FBU GCRIS Standard Database (Fenerbahçe University)
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Deprem Sonrası Travma Düzeyinin Belirlenmesi ve Fiziksel Aktivite Durumu İle İlişkisinin İncelenmesi
No full textAmaç: Çalışmanın amacı; 06 Şubat 2023’te meydana gelen Pazarcık-Elbistan merkezli depremler sebebiyle kişilerde oluşan travma düzeyinin, kişinin fiziksel aktivite durumu ile ilişkisini incelemektir. Aynı zamanda, kişilerde deprem sonrası ağrı varlığının sorgulanması ve bu durumun travma düzeyi ile ilişkisini ortaya koymaktır. Yöntem: Veriler çevrimiçi olarak Google formları aracılığıyla toplandı, 18-65 yaş arası 388 gönüllü katılımcı (299 kadın, 89 erkek) çalışmaya dahil edildi. Katılımcıların genel özelliklerini belirlemek için “Sosyodemografik Bilgi Formu”, travma düzeyini değerlendirmek için “Deprem Sonrası Travma Düzeyini Belirleme Ölçeği” (DSTDBÖ) ve fiziksel aktivite durumlarını belirlemek için “Uluslararası Fiziksel Aktivite Anketi Kısa Formu” (IPAQ-KF) kullanıldı. Bulgular: Deprem bölgesinde bulunma durumuna göre DSTDBÖ genel puan ortalamaları arasında anlamlı fark saptandı (p<0,001). Deprem bölgesinde bulunan 126 kişinin DSTDBÖ genel puan ortalaması 57,66±19,87 iken, bölgede bulunmayan 262 kişinin ortalaması 49,00±18,49 olarak bulundu. Spearman korelasyon analiziyle deprem bölgesinde olan ve olmayan bireylerin IPAQ-KF toplam puanları, DSTDBÖ alt faktör ve toplam puanları arasındaki ilişki incelenmiş olup sadece “Bilişsel Yapılandırma” alt faktörü ile IPAQ-KF toplam puanları arasında anlamlı bir ilişkiyi yansıtmayan negatif zayıf ilişki bulundu (deprem bölgesinde olanlar için Spearman korelasyon katsayı değeri =-0,18, p=0,042). Ve deprem sonrası ağrı yaşayan bireylerin DSTDBÖ puanları, ağrı yaşamayanlardan daha yüksek olarak saptandı (p=0,000). Sonuç: Bu çalışma ile deprem sonrası travma düzeyinin, fiziksel aktivite ile negatif ilişki gösterdiği belirlendi. İnaktif bireyler daha yüksek travma düzeylerine sahipken, minimal aktif bireylerde travma düzeyleri daha düşük bulundu. Bu bulgular, deprem sonrası fiziksel aktivitenin artırılmasının travma düzeylerini azaltmada etkili bir strateji olabileceğini göstermektedir. Bu alanda daha fazla araştırma, eğitim ve proje çalışmalarının yapılması gerekmektedir
Post Challenge Effects of OZG-38.61.3 Gamma Irradiated SARS-CoV-2 Vaccine on Organ Protection in Transgenic Mouse Model
No full textObjective: Coronavirus disease 2019 (COVID-19) is an infectious outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV 2) and virus-related deaths are increasing day by day. For this reason, vaccine studies and their urgent use are of great importance to prevent the pandemic. In this study, multi-organ damages caused by SARS-CoV-2 virus in human- angiotensin-converting enzyme type 2 (ACE2) transgenic mice and the protective effects of OZG-38.61.3 gamma irradiated SARS-CoV-2 vaccine against viral damage were investigated. Methods: For this purpose, transgenic K18-hACE2 BALB/c mice were randomly allocated into 4 groups, negative control group (NC), positive control group (PC, SARS-CoV-2 infected), and 2 different doses of OZG-38.61.3 vaccine (Challenge 1, dose of 10 13 and Ch2, 10 14 viral particle after SARS-CoV-2 infection). After the administrations, lung, heart and kidney tissues were examined by histopathological, immunohistochemical and TUNEL analysis. Results: Our results showed that the vaccine doses decreased the apoptosis, oxidative stress and inflammation parameters caused by virus in lung, heart, and kidney tissues. It was also found that the vaccine protected the expressions of tight junction proteins in the kidneys. Conclusion: According to our findings, it is suggested that the OZG-38.61.3 can be an effective and protective vaccine that can be safely used against the SARS-CoV-2 virus
Exploring the Dynamic and Spillover Effects of Renewable Energy, Energy Consumption, and Financial Growth on SDG 13: Evidence from India and China
No full textClimate change represents a critical global challenge, propelled by increasing greenhouse gas emissions, industrial growth, and reliance on fossil fuels. The United Nations’ Sustainable Development Goal (SDG) 13 underscores the imperative for immediate climate action and sustainable energy policies. This study seeks to analyze the influence of energy consumption, renewable energy transition, and financial development in India and China on climate change mitigation, in accordance with Sustainable Development Goal (SDG) 13. The energy policies and financial mechanisms of the two largest emerging economies and carbon emitters are pivotal to global sustainability. The primary research question of this study is, how do India’s and China’s energy sectors and financial development influence climate change mitigation efforts? The findings reveal that despite advancements in renewable energy, both nations continue to struggle with high carbon emissions and environmental degradation. China’s substantial investments in clean energy and financial instruments, including green bonds, have facilitated emission reductions, while India encounters infrastructural and financial limitations despite its ambitious sustainability objectives. The study underscores the necessity of integrating financial development with sustainable energy initiatives to reduce environmental harm. By evaluating the environmental consequences of energy policies, this research contributes to the broader discourse on sustainability and the role of major economies in global climate mitigation efforts. © 2025 Elsevier B.V., All rights reserved
In Vivo and In Silico Evaluation of the Effects of Parsley (Petroselinum Crispum L.) Extract on Small Intestinal Tissue in Scopolamine-Induced Cognitive Dysfunction Model
No full textThe brain-small intestine connection has become important in neurodegenerative diseases in recent years. In particular, the discovery of the relationship between Alzheimer's disease (AD) and the small intestine and the examination of the effects of AD on this tissue are important in this respect. Our study aimed to understand the effects of the experimentally created AD model in rats on the small intestinal tissue and the protective effect of the extract prepared from parsley leaves (PE). The experimental animals were divided into four groups in the study; Control, Scopolamine (Scop), Scop + PE and Scop + Galantamine (GAL). Oxidative stress parameters and activities of some important enzymes were examined in small intestinal tissues taken as a result of the experimental protocol. Additionally, in silico studies were carried out for bioactive molecules found in parsley leaves using data obtained from in vivo enzyme activity results. It was found that parameters examined for the damaged group, Scop, were reversed by PE and GAL treatment. As a result of in silico studies, it was determined that oxypeucedanin and phylloquinone had higher binding affinity than rutin for acetylcholinesterase (AChE). It has been observed that oxidative damage in the small intestine due to AD can be treated by the PE
Simülakrın Cazibesi ve Modern Toplumun Özgünlük Revizyonu: E-Gerilla Pazarlama Uygulamaları
Full text linkJean Baudrillard’ın simülakr kavramı üzerine yaptığı derinlemesine çalışmalar, modern toplumun karşı karşıya olduğu zorlukların ve tehlikelerin anlaşılmasına önemli bir bakış açısı sunmaktadır. Baudrillard, teknolojinin ilerlemesiyle birlikte gerçeklik ile sanal arasındaki sınırların giderek bulanıklaştığını ve bu durumun bireyi gerçek olmayan bir “gerçeklik” algısına sürüklediğini öne sürer. CGI (Computer Generated Imagery: Bilgisayarla Üretilen Görselleştirme) teknolojisiyle üretilen görüntüler, günümüzde bu simülasyonun en belirgin örneklerinden biridir. Geleneksel gerilla pazarlama yöntemleri bir süredir e-gerilla pazarlama adı altında CGI teknolojisi kullanılarak sosyal medya aracılığıyla geniş kitlelere ulaşan yaratıcı kampanyaların vitrini haline gelmiştir. Bu yeni nesil gerilla pazarlama yönteminin, yaratıcılığın sınırlarını zorlayarak dikkat çekici kampanyalar ürettiği yadsınamaz bir gerçek. Ancak eğer bir deneyim tamamen yapay bir ortamda gerçekleşiyorsa, bu deneyimin özgünlüğü sorgulanabilir mi? Mevcut çalışma, Jean Baudrillard’ın simülasyon teorisini merkeze alarak, ortaya çıkan yeni gerçeklik algısını ve bu algının özgünlük üzerindeki etkilerini, e-gerilla pazarlama uygulamaları üzerinden ele almayı amaçlamaktadır. Bu doğrultuda, amaçlı örnekleme yöntemiyle seçilen Türkiye’deki CGI reklamlar, Baudrillard’ın üç aşamalı çerçevesine göre yorumlanmıştır. Ardından, gerçek ve temsil arasındaki geleneksel bağın kopuşu ve gerçeğin yerini alan hipergerçekliğin izleyici deneyimini nasıl şekillendirdiği kullanıcı yorumlarıyla ortaya konmuştur. Elde edilen bulgular, CGI teknolojisiyle hayata geçirilen e-gerilla pazarlama uygulamalarının gerçeklik ile kurgu arasındaki çizgiyi bulanıklaştırdığını ve izleyicinin gerçeklik algısını bozarak toplumsal bağlamda anlam kaybına yol açtığını göstermektedir. Bu süreçte, izleyicinin dünya anlayışı, değerleri ve beklentileri yeniden şekillenirken bireysel deneyimi, dolayısıyla özgünlük anlayışı da değişmektedir. Sonuç olarak, CGI içeriklerin ve e-gerilla pazarlama uygulamalarının yaygınlaşması, gerçeklik ve kurgunun iç içe geçtiği bir dünyada bizi özgünlük kavramını yeniden değerlendirmeye zorlamaktadır
Burn Rehabilitation: Evaluation of Physiotherapists' Knowledge and Awareness Levels
No full textObjective: The aim of this study was to evaluate the level of knowledge and awareness of physiotherapists working in Turkey about burn rehabilitation. Method: This was a cross-sectional study conducted between March and June 2025 and data were collected using Google Form. A total of 324 people were included in the study. The level of knowledge and awareness of the participants about burn rehabilitation was evaluated with 28 questions created by taking expert opinion. Results: While 25.6 % of participants had experience in burn rehabilitation, only 1.2 % frequently encountered burn patients. Although 60.5 % had taken courses on burn rehabilitation, only 15.1 % considered their knowledge sufficient. Correct response rates to key knowledge questions were 78.7 % for exercise applicability, 79.6 % for timing, 54.6 % for the most common burn type in Turkey, 35.8 % for edema management, and 13 % for pressure garment duration, revealing gaps in clinical knowledge. Additionally, 92.9 % believed early physiotherapy improves recovery, and 98.4 % reported positive effects on quality of life. Discussion: Our results indicate that although most physiotherapists had taken courses on burn rehabilitation, their knowledge remains insufficient, whereas their awareness is high, underscoring the need for targeted training and certification programs
TiO2@ZIF-8 Hybrid as a Type II Heterojunction Photocatalyst:Adsorption/Photocatalytic Properties, Kinetics, and Effect of Humidity
No full textTiO2@ZIF-8 hybrid and its humidified forms are synthesized as type 2 heterojunction systems using a facile sol-gel method at different relative humidity (RH) conditions. The hybrids' surface characteristics and optical properties are thoroughly examined, followed by investigations into adsorption capacities and photocatalytic activities using anionic-methyl orange (MO) and cationic-methylene blue (MB) dyes. TiO2@ZIF-8 hybrid generates a mesoporous structure with a higher surface area (135.6 m2 g-1) than bare TiO2 (40.1 m2 g-1). Band gap energies of TiO2@ZIF-8 (3.00 eV) and humidified hybrids (2.95-2.91 eV) decrease compared to the individual phases of TiO2 (3.08 eV) and ZIF-8 (4.9 eV). XPS analysis verifies the electron donation from ZIF-8 to TiO2. Adsorptions of MO and MB differ depending on the affinities of MO or MB's functional groups on the TiO2@ZIF-8 and humidified hybrids. TiO2@ZIF-8 demonstrates 98.7% MO and 89.5% MB degradations within 100 min irradiation. Dark adsorption studies follow Langmuir model with Langmuir constants of KL = 0.445 L mg-1 for MO in the presence of TiO2@ZIF-8 and KL = 0.409 L mg-1 for MB in the presence of TiO2@ZIF-8 (84% RH). Meanwhile, pseudo-second-order kinetic model is applicable for dark experiments with rate constants of k2 = 0.918 g mg-1 min-1 for MO in the existence of TiO2@ZIF-8 and k2 = 0.917 g mg-1 min-1 for MB in the existence of TiO2@ZIF-8 (84% RH). Under irradiation, TiO2@ZIF-8 (84% RH) has higher first-order rate constant 'k' values for both MO (0.0134 min-1) and MB (0.0146 min-1) relative to that of TiO2@ZIF-8 (0.0129 min-1 for MO and 0.0112 min-1 for MB). Based on Langmuir-Hinshelwood model, TiO2@ZIF-8 (84% RH)) shows the highest adsorption coefficients (K) of 0.164 L mg-1 for MO and 0.192 L mg-1 for MB and rate constants (k) of 0.197 mg L-1 min-1 for MO and 0.182 mg L-1 min-1 for MB. Notably, the hybrids maintain high stability and photocatalytic efficiency after four consecutive degradation cycles, highlighting their potential for sustainable environmental remediation.Bogazici Universitesi Bogazici University Research Fund [BAP 22BD8/19362]This study was supported by Bogazici University Research Fund Grant Number-BAP 22BD8/19362.Science Citation Index Expande
From Global Evidence to Local Action Plan: A Novel Building Decarbonization Maturity Scale and Roadmap for nZEB Office Buildings in Developing Contexts − Case of Türkiye
No full textTo effectively combat climate change, various policies and strategies are being developed to reduce emissions by 2050. The construction sector assumes a pivotal role in achieving decarbonization targets. It is imperative to acknowledge the potential of practices in developing countries, which can provide the critical part of carbon reduction on a global scale. In this context, Nearly Zero Energy Buildings (nZEB) are attracting global attention as a key component of sustainable construction and urban regeneration. Despite high level of energy efficiency and potential to utilize renewable energy, nZEBs have not found widespread application in developing countries. This study benefits from a systematic review of the whole-life decarbonization process of nZEB office buildings. The study evaluated policy frameworks, implementation, and potential emission reduction strategies through energy efficiency measures, material selection, and the integration of renewable energy. In response, the study proposes a structured, context-sensitive decarbonization maturity scale and roadmap to guide policy and practice in developing countries and utilized Türkiye as a case study example. The findings reveal that Türkiye’s current nZEB definition positions it at Level 2 (Emerging) on the decarbonization maturity scale. The country’s high carbon intensity signals the urgency of prioritizing demand reduction and efficiency. Despite enhancements, nZEB offices in Türkiye exhibit high carbon emissions, with operational emissions ranging from 7.5 to 35 kgCO2-eq/m2/year and embodied carbon from 182 to 201 kgCO2-eq/m2. As a result, the maturity scale identifies leverage points offering a mechanism to benchmark progress and accelerate climate action in line with international examples approaching Level 5. © 2025 Elsevier B.V., All rights reserved
Gait Dynamics and Locomotor Function in Familial Mediterranean Fever: A Comparative Study with Healthy Peers
No full textScience Citation Index Expande
Effectiveness of Vibration in Reducing Pain and Improving Satisfaction During Subcutaneous Injections: A Randomized Crossover Clinical Trial
No full textÇiriş Yıldız, Cennet/0000-0002-1351-5439; Yildirim, Dilek/0000-0002-6228-0007;AimThe pain experienced during and after the injection may cause discomfort and lead individuals to develop a negative perception toward future injections. This study aimed to evaluate the impact of vibration stimulation on pain induced by subcutaneous injections and patient satisfaction.MethodsThis was a prospective, randomized, single-blind, crossover study design. Data were collected from 85 patients. Vibration and non-vibration subcutaneous anticoagulant injections were administered randomly by the same investigator following a standardized procedure. Pain and satisfaction were evaluated by a study-blind investigator using the Visual Analogue Scale immediately after the injection. Data were analyzed using descriptive statistics, the Student's t-test, paired sample test, and a generalized linear mixed model.ResultsA total of 175 injections were analyzed. It was found that the pain level of patients was lower when vibration was applied (4.06 +/- 1.68 vs. 5.32 +/- 2.19, p = 0.004). Additionally, patient satisfaction was higher when vibration was used (7.17 +/- 1.71vs. 5.97 +/- 2.46, p = 0.011).ConclusionThe results of this study demonstrated that vibration was effective in reducing the pain associated with subcutaneous anticoagulant injections and in increasing patient satisfaction. Vibration can be used as a method to alleviate pain from subcutaneous anticoagulant injections and enhance patient satisfaction. Clinically, this suggests that incorporating vibration during subcutaneous injections can be a simple, non-pharmacological strategy to improve patient comfort and adherence to therapy