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Where Are We and What Should We Do in Cleaner Production Transformation
No full textUntil recently, production models developed according to market conditions focused on reducing costs and increasing profitability at the expense of the destruction of natural resources and the deterioration of ecological balance and human health. However, today, with the effects of the deterioration in the ecosystem reaching sensible dimensions and being accepted as a global threat, a new production approach is needed. Due to environmental pressures, new markets and scarce resources, development, and economic growth are being tried to be redefined. Traditional production methods and environmental technologies are no longer sufficient to provide resource efficiency and increase environmental performance. Therefore, the need for new systems, processes and technologies has arisen for the restructuring of the industry and the creation of green business models. In this chapter, it is discussed how the cleaner production approach will contribute to this transformation, considering the green transformation efforts in question and considering the current situation of the Turkish industry. © 2023, IGI Global
Design Process and Digital Storytelling on the Axis of Similarities and Differences
Get PDFThe design process, which expresses the act of designing in line with a thought and the steps that make up the product resulting from this action, constitutes the essence of design education studio environments. The methods and thought approaches that can be followed in this process are always among the issues questioned. With the study, this issue is approached through digital stories. The fact that digital storytelling, which is a lot of research in terms of its contributions in education-related fields, hasn't yet taken place sufficiently in the field of design education constitutes the starting point of the study. So, the study created with qualitative research method aims to raise awareness of the space design education literature on digital storytelling. In order to gain this awareness, the similarities and differences of the digital storytelling and design process has analyzed. The study determined that the design process and digital storytelling intersect with aspects of making implicit information visible, occurring in line with a problem or starting point, and including similar process stages. However, differences exist between these two concepts. This result provides a theoretical framework for those who want to benefit from digital storytelling.Emerging Sources Citation Inde
Effects of Computer-Based Balance Exercises on Balance, Pain, Clinical Presentation and Nerve Function in Patients With Diabetic Peripheral Neuropathy: a Randomized Controlled Study
Get PDFObjective:To evaluate the use of a computer-based biodex balance exercise system (BBS) on balance, neuropathic pain, clinical presentation and nerve function in patients with diabetic peripheral neuropathy (DPN). Methods: A total of 32 participants with DPN were randomly assigned in a 1:1 ratio to an intervention group (IG) or control group (CG). The IG performed exercises using the BBS twice weekly for 8 weeks, while CG were informed regarding diabetes self-management. At baseline and after study completion, participants underwent balance (postural stability and fall risk) and neuropathic pain assessment (DN4 questionnaire) and were screened using the Michigan Neuropathy Screening Instrument and nerve conduction test. Results: Among the baseline participants, 14 in the IG and 13 in the CG completed the study. Balance training improved postural stability (overall, p<0.001), fall risk (p<0.001), neuropathic pain (p=0.01) and symptoms (p<0.001), and clinical presentation (p=0.02), but not nerve function, within the IG. At follow-up, IG displayed significantly improved stability (p<0.001) and fall risk (p=0.02) and decreased neuropathic symptoms (p=0.01) compared to the CG. Conclusion: Computer-based balance exercises improve balance, pain, and clinical presentation of DPN, but not nerve function, in patients with DPN.Science Citation Index Expande
Paricalcitol Protects Against Hydrogen Peroxide-Induced Injury in Endothelial Cells Through Suppression of Apoptosis
No full textThe vascular endothelium is one of the main targets of oxidative stress which plays an important role in the pathophysiology of vascular damage. Recent studies show that vitamin D can positively regulate endothelial functions in various chronic diseases and in cases of increased oxidative stress. In our study, we investigated the restorative and protective potentials of paricalcitol which is frequently used in patients with chronic renal failure, a vitamin D analogue, in human umbilical vein endothelial cells (HUVEC) before and after H2O2-induced oxidative stress. Paricalcitol treatment after the oxidative stress induced by H2O2 increased cell viability in endothelial cells depending on the dose that was used. While paricalcitol (500 nM) decreased caspase-3 activity and mitochondrial membrane potential loss, it increased nitric oxide (NO) production and reduced glutathione (GSH) levels. Paricalcitol treatment before oxidative stress increased cell viability. It increased NO production and mitochondrial membrane potential while significantly reducing caspase-3 activity. While paricalcitol caused a significant inhibition of protein disulfide isomerase (PDI) reductase activity in healthy endothelial cells, it did not cause a significant change on the PDI reductase activity under oxidative stress conditions. Present study showed that paricalcitol has restorative and protective effects on endothelial cells against oxidative injury, but these effects occur at high concentrations of paricalcitol.Marmara University Scientific Research Projects Unit [SAG-C-DRP-111115-0503]The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The study was supported by a grant from Marmara University Scientific Research Projects Unit (Project No: SAG-C-DRP-111115-0503).Science Citation Index Expande
“Barış Akarsu Merhaba” Filminin İzlerkitle Üzerindeki Etkisinin Duygu Analizi Yöntemiyle Değerlendirilmesi
Get PDFSosyal medya, bireylere, fikirlerini ifade edebilmeleri, belirli konularda bilgi ve fikir alışverişi yapabilmeleri imkanı sağlamaktadır. Günümüzde sosyal medya forum sayfalarının, tartışma sitelerinin artmasıyla birlikte, sosyal medyanın iki yönlü bir iletişim şekli oluşunun sonucu olarak kamuoyunun belirli konulardaki duygu ve düşünceleri çeşitli yöntemlerle saptanabilmektedir. Sinema da bu konulardan biridir ve vizyondaki veya dijital video platformlarındaki filmler hakkında insanların ne düşündüğü tespit edilip değerlendirilebilmektedir. Bu çalışmada, 2022 yılında vizyona giren “Barış Akarsu Merhaba” filminin, duygu analizi yöntemi kullanılarak izleyicinin film hakkındaki duygu ve düşüncelerinin değerlendirmesi yapılacaktır. Duygu analizi yöntemi kullanılarak yapılacak olan araştırmada değerlendirme sınırlılıkları kapsamında platform olarak Ekşi Sözlük seçilmiştir. Araştırmanın Ekşi Sözlük ile sınırlandırılmasının nedeni Türkiye’de sözlük tabanlı platformlar arasından en çok bilinen ve en sık ziyaret edilen platform olmasıdır (SimilarWeb, 2022). Aynı zamanda, içeriklerin kısa ve yazı formatında olması nedeniyle bu platform tercih edilmiştir. Araştırmada, izleyicilerin film hakkında olumlu, olumsuz ve nötr görüşleri ile bu görüşlerin alt başlıkları nedenleri ile analiz edilecektir. Analiz sonucunda, kullanıcıların büyük çoğunluğunun film hakkında olumsuz değerlendirmede bulunduğu, bu olumsuz değerlendirmelerden en yüksek oranın ‘yapım’ alt başlığına ait olduğu gözlemlenmiştir. Aynı zamanda, özellikle Türkiye’de çok fazla biyografi türünde film yapıldığı ve kişilerin artık izlememeyi tercih ettikleri görülmüştür. Ayrıca, oyunculuğun çok beğenilmesine rağmen filme konu olan gerçek kişinin, filminin yapılmasının gereksiz olduğu ve bunun maddi çıkar kaygısı taşıdığı sonucuna varılmıştır
Melatonin Improves Liver and Pancreatic Tissue Injuries in Diabetic Rats: Role on Antioxidant Enzymes
Get PDFERTIK, Onur/0000-0001-5437-3513; BAYRAK, Bertan Boran/0000-0002-0700-5096; Sener, Goksel/0000-0001-7444-6193PurposeMelatonin (Mel) is an indolamine mainly synthesized by the pineal gland and many other organs. It plays an important role in scavenging free radicals and stimulating antioxidant enzymes. The goal of this study was to investigate the effect of Mel and/or insulin treatment on oxidative liver and pancreas injuries in diabetic rats.MethodsMale Wistar albino rats were assigned into 5 groups. Group I: control animals. Group II: diabetes was induced via a single dose of STZ (60 mg/kg) administered intraperitoneally. Group III: diabetic rats treated with Mel (10 mg/kg/day). Group IV: diabetic rats given insulin (6U/kg) subcutaneously. Group V: diabetic rats that received insulin and Mel at the same dose and time. After 12 weeks of the experiment, the animals were decapitated, liver and pancreas tissues were collected.ResultsThe results indicated that reduced glutathione levels in liver and pancreatic tissue decreased, while protein carbonyl, advanced oxidized protein products and lipid peroxidation levels were elevated in diabetic group. Antioxidant enzyme activities decreased in liver tissues but increased in pancreatic tissues of the diabetic group. Administration of Mel, insulin or Mel + insulin reversed these biochemical changes in the diabetic animals.ConclusionThis work shows that in long-term oxidative stress conditions caused by STZ-induced diabetes, either Mel or Mel + insulin administration may improve the deteriorated oxidant/antioxidant system in both the liver and pancreas tissues. These results suggested that Mel alone or Mel + insulin treatments might have a significant role in protecting against liver and pancreatic damage in STZ diabetic rats via different antioxidant effects.Emerging Sources Citation Inde
Hipergerçeklik Çağında Medya ve Tüketim
Get PDFYeni medya teknolojilerinin gelişmesiyle birlikte internet, en önemli tüketim alanlarından biri haline gelmiştir. Yeni teknolojiler, tüketimde “sembolik değiş tokuşun” daha hızlı bir şekilde gerçekleşmesini sağlarken, online alışveriş yapanlar arasında etkileşimi mümkün kılarak, bireylerin değer biçme yapılarını da yeniden şekillendirmektedir. Günümüzde blockchain tabanlı Metaverse kapsamında oluşturulan hipergerçeklikte, tüketicilerin ilgili ürünü evlerinin konforunda, sanki fiziksel olarak mağazaya gitmişler gibi, 360 derece deneyimlemesi olasıdır. Bu noktada, tüketici geribildirimi de ‘anda’ eşzamanlı olarak alınabilmektedir; dolayısıyla ürün kişiselleştirmelerine de imkan tanınmaktadır. Metaverse içerisinde; fiziksel gerçeklik dijital kurguyla harmanlanarak, evren ötesi denilen siber alanda, çağımızın ‘üretüketicisiyle’ (prosumer) buluşmaktadır. Tüketim sürecinin her mecraya, ortama, zamana uygun şekilde yeniden şekillendirilebilmesi, özellikle bu alanda yeni medya teknolojilerinin sunduğu tüm imkanların kullanılmasını mümkün kılmıştır. Bu çalışma kapsamında; sanal gerçeklik teknolojileri ile kullanıcılarına karma gerçeklik (mixed reality) deneyimi sunan ve ilk sanal gerçeklik müzik-eğlence platformu olarak konumlandırılan “CEEK” ele alınarak, medyanın hipergerçeklik çağında nasıl tüketilmeye başlandığı Jean Baudrillard’ın “Simülasyon Kuramı” kapsamında irdelenecektir. Bu bağlamda, alanındaki ilk örnek olması sebebi ile CEEK platformu örnek vaka çalışması olarak seçilmiştir. Araştırmanın bulguları arasında; platformda sanal ve artırılmış gerçeklik teknolojileri ile yaratılan “doğrudan katılımcı deneyimi” sayesinde bireylerin ortak deneyim simülasyonları içerisine girdikleri saptanmıştır. Platform kapsamında ünlü iş insanları çeşitli eğitimler vermekte, konserler düzenlenmekte, çeşitli eğlence programları gösterilmektedir. Deneyim esnasında sanal gerçeklik gözlüğü kullanımının bireylerin kendi evlerinden Dubai çöllerindeki canlı bir konsere ya da Amerikan ligindeki canlı bir spor etkinliğine sanal olarak katılmalarının mümkün olduğu ve hatta zamanda geriye gidilerek kayda alınmış herhangi bir konser, etkinlik, festival gibi içeriklere de sanal gerçeklik gözlüğü kullanılarak sanki o tarihte oradaymış gibi katılmanın mümkün olduğu gözlemlenmiştir. Platformun kullanıcılarına sunduğu \"ortak deneyim simülasyonu\", herhangi bir kodlama bilgisi olmadan onların da sanal gerçeklik üretimine dahil olmalarını sağlıyor. Böylece, platform katılımcıları, sunulan \"hiper-gerçeklik\" içindeki dijital \"yaşamlarının\" her alanında \"üretüketici\" kimliklerini koruyabilmektedirler
The Factors Associated With School Readiness: Sensory Processing, Motor, and Visual Perceptual Skills, and Executive Functions in Kindergarten Children
No full textAydoner Bektas, Selen/0000-0002-0663-1802Many developmental skills are related to children's school readiness in the early years, and these skills are essential for later achievement. Some of these skills include sensory processing, motor and visual perceptual skills, and executive functions. To date, limited research has examined these skills associated with school readiness. This study investigated the relationship between sensory processing, motor and visual perceptual skills, and executive functions, and school readiness in kindergarten children. A total of 138 kindergarten children administered the Sensory Profile, the Bruininks-Oseretsky Test 2- Brief Form, the Test of Visual Perceptual Skills-3, the Childhood Executive Functioning Inventory, and the Primary School Readiness Scale. The results showed that sensory processing, motor and visual perceptual skills, and executive functions were correlated with children's school readiness, and these skills were also highly predictive of children's school readiness (p < 0.05). It is necessary for future studies to consider these skills when assessing school readiness and to include strategies to develop these skills in intervention programs.All authors thank the participants of this study.All authors thank the participants of this study.Science Citation Index Expande
Effects of Adolescent Tactile Stimulation on Epilepsy and Depression in Rats With Genetic Absence Epilepsy
No full text[No Abstract Available]Science Citation Index Expande
Forty Years of Event Graphs in Research and Education
No full textForty years ago, in 1983, Lee Schruben proposed the Event Graph formalism and modeling language, subsequently defining the paradigm of Event-Based Simulation, in a precise way, which had been pioneered 20 years before by SIMSCRIPT. The purpose of this panel is for a group of Event Graph researchers both from Operations Research and Computer Science, including the inventor of Event Graphs and one of his former PhD students who has made essential contributions to their theory, to discuss their views on the history and potential of Event Graph modeling and simulation. In particular, the adoption of Event Graphs as a discrete process modeling language in Discrete Event Simulation and in Computer Science, and their potential as a foundation for the entire field of Discrete Event Simulation and for the fields of process modeling and AI in Computer Science is debated. © 2023 IEEE.King Fahd University of Petroleum and Minerals, KFUP