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Optimized Deep Neural Network for Attack Detection in Cyber-Physical Systems for Smart Healthcare Using Modified Ant Lion Optimization
No full textAssociazione Italiana per l'Intelligenza Artificiale (AIxIA); Associazione per la Matematica Applicata alle Scienze Economiche e Sociali (A.M.A.S.E.S.); Master's Program in Management of Small and Medium Enterprises; NODES (Nord Ovest Digitale E Sostenibile) project - Spoke 3 Industria del turismo e culturaThe widespread implementation of innovative healthcare systems brings about notable security risks, especially in cyber-physical systems (CPS). Ensuring patient safety and system performance is crucial in CPS, particularly when detecting and preventing attacks. This paper discusses smart healthcare systems and presents a modified deep neural network (DNN) model that can effectively classify various types of attacks on CPS. In addition, we present a modified Ant Lion Optimization (ALO) algorithm that enhances the model’s accuracy and reliability when combined with ensemble methods. By incorporating multiple feature selection techniques, the voting-based ensemble selection method improves the ability to detect attacks by leveraging the importance of the rankings of each feature assessed in those approaches. This enhances the recovery of vital data while minimizing the number of characteristics utilized for identification. Our optimized DNN model outperforms traditional approaches regarding real-time attack detection in smart healthcare system networks. From a theoretical standpoint, the methods outlined in the paper have the potential to enhance the security measures implemented in the construction of CPS and significantly bolster the resilience of smart healthcare systems against the latest cyber threats. The optimized DNN, which was further optimized with the help of the modified ALO algorithm, returned excellent results, with a carpet accuracy of 99.5%, a precision of 99.3%, a recall of 99.4%, an F1-score of 99.35%, and an ROCAUC of 0.995. Such metrics illustrate the model’s effectiveness in detecting and classifying different cyberattack forms with a high accuracy rate. © 2025 Elsevier B.V., All rights reserved
Integración De Herramientas De Inteligencia Artificial En La Educación De Arquitectura De 8 Interiores: Un Estudio Sobre Representaciones Textuales Y Visuales
No full textDespite numerous Artificial Intelligence (AI) applications in the field, there is currently a lack of empirical evidence supporting their integration into design education, as well as limitations due to the novelty of these applications. Therefore, this study proposes a workflow integrating AI-assisted ideation and visualization into interior architecture education. An empirical study was conducted with six interior architecture students.The design process has been researched in addition to capturing the functional limitations and difficulties encountered by students who experienced the suggested educational framework.The findings were analyzed using descriptive analysis, a qualitative research method.Findings revealed that AI tools can effectively support the early design phase with the recommended workflow. However, participants often struggled to apply it critically, relying heavily on AI suggestions.This study provides a novel perspective by elucidating the potential benefits, challenges and impacts of AI applications in interior architecture education.Emerging Sources Citation Inde
A Rare Case of Bilateral Preiser’s Disease Originating from the Distal Pole of the Scaphoid
No full textThe scaphoid bone – os naviculare manus – is an important bone in that it is located within the proximal row of carpal bones and articulates with both the radius and other carpal bones. Preiser’s disease is a rare entity and is commonly asSociated with avascular necrosis of the scaphoid without fracture or trauma. This case study describes a 55-year-old female patient who visited our outpatient clinic complaining of five months' worth of pain and swelling on both of her wrists. The patient had no history of trauma or prolonged steroid use. The patient had pain around the thenar region and anatomical snuff box on both wrists. On a 2-directional wrist radiograph, the distal part of the scaphoid bone showed signs of subchondral sclerosis. Magnetic Resonance Imaging (MRI) was performed to verify the diagnosis. MRI of the patient's wrist revealed bone edema at the distal pole of the scaphoid which was asSociated with Preiser’s disease. In this case study, we present a patient who had bilateral Preiser's illness that began at the distal pole
Molten Salt Reactor Neutronics and Fuel Cycle - Review of Advancements and Potential Future Research Directions
No full textGeneration IV nuclear reactor designs, like molten salt reactors (MSRs), provide passive safety and improved economics by dissolving fuel with liquid salt and moving it through the heat exchangers and core. Notwithstanding the technology's enormous potential, there is a dearth of comprehensive studies that use bibliometric and systematic review techniques to examine the development and patterns of the MSR technology. This paper adopts the bibliometric review approach using the VOSviewer and Bibliometrix package in R software to analyze the global research landscape of MSR technology between 2000 and 2024. The findings show that international collaboration is increasing in the field of advanced reactor designs and fuel cycle technologies, notably involving MSRs, thorium fuel cycles, and advanced simulation models. The research clusters indicate a multidisciplinary nature involving nuclear chemistry, reactor physics, materials science, and computational modelling. This notwithstanding, challenges such as salt purity, corrosion-resistant materials, and long-term safety are still barriers. Future research should therefore optimise fuel cycles and make advances in core designs for mini reactors while transmutating waste to reduce the radioactive inventory. Also, simulation tools should be developed further, especially in areas such as isotope transmutation and neutron transport, to increase the scalability, efficiency, and sustainability of MSR.Science Citation Index Expande
Observation of WZγ Production and Constraints on New Physics Scenarios in Proton-Proton Collisions at √s=13 Tev
No full textElliot, Alison/0000-0003-0921-0314; Gutsche, Oliver/0000-0002-8015-9622; Dominguez, Aaron/0000-0002-7420-5493; Klyukhin, Vyacheslav/0000-0002-8577-6531; Kyberd, Paul/0000-0002-7353-7090; Rinkevicius, Aurelijus/0000-0002-7510-255X; Niedziela, Jeremi/0000-0002-9514-0799; Rappoccio, Salvatore/0000-0002-5449-2560; Basile, Chiara/0000-0003-4486-6482; Lorusso, Marco/0000-0003-4033-4956; Strautnieks, Normunds Ralfs/0000-0003-4540-9048; Cuffiani, Marco/0000-0003-2510-5039; Dubinin, Mikhail/0000-0002-7766-7175; Erice Cid, Carlos Francisco/0000-0002-6469-3200; Papageorgakis, Christos/0000-0003-4548-0346; Aarrestad, Thea/0000-0002-7671-243X; Paulini, Manfred/0000-0002-6714-5787; Muñoz Díaz, Conrado/0009-0001-3417-4557; Lee, Jeongeun/0000-0002-5351-7201; Lasaosa García, Clara/0000-0003-2726-7111; Figueiredo, Diego/0000-0003-2514-6930; Vilela Pereira, Antonio/0000-0003-3177-4626; Grummer, Aidan/0000-0003-2752-1183; Navarrete Ramos, Efren/0000-0002-5180-4020; Lohezic, Victor/0009-0008-7976-851X; Ruabhatla, Sahithi/0000-0002-7366-4225; Pigazzini, Simone/0000-0002-8046-4344; Cepeda, Maria/0000-0002-6076-4083; Conway, John/0000-0003-2719-5779; Leonardo, Nuno/0000-0002-9746-4594; Clement, Emyr/0000-0003-3412-4004; Meena, Meena/0000-0003-4536-3967; De Souza Lemos, Dener/0000-0003-1982-8978; Martinez Ruiz Del Arbol, Pablo/0000-0002-7737-5121; Guglielmi, Valentina/0000-0003-3240-7393; Meridiani, Paolo/0000-0002-8480-2259; Kumar, Arun/0000-0002-5180-6595; Heredia De La Cruz, Ivan/0000-0002-8133-6467; Collard, Caroline/0000-0002-5230-8387; Sharma, Ram Krishna/0000-0003-1181-1426; Zorbakir, Ibrahim Soner/0000-0002-5962-2221; Arneodo, Michele/0000-0002-7790-7132; Kim, Bobae/0000-0002-9539-6815; Zuolo, Davide/0000-0003-3072-1020; Chahal, Gurpreet Singh/0000-0003-0320-4407; Reimers, Arne Christoph/0000-0002-9438-2059; Ruales, Anderson/0000-0003-0826-0803; Alcaraz Maestre, Juan/0000-0003-0914-7474; Sculac, Toni/0000-0002-9578-4105; Grab, Christophorus/0000-0002-6182-3380; Everaerts, Pieter/0000-0003-3848-324X; Sahasransu, Abanti Ranadhir/0000-0003-1505-1743; Jabusch, Henrik Ronald/0000-0003-2444-1014; Presilla, Matteo/0000-0003-2808-7315; Haddad, Yacine/0000-0003-4916-7752; Naimuddin/0000-0003-4542-386X; Zucchetta, Alberto/0000-0003-0380-1172; Ravera, Fabio/0000-0003-3632-0287; Llorente Merino, Javier/0000-0003-0027-7969; Mudholkar, Tanmay/0000-0002-9352-8140; Verdier, Patrice/0000-0003-3090-2948; Colombina, Federica Cecilia/0009-0008-7130-100X; Kogler, Roman/0000-0002-5336-4399; González Caballero, Isio/0000-0002-8087-3199; Lucchini, Marco Toliman/0000-0002-7497-7450; Redondo, Ignacio/0000-0003-3737-4121; Ko, Sanghyun/0000-0003-4377-9969; Matchev, Konstantin/0000-0003-4182-9096; Sharma, Varun/0000-0003-1287-1471; Anosov, Konstantin/0000-0003-2694-6542; Bhowmik, Sandeep/0000-0003-1260-973X; Legger, Federica/0000-0003-1400-0709; Steggemann, Jan/0000-0003-4420-5510; Rizzi, Anea/0000-0002-4543-2718; Wittich, Peter/0000-0002-7401-2181; Trevisani, Nicolò/0000-0002-5223-9342; Botta, Cristina/0000-0002-8072-795X; Dallavalle, Gaetano Marco/0000-0002-8614-0420; Cousins, Robert/0000-0002-5963-0467; Fernandez Menendez, Javier/0000-0002-5213-3708; Vaselli, Francesco/0009-0008-8227-0755; Das, Pallabi/0000-0002-9770-1377; Cumalat, John/0000-0002-6032-5857; Mcginnis, Michael/0000-0002-9833-6316; Luongo, Fabio/0000-0003-2743-4119; Brooke, James/0000-0003-2529-0684; Simkina, Polina/0000-0002-9813-372X; Fehérkuti, Anna/0000-0002-5043-2958; Ribeiro Lopes, Beatriz/0000-0003-0823-447X; Faccioli, Pietro/0000-0003-1849-6692; Abbiendi, Giovanni/0000-0003-4499-7562; Motta, Jona/0000-0003-0985-913X; Petković, Ano/0009-0005-9565-6399; D'Amante, Valeria/0000-0002-7342-2592; Purohit, Arnab/0000-0003-0881-612X; Tonelli, Guido Emilio/0000-0003-2606-9156; Poncet, Océane/0000-0002-5346-2968; Pereira, Miguel/0000-0003-4296-7028; Benaglia, Anea Davide/0000-0003-1124-8450; Chatterjee, Sayan/0000-0003-0185-9872; Taylor, Lucas/0000-0002-6584-2538; De La Cruz Burelo, Eduard/0000-0002-7469-6974; Yang, Tianyu Justin/0000-0003-4317-4660; Alves, Gilvan/0000-0002-8369-1446; Flaecher, Henning/0000-0002-5371-941X; Muhammad, Muhammad Abdullah Abdulfattah/0000-0002-7322-3374; Waltenberger, Wolfgang/0000-0002-6215-7228; Murillo Quijada, Javier Alberto/0000-0003-4933-2092; , Israr/0009-0000-6580-901X; Yigitbasi, Efe/0000-0002-9595-2623; Gonzalez Lopez, Oscar/0000-0002-4532-6464; Hacışahinoğlu, Burak/0000-0002-2646-1230; Russell, Lucas/0000-0002-6502-2185; Agicevic, Marko/0000-0003-1967-6783; Stäger, Fabian/0009-0003-0724-7727; Urda, Lourdes/0000-0002-7865-5010; Pérez Adán, Danyer/0000-0003-3416-0726; Bortignon, Pierluigi/0000-0002-5360-1454; Ganakota, Abhijith/0000-0003-4860-3233; Fiorendi, Sara/0000-0003-3273-9419; Reis, Thomas/0000-0003-3703-6624; Pieri, Marco/0000-0003-3303-6301; Giommi, Luca/0000-0003-3539-4313; Wardle, Nicholas/0000-0003-1344-3356; Lassila-Perini, Kati/0000-0002-5502-1795; Blekman, Freya/0000-0002-7366-7098; Ivanov, Anew/0000-0002-9270-5643; Litov, Leandar/0000-0002-8511-6883; Whalen, Kathleen/0000-0002-9383-8763; Backhaus, Malte/0000-0002-5888-2304; D'Enterria, David/0000-0002-5754-4303; Geurts, Frank/0000-0003-2856-9090; Maid, Christopher/0000-0003-3301-2246; Meola, Sabino/0000-0002-8233-7277; Portales, Louis/0000-0002-9860-9185; Mora Herrera, Maria Clemencia/0000-0003-3915-3170; Herndon, Matthew/0000-0003-3043-1090; Smith, Wesley/0000-0003-3195-0909; Orzari, Breno/0000-0003-4232-4743; Ecklund, Karl/0000-0002-6976-4637; Cappati, Alessana/0000-0003-4386-0564; Savva, Klitos/0009-0000-7646-3376; Blumenfeld, Barry/0000-0003-1150-1735; Christoforou, Konstantinos/0000-0003-2205-1100; Lipton, Ronald/0000-0002-6665-7289; Chatterjee, Suman/0000-0003-2660-0349; Padula, Sana S/0000-0003-3071-0559; Al Kadhim, Ali/0000-0003-3490-8407; Gomez Espinosa, Tirso Alejano/0000-0002-9443-7769; Alexe, Cristina-Aneea/0000-0003-4981-2790; Vischia, Pietro/0000-0002-7088-8557; Mendizabal, Mikel/0000-0002-6506-5177; Schulte, Jan-Frederik/0000-0003-4421-680X; Alibordi, Muhammad/0000-0002-7535-7149; Reichert, Joseph/0000-0003-2110-8021; Perez Dengra, Carlos/0000-0003-2821-4249; Anea, Jeremy/0000-0002-8298-7560; Wilson, Graham/0000-0003-0917-4763; Li, Qiang/0000-0002-8290-0517; Acharya, Shriniketan/0009-0001-2997-7523; Wang, Dayong/0000-0002-9013-1199; Zanetti, Marco/0000-0003-4281-4582; Ha, Seungkyu/0000-0003-2538-1551; Petrucciani, Giovanni/0000-0003-0889-4726; D'Anzi, Brunella/0000-0002-9361-3142; Josa Mutuberria, Isabel/0000-0002-4985-6964; Klanner, Robert/0000-0002-7004-9227; Navarro-Tobar, Álvaro/0000-0003-3606-1780; Connor, Patrick/0000-0003-2500-1061; Park, Mary/0000-0003-4282-1969; Manzoni, Riccardo Anea/0000-0002-7584-5038; Hurtado Anampa, Kenyi/0000-0002-9779-3566; Shchelina, Ksenia/0000-0003-3742-0693; Lawhorn, Jay/0000-0002-8597-9259; Mukherjee, Soumya/0000-0003-3122-0594; Leonidou, Christos/0009-0008-6993-2005; Cassese, Antonio/0000-0003-3010-4516; Röwert, Nicolas/0000-0002-4745-5470; Lorkowski, Florian/0000-0003-2677-3805; Eimanis, Karlis/0000-0003-0972-5641; Kunnawalkam Elayavalli, Raghav/0000-0002-9202-1516; Jaramillo Gallego, Johny/0000-0003-3885-6608; Pizzati, Giorgio/0000-0003-1692-6206; Ebrahimi, Aliakbar/0000-0003-4472-867X; Tosi, Silvano/0000-0002-7275-9193;A measurement of the WZ gamma triboson production cross section is presented. The analysis is based on a data sample of proton-proton collisions at a center-of-mass energy of root s = 13 TeV recorded with the CMS detector at the LHC, corresponding to an integrated luminosity of 138 fb(-1). The analysis focuses on the final state with three charged leptons, l(+/-)nu l(+)l(-), where l = e or mu, accompanied by an additional photon. The observed (expected) significance of the WZ gamma signal is 5.4 (3.8) standard deviations. The cross section is measured in a fiducial region, where events with an l originating from a tau lepton decay are excluded, to be 5.48 +/- 1.11 fb, which is compatible with the prediction of 3.69 +/- 0.24 fb at next-to-leading order in quantum chromodynamics. Exclusion limits are set on anomalous quartic gauge couplings and on the production cross sections of massive axionlike particles.FWF; FNRS; FWO (Belgium); CNPq; CAPES; FAPERJ; FAPERGS; FAPESP (Brazil); BNSF (Bulgaria); MoST; NSFC (China); CSF (Croatia); RIF (Cyprus); SENESCYT (Ecuador); ERC PRG [MoER TK202]; Academy of Finland; MEC; CEA; CNRS/IN2P3 (France); SRNSF; BMBF; DFG; HGF (Germany); NKFIH (Hungary); DAE; DST; IPM; SFI (Ireland); INFN (Italy); NRF (Republic of Korea); MES (Latvia); MOE; UM (Malaysia); BUAP; CONACYT; UASLP-FAI (Mexico); PAEC (Pakistan); FCT (Portugal); MESTD (Serbia); PCTI (Spain); MOSTR (Sri Lanka); Swiss Funding Agencies (Switzerland); NSTDA; TUBITAK; DOE; NSF (USA); Marie-Curie program; European Research Council; Horizon 2020 Grant [675440, 724704, 752730, 758316, 765710, 824093, 101115353, 101002207]; COST Action [CA16108]; Leventis Foundation; Alfred P. Sloan Foundation; Alexander von Humboldt Foundation; Science Committee [22rl-037]; Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIABelgium); Beijing Municipal Science & Technology Commission [Z191100007219010]; Fundamental Research Funds for the Central Universities (China); Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; Shota Rustaveli National Science Foundation [FR-22-985]; Deutsche Forschungsgemeinschaft (DFG) [Strategy-EXC 2121, 400140256-GRK2497]; Hellenic Foundation for Research and Innovation (HFRI) [2288]; Hungarian Academy of Sciences; NKFIH [K 131991, K 133046, K 138136, K 143460, K 143477, K 146913, K 146914, K 147048, 2020-2.2.1-ED-2021-00181, TKP2021-NKTA-64, 2021-4.1.2-NEMZ_KI2024-00036]; Council of Science and Industrial Research, India - NextGenerationEU program (Italy); Latvian Council of Science; Ministry of Education and Science [2022/WK/14]; National Science Center; Opus [2021/41/B/ST2/01369, 2021/43/B/ST2/01552]; Fundacao para a Ciencia e a Tecnologia [CEECIND/01334/2018]; National Priorities Research Program by Qatar National Research Fund [MICIU/AEI/10.13039/501100011033]; ERDF/EU; Programa Severo Ochoa del Principado de Asturias (Spain); National Science, Research and Innovation Fund via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation [B39G670016]; Kavli Foundation; Nvidia Corporation; SuperMicro Corporation; Welch Foundation [C-1845]; Weston Havens Foundation (USA)We congratulate our colleagues in the CERN accelerator departments for the excellent performance of the LHC and thank the technical and administrative staffs at CERN and at other CMS institutes for their contributions to the success of the CMS effort. In addition, we gratefully acknowledge the computing centers and personnel of the Worldwide LHC Computing Grid and other centers for delivering so effectively the computing infrastructure essential to our analyses. Finally, we acknowledge the enduring support for the construction and operation of the LHC, the CMS detector, and the supporting computing infrastructure provided by the following funding agencies: SC (Armenia), BMBWF and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, FAPERGS, and FAPESP (Brazil); MES and BNSF (Bulgaria); CERN; CAS, MoST, and NSFC (China); MINCIENCIAS (Colombia); MSES and CSF (Croatia); RIF (Cyprus); SENESCYT (Ecuador); ERC PRG, RVTT3 and MoER TK202 (Estonia); Academy of Finland, MEC, and HIP (Finland); CEA and CNRS/IN2P3 (France); SRNSF (Georgia); BMBF, DFG, and HGF (Germany); GSRI (Greece); NKFIH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); MSIP and NRF (Republic of Korea); MES (Latvia); LMTLT (Lithuania); MOE and UM (Malaysia); BUAP, CINVESTAV, CONACYT, LNS, SEP, and UASLP-FAI (Mexico); MOS (Montenegro); MBIE (New Zealand); PAEC (Pakistan); MES and NSC (Poland); FCT (Portugal); MESTD (Serbia); MICIU/AEI and PCTI (Spain); MOSTR (Sri Lanka); Swiss Funding Agencies (Switzerland); MST (Taipei); MHESI and NSTDA (Thailand); TUBITAK and TENMAK (Turkey); NASU (Ukraine); STFC (United Kingdom); DOE and NSF (USA). Individuals have received support from the Marie-Curie program and the European Research Council and Horizon 2020 Grant, Contracts No. 675440, No. 724704, No. 752730, No. 758316, No. 765710, No. 824093, No. 101115353, No. 101002207, and COST Action CA16108 (European Union); the Leventis Foundation; the Alfred P. Sloan Foundation; the Alexander von Humboldt Foundation; the Science Committee, Project No. 22rl-037 (Armenia); the Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIABelgium); the Beijing Municipal Science & Technology Commission, No. Z191100007219010 and Fundamental Research Funds for the Central Universities (China); the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Shota Rustaveli National Science Foundation, Grant No. FR-22-985 (Georgia); the Deutsche Forschungsgemeinschaft (DFG), among others, under Germany's Excellence Strategy-EXC 2121 "Quantum Universe"-390833306, and under Project No. 400140256-GRK2497; the Hellenic Foundation for Research and Innovation (HFRI), Project No. 2288 (Greece); the Hungarian Academy of Sciences, the New National Excellence Program-UNKP, the NKFIH research Grants No. K 131991, No. K 133046, No. K 138136, No. K 143460, No. K 143477, No. K 146913, No. K 146914, No. K 147048, No. 2020-2.2.1-ED-2021-00181, No. TKP2021-NKTA-64, and No. 2021-4.1.2-NEMZ_KI2024-00036 (Hungary); the Council of Science and Industrial Research, India; ICSC-National Research Center for High Performance Computing, Big Data and Quantum Computing and FAIR-Future Artificial Intelligence Research, funded by the NextGenerationEU program (Italy); the Latvian Council of Science; the Ministry of Education and Science, Project No. 2022/WK/14, and the National Science Center, Contracts No. Opus 2021/41/B/ST2/01369 and No. 2021/43/B/ST2/01552 (Poland); the Fundacao para a Ciencia e a Tecnologia, Grant No. CEECIND/01334/2018 (Portugal); the National Priorities Research Program by Qatar National Research Fund; MICIU/AEI/10.13039/501100011033, ERDF/EU, "European Union NextGenerationEU/PRTR," and Programa Severo Ochoa del Principado de Asturias (Spain); the Chulalongkorn Academic into Its 2nd Century Project Advancement Project, and the National Science, Research and Innovation Fund via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation, Grant No. B39G670016 (Thailand); the Kavli Foundation; the Nvidia Corporation; the SuperMicro Corporation; the Welch Foundation, Contract No. C-1845; and the Weston Havens Foundation (USA).Science Citation Index Expande
Algılanan Ebeveyn Kabul-Reddi ile Reddedilme Duyarlılığı Arasındaki İlişkide Kardeş İlişkilerinin Aracı Rolü
No full textBu çalışma algılanan ebeveyn kabul-reddi ile reddedilme duyarlılığı arasındaki ilişkide kardeş ilişkilerinin aracılık rolünü incelemeyi amaçlamaktadır. İlişkisel tarama modelinde gerçekleştirilen araştırmanın evrenini İstanbul'da yaşayan 18-44 yaş arası bireyler oluşturmaktadır. Araştırmanın örneklemi ise kolayda örnekleme yöntemi ile belirlenen 403 kişiden oluşmaktadır. Verilerin anket yöntemi ile elde edildiği çalışmada veri toplama aracı olarak Sosyodemografik Form, Yetişkin Ebeveyn Kabul-Red Ölçeği Kısa Form, Reddedilme Duyarlılığı Ölçeği ve Yaşam Boyu Kardeş İlişkileri Ölçeği kullanılmıştır. Anketler, gönüllülük esasına göre internet üzerinden Google Forms aracılığıyla katılımcılara ulaştırılmıştır. Katılımcılardan elde edilen veriler 'SPSS 30.0' istatistik paket programı kullanılarak analiz edilmiştir. Verilerin normal dağılımının tespit edilmesinden sonra katılımcıların ebeveyn kabul reddi, reddedilme duyarlılığı ve kardeş ilişkileri düzeylerinin demografik değişkenlere göre farklılaşıp farklılaşmadığını belirlemek için bağımsız gruplar t testi ve tek yönlü varyans analizi kullanılmıştır. Değişkenler arasındaki ilişki analizinde Pearson Korelasyon analizi ve aracılık modelini test etmek amacıyla Process Macro programı kullanılmıştır. Analizler sonucunda, ebeveyn kabul reddi ile reddedilme duyarlılığı arasında pozitif yönde anlamlı bir ilişki olduğu bulunmuştur. Ebeveyn kabul reddi ile yaşam boyu kardeş ilişkileri arasında negatif yönde anlamlı bir ilişki bulunmuştur. Reddedilme duyarlılığı ile kardeş ilişkileri arasında negatif yönde anlamlı bir ilişki bulunmuştur. Ayrıca ebeveyn kabul/reddi ile reddedilme duyarlılığı arasındaki ilişkide kardeş ilişkilerinin tam aracılık rolünün olduğu bulunmuştur. Araştırmadan elde edilen sonuçlar mevcut literatür çerçevesinde değerlendirilmiş ve tartışılmıştır.This study aims to examine the mediating role of sibling relationships between perceived parental acceptance-rejection and rejection sensitivity. The participants of the research conducted in the relational screening model consists of individuals between the ages of 18-44 living in Istanbul. The sample of the research consists of 403 people determined by the convenience sampling method. In the study where the data were obtained by the survey method, Sociodemographic Form, Adult Parental Acceptance-Rejection Scale Short Form, Rejection Sensitivity Questionaire and Lifespan Sibling Relationship Scale were used as data collection tools. The surveys were delivered to the participants via Google Forms on a voluntary basis. The data obtained from the participants were analyzed using the 'SPSS 30.0' statistical package program. After determining the normal distribution of the data, independent groups t test and one-way analysis of variance were used to determine whether the participants' levels of parental acceptance rejection, rejection sensitivity and sibling relationships differed according to demographic variables. In the analysis of the relationship between the variables, Pearson Correlation analysis and Process Macro program were used to test the mediation model. As a result of the analyses, a positive significant relationship was found between parental acceptance rejection and rejection sensitivity. A negative significant relationship was found between parental acceptance rejection and lifelong sibling relationships. A negative significant relationship was found between rejection sensitivity and sibling relationships. In addition, it was found that sibling relationships had a full mediating role in the relationship between parental acceptance/rejection and rejection sensitivity. The results obtained from the research were evaluated and discussed within the framework of the existing literature
Simultaneous Investigation of sST2, IL-33, and Caspase-3 Serum Levels in Non-Small Cell Lung Cancer
No full textBackground/Aim: Non-small cell lung cancer (NSCLC) is a type of lung cancer with a high mortality rate. Many molecular and biochemical mechanisms are involved in its development, among which the suppression of tumorigenicity-2 protein (ST2) signaling pathway. Soluble ST2 (sST2) competes with transmembrane ST2 (ST2 ligand) for IL-33 binding. Activation of IL-33/ST2 pathway leads to M2 macrophage polarization, which promotes tumor progression. Since Caspase-3 is implicated in the regulation of IL-33 activity, the present study aimed to analyze the serum levels of IL-33, sST2, and caspase-3 in non-small cell lung cancer patients, compare them with control samples, and simultaneously investigate their predictive capacity. Materials and Methods: In this study, sST2 protein, IL-33, and caspase-3 levels were investigated using the ELISA method in serum samples collected from 25 patients diagnosed with non-small cell lung cancer and 25 completely healthy volunteer individuals. In the study, receiver operating characteristic (ROC) analysis was performed to evaluate the diagnostic power of the biomarkers. Results: Serum IL-33 levels were found to be significantly elevated in patients compared to the control group (p0.05). Conclusion: NSCLC patients are characterized by increased IL-33 and caspase-3 serum levels. These findings suggest that these markers could serve as valuable diagnostic and prognostic indicators, in addition to being potential therapeutic targets.Science Citation Index Expande
Solutions of the Fractional-Order HIV Infection System of T-Cells by Exploiting a Radial Basis Neural Network Procedure
No full textMotivation: The present research is investigating the numerical performances of the fractional-order nonlinear model of the human immunodeficiency virus (HIV) infection system of T-cells or CD4+ T-cells by implementing a computational stochastic scheme. The mathematical fractional-order HIV model is presented in concentration of susceptible cells, septic T-cells-based HIV, and free HIV virus elements in the blood. Method: The structure of the solver is designed by the Levenberg-Marquardt backpropagation neural network (LMBNN), activation radial basis (RB) function in the single hidden layer with fifteen number of neurons. A reference data are obtained through the improved Euler method, which is tested through the proposed solver by taking the statistics 80% for training, 10% for testing, and 10% for authentication. Results: The approximate outcomes obtained through the designed solver are compared with the reference outcomes, which perform the correctness of the scheme. Moreover, the negligible absolute error measures together with different tests including state transition, error histogram, and correlation validate the correctness of the proposed procedure. Novelty: The designed neural network process using the LMBNN together with the RB activation function has never been implemented before to present the results of the fractional-order HIV model.Science Citation Index Expande
Cerrahi Onkoloji Temelli Check-Up Programı Ve Asemptomatik Patolojilerin Belirlenmesi
No full textGiriş: Çalışmamızın amacı check-up amacıyla başvuran sağlıklı bireylerin bulgularını paylaşmak, check-up programlarının benign ve malign patolojilerin erken tanısındaki etkinliğini saptamaktır. Yöntemler: Check-up programı dahilinde; tüm olgulara postero-anterior akciğer grafisi, tiroid ve batın ultrasonografisi yapılmıştır. Tüm kadın olgulara meme ultrasonografisi ve 40 yaşından büyüklere mamografi uygulanmıştır. Hemogram ve rutin biyokimyasal testlerle birlikte gaytada gizli kan, karsinoembriyonik antijen ve erkeklerde prostat spesifik antijen testi yapıldı. Radyolojik görüntüler ve raporlar retrospektif olarak tarandı, laboratuvar sonuçlarından ise gaytada gizli kan, karsinoembriyonik antijen ve erkeklerde prostat spesifik antijen testi değerleri incelendi. Meme radyolojisinde meme görüntüleme raporlama ve veri sistemi (BIRADS), tiroid radyolojisinde tiroid görüntüleme raporlama ve veri sistemi (TIRADS) sistemi kullanılarak sınıflandırma yapıldı. Batın ultrasonografi bulguları organ spesifik olarak ayrı ayrı değerlendirildi. Bulgular: Çalışmaya 1411 olgu dahil edildi. Olguların %49,4’ü kadın, %50,6’sı ise erkek, median yaş 50 idi. Olguların %5,31’inde karaciğerde benign lezyon, %4,7’sinde böbrek taşı, %5,7’sinde kolelitiyazis, kadın olguların %2,72’sinde benign jinekolojik kitle tespit edildi. Erkeklerin %20’sinde benign prostat hiperplazisi görüldü. %3,8’inde tiroid bezinde malignite şüpheli nodül görüldü ve biyopsi önerildi. Meme Ultrasonu yapılan olguların %0,28’inde, mamografi yapılanların ise %0,8’inde malignite şüpheli lezyon saptandı ve biyopsi önerildi. Olguların hepsine akciğer grafisi çekildi. %75,4’ünde normal, %22’sinde minör, %2,6’sında ise majör akciğer parankim bulguları saptandı ve bu olgulara toraks bilgisayarlı tomografisi ile ileri tetkik önerildi. Sonuç: Çalışmadaki sonuçlarımıza göre; etkin check-up programları benign lezyonlarda tanı ve takibi sağladığından, malign veya premalign lezyonlarda ise erken tanı ve tedavi şansı sunduğundan toplum sağlığı açısından yararlı bulunmuştur
Search for Jet Quenching with Dijets from High-Multiplicity Ppb Collisions at = 8.16 TeV
No full textThe first measurement of the dijet transverse momentum balance xj in proton-lead (pPb) collisions at a nucleon-nucleon center-of-mass energy of = 8.16 TeV is presented. The xj observable, defined as the ratio of the subleading over leading jet transverse momentum in a dijet pair, is used to search for jet quenching effects. The data, corresponding to an integrated luminosity of 174.6 nb−1, were collected with the CMS detector in 2016. The xj distributions and their average values are studied as functions of the charged-particle multiplicity of the events and for various dijet rapidity selections. The latter enables probing hard scattering of partons carrying distinct nucleon momentum fractions x in the proton- and lead-going directions. The former, aided by the high-multiplicity triggers, allows probing for potential jet quenching effects in high-multiplicity events (with up to 400 charged particles), for which collective phenomena consistent with quark-gluon plasma (QGP) droplet formation were previously observed. The ratios of xj distributions for high- to low-multiplicity events are used to quantify the possible medium effects. These ratios are consistent with simulations of the hard-scattering process that do not include QGP production. These measurements set an upper limit on medium-induced energy loss of the subleading jet of 1.26% of its transverse momentum at the 90% confidence level in high multiplicity pPb events. © The Author(s) 2025.Science Citation Index Expande