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Diyetisyenlikte Mesleki Yetkinlik İzlem Sisteminin Oluşturulması: Türkiye’de Mevcut Durum ve Gelişim Olanakları
Get PDFGünümüzde sağlık hizmetlerinde kalite, etkililik ve hasta güvenliği gibi kavramların giderek daha fazla önem kazanması, sağlık mesleklerinde mesleki yeterlilik ve yetkinlik düzeylerinin izlenmesini zorunlu hale getirmiştir. Küreselleşmenin, bilgi ve iletişim teknolojilerindeki gelişimin ve sağlık hizmetlerinde değişen ihtiyaçların etkisiyle, sağlık profesyonellerinden yalnızca mesleki bilgi sahibi olmaları değil, aynı zamanda bu bilgiyi etkili bir biçimde kullanabilmeleri, etik ilkelere uygun hareket edebilmeleri, kendilerini sürekli geliştirebilmeleri ve dijitalleşmeye uyum sağlayabilmeleri beklenmektedir. Bu bağlamda, diyetisyenlik mesleği de disipliner yapısını güçlendiren, bilim temelli uygulamaları önceleyen ve mesleki standartlarını geliştiren bir profesyonelleşme süreci içerisindedir. Tedavi ve rehabilite edici diyetetik hizmetlerden, koruyucu toplum beslenmesi, beslenme bilimi ve toplu beslenme sistemlerine uzanan geniş bir çalışma alanına sahip diyetisyenler için, sahip olunması gereken bilgi, beceri ve tutumların sistemli bir şekilde tanımlanması ve izlenmesi büyük önem taşımaktadır. Bu çalışmada, diyetisyenlikte mesleki yetkinlik izlem sisteminin oluşturulmasının gerekliliği ele alınmakta, Türkiye’deki güncel durum değerlendirilmekte ve uygulanabilir bir sistemin temel yapı taşları tartışılmaktadır
A Randomized Trial of Cervical Stabilization Exercise Training via Telerehabilitation for Migraine
No full textPurpose: To compare the effects of cervical stabilization exercise training via telerehabilitation (CSET-T) in addition to standard treatment on pain, forward head posture, cervical mobility, muscle performance, functional status, sleep quality, and quality of life in individuals with migraine in comparison to the standard treatment alone. Methods: The control group (n = 20) received standard treatment alone (medication+recommendations). The stabilization group (n = 20) was given CSET-T in addition to standard treatment 3 days a week for 8 weeks. Pain characteristics were assessed by using a pain diary, whereas forward head posture and cervical mobility were measured using a goniometer, cervical muscle performance (CMP) by using a pressure biofeedback unit, functional status by using the Migraine Disability Assessment Scale (MIDAS), sleep quality by using the Jenkins Sleep Scale (JSS), and quality of life by using the Headache Impact Test-6 (HIT-6). Results: Given the group-time interaction, it was found that pain frequency, intensity, duration, MIDAS, JSS, and HIT-6 scores decreased more significantly in the stabilization group when compared to the control group (p < .05). Moreover, the craniovertebral angle, cervical range of motions, and CMP values increased significantly more in the stabilization group (p < .05). It was found that there was no statistically significant difference between the groups in terms of compliance with standard treatment (p = .665). Conclusions: The study revealed that CSET-T in addition to standard treatment is superior to standard treatment alone in reducing pain, improving forward head posture, cervical mobility, muscle performance, functional status, and quality of life in individuals with migraine. © 2025 Elsevier B.V., All rights reserved
Magnetic Molecularly Imprinted Polymer Synthesis and Application for Selective Separation of Quercetin
No full textQuercetin (QUE) is the most active compound in the flavone family, commonly found in the leaves, fruits, and flowers of many plants. The separation of QUE from various plant matrices has been a key research area due to its antioxidant, anti-inflammatory, antiviral, and antitumor properties. In this study, the conditions for synthesizing MMIPs and their use in QUE recovery were examined. Iron (II) chloride tetrahydrate (FeCl2·4H2O) and iron (III) chloride hexahydrate (FeCl3·6H2O) were used to prepare magnetic nanoparticles, and Fe3O4 was synthesized. Tetraethyl orthosilicate (TEOS) was used to coat the resulting Fe3O4 surface with silica. [3-(methacryloxy)propyl] trimethoxysilane (γ-MPS) was used to functionalize the surface of the formed Fe3O4@TEOS structure. The synthesis was carried out using QUE as the template molecule; tetrahydrofuran (THF), ethanol (EtOH), and a solvent mixture of acetone and acetonitrile (ACN) (3:1, v/v) served as porogen solvents; acrylamide (AM), methacrylic acid (MAA), and 4-vinylpyridine (4-VP) were used as functional monomers; ethylene glycol dimethacrylate (EDMA) served as the cross-linker, and 2,2’-azobisisobutyronitrile (AIBN) was used as the initiator at different molar ratios (T:M:CrL, 1:4:20, 1:8:20, and 1:8:40). The recognition and selectivity properties of these polymers were evaluated based on absorbance values at 370 nm obtained through equilibrium assays, which used QUE solutions prepared in THF, ACN, and 50% (v/v) EtOH solvent mixtures at different ratios. It was established that the magnetic imprinted polymer prepared with a 50% (v/v) EtOH solvent mixture and molar ratios of 1:8:40 (QUE:4-VP:EDMA) exhibited the highest adsorption capacity and imprinting factor. Using the prepared QUE-MMIP, QUE was recovered with 33% efficiency from red onion peel extract
A Comparative Study of Biochemical, Antimicrobial Effects and Phytochemical Composition Analysis of Glycyrrhizaglabra L. Varieties Root Extracts
No full textPlants are the significant global interest as alternative treatment sources with their biologically activecompounds. This study compares the chemical composition and the antioxidant, antidiabetic, and antimicrobialproperties of ethanol extracts of G. glabra L. two different varieties from different regions. The phytochemicalcompositions was determined using GC-MS. Additionaly, total phenolic (TPC), flavonoid (TFC) and triterpene (TTC)contents were determined. Glycyrrhizic acid contents were analysed by HPLC. G. glabra var. glandulifera (GF1) showedthe highest antioxidant activity. All extracts had strong antidiabetic effects, besides GF1 showing the highest effect. TheMIC values was determined against 8 bacterial and 1 yeast strain and values ranged from 2.500 to 0.500; 2.500 to 0.714;2.500 to 0.714 for G. glabra var. glabra (GB), GF1, G. glabra var. glandulifera (GF2) respectively. Phytochemical studies haveshown that TPC was 100.60±5.06, 127.90±0.30, 69.01±0.30 mg GAE /g extract; TFC was 80.07±0.15, 25.35±0.0, 16.58±0.31mg KE/g and TTC was 217.30±6.05,172.40±2.17, 126.30±4.50 mg OE/g extract for GB, GF1, GF2, respectively. GF1 inparticular has the highest glycyrrhizic acid content. This study will contribute to the creation of new treatment strategiesand potential therapeutic agents in addition to the use of G. glabra L. in traditional treatments. Our study is also apreliminary study for future studies
Unraveling the Persistent Renal Impact of Intrauterine Growth Restriction and Catch-Up Growth: Integrating Morphological Insights with Metabolomic Profiling
No full textThe study aimed to investigate the long-term effects of IUGR and consequent catch-up growth on metabolic health by using a comprehensive approach that included histopathological, immunohistochemical, biochemical, and metabolomics analyses. Sprague-Dawley pregnant rats either undergo bilateral uterine artery ligation or a sham surgery on the 19th day of gestation. The offspring reached catch-up growth, kidney samples were collected at postnatal weeks 2, 4, and 8 for analysis. IUGR rats exhibited a spectrum of changes including reduced glomeruli number, proliferating cell number, altered oxidative stress markers, various enzymes involved in Krebs cycle, mitochondrial dynamics, and energy metabolism. Examination of the 8-week-old cohort identified a broader spectrum of metabolic alterations, notably in the biosynthesis of phenylalanine, tyrosine, and tryptophan, phenylalanine, tyrosine, glyoxylate, dicarboxylate, pyruvate, alanine, aspartate, and glutamate metabolism, glycolysis/gluconeogenesis and citrate (TCA) cycle. Our metabolomics analysis provides insights into the potential disease susceptibility of individuals born with IUGR, including obesity, diabetes, hypertriglyceridemia, cardiovascular diseases, and mental retardation. These findings underscore the intricate interplay between intrauterine conditions and long-term metabolic health outcomes, highlighting the need for further investigation into preventive and therapeutic strategies to mitigate the risk of metabolic diseases in individuals with a history of IUGR.Scientific Research Unit of Bezmialem Vakif University [20220411]This work was supported by the Scientific Research Unit of Bezmialem Vakıf University (Grant number: 20220411)
Parkinson Hastalarında Algılanan ve Gerçek-Zamanlı Çiftgörev Performansının Farklı Motor-Kognitif Çift-Görev Eşleşmeleri Altında İncelenmesi
Get PDFAmaç: Parkinson hastalarında çift görev koşulları altında ortaya çıkan zorluklar, bireylerin öznel algılarına dayalı ölçekler ile ya da performans testleri aracılığıyla değerlendirilebilmektedir. Ancak bu iki değerlendirme yöntemi arasındaki ilişki henüz yeterince açıklığa kavuşmamıştır. Bu çalışmanın amacı, Parkinson hastalarında algılanan çift görev performansı ile gerçek zamanlı performans testleri arasındaki ilişkiyi incelemek ve farklı çift görev türlerine bağlı olarak gözlemlenen performans farklılıklarını değerlendirmekti. Yöntem: Çalışmaya, İdiyopatik Parkinson hastalığı tanısı almış, Hoehn-Yahr evre 1 ila 3 arasında olan, MiniMental Durum Değerlendirme puanı en az 21 olan ve demans öyküsü bulunmayan toplam 117 birey dahil edilmiştir. Gerçek zamanlı çift görev performansı, Zamanlı Kalk Yürü Testi'ne entegre edilen motor ve bilişsel ikincil görevler ile Altı Nokta Adım Testi kullanılarak değerlendirilmiştir. Algılanan performans düzeyi ise İkili Görev Anketi ile ölçülmüştür. İstatistiksel analizlerde Spearman korelasyon katsayısı ve Friedman testi kullanılmıştır. Bulgular: Katılımcıların yaş ortalaması 62,44 ± 10,06 yıl, hastalık süresi ortalaması ise 6,34 ± 4,69 yıldır. Algılanan performans ile Zamanlı Kalk Yürü Testi’nin bilişsel görevli versiyonu arasında (r=0,214; p=0,02) ve motor görevli versiyonu arasında (r=0,277; p=0,002) istatistiksel olarak anlamlı fakat zayıf düzeyde ilişkiler saptanmıştır. Altı Nokta Adım Testi ile algılanan performans arasında anlamlı bir ilişki gözlenmemiştir (r=0,165; p=0,075). Ayrıca, Zamanlı Kalk Yürü Testi’ne entegre edilen motor görevli koşulda gözlemlenen çift görev yükü, bilişsel görevli koşula kıyasla anlamlı düzeyde daha yüksek bulunmuştur (Z=-4,4; p<0,001). Sonuç: Algılanan ve gerçek-zamanlı çift-görev performansı arasındaki zayıf ilişki değerlendirmede bu iki alanın ayrı ayrı gözden geçirilmesi gerektiğini göstermektedir. Ayrıca, yürüme görevine eşlik eden ikincil görevin türü bireylerin çift görev performansı üzerinde farklı sonuçlara neden olabilir. Parkinson hastalarında bu etkilerin ayrıntılı olarak incelenmesi daha etkin rehabilitasyon planı için yol gösterici olacaktır
Kronik Migren Tanılı Bireylerde Fiziksel Aktivite Düzeyi, Ağrı Özellikleri, Katastrofizasyonu, Santral Sensitizasyon ve Fonksiyonel Durum Parametrelerinin Araştırılması-Kesitsel Çalışma
Get PDFAmaç: Bu çalışmanın amacı, kronik migren tanılı bireylerde fiziksel aktivite (FA) düzeyi ile ağrı özellikleri ve katastrofizasyonu, santral sensitizasyon ve fonksiyonel durum arasındaki ilişkiyi incelemekti. Yöntem: Çalışmaya kronik migren tanısı alan 116 birey [yaş: 33,00 (19,00-55,00) yıl] dahil edildi. Fiziksel ve sosyodemografik özellikler, migren ile ilgili klinik bilgiler kaydedildi. Ağrı özellikleri kapsamında ağrı şiddeti ve ağrı süresi kaydedildi. FA düzeyi “Uluslararası Fiziksel Aktivite Anketi-Kısa Formu” ile, ağrı katastrofizasyonu “Ağrıyı Felaketleştirme Ölçeği” ile, santral sensitizasyon “Santral Sensitizasyon Ölçeği” ile, ve fonksiyonel durum “Migrene Bağlı Dizabilite Değerlendirme Ölçeği” ile değerlendirildi. Bulgular: Bireylerin %30,20’sinin (n=35) inaktif, %47,40’ının (n=55) minimal aktif ve 22,40’ının (n=26) aktif olduğu görüldü. FA düzeyi ile ağrı şiddeti (r=-0,245, p=0,008), ağrı süresi (r=-0,208, p=0,025) ve ağrı katastrofizasyonu (r=-0,190, p=0,041) arasında negatif yönde zayıf bir ilişki bulunurken, FA düzeyi ile santral sensitizasyon (r=-0,198, p=0,033) arasında çok zayıf bir ilişki bulundu. FA düzeyi ile fonksiyonel durum arasında ilişki olmadığı saptandı (p>0,05). Sonuç: Çalışmanın sonucunda kronik migren tanılı bireylerin FA düzeyi arttıkça ağrı şiddeti, süresi, katastrofizasyonu ve santral sensitizasyonun azaldığı görüldü. Ayrıca FA düzeyi ile fonksiyonel durum arasında ilişki olmadığı bulundu. Düzenli FA’nın faydaları göz önünde bulundurulduğunda kliniklerde bu bireylere özgü FA programlarının oluşturulması teşvik edilmelidir
Integration of Artificial Intelligence Tools into Interior Architecture Education: A Study on Textual and Visual Representations
No full textDespite numerous Artificial Intelligence (AI) applications in the field, there is currently a lack of empirical evidence supporting their integration into design education, as well as limitations due to the novelty of these applications. Therefore, this study proposes a workflow integrating AI-assisted ideation and visualization into interior architecture education. An empirical study was conducted with six interior architecture students.The design process has been researched in addition to capturing the functional limitations and difficulties encountered by students who experienced the suggested educational framework.The findings were analyzed using descriptive analysis, a qualitative research method.Findings revealed that AI tools can effectively support the early design phase with the recommended workflow. However, participants often struggled to apply it critically, relying heavily on AI suggestions.This study provides a novel perspective by elucidating the potential benefits, challenges and impacts of AI applications in interior architecture education
Advances in Ferritin Biosensors: Rapid and Cost-Effective Iron Level Assessment
No full textIron is an essential element crucial for oxygen transport in the bloodstream; however, deviations from its normal physiological levels can result in health complications. Iron deficiency is a widespread condition and a leading cause of anemia globally. Conversely, excessive iron accumulation can cause severe liver damage, such as cirrhosis, by exacerbating oxidative stress. Consequently, assessing iron status through biomarkers like ferritin, which is a protein that reflects the body’s iron stores, is critical for diagnosing iron-related disorders accurately. The ferritin test, which measures the concentration of ferritin protein in the blood, is a standard method for iron analysis. However, frequent hospital visits for such testing can be both time-intensive and expensive. This has driven significant interest in developing rapid and cost-effective methods for ferritin detection. To meet this demand, a variety of biosensors have been designed using diverse techniques to enable convenient ferritin analysis. Despite considerable advancements in biosensor technologies, a comprehensive classification and analysis of these devices remain lacking, leaving researchers without a unified understanding of their comparative strengths and limitations. This review addresses this gap by systematically categorizing ferritin biosensors based on their underlying mechanisms. The review explores electrochemical biosensors, such as those based on graphene, microfluidics, and ZnO–Mn3O4 nanocomposites, as well as electrical biosensors using quantum dots or gold nanorods. Additionally, optical biosensors, including photonic crystal sensors, surface plasmon resonance systems and magnesium sulfide nanosheets are discussed in detail. Unconventional and immunoassay-based biosensors, such as nanodiamond-based magnetic sensors and nanowire FETs, are also examined to highlight the breadth of detection strategies available. With the rising prevalence of iron-related disorders and the limitations of traditional diagnostic tools, this review underscores the critical need for portable, rapid, and cost-effective ferritin biosensing technologies, offering insights relevant to both clinical practice and future research. © 2025 Elsevier B.V., All rights reserved
Examination of the Mental Health Status of University Students Directly or Indirectly Affected by the Earthquake
No full textObjective: This study examines the mental health status of university students directly affected by the earthquake in the disaster zone and those indirectly affected by being outside the earthquake zone during the Kahramanmaraş earthquake that struck Turkey on February 6, 2023. Methods: A total of 109 students from 37 universities in 24 cities participated. Data were collected using an online survey that included a Demographic Information Form, the Impact of Event Scale-Revised (IES-R), the Earthquake Anxiety Scale, the DSM-5 PTSD checklist, and the Depression-Anxiety-Stress Scale-21. Mental health outcomes of directly and indirectly affected students were compared. Results: Students directly affected showed significantly higher levels of post-traumatic stress disorder (PTSD), depression, anxiety, and earthquake-related anxiety. Among indirectly affected students, females reported higher IES-R, PTSD, and earthquake anxiety scores than males. Regression analysis identified factors such as earthquake exposure, loss of relatives, involvement in search and rescue, and relocation as linked to adverse mental health outcomes. Conclusion: Although students directly affected by the earthquake are at greater risk for PTSD, depression, and anxiety, both groups face significant mental health problems. As these effects may be ongoing rather than temporary, the role of occupational therapy in promoting occupational engagement and mental health in disaster management is noteworthy. © The Author(s) 2025Science Citation Index Expanded - Social Science Citation Inde