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Assessment of Breastfeeding Self-Efficacy in Nursing Mothers Following Earthquakes: A Case Study of the Kahramanmaraş Earthquakes in Turkey
No full textBackground: Natural disasters disproportionately impact vulnerable populations, particularly mothers and infants. Research indicates that during such events, mothers often favor formula and supplementary feeding over breastfeeding. Self-efficacy is a critical determinant influencing breastfeeding practices in disaster contexts. Objectives: This study aimed to examine the breastfeeding characteristics and self-efficacy of nursing mothers following the Kahramanmara & scedil; earthquakes. Methods: This descriptive study was conducted at the Children's Polyclinic of Iskenderun State Hospital in Turkey from August 1 to August 31, 2023. A total of 54 mothers with infants aged 0-1 year at the time of the earthquake, who continued to breastfeed (providing breast milk for at least one feeding), were selected using a non-probability purposive sampling method. During the study period, all eligible mothers visiting the polyclinic who met the inclusion criteria were evaluated. Data were collected using a "Descriptive Data Form" and the "Breastfeeding Self-Efficacy Short Form Scale". Statistical analyses were performed using SPSS version 23, employing Independent Samples t-tests, Mann-Whitney U tests, and One-Way ANOVA for group comparisons. A P-value of less than 0.05 was considered statistically significant. Results: The mean breastfeeding self-efficacy score among mothers was 58 +/- 5.87 (minimum 40; maximum 70). Mothers who exclusively breastfed their infants had significantly higher self-efficacy scores compared to those who introduced formula (P = 0.021) Among the mothers surveyed, 81.5% reported that their breastfeeding was affected by the earthquake; 41% cited issues related to privacy, while 27% faced challenges regarding shelter. Prior to the earthquake, 72% of infants were exclusively breastfed; however, this figure decreased as 81.5% of infants began receiving complementary foods alongside breast milk post-earthquake. Conclusion: The findings indicate that mothers breastfeeding self-efficacy is at a moderate level. Additionally, mothers reported alterations in their breastfeeding practices compared to the pre-earthquake period. These results underscore the importance of promoting breastfeeding in disaster-affected areas and highlight the critical role of midwives in supporting these efforts.Emerging Sources Citation Inde
Genç Erişkinlerde Kor Endurans, El Kavrama Kuvveti ve Reaksiyon Süresi Arasındaki İlişki
Full text linkAmaç: Çalışmanın amacı, genç erişkinlerde kor endurans, el kavrama kuvveti ve reaksiyon süresi arasındaki ilişkiyi incelemektir. Yöntem: Bu kesitsel ve gözlemsel çalışmaya yaş ortalaması 21,07 (1,46) olan 52 lisans öğrencisi dahil edilmiştir. Kor enduransı (McGill'in Kor Endurans Testleri), el kavrama kuvveti (Jamar Hidrolik El Dinamometresi) ve alt ekstremite reaksiyon süresi (OptoGait cihazı) değerlendirilmiştir. Bulgular: Sol-sağ gövde lateral kor enduransı testi ile sağ (sırasıyla; r=0,51; r=0,47; p<0,001) ve sol el kavrama kuvveti (sırasıyla; r=0,52; r=0,51; p<0,001) arasında orta düzeyde, pozitif bir korelasyon bulundu. Sol-sağ gövde lateral kor enduransı testi ile sağ alt ekstremite reaksiyon süresi (sırasıyla; r=-0,38; p=0,005; r=-0,39; p=0,004) arasında zayıf, negatif bir korelasyon bulundu. Sol ve sağ el kavrama kuvveti ile sağ alt ekstremite reaksiyon süresi arasında da zayıf, negatif bir korelasyon vardı (sırasıyla; r=-0,32; p=0,02; r=-0,37; p=0,006). Ayrıca, sağ dominant bacağa sahip katılımcılarda, sağ alt ekstremite reaksiyon süresi ile sağ el kavrama kuvveti arasında orta düzeyde, negatif bir korelasyon (r=-0,40; p=0,01) ve sol ve sağ gövde lateral kor enduransı testi ile zayıf, negatif bir korelasyon (sırasıyla; r=-0,35; p=0,03; r=-0,33; p=0,04) bulundu. Sonuç: Bu çalışmanın bulguları, kor enduransı, el kavrama kuvveti ve reaksiyon süresi arasında bir ilişki olduğunu göstermektedir ve bu alanda çalışan profesyoneller için değerli bir kaynak sağlayabilir. Bu parametreler arasındaki ilişki, yaralanma, rehabilitasyon süreci ve sporda performans artışı gibi konularda gerekli egzersizlerin planlanmasında faydalı olabilir
Üniversite Öğrencilerinin Yaşam Doyumu Düzeyleri Üzerinde Kariyer Uyum Yeteneği ve Yükseköğretime Bağlılığın Yordayıcı Rollerinin İncelenmesi
Full text linkMotor Imagery-Based Individualized Alpha Transcranial Alternating Current Stimulation: Effects on Brain Oscillations and Motor Function
No full textScience Citation Index Expanded - Social Science Citation Inde
Finansal Stres Düzeyi ve Algılanan Yönetici Desteğinin İşten Ayrılma Niyeti Üzerindeki Etkilerinin İncelenmesi
Full text linkGünümüz dünyasında stres kaynaklarının sayısı oldukça fazladır. İnsanların en temel stres kaynaklarından biri de finansal stres düzeyidir. Özel yaşamın yanı sıra iş yaşamına olan etkileri de göz önüne alındığında finansal stres ile ilgili yapılan çalışmaların sınırlı olduğu dikkati çekmektedir. Finansal stresin iş yaşamına olan etkilerini araştırmak gerek çalışanların iş yerinde kurduğu ilişkiler bakımından gerekse işten ayrılma niyetlerine olan etkisi açısından önem teşkil etmektedir. Bu amaçla çalışmada, finansal stresin ve algılanan yönetici desteğinin işten ayrılma niyeti ile olan ilişkilerini belirlemek ve aracılık model testi gerçekleştirmek hedeflenmiştir. Türkiye’de özel sektörde aktif olarak çalışan toplam 390 katılımcıdan kolayda örnekleme yöntemiyle ve çevrim içi olarak veri toplanmıştır. Yapılan analizler sonucunda, işten ayrılma niyeti ile finansal stres arasında pozitif; algılanan yönetici desteği ile negatif yönde ilişkiler bulunduğu belirlenmiştir. Ayrıca, finansal stresin işten ayrılma niyeti üzerinde algılanan yönetici desteğinin kısmi aracılık rolünün bulunduğu saptanmıştır. Çalışmanın, çalışanların finansal stres düzeylerinin örgütsel davranışa olan yansımalarını ele alması bakımından katkı sunması beklenmektedir
The Effect of Combined Core Training Intervention on Ball Throwing Velocity and Jump Performance in Competitive Young Female Handball Players
No full textBackground and Study Aim Handball is a dynamic team sport that requires a combination of technical, tactical, and physical abilities. Among the key physical components, throwing velocity and vertical jump performance are essential for successful gameplay. These skills rely not only on upper and lower limb strength but also on core muscle function. The aim of this study is to investigate the impact of a combined core training intervention on ball throwing velocity and vertical jump performance in young competitive female handball players. Material and Methods A total of 28 young female handball players ((X) over bar = 17.21 +/- 0.74 years, 169 +/- 5 cm body height, 62.07 +/- 7.43 kg body weight) participated in the study. They were divided into an experimental group (EG = 14) and a control group (CG = 14). Both groups underwent a pretest to assess ball throwing velocity and vertical jump performance. After the initial measurements, the CG followed a standard training regimen. The EG completed an intervention program comprising six combined core exercises, performed three times per week for eight weeks. The same measurements were repeated after the program. A 2x2 repeated measures ANOVA was used to determine differences between EG and CG. The main effects of time (pretest and posttest), group, and the time*group interaction were evaluated. Results No changes were observed in the ball throwing velocity or jump performance of the CG between pretest and posttest. However, significant improvements were found in the EG for both ball throwing velocity and vertical jump performance (F = 47.467, p <.001, eta(2) =.646). Conclusions Designing core training programs in a sport-specific manner plays a significant role in developing athletes who require both general and specialized training
In Vitro Efficacy of Sumac (Rhus coriaria) Extracts Against Leishmania Tropicana and Leishmania Mexicana: A Preliminary Study from Turkiye
Full text linkObjective: Cutaneous leishmaniasis (CL) is a common clinical manifestation of leishmaniasis. Here, the in vitro anti-leishmanial efficacy of sumac extracts was tested for the first time on both Leishmania (L.) tropica and L. mexicana isolates using Rhus (R.) coriaria plant, which was collected in western Anatolia. Materials and Methods: The dried and powdered fruits of R. coriaria were macerated in acetone, ethyl alcohol, and ethyl alcohol-water mixture at room temperature for two days. The pooled extracts were evaporated under reduced pressure and lyophilized form for the study. Isolates of L. tropica and L. mexicana in Acibadem University R&D Laboratory were initially thawed and cultivated in NNN medium. Assessments were made using the haemocytometer and MTT methods at 24 and 48 h, compared with meglumine antimoniate as the control group. Results: For L. tropica, the effective concentration ranges of the extracts and the infusion were found to be 578.13-289.06 pg/mL and 289.06-144.53 pg/mL, respectively. For L. mexicana, the ranges were found to be 289.06-144.53 pg/mL and 144.53-72.27 pg/mL, respectively. It was shown that all extracts of R. coriaria were effective against both L. tropica and L. mexicana in higher doses, compared to meglumine antimoniate. Conclusion: An interesting finding was that higher sumac doses were required to eliminate L. tropica of the Old World, compared to L. mexicana of the New World. In addition, the aqueous alcohol extract showed efficacy that lasted for 48 h in half doses compared to others in L. tropica. Further assessments for both the identification of the active compounds within R. coriaria and their efficacy in vivo are planned.Pamukkale University Scientific Projects Coordination Unit [2023TAP001]This study was derived from a project funded by Pamukkale University Scientific Projects Coordination Unit (Project No:2023TAP001)
Recognition of Clove (Eugenia Caryophyllata) Oil Adulteration by Monitoring Phenolic and Antioxidative Fingerprint Markers Utilizing Online HPLC Post Column and Spectrophotometric Assays With Chemometric Analysis
No full textThis research aims to develop a reliable and versatile methodology for authenticating clove (Eugenia caryophyllata) oil (CLO). Key variables included total antioxidant capacity (TAC), total phenolic content (TPC), quantitative analyses and/or individual antioxidant capacity of fingerprint markers including eugenol (EUG) and tocopherol isomers (alpha-T, gamma-T, and delta-T) using reversed-phase liquid-chromatography (RP-HPLC) with post-column detection. A total of 28 commercial CLO samples (certified as 100% pure and other commercial samples), potential adulterants like vegetable oils (sunflower oil (SFO) and corn oil (CO)), and 14 synthetically adulterated CLO samples blended with varying proportions (ranging from 5 to 50%) of SFO and CO were analyzed. The EUG content and antioxidant capabilities of each marker were ascertained by online RP-HPLC analysis with post column detection utilizing CUPRAC (cupric reducing antioxidant capacity). EUG content in commercial CLO ranged from 1.46 to 98.06 mg g(-1), while TAC ranged between 18.54 and 748.46 mu mol g(-1) Trolox equivalents (TE), as determined by the online HPLC-CUPRAC method. Depending on the type and ratio of adulterating oils, a considerable decrease in the TAC values of virgin CLO was recorded. Classification of the commercial and synthetically adulterated CLOs (total of 42 samples) was performed using partial least square discrimination analysis (PLS-DA) and hierarchical cluster analysis (HCA). Adulteration levels above > 5% were successfully detected with 95% confidence. Thus, the proposed chemometric strategy combining selected chemical markers and TAC data demonstrated high potential for authenticating CLO. This technique provides a more focused investigation alternative for determining the authenticity and quality of commercial CLO.Turkish Scientific and Technical Research Council (2247-A) [120C134]Turkish Scientific and Technical Research Council (2247-A), 120C134
Investigation of Novel Nimesulide Derivatives Against Breast Cancer
No full textThis study focused on the synthesis of novel nimesulide semicarbazone derivatives and the evaluation of their cytotoxic potential against luminal-A (MCF-7) and triple-negative (MDA-MB-231) breast cancer cell lines. Additionally, their effects on mitochondrial membrane potential (MMP), apoptosis, and mitogen-activated protein kinase (MAPK) pathway modulation were investigated. Breast cancer remains the most prevalent malignancy among women, with luminal-A and triple-negative subtypes posing significant therapeutic challenges due to drug resistance and the lack of effective targeted treatments. The MAPK pathway plays a crucial role in breast cancer progression, making its inhibition a promising therapeutic approach. Non-steroidal anti-inflammatory drugs (NSAIDs), particularly nimesulide, have demonstrated anticancer potential beyond their well-established anti-inflammatory properties. Accordingly, the semicarbazone moiety was incorporated into the molecular scaffold to enhance the antiproliferative efficacy of nimesulide derivatives, as it has been reported to exhibit cytotoxic and apoptosis-inducing effects across various cancer cell lines. A series of nimesulide semicarbazone derivatives (5a-m) were synthesized through multi-step reactions and characterized using elemental analysis, FT-IR, 1H NMR, 13C NMR and Mass spectroscopy (5e). In silico studies were performed to predict their binding affinities to MAPK12. The cytotoxic effects of the synthesized compounds were assessed by determining IC50 values in MCF-7 and MDA-MB-231 cell lines (CCK8 test). Compounds exhibiting strong cytotoxic activity were further examined for their impact on MMP depolarization (JC-1 assay), apoptosis induction (Annexin V-FITC/PI staining), and MAPK pathway modulation (Western blotting of p-ERK and ERK protein). Molecular docking results indicated that the synthesized compounds exhibited favorable interactions with MAPK12, with compound 5e showing one of the highest binding affinity (-9.29 kcal/mol, Ki = 0.154 mu M). Cytotoxicity assays revealed that compound 5e had the lowest IC50 values (11.77 +/- 0.26 mu M in MCF-7; 20.72 +/- 0.25 mu M in MDA-MB-231), demonstrating significantly higher cytotoxicity than nimesulide. JC-1 assays confirmed that compound 5e induced MMP depolarization at higher concentrations, suggesting apoptosis activation. Flow cytometry analysis further validated a substantial increase in apoptotic cell populations following treatment with compound 5e. Western blot results showed a dose-dependent decrease in p-ERK levels in both MCF-7 and MDA-MB-231 cells, confirming MAPK pathway inhibition. These findings support that nimesulide-based semicarbazones, particularly compound 5e, exhibit potent antiproliferative and pro-apoptotic activity via MAPK pathway modulation, offering a promising avenue for the development of targeted breast cancer therapies.Scientific Research Projects Commision of Bahcesehir University (BAU) [BAP.2022-02.52]This study was supported by Scientific Research Projects Commision of Bahcesehir University (BAU), project number is BAP.2022-02.52. Starting compound, Nimesulid; was obtained from Deva Ilac San. Tic. A. S
The Therapeutic Role of Ginseng in Promoting Hippocampal Neurogenesis and Ameliorating Cognitive Function Following Whole Brain Radiotherapy in Rats
No full textWhole-brain radiotherapy (WBRT) is a prevalent technique for managing multiple intracranial metastases, however, the cognitive damage in long-term survivors due to WBTR is a critical concern that impacts patients' quality of life. Panax ginseng, a bioactive compound recognized for its neuroprotective benefits, also enhances cognitive functions, including memory and learning. This study aims to examine the potential protective effects of Panax ginseng supplementation on cognitive dysfunction and the levels of neurogenesis-related proteins in the hippocampus of rats that underwent WBRT, which was delivered as 3 fractions of 6 Gy (total dose 18 Gy) using a linear accelerator. Thirty-six male Sprague-Dawley rats were divided into three groups: radiation, ginseng treatment, and control. After 60 days of Panax ginseng administration (100 mg/kg), behavior tests (Morris water maze and novel object recognition) were performed, followed by western blot analysis of the hippocampus. Results indicated that Panax ginseng supplementation ameliorated radiation-induced cognitive impairments. Additionally, western blot analyses revealed that Panax ginseng promoted neuronal recovery and neuroplasticity processes in the hippocampus, simultaneously exhibiting a neuroprotective mechanism by reducing apoptosis and neurotoxicity markers. Panax ginseng ameliorates cognitive dysfunction after WBRT by enhancing neurogenesis and diminishing cell death in the hippocampus