Atılım Academic Archive (Atılım University)
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Kamusallık Bağlamında Kentsel Arayüzler: Ulus-Bankalar Caddesi Örneği, Ankara
Full text linkArayüzler kamusal dış mekân ile özel mekân arasında bağlantı kuran, kentsel dokuyu okumayı sağlayan, kentlinin kente açıldığı, kentsel mekânın dış yüzeyleridir. Kent, kentli ve yapı arasında bağlantıyı sağlayan arayüzler, özel alan ve kamusal alan arasındaki geçirgenliği ve sürekliliği sağlayarak kamusal yaşamı güçlü kılar. Özel alan ile kamusal alan arasında kurulan yaya, zemin, yapı ve işlev bağlantıları esnek, geçirgen mekânlara dönüşür. Bu işlevsel ve yapısal bağlantılarının yanı sıra arayüzler, sosyal hayatın ve sosyal ilişkilerin kurulmasında, bu ilişkilerin beslenmesinde ve gündelik aktivitelerin sürdürülmesinde önemli bir rol oynar. Bu çalışmada, Ankara kentinin başkent olma sürecinde kültürel ve tarihi bir alanı olan Ulus Bankalar Caddesi üzerinde yer alan kentsel arayüzlerin tespiti ve analizi yapılarak geçmişten günümüze kentsel arayüzlerin değişimi/dönüşümü incelenmiştir. Araştırmanın temel kavramsal çerçevesini oluşturan kamusal alan, özel alan ve bu iki alanın arasında geçiş özelliği taşıyan kentsel arayüz kavramları ele alınmış ve farklı teorisyenlerin bu kavramları kentsel mekânla ilişkilendirme biçimleri ortaya konmuştur. Yurtiçi ve yurtdışında kentsel arayüz oluşumuna imkân sunan yapı örnekleri üzerinden değerlendirmeler yapılmıştır. Yerinde tespit ve gözlemlere dayanarak yapılan analizler, anket çalışması sonucundaki kullanıcı verileri ile desteklenmiştir. Anket çalışması, kullanım ve aktiviteler, konfor ve imaj, erişim ve bağlantılar, sosyallik ve duyumsal/algısal değerlendirme başlıkları altında; kullanıcıların çalışma alanındaki kentsel mekân ile kurdukları ilişki, kullanımları ve algılarını derinlemesine incelemek ve ortaya çıkarmak için yapılmıştır. Elde edilen veriler sayesinde Bankalar Caddesi'nin biçimsel özelliklerine bağlı olarak hem kullanım şekilleri hem de kullanılamama nedenleri, dolayısı ile kullanıcıların alandaki sosyal aktiviteleri, alandaki algısal deneyimleri, beklentileri ve ihtiyaçları tespit edilmiştir. Ulus Bankalar Caddesi'nde sınırları belirlenen alandaki kentsel arayüzlerin biçimsel özellikleri bakımından arayüz olma nitelikleri ortaya çıkartılmış, işlevsellikleri sorgulanmıştır. Ortaya çıkan bulgularda kentsel arayüzlerin biçimsel özellikleri bakımından arayüz olma niteliği taşıdığı ancak işlevsel özelliklerine bakıldığında, kamusallık barındırmakta eksik kaldığı tespit edilmiştir.Interfaces are the outer surfaces of urban space that establish a connection between public and private spaces, enable the reading of the urban fabric, and open up the city to the city. Interfaces that provide the connection between the city, the citizen and the building strengthen public life by ensuring permeability and continuity between private and public spaces. Pedestrian, ground, structure and functional connections established between private and public areas turn into flexible, permeable spaces. In addition to these functional and structural connections, interfaces play an important role in establishing social life and social relations, nourishing these relations and sustaining daily activities. In this study, the urban interfaces located on Ulus Bankalar Street, which is a cultural and historical area of Ankara during its process of becoming a capital city, were identified and analyzed, and the change/transformation of urban interfaces from past to present was examined. The concepts of public space, private space and the urban interface, which are the transitional features between these two areas, which constitute the main conceptual framework of the research, were discussed and the ways in which different theorists relate these concepts to urban space were revealed. Evaluations were made on examples of structures that enable urban interface formation both domestically and internationally. Analyses based on on-site detection and observations were supported by user data from the survey study. The survey study was conducted to deeply examine and reveal the relationship, uses and perceptions of the users with the urban space in the study area under the headings of use and activities, comfort and image, access and connections, sociability and sensory/perceptual evaluation. Thanks to the data obtained, both the usage patterns and the reasons for non-usage of Bankalar Street, depending on its formal characteristics, and therefore the social activities of the users in the area, their perceptual experiences, expectations and needs in the area were determined. The physical characteristics of the urban interfaces in the area defined on Ulus Bankalar Street were revealed and their functionality was questioned. The findings revealed that urban interfaces have the characteristics of being interfaces in terms of their physical features, but they fall short of containing publicity when their functional features are considered
In-Vivo Antioxidant and Therapeutic Effects of Ellagic Acid on Ischemia-Reperfusion Injury in Skeletal Muscle
No full textAim: Skeletal muscle ischemia-reperfusion (IR) injury is a critical clinical issue characterized by oxidative stress, inflammation, and tissue damage, potentially leading to systemic organ dysfunction. Ellagic acid (EA), a naturally occurring polyphenolic compound, is widely recognized for its strong antioxidative, anti-inflammatory, and antiapoptotic effects demonstrated in various preclinical studies. This study sought to assess the therapeutic effects of EA in a rat model of lower extremity IR injury, focusing on histopathological and biochemical parameters. Material and Methods: 24 male Albino Wistar rats were randomly divided into four groups: Sham, EA, IR, and IR+EA. IR injury was induced by occluding the infrarenal abdominal aorta for 45 minutes, followed by 120 minutes of reperfusion. EA (40 mg/kg) was administered intraperitoneally prior to reperfusion. Left gastrocnemius muscle samples were collected for histopathological and biochemical analyses, including TOS, TAS, OSI, levels and PON-1 enzyme activity. Results: The IR group showed marked muscle injury, with a significantly higher total injury score (10.00±0.63) compared to the Sham (2.00±0.58) and EA groups (2.00±0.52) (p<0.001, both). The IR-EA group demonstrated notable improvement, with a reduced total injury score (6.17±0.54), which was also significantly lower than the IR group (p<0.001). Biochemically, TAS levels and PON-1 activity significantly decreased while TOS and OSI levels increased in the IR group compared to the sham and EA groups. In addition, EA treatment significantly increased TAS levels and PON-1 activity while reducing TOS and OSI levels in the IR-EA group compared to the IR group (p=0.039, p=0.045, p=0.045, p=0.007, respectively). Conclusion: EA effectively mitigated skeletal muscle damage induced by IR injury through its antioxidative, anti-inflammatory, and antiapoptotic mechanisms. The results suggest that EA exhibits potential effects as a therapeutic agent in managing IR-related injuries. © 2025, Turkish National Vascular and Endovascular Surgery Society. All rights reserved
Enhancing Sustainable Machining of Inconel 718 Using Multi-Walled Carbon Nanotubes and TiO2based Nanofluid Minimum Quantity Lubrication
No full textInconel 718 is extensively utilized especially in the aerospace sector due to its outstanding resistance to creep and corrosion, along with its capability to maintain strength at high temperatures. However, its high work hardening rate and low thermal conductivity present significant challenges in machining processes, including the need for extensive use of coolants, shortened tool life, and the necessity for post-processing operations for adequate surface quality, all of which hinder sustainable manufacturing. To address these issues, an innovative cooling/lubrication method, Nanofluid Minimum Quantity Lubrication (NMQL), aims to enhance the sustainable machining of Inconel 718 by minimizing these problems. NMQL involves the aerosolized delivery of nanoparticle-enriched nanofluid oil with compressed air to the cutting zone. In this way, NMQL utilizes the nanoparticles' cooling and lubrication abilities, resulting in lower cutting forces, reduced surface roughness, and decreased tool wear compared to other cooling/lubrication conditions, thereby improving machining performance. This study compares the performance of NMQL in terms of cutting forces, surface roughness and topography, and subsurface microhardness, using Multi-Walled Carbon Nanotubes (MWCNT) and TiO2nanoparticles, with Conventional Cutting Fluids (CCF), aiming to achieve more sustainable machining of Inconel 718. Also, a sustainability assessment was done using Pugh Matrix Approach in order to find the most sustainable cooling option. © 2025 Elsevier B.V., All rights reserved
Investigation the Effect of Rigid Taping on Knee and Hip Joint Kinematics in Chronic Stroke Patients With Knee Hyperextension Gait
No full textAritan, SerdarBackground: Although stroke patients gain an advantage in gait due to the knee hyperextension that occurs during the stance phase, this situation disrupts the biomechanical structure of the knee and increases the risk of injury to the capsular and ligamentous structures. The aim of this study was to examine the effects of rigid taping on hyperextension control and pelvic kinematics in stroke patients with knee hyperextension during the stance phase of gait. Research question: Does rigid taping have an effect on hyperextension control and pelvic kinematics in stroke patients with knee hyperextension? Methods: Thirty stroke patients aged between 40 and 70 were included in this pre-postintervention study. Kinematic assessment of gait was performed using a motion analysis system (Vicon Ltd, Bilston). Then, the rigid taping was applied to the patients using the hyperextension taping technique, and the kinematic analysis of the gait was repeated with the motion analysis system. Results: It was found that the rigid taping for the knee hyperextension significantly reduced the knee hyperextension (p < 0.05). Additionally, it was observed that the rigid taping significantly reduced the pelvic retraction (p < 0.05). However, no change was observed in the pelvic drop with the rigid taping application. Significance: Our results showed that the rigid taping effectively controlled the knee hyperextension. It was thought that the rigid taping application contributed to reducing knee hyperextension and pelvic retraction because it mechanically gave the knee a flexion moment and provided proprioceptive input.Science Citation Index Expande
Clinicopathological Predictors of Central Lymph Node Metastasis in Clinically Node-Negative Papillary Thyroid Carcinoma: A Retrospective Cohort Analysis
No full textPurposeThis retrospective cohort study aimed to identify clinicopathological predictors of central lymph node metastasis (CLNM) in patients with papillary thyroid carcinoma (PTC).MethodsA total of 503 patients with PTC who underwent thyroidectomy with central lymph node dissection were included. Preoperative clinical data, ultrasonographic features, and postoperative histopathological characteristics were analyzed.ResultsCLNM was detected in 209 (41.55%) patients. Male sex (odds ratio [OR] = 3.12, 95% CI: 1.82-5.35), irregular nodule borders (OR = 2.02, 95% CI: 1.25-3.26) and higher risk categories in the American Thyroid Association (ATA) ultrasonographic pattern stratification system (OR = 13.312, 95% CI: 8.623-20.551) were identified as independent preoperative predictors of CLNM. A simplified model incorporating only the ATA ultrasonographic pattern stratification system and male sex achieved 83.5% accuracy in predicting CLNM. Histopathological evaluation revealed lymphovascular invasion (OR = 4.61, 95% CI: 2.81-7.55), extrathyroidal extension (OR = 2.41, 95% CI: 1.52-3.83), and multifocality (OR = 1.58, 95% CI: 1.04-2.40) as independent predictors of CLNM, while lymphocytic thyroiditis (OR = 0.59, 95% CI: 0.39-0.89) was a protective factor.ConclusionThis study establishes that ATA ultrasonographic suspicion patterns combined with the male sex provide an accurate and simplified model for preoperative CLNM prediction in PTC, outperforming complex nomograms. Key independent predictors included male sex, irregular nodule margins, ATA high-risk patterns, lymphovascular invasion, extrathyroidal extension, and multifocality, while lymphocytic thyroiditis was protective. According to the current study, risk assessment and personalized management should favor a holistic approach, rather than focusing solely on individual risk factors
Evaluation of Space Efficiency, Structural Systems, Material Applications, and Design of High-Rise Structures in South Korea
No full textThis study examines 61 South Korean towers, analyzing their architectural configu-rations, structural systems, material applications, and spatial efficiencies. Findings indicate a pre-dominance of central core configurations and prismatic forms, reinforcing a function-driven approach to vertical urbanism. Structural system preferences highlight the widespread use of out-riggered frames, ensuring lateral stability while optimizing floor layouts. Material selection trends reveal a reliance on concrete, aligning with global patterns, while composite materials (25%) are used in high-performance supertall structures. Functionally, residential high-rises dominate, with mixed-use (2%) and office towers (11%) remaining limited. This research also identifies an aver-age spatial efficiency of 76%, aligning with international benchmarks, though variations exist across cities due to core-to-gross floor area ratios, structural constraints, and service core alloca-tions. This research underscores South Korea’s strategic high-rise development, prioritizing space optimization, structural efficiency, and economic feasibility. However, opportunities re-main for increased functional diversity, broader hybrid material adoption, and greater integration of sustainable design innovations. These findings contribute to global skyscraper analysis, offering insights into high-rise architecture’s role in urban resilience and density management. © 2025 Aktaş et al
The Relationship Between Burnout, Caring Behaviors, and Emotional Intelligence in Oncology Nurses
No full textThe Sixth International Workshop on Nonlinear Analysis and Its Applications Preface by the Guest Editors
No full textFixed Point Results on Perturbed B-Metric Space
No full textIn this paper, we introduce the notion of perturbed b-metric spaces and consider some basic topological notions on this new abstract structure. In addition, we shall discuss the existing and uniqueness of a fixed point in the setting of perturbed b-metric spaces
Development and In-Vitro Evaluation of Gallium-68 Labelled Staphylococcus Aureus-Specific Aptamer as a Potential PET Agent for Infection Imaging
No full textBackground: Staphylococcus aureus (S. aureus) is the most common causative pathogen associated with a wide range of infections, from mild to life-threatening conditions such as osteomyelitis, endocarditis, and pneumonia. Early detection and reliable differentiation between infection and sterile inflammation are essential for accurate diagnosis and effective treatment. However, most radiopharmaceuticals currently available fail to discriminate between these conditions, underscoring the need for infection-specific imaging agents. Materials and Methods: In this study, a Gallium-68 (Ga-68)-labeled S. aureus-specific aptamer was developed as a potential PET infection imaging probe. Aptamers were selected using the cell-systematic evolution of ligands by exponential enrichment (SELEX) method, and their specificity was verified by fluorescence-based binding assays. Radiolabeling was achieved via DOTA chelation, and radiochemical purity was determined. Additionally, in vitro binding assays were performed with S. aureus, while Escherichia coli (E. coli) served as a control. Results: The aptamer exhibited an affinity constant (Kₐ) of 2260 ± 634 CFU/ mL and a linear detection range of 250-2×10⁴ CFU/mL, with a limit of detection of 171 CFU/mL for S. aureus. The Ga-68-labeled aptamer demonstrated radiochemical purity greater than 99%. In vitro binding increased linearly with rising S. aureus concentrations (10³-2×10⁴ CFU/mL), while minimal binding to E. coli confirmed its specificity. Conclusion: These results demonstrate that the Ga-68-labeled S. aureus-specific aptamer holds promise as an infection-targeted PET imaging agent. Although currently limited to in vitro evaluation, such aptamer-based radiopharmaceuticals may contribute to improved diagnosis and imaging of infectious diseases. © 2025, Novin Medical Radiation Institute. All rights reserved