FBU GCRIS Standard Database (Fenerbahçe University)
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NADPH Oxidase-2 Inhibitor Apocynin Attenuates High-Fat Diet-Induced Kidney and Bladder Injury
No full textObjective: This study aimed to evaluate the effects of NADPH oxidase-2 (NOX-2) inhibitor apocynin (APC) on high-fat diet (HFD)induced renal and bladder injury. Materials and Methods: Wistar albino rats were divided into 4 groups: Control, HFD, HFD+dimetyl sulfoxide (DMSO), and HFD+APC. Rats in HFD, HFD+DMSO, and HFD+APC groups were fed with HFD for sixteen weeks. In the last 4 weeks of the experiment, either DMSO or APC (25 mg/kg, dissolved in DMSO) was applied to the HFD+DMSO or HFD+APC groups. Lipid profiles and leptin values were measured in blood serum. Renal and bladder oxidant/antioxidant parameters, histological changes in the tissues, NOX-2-, nuclear factor kappa B (NF-& kgreen;B)-immunopositive and apoptotic cells were evaluated. Results: At the end of the experiment, leptin, cholesterol, and triglyceride levels were higher and high-density lipoprotein levels were lower in the HFD and HFD+DMSO groups compared to controls. In these experimental groups, an increase in malondialdehyde, 8-hydroxy-deoxyguanosine and myeloperoxidase levels and a decrease in glutathione levels, as well as an increase in collagen, NOX-2-and NF & kgreen;-B-immunopositive and apoptotic cells were found. Also, a deterioration in kidney and bladder morphology was observed. All these biochemical and histopathological findings improved in the HFD+APC group. Conclusion: High-fed diet causes renal and bladder injury by increasing NOX-2 activity and inflammation via oxidative stress. APC might alleviate tissue injury by inhibiting oxidative stress.Marmara University Scientific Research Project Committee [TTU: 2020-10107]This study was financially supported by the Marmara University Scientific Research Project Committee (TTU: 2020-10107).Emerging Sources Citation Inde
A Unique Web 3 Product-NFT Usage in Healthcare
No full textNon-fungible tokens (NFTs) have gained immense popularity and value in recent years. After the Web 3 revolution, many new products have been constructed based on smart contracts or powerful software agreements. One of the most exciting products of Web 3 is NFT, with their increasing popularity, high volatility, and significant price movements making them popular in trading activities. Although many people, investors and researchers perceive NFTs as a trading product, the smart contract and metadata, both of which make up of NFT structure, offer valuable support for the big data storage and processing fields. In recent years, researchers have proposed different uses of NFTs in healthcare systems to improve the quality of services by using NFTs' versatile data storage architecture. In this study, the capability of NFTs in the storage of health data is investigated, the usage and usage proposals of NFTs in health are examined, and probable usage areas in health sciences are evaluated. The uniqueness of this study is, using NFTs as the dead parental data storage in which the metadata does not need to be mitigated, but the stored data is very valuable for doctors to assess the genetic illnesses comes from parental DNAs.Scientific and Technological Research Council of Turkey (TUBITAK) [1059B192200941]This work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) Grant Agreement No. 1059B192200941
Assessment of Cross-Cultural Adaptations and Patient-Reported Outcome Measures Relevant To Shoulder Disorders in Turkish: a Systematic Review Using the Cosmin Methodology
No full textBackground There are many shoulder assessment outcome measures in the literature that have been studied for validity and reliability. However, there is no study examining the Turkish-adapted patient outcome measures (PROMs) on the shoulder according to the COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) checklist. In addition, there is a small number of studies that carry out this examination on the shoulder internationally. Determining the most appropriate questionnaires for clinical use will also be an important guide in patient evaluation by filling the gap in both literature and clinical aspects.Objective Our aim in this study is to identify the valid and reliable Turkish scales used to evaluate shoulder pain and disability, to reveal how compatible these scales are with the aspects of study quality and psychometric quality according to COSMIN criteria list.Methods A systematic search was performed in the following electronic databases: MED-LINE, Web of Science (WOS), EMBASE, SCOPUS, and ULAKBIM were searched from inception to September 2024.Results A total of 2890 articles were found in the databases. Four articles were included additionally without a search. Then, after eliminating the duplicates, 2231 articles were included based on the title and abstract search. 63 articles were included in full-text review. After the full-text review, according to our criteria, 29 articles were included in the systematic review. According to the assessment by the COSMIN checklist, 28 articles received the final classification of "inadequate". Only 1 article (UCLA-Tr) received the final classification of "adequate".Conclusion There is a wide range of Turkish PROMs available for the shoulder, with only one fully meeting COSMIN methodology criteria. However, this does not imply that other PROMs lack clinical utility. Future studies should focus on refining PROMs by incorporating MCID and PASS scores and prioritizing their responsiveness to enhance their clinical relevance. Additionally, variations in PROM performance across different patient populations highlight the need for context-specific evaluations to ensure their applicability in diverse clinical settings.Trial registration PROSPERO registration number: CRD42022298425.Science Citation Index Expande
Prevalence of Colistin-Resistant Klebsiella Pneumoniae Isolates in Turkey Over a 20-Year Period: a Systematic Review and Meta-Analysis
No full textKlebsiella pneumoniae is one of the leading causes of healthcare-associated infections and poses challenges in its treatment owing to its high antibiotic resistance. The development of resistance to colistin, which is used as a last resort, has become a major public health problem worldwide. This study was planned according to the PRISMA guidelines and included studies reporting the prevalence of colistin-resistant K. pneumoniae in Turkey between 2004 and 2024 through a systematic literature review. A total of 28 original research articles were included in the meta-analysis. Data were analyzed using the SPSS and CMA software. The pooled colistin resistance of a total of 8916 K. pneumoniae strains from 28 studies included in this meta-analysis was found to be 1.63% (95% CI: 1.51–3.12). Colistin resistance increased significantly over time. A higher resistance rate was detected in the strains tested using the EUCAST guidelines and broth microdilution method. The year of the study and validation methods contributed to the heterogeneity observed in the studies. This meta-analysis reveals that colistin-resistant K. pneumoniae strains have increased over time in Turkey. Current data show that colistin resistance is not only a laboratory finding but has become a crisis, requiring urgent action in terms of hospital infection management and patient safety. Regional and global measures should be taken to ensure the appropriate use of antibiotics to control the development of resistance. © 2025 by the authors.Science Citation Index Expande
Measuring Shoulder Abduction Strength Using 2 Different Dynamometers: Comprehensive Intrarater and Interrater Reliability and Validity
No full textObjective: The purpose of this study is to investigate the intrarater and interrater reliability of handheld dynamometer (HHD) measurements in assessing isometric muscle strength of the shoulder abductors and to compare these results with those obtained using a fixed dynamometer (FD). Methods: The study involved 25 voluntary participants, all over the age of 18, asymptomatic (with no injuries in the upper extremity), and not engaged in overhead sports. The participants were evaluated twice by 2 different testers who were experienced in orthopedic rehabilitation, at 90 degrees of shoulder abduction in the scapular plane. On the first measurement day, Tester 1 performed measurements using both HHD and FD, while on the second measurement day, both testers used only the HHD. A 3-to 7-day interval separated the 2 measurement sessions. Paired-samples t-tests were used to evaluate the systematic bias between the testers. Spearman's rank correlation coefficient, intraclass correlation coefficient, standard error of measurement, and minimal detectable change were calculated. The statistical significance level was accepted as P < .05. Results: Data from 22 participants (15 women, 7 men; mean age: 23.00 +/- 3.19 years) were analyzed, as 3 individuals did not attend the final assessment. A strong correlation (r = 0.772) was found between Tester 1's HHD measurements and FD, while a similarly strong correlation (r = 0.748) was observed for Tester 2's HHD measurements. Excellent intrarater reliability (intraclass correlation coefficient [ICC]= 0.941) was found between Tester 1's measurements, and excellent interrater reliability (ICC= 0.889) was found between testers. Conclusion: Handheld dynamometer has demonstrated excellent interrater and intrarater reliability and high validity for assessing shoulder abductor muscle strength in research and clinical use. Since the muscle strength of testers using the HHD may influence the results, the FD may be a more appropriate option when the study population is stronger than the testers. Studies involving different clinical populations and testers with varying experience levels are needed to improve the relevance of the results. Level of Evidence: Level III, Diagnostic Study
Accelerated Planar Development of Convex Free-Form Mesh Patches Using a Variable Step-Size Energy Dissipation Approach
No full textFree-form complex surfaces are prevalent in modern graphic applications. With the increasing prevalence of complex 3D surfaces enabled by advances in range scanning and 3D printing technologies, minimising parameterization times for large meshes has become crucial. This paper proposes an efficient approach for the planar development of convex free-form mesh patches using an improved energy-based technique with a variable step-size algorithm. Building upon the energy model of Wang et al., our study addresses the limitations of conventional energy dissipation algorithms, which employ fixed step sizes. The proposed variable step-size method, particularly suitable for convex or disk-shaped mesh surfaces, dynamically adjusts steps, significantly reducing energy dissipation iterations. Leveraging our previous geometric flattening method, we further enhance planar surface development using an advanced mass-spring-based approach. Here, we show that our method accelerates the mechanical flattening process while maintaining high accuracy, achieving a shape error of 0.400 and an area error of 0.147 after 36 iterations for the Surf1 patch, reducing the required iterations by nearly half compared to the fixed step-size method. This study contributes to advancing the field of surface parameterization and flattening, with potential applications in various industries
Cell-Based Therapy for Cancer in Regenerative Medicine
No full textRegenerative medicine focuses on developing and applying new cell-based therapies to heal tissues and organs and restore function lost due to aging, disease, tissue damage, or cancer. Cancer is a complex disease. It can occur with dysfunction in multiple systems, including DNA repair and apoptotic and immune functions. One form of regenerative medicine is cancer immunotherapy. In cancer immunotherapy, the immune system is activated, replaced, engineered, or regenerated to fight cancer. Stem cells are the most widely used for cancer immunotherapy. Stem cells have a natural capacity for self-healing via asymmetric division. Mesenchymal stem cells (MSCs) are a specific group of stem cells that have the potential to be used most often in regenerative medicine. In addition to MSCs, induced pluripotent stem cells (iPSCs) and hematopoietic stem cells (HSCs) are used in regenerative medicine for cancer treatment. This chapter will discuss using different types of stem cells in other cancers and the pros and cons of using stem cell-based therapies. © 2025 Elsevier B.V., All rights reserved
The Relationship Between Internalized Stigmatization and Depression Among Adolescents With Substance Use: A Cross-Sectional Study
No full textAkupunkturun İnfertilite Tedavisinde Canlı Doğum ve Gebelik Sonuçlarına Etkisi: Sistematik Derleme
Get PDFGiriş: İnfertilite tedavisi teknolojinin gelişmesiyle önemli sonuçlar elde etmiş olsa da, başarı sonucunu arttırmak adına infertilite tedavisi ile birlikte kullanılan tamamlayıcı/alternatif tedavilere yönelim artmaktadır. Amaç: Bu sistematik derlemede infertilite tedavisinde akupunktur uygulamasının, gebelik ve canlı doğum sonuçları üzerine etkisini inceleyen araştırma sonuçlarını sistematik olarak değerlendirmek amaçlanmıştır. Yöntem: Bu sistematik derleme başlangıç yıl sınırı yapılmadan Ağustos 2023- Ekim 2023 tarihleri arasında Cochrane, Science Direct ve Pubmed veri tabanları tarandı. Yayınlanan 847 çalışmadan 15 çalışma inceleme kapsamına alındı. Bulgular: Sistematik derlemeye dahil edilen 15 çalışmadan; 6 çalışmada akupunkturun canlı doğum sonucunu olumlu etkilediği 8 çalışmada ise etkilemediği belirlenmiştir. 1 çalışmada örneklem grubundaki kadınların canlı gebelik oranı etkilenmese de 35 yaş üstü kadınlarda akupunkturun etkili olduğu sonucu elde edilmiştir. Çalışmalarda akupunkturun farklı zamanlarda, farklı bölgelere uygulanması, kontrol gruplarında hiç akupunktur uygulanmayan veya plasebo akupunktur uygulanan (sahte iğne ile gerçek akupunktur grubu ile aynı bölgeye uygulananlar veya akupunktur bölgesi olmayan yerlere uygulananlar) grupların oluşturulması gibi heterojeniteler bulunmaktadır. Sonuç: 15 çalışmanın incelendiği sistematik derlemede; akupunkturun gebelik ve canlı doğum oranlarını arttırdığını belirten ve etkilemediği sonucuna ulaşan çalışma sayıları birbirine çok yakındır. Akupunktur uygulanmasının infertilite tedavisinde yer alması, tartışmalı bir konu olarak devamlılığını korumakta ve konu ile ilgili kanıt düzeyi yüksek randomize kontrollü çalışmalara ihtiyaç duyulmaktadır
Corrigendum to “on Clinical Nurses’ Views About Diversities- A Qualitative Study”
No full textIn the original published version of this article, there were unwanted reference links in 2.3. Sample and setting and new references [1], [2] and [3] has been added in the revised version removing the older reference [1]. The original manuscript showed the Introduction, 2.3. Sample and setting and reference [1] as below: Until the beginning of the 20. century, nearly all civilized societies were controlled by upper-class white men. As a result, diverse people from the leading culture were marginalized based on ethnicity, race, religion, language, sex, or sexual orientation. The “Diversity management" concept first emerged in the United States of America (USA) to manage personal and cultural differences among employees. Later, globalization became a worldwide concept parallel with the internationalization of businesses, employees, and clients [1]. Snowball sampling was applied. Inclusion criteria were working in a hospital in Istanbul for at least one year [1], three years or more of professional experience [2], bachelor's or upper degrees in nursing education [3] and working as a staff or a manager nurse [4]. [1] J.L. Bronstein, D.I. Bolnick, “Her joyous enthusiasm for her life-work …”: early women authors in the American naturalist, Am. Nat. 192 (6) (2018) 655–663. The corrected version of Introduction with relevant references and 2.3. Sample and setting are as below: Until the beginning of the 20. century, nearly all civilized societies were controlled by upper-class white men [1]. As a result, diverse people from the leading culture were marginalized based on ethnicity, race, religion, language, sex, or sexual orientation [2]. The “Diversity management” concept first emerged in the United States of America (USA) to manage personal and cultural differences among employees. Later, globalization became a worldwide concept parallel with the internationalization of businesses, employees, and clients [3]. Snowball sampling was applied. Inclusion criteria were: 1. working in a hospital in Istanbul for at least one year, 2. three years or more of professional experience, 3. bachelor's or upper degrees in nursing education 4. and working as a staff or a manager nurse. [1] Judy, R. W., & d'Amico, C. (1997). Workforce 2020: Work and workers in the 21st century. Hudson Institute, Herman Kahn Center, PO Box 26–919, Indianapolis, IN 46226; tele. [2] Penaluna, B. E., Arismendi, I., Moffitt, C. M., & Penney, Z. L. (2017). Nine proposed action areas to enhance diversity and inclusion in the American Fisheries Society. Fisheries, 42(8), 399–402. [3] Hiranandani, V. (2012). Diversity management in the Canadian workplace: Towards an antiracism approach. Urban Studies Research, 2012(1), 385806. The authors apologize for the errors. © 2025 The Author(s