpek/0000-0001-8782-9943Design thinking, defined in its simplest form as a creative problem-solving process, is interpreted in various ways in the literature, with differing models and components. This study, motivated by the need to identify gaps in existing approaches and to clarify the concept of design thinking, aims to define its key components within the context of spatial design education. To achieve this objective, the study employed qualitative research methods. To collect data, the study utilized both a literature review and content analysis techniques. By categorizing the collected data, it was concluded that design thinking consists of three fundamental components: cognitive-rational, emotional-intuitive, and practical. These components were elaborated upon with subcategories based on literature data, and a comprehensive model proposal for use in space design education was developed. The proposal put forward in this study is significant in clarifying the concept of design thinking and its constituent components. On the other hand, the potential of the proposed model to offer guiding alternatives for the problem-solving process in design studios at various levels and to make design thinking more explicit can be attributed to the pedagogical contributions of this study. From a practical perspective, the study is considered to have the potential to directly inform practice by proposing concrete and applicable steps that can be implemented within the design process. For future research based on this study, it is recommended that the potential contributions of the proposed model be explored through its application in actual design processes. Furthermore, expandingthe theoretical scope by questioning different approaches to the components of design thinking is also suggested
Women’s Self-Transcendence Levels After a Cesarean Birth and Its Contributing Variables
No full textBackground: A Cesarean birth has significant implications for women’s physical and psychological health. However, limited studies have explored self-transcendence, as a measure of well-being, and its contributing variables during the postpartum period. Purpose: This study aimed to determine the levels of self-transcendence among women after a Cesarean birth and to explore the contribution of demographic and obstetric variables. Methods: This descriptive correlational study used a convenient sample of 232 women (aged 19-49 years) who completed questionnaires in teaching and private hospitals. Results: Overall, 55% (n=128) of women had high levels of self-transcendence, with a mean score of 45.8 (SD=6.1) out of 60. Self-transcendence was negatively correlated with the number of Cesarean births (r=-0.21, p < 0.001). Higher self-transcendence levels were found among women who gave birth at private hospitals (rpb= 0.41, p < 0.001). Conclusion: A Cesarean birth can be an opportunity for self-transcendence and psychological well-being for women, depending on demographic and obstetric variables. Implications for Nursing: The findings of this study may inform healthcare professionals, especially maternity nurses, in understanding psychological dimensions associated with Cesarean birth. © 2025 Elsevier B.V., All rights reserved
Aqueous Parsley (Petroselinum crispum) Extract Ameliorated Methotrexate-Induced Brain and Small Intestine Damage in Rats
No full textMethotrexate (MTX) is a widely used antiarthritic and chemotherapeutic agent known to cause damage to various tissues. This study investigated the potential protective effects of parsley extract against MTX-induced brain and intestinal tissue damage. Sprague-Dawley rats were divided into control, control + parsley, MTX, and MTX + parsley. MTX (20 mg/kg, i.p.) was administered to the MTX and MTX + parsley groups. The control + parsley, and MTX + parsley groups were administered 2 g/kg parsley extract by oral gavage for five consecutive days. After the fifth day, brain and small intestinal tissues were taken. Total protein, nitric oxide, lipid peroxidation, glutathione levels, tissue factor, superoxide dismutase, and glutathione S-transferase activities were determined in these tissues. The protein profiles of the tissues were evaluated using SDS polyacrylamide gel electrophoresis. Parsley administration caused a decrease in lipid peroxidation levels in both tissues of the MTX group. On the other hand, glutathione level, glutathione-S-transferase, and superoxide dismutase activities were found to be increased. On the other hand, parsley decreased the nitric oxide level which was increased in the intestinal tissues of the MTX group. There was no significant change in brain nitric oxide level and tissue factor activity between groups. MTX and parsley administration altered protein expression, leading to the appearance or disappearance of specific bands in intestinal and brain tissues. In conclusion, parsley alleviated MTX-induced damage in brain and intestinal tissues by reducing lipid peroxidation and modulating antioxidant defenses
Is It Fear or Pain Understanding It's Impact on Physical Performance and Rumination in Children with Rheumatic Diseases
No full textScience Citation Index Expande
Pembe Yalı'nın Yeniden İşlevlendirilmesi: Türkiye Mimari Mirası Koruma Bildirgesi ve Ahşap Mimari Mirasın Korunması için İlkeler Kapsamında Değerlendirme
No full textIt is known that Pembe Yalı, located in Beykoz District of Istanbul Province, was built in the 19th century. The building has the importance of being one of the 366 mansions in the Bosphorus, which are historical monuments. The aim of the study was to evaluate the project in the context of Icomos Turkey Architectural Heritage Conservation Charter. While preparing the study, the general scanning model and the documentary scanning model from qualitative research methods were used. By using the documentary scanning method, the old and new projects and photographs of the Pembe Yalı, which is the subject of the research, were accessed. The restoration process of the building, whose projects were prepared by the author and her team, was compiled from project and application experiences. Using the documentary scanning model, the Turkey Architectural Heritage Conservation Charter was examined and the Principles for the Conservation of Wooden Built Heritage were also taken into consideration. The findings were evaluated using the content analysis method. In the research, it is aimed to evaluate the structural problems, the methods used and the analysis and the refunctioning process of the Pink Mansion in the design phase. © 2025 Elsevier B.V., All rights reserved
In Vitro Investigation of the Effects of Octenidine Dihydrochloride on Nasal Septum Squamous Carcinoma Cells
No full textBackground/Objectives: The aim of this study was to investigate the cytotoxic, genotoxic, apoptotic, and anti-inflammatory effects of the antiseptic agent octenidine dihydrochloride (OCT-D) on the RPMI-2650 cell line derived from human nasal mucosa in vitro. Methods: RPMI-2650 cells and Human Umbilical Cord Endothelial Cells (HUVECs) were treated with various concentrations of OCT-D (0.00625-0.4%) for 12 and 24 h. Cell viability was assessed using the WST-1 assay, while DNA damage was assessed using the comet and micronucleus (MN) assays. Apoptotic activity was determined using Annexin V flow cytometry and fluorescence microscopy. Intracellular reactive oxygen species (ROS) levels were measured, and inflammatory cytokines (IL-1 beta, IL-6, TNF-alpha, and IFN-gamma) were measured by Enzyme-Linked Immunosorbent Assay (ELISA). The mRNA expression of genes associated with apoptosis, oxidative stress, and inflammation was analyzed using RT-PCR. Results: OCT-D caused dose- and time-dependent cytotoxicity, and RPMI-2650 cells showed greater resistance compared to HUVECs. While a strong apoptotic response was observed in HUVECs, RPMI-2650 cells exhibited limited apoptosis. OCT-D was found to cause dose-dependent DNA damage and an increase in MN in both cell lines. OCT-D significantly reduced cytokine levels and ROS production in both cell types. RT-PCR results supported its anti-inflammatory and antioxidant effects at the molecular level. Conclusions: In conclusion, this study demonstrated that OCT-D exhibited minimal cytotoxic and apoptotic effects in RPMI-2650 cells, but affected vascular structure by inducing apoptosis in endothelial cells. These findings provide important evidence that OCT-D can be used as a potential adjunctive agent in nasal treatments, and these data need to be supported by preclinical and clinical studies.Sakarya University Scientific Research Projects Coordination Office [2024-25-54-23]This research was funded by the Sakarya University Scientific Research Projects Coordination Office (grant number 2024-25-54-23)