FBU GCRIS Standard Database (Fenerbahçe University)
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Turkish Translation/Cultural Adaptation and Psychometric Analyses of the Affordances in the Home Environment for Motor Development-Infant Scale (ahemd-Is)
Elbasan, Bulent/0000-0001-8714-0214; ZORLULAR, Rabia/0000-0001-9007-553XIn this study we translated the Affordances in the Home Environment for Motor Development-Infant Scale (AHEMD-IS) into Turkish, adapted the instrument culturally, examined its psychometric properties within a Turkish population, and identified its limitations. We administered the AHEMD-IS to families of 65 premature or full-term Turkish infants and repeated this testing for 17 families after one-two weeks to establish test-retest reliability. We calculated the Intraclass Correlation Coefficient (ICC) and Cronbach alpha coefficient to assess reliability, and we evaluated test validity using the Spearman's correlation coefficient and correlations with the Bayley-III motor development score. The Cronbach Alpha coefficient of the questionnaire was 0.846, and, for test-retest reliability, the ICC score was 0.830. The Turkish AHEMD-IS total score was moderately correlated with the Bayley-III fine motor development score (r = 0.469, p < 0.001), the Bayley-III gross motor development score (r = 0.533, p < 0.001), and the Bayley-III total motor development score (r = 0.526, p < 0.001). The Turkish version of the AHEMD-IS was found to be valid and reliable for children born prematurely or at full-term. The use of this questionnaire in Turkey will facilitate the creation of a home environment that will support motor development in children between 3-18 months of age.Social Science Citation Inde
An Analysis of the Gross Motor Skills of Children Aged 3-6 Years With Autism Spectrum Disorder in Comparison With Their Typically Developing Peers
The aim of this study is to examine the motor skill levels of children aged 3-6 years with Autism spectrum dis-order (ASD) in comparison with their typically devel-oping (TD) peers and to reveal their needs for motor support programs. The research group consisted of 88 participants aged 3-6 years, including 43 children (40 boys and 3 girls) diagnosed with ASD attending spe-cial education and rehabilitation institutions, and 45 TD children (23 boys and 22 girls) receiving pre-school education in a private institution (ASD=57.4 months, +/- 9.32 - TD=59.06 months, +/- 8.61). The Peabody Devel-opmental Motor Scale-2 (PDMS-2) and the Turkish Ver-sion of the Gilliam Autism Rating Scale-2 (GARS-2-TV) were used as data-collection tools in the study. The Mann-Whitney U test was used for the two-group com-parisons of the parameters that did not exhibit normal distribution in the analysis of the data. The Spearman correlation analysis was applied to determine the relationship between the variables. The significance was evaluated at the p<0.05 level. As a result of the research, the balance, locomotor and manipula-tive skills and total gross motor scores of the children with ASD were found to be lower than those of the TD children (p<0.05). In addition, it was observed that there was a significant correlation between GARS-2 -TV scores and PDMS-2 scores of the children with ASD (p<0.05).Emerging Sources Citation Inde
The Relationship Between Critical Thinking Skills and Caregiving Roles of Nurses
Background: Critical thinking is a skill highly needed by nurses to solve problems effectively and make the best decisions in clinical environments. Aim: The purpose of this study was to evaluate the relationship between critical thinking skills and the caregiving roles of nurses. Methods: This descriptive study included 220 nurses working in a training and research hos- pital. The data were collected between February and March 2021 using an online question- naire containing the “Nurse Information Form,” “Nursing Critical Thinking in Clinical Practice Questionnaire,” and “Attitude Scale for Nurses in Caregiving Roles (ASNCR).” The data were analyzed using percentages, means, standard deviation, Shapiro–Wilk, and Spearman’s cor- relation tests. Results: The nurses’ mean age was 30.35 ± 7.25 years and they were mostly female (98.2%) and had bachelor’s degree (69.1%), single (51.4%), and worked as nurses for 7.71 ± 7.54 mean years. The lowest mean score received by nurses from the Nursing Critical Thinking in Clinical Practice Questionnaire was (Mean = 19.54, SD = 4.02) in the technical dimension, and their lowest mean score was from the ASNCR was from the attitude towards nurses’ roles in treatment process dimension (Mean = 4.26, SD = 0.76). A moderate, positive, and statisti- cally significant (P < 0.001) correlation was found between the total scores and dimension scores of both scales. Conclusions: This study found that caregiving roles and critical thinking levels of nurses were above the mean score. It is important to increase the awareness of nurses about criti- cal thinking and decision-making skills in the professional education process. Nurse manag- ers may take an active role in nurturing critical thinking skills for effective outcomes
Kolostrum ve Olgun Anne Sütünün Makro Besin Ögesi Bileşimini Etkileyen Maternal Faktörler
Amaç: Bu çalışmada, kolostrum ve olgun süt bileşimindeki farklılıkların belirlenmesi ve maternal faktörlerin anne sütü makro besin ögeleri ile ilişkisinin incelenmesi amaçlanmıştır. Bireyler ve Yöntem: Kesitsel ve tanımlayıcı tipteki bu çalışmaya, postpartum birinci günde bebeklerini beslemeye başlamış 50 gönüllü kadın katılmıştır. Demografik özellikler, doğum şekli, gebelik başlangıcındaki vücut ağırlığı ve gebelik dönemindeki vücut ağırlık kazanımına ilişkin bilgiler anket formu ile yüz yüze elde edilmiştir. Annelerden doğum sonrası hastanede kaldıkları ilk 72 saatlik süre içerisinde kolostrum, yenidoğanın birinci ay ilk sağlık kontrolü için hastaneye geldiklerinde olgun süt örnekleri alınmıştır. Anne sütü makro besin ögesi içeriği, bir orta kızılötesi transmisyon spektrometresi ile ölçülmüştür. Bulgular: Yaş ortalamaları 28.21±5.61 yıl olan kadınların %32.0’si çalışmaktadır. Kolostrum ve olgun sütün enerji, karbonhidrat ve protein değerlerinin benzer (p>0.05), kolostrumun yağ içeriğinin, olgun süte kıyasla yüksek olduğu belirlenmiştir (p=0.045). Kolostrumun protein değeri ile gebelik sonrası beden kütle indeksi (BKİ) değeri arasında pozitif yönde ilişki (OR=1.619, p=0.039) bulunurken, maternal faktörlerin olgun sütün makro besin ögelerine etkisi bulunmamıştır (p>0.05). Sonuç: Kolostrum ile olgun sütün yağ miktarının farklı olduğu, maternal faktörlerden sadece BKİ’nin kolostrumun bileşimini etkilediği belirlenmiştir
Antioxidants, Enzyme Inhibitory Activities, and Phytochemical Profiles of Seven Medicinal Plants Grown With Organic Farming Techniques
OZUPEK, BURCIN/0000-0003-2159-9860In this study, the potential antihyperlipidemic, antidiabetic, and antiobesity effects of extracts obtained via infusion techniques from Artemisia absinthium L., Achillea millefolium L., Calendula officinalis L., Fumaria officinalis L., Mentha piperita L., Origanum onites L., and Urtica dioica L. grown with organic farming techniques were investigated using enzyme inhibition methods (alpha-glucosidase, pan-creatic cholesterol esterase, pancreatic lipase, and alpha-amylase). It is important that natural compounds or extracts to be used in the treat-ment of metabolic problems have antioxidant effects. The antioxidant effects of these species were tested in terms of ABTS and DPPH radical scavenging activity, ferric reducing power, and metal chelating capacity. Extracts (2 mg/mL) of M. piperita (91.43 +/- 0.90%) and O. onites (70.18 +/- 2.02%) showed potent inhibitory effects on the alpha-glucosidase enzyme. Among all species, only O. onites extract ex-erted an inhibitory effect on the cholesterol esterase enzyme close to that of reference compound simvastatin. While all extracts were effective in the tested antioxidant activity methods, it was determined that the M. piperita and O. onites extracts displayed particularly significantly strong activities in terms of ferric reducing power, ABTS radical scavenging effect, and metal chelating capacity. The total flavonoid and phenolic contents of all extracts were determined. The compositions of the most active extracts were analyzed for pheno-lic acids and flavonoids using RP-HPLC. The results of RP-HPLC analysis showed that the levels of ellagic acid (0.923 +/- 0.000 g/100 g extract) in the M. piperita extract and rosmarinic acid (0.813 +/- 0.003 g/100 g extract) in the O. onites extract were high. As a result, all species grown with organic farming techniques except U. dioica were found to have high antioxidant effects. In light of these findings, it was concluded that M. piperita and O. onites grown with organic farming techniques showed strong inhibitory effects in terms of the tested activities, especially for alpha-glucosidase and pancreatic cholesterol esterase, and that in vivo studies and activity-guided isolation studies should be conducted on these species in the future.Science Citation Index Expande
Covıd-19 Döneminde Mültecilere Çevrim İçi Psikolojik Destek Sağlayan Ruh Sağlığı Profesyonellerinin Deneyimleri: Nitel Çalışma
Bu çalışmanın amacı, COVID-19 döneminde mültecilere yönelik ruh sağlığı desteği sunan profesyonellerin çevrim içi psikolojik destek deneyimlerinin incelenmesidir. Fenomenolojik desende yapılan bu çalışmada pandemi döneminde mültecilere çevrim içi psikolojik destek sağlayan ve Türkiye’de ikamet eden on ruh sağlığı profesyoneli ile derinlemesine çevrim içi görüşmeler yapıldı. Veriler tematik analiz yöntemi ile analiz edildi. Görüşmeden elde edilen veriler, beş ana tema ve on dokuz alt tema altında toplandı. Bu temalarda ruh sağlığı profesyonellerinin çevrim içi psikolojik desteğe yönelik ön yargıları ve bu sürece adaptasyon süreçleri; mültecilerle çalışırken çevrim içi psikolojik desteğin avantajları ve dezavantajları, çevrim içi psikolojik destek sürecinde yaşanan duygular ve bazı zor durumlardaki baş etme yöntemleri ile ilgili bulgular elde edildi. Ruh sağlığı profesyonellerinin bildirdiği zorlukların başında pandemi döneminde mültecilere sınırlı olanaklar dâhilinde çevrim içi psikolojik destek sunmaları ve dışsal sorunların psikolojik sorunların çevrim içi olarak çalışılmasında yarattığı güçlükler yer alırken; en önemli gereksinimleri çevrim içi ruh sağlığı hizmetini sürdürmenin inceliklerini öğrenme olduğu saptandı. Bu nedenle mültecilerle çalışan ruh sağlığı profesyonellerinin özellikle çevrim içi çalışırken daha fazla desteklenmeye ihtiyaçları olduğu ve alanda bu konuda gelecekte daha fazla çalışmanın yapılması gerektiği düşünülmektedir
An International Multicenter Mental Health Standardized Patient Simulation on Nursing Students? Beliefs Toward Mental Health Conditions
Dikec, Gul/0000-0002-7593-4014; Ozkara San, Eda/0000-0002-4191-9246Background: Negative beliefs can be a barrier to provide quality nursing care for persons living with mental health conditions. This international SP simulation study explored nursing students' beliefs toward persons with mental health conditions in the United States (US) and Turkey before and after participating in a mental health standardized patient simulation. Methods: A quasi-experimental study design was used in two settings in two countries. Measures included a socio-demographic survey and the Beliefs toward Mental Illness scale. Results were analyzed using paired sample t-test, independent t-test, and chi-square tests. Results: Students in the US had significantly lessened negative attitudes toward persons with mental health conditions when compared to the Turkey group. Conclusion: SP simulation may offer opportunities to improve nursing students' beliefs toward persons with mental health conditions.Science Citation Index Expanded - Social Science Citation Inde
Synthesis and Evaluation of Novel Metacetamol Derivatives With Hydrazone Moiety as Anticancer and Antimicrobial Agents
Mega Tiber, Pinar/0000-0003-0819-0702; NIGIZ, Seyma/0000-0002-8354-5107; Orun, Oya/0000-0003-1581-2207; Gunduz, Miyase Gozde/0000-0002-2287-9509; Ozkul Kocak, Ceren/0000-0002-0921-5863By exploiting the wide biological potential of the hydrazone scaffold, a series of hydrazone derivatives were synthesized, starting from N-(3-hydroxyphenyl)acetamide (metacetamol). The structures of the compounds were determined using IR, H-1 and C-13-NMR, and mass spectroscopic methods. The obtained molecules (3 a-j) were evaluated for their anticancer potential against MDA-MB-231 and MCF-7 breast cancer cell lines. According to the CCK-8 assay, all tested compounds showed moderate to potent anticancer activity. Among them, N-(3-(2-(2-(4-nitrobenzylidene)hydrazinyl)-2-oxoethoxy)phenyl)acetamide (3 e) was found to be the most effective derivative with an IC50 value of 9.89 & mu;M against MDA-MB-231 cell lines. This compound was further tested for its potential effects on the apoptotic pathway. Molecular docking studies was also carried out for 3 e in the colchicine binding pocket of tubulin. Additionally, compound 3 e also demonstrated effective antifungal activity, particularly against Candida krusei (MIC=8 & mu;g/ml), indicating that nitro group at the 4(th) position of the phenyl ring was the most preferable substituent for both cytotoxic and antimicrobial activity. Our preliminary findings suggest that compound 3 e could be exploited as a leading structure for further anticancer and antifungal drug development.TUBITAK [2209-A, 1919B012202388]& nbsp;The authors would like to thank TUBITAK [2209-A] for partially providing financial support (Project No: 1919B012202388). M. G. G. would like to thank Prof. Dr. Gerhard Wolber, Freie Universitaet Berlin, for providing the license for LigandScout 4.4.Science Citation Index Expande
Aylak Adam Romanı: Varoluşçu Bir Bakış
“Varoluş özden önce gelir” sözüyle özetlenebilecek varoluşçuluk 19. yüzyılın sonlarında edebiyat, tiyatro ve psikoloji başta olmak üzere pek çok alana etki etmiştir. Bu çalışmanın amacı, Türk edebiyatının önemli isimlerinden biri olan Yusuf Atılgan’ın Aylak Adam romanını varoluşçu felsefenin ve psikolojinin temel kavramlarını göz önünde bulundurarak incelemektir. Bu kapsamda öncelikle eserin yazarı olan Yusuf Atılgan hakkında kısa bir bilgilendirme yapılacaktır. İzleyen bölümlerde adı geçen eserde yaşanan olaylar ve ana karakter (C.) varoluşçu felsefenin önde gelen isimlerinin üzerine düşündükleri bazı kavramlar çerçevesinde yorumlanacaktır. Bu çalışma, soyut bir kavram olan varoluşçuluğun ve onun ortaya attığı meselelerin Türkçe kaleme alınmış Aylak Adam romanında nasıl kurgulandığını ve şekillendiğini göstermenin bir aracı olmayı hedeflemektedir
Qualitative and Artificial Intelligence-Based Sentiment Analyses of Anti-Lgbti Plus Hate Speech on Twitter in Turkey
OBAN, Volkan/0000-0003-1046-9155; Dogan, Muzaffer Berna/0000-0003-0626-6582; Dikec, Gul/0000-0002-7593-4014The aim of this study was to evaluate hate speech in Turkish LGBTI+-related tweets during a one-month period of artificial intelligence-based sentiment analyses. Turkish tweets related to LGBTI+, were retrieved using Python library Tweepy and were evaluated by sentiment analysis. The researchers then performed a qualitative analysis of the most frequently liked and retweeted tweets (n = 556). Sentiment analysis revealed that 69.5% of tweets were negative, 23.3% were neutral, and 7.2% were positive. The qualitative analysis was grouped under seven themes: LGBTI+ Club; Terrorism and Terrorist Organization Membership; Perversion, Illness, Immorality; Presence in History; Religious References; Insults; and Humiliation. The results of this study show that anti-LGBTI+ hate speech in Turkey is significant in terms of both quality and quantity. As LGBTI+ individuals are at risk for excess mental distress and disorders, it is important to understand the risks and other factors that ameliorate stress and contribute to mental health in social media.Science Citation Index Expanded - Social Science Citation Inde