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Evaluating the Diagnostic Potential of CC-125 and miRNA Levels in Endometriosis: A Narrative Review
No full textEndometriosis, a common and complex gynecologic disorder, continues to pose a challenge to clinicians in diagnosis process due to its complexity. The aim of this review was to examine cancer antigen-125 (CA-125) and microRNAs (miRNAs) as biomarkers in endometriosis pathophysiology and their investigational potential roles in clinical diagnostics and prognostics. In this narrative review, a variety of studies are reviewed, including cross-sectional, case-control, and prospective designs, examining a broad spectrum of patient demographics, clinical features, and biomarker (CA-125 and miRNA) expression levels. While frequently elevated in endometriosis, CA-125 is limited by low specificity and sensitivity, preventing its use as a standalone diagnostic tool; its primary utility remains in monitoring established disease and, adjunctively, with other clinical parameters. miRNAs have gained attention as molecular regulators implicated in the disease process, suggesting potential avenues for noninvasive diagnostics and a better understanding of pathogenesis. The combined analysis of biomarker panels, rather than single markers, may present a shift towards more personalized strategies. The convergence of CA-125 and miRNA research represents a promising advance, potentially leading to more accurate diagnostics and personalized treatment. Future research should focus on standardizing methodologies, expanding study cohorts, and integrating findings into clinical practice to fully harness the potential of these biomarkers.imageScience Citation Index Expande
Search for Heavy Neutral Higgs Bosons A and H in the T(t)over-BarZ Channel in Proton-Proton Collisions at 13 TeV
No full textVannerom, David/0000-0002-2747-5095; Viinikainen, Jussi/0000-0003-2530-4265; Kyberd, Paul/0000-0002-7353-7090; Moureaux, Louis/0000-0002-2310-9266; Pesaresi, Mark/0000-0002-9759-1083; Grandi, Claudio/0000-0001-5998-3070; Karneyeu, Anton/0000-0001-9983-1004; Chatterjee, Suman/0000-0003-2660-0349; Lampen, Tapio/0000-0002-8398-4249; Mitra, Soureek/0000-0002-3060-2278; Yazgan, Efe/0000-0001-5732-7950; Zhang, Yousen/0000-0002-6812-761X; Garcia, Francisco/0000-0002-4023-7964; Kirschenmann, Henning/0000-0001-7369-2536; Hall, Geoffrey/0000-0002-6299-8385; Linden, Tomas/0009-0002-4847-8882; D'Anzi, Brunella/0000-0002-9361-3142; Wilson, Graham/0000-0003-0917-4763; Smith, Nicholas/0000-0002-0324-3054; Martikainen, Laura/0000-0003-1609-3515; Giacomelli, Paolo/0000-0002-6368-7220; Csanad, Mate/0000-0002-3154-6925; Tapper, Alexander/0000-0003-4543-864X; Luukka, Panja/0000-0003-2340-4641; Pasztor, Gabriella/0000-0003-0707-9762; Barroso Ferreira, Mapse/0000-0003-3904-0571; Rantanen, Milla-Maarit/0000-0002-6764-0016;A direct search for new heavy neutral Higgs bosons A and H in the t (t) over barZ channel is presented, targeting the process pp -> A -> ZH with H -> t (t) over bar. For the first time, the channel with decays of the Z boson to muons or electrons in association with all-hadronic decays of the t (t) over bar system is targeted. The analysis uses proton-proton collision data collected at the CERN LHC with the CMS experiment at root s = 13 TeV, which correspond to an integrated luminosity of 138 fb(-1). No signal is observed. Upper limits on the product of the cross section and branching fractions are derived for narrow resonances A and H with masses up to 2100 and 2000GeV, respectively, assuming A boson production through gluon fusion. The results are also interpreted within two-Higgs-doublet models, where A and H are CP-odd and CP-even states, respectively, complementing and substantially extending the reach of previous searches.Marie-Curie programme; European Research Council; Horizon 2020 Grant [675440, 724704, 752730, 758316, 765710, 824093, 101115353, 101002207]; COST Action [CA16108]; Leventis Foundation; Alfred P. Sloan Foundation; Alexander von Humboldt Foundation; Science Committee [22rl-037]; Belgian Federal Science Policy Office; Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium); FWO (Belgium) under the "Excellence of Science - EOS [30820817]; Beijing Municipal Science & Technology Commission [Z191100007219010]; Fundamental Research Funds for the Central Universities (China); Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; Shota Rustaveli National Science Foundation [FR-22-985]; Deutsche Forschungsgemeinschaft (DFG) [EXC 2121, 390833306, 400140256 - GRK2497]; Hellenic Foundation for Research and Innovation (HFRI) [2288]; Hungarian Academy of Sciences [K 131991, K 133046, K 138136, K 143460, K 143477, K 146913, K 146914, K 147048, 2020-2.2.1-ED-2021-00181, TKP2021-NKTA-64, 2021-4.1.2-NEMZ_KI]; Council of Science and Industrial Research, India - NextGenerationEU program (Italy); Latvian Council of Science; Ministry of Education and Science [2022/WK/14]; National Science Center [Opus 2021/41/B/ST2/01369, 2021/43/B/ST2/01552]; Fundacao para a Ciencia e a Tecnologia [CEECIND/01334/2018]; National Priorities Research Program by Qatar National Research Fund; ERDF "a way of making Europe [MDM-2017-0765]; Programa Severo Ochoa del Principado de Asturias (Spain); National Science, Research and Innovation Fund via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation [B39G670016]; Kavli Foundation; Nvidia Corporation; SuperMicro Corporation; Welch Foundation [C-1845]; Weston Havens Foundation (USA)Individuals have received support from the Marie-Curie programme and The European Research Council and Horizon 2020 Grant, contract Nos. 675440, 724704, 752730, 758316, 765710, 824093, 101115353, 101002207, and COST Action CA16108 (European Union); the Leventis Foundation; The Alfred P. Sloan Foundation; the Alexander von Humboldt Foundation; the Science Committee, project no. 22rl-037 (Armenia); the Belgian Federal Science Policy Office; the Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture (FRIA-Belgium); the F.R.S.-FNRS and FWO (Belgium) under the "Excellence of Science - EOS'' - be.h project n. 30820817; the Beijing Municipal Science & Technology Commission, No. Z191100007219010 and Fundamental Research Funds for the Central Universities (China); The Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Shota Rustaveli National Science Foundation, grant FR-22-985 (Georgia); the Deutsche Forschungsgemeinschaft (DFG), among others, under Germany's Excellence Strategy - EXC 2121 "Quantum Universe'' - 390833306, and under project number 400140256 - GRK2497; the Hellenic Foundation for Research and Innovation (HFRI), Project Number 2288 (Greece); the Hungarian Academy of Sciences, the New National Excellence Program - UNKP, the NKFIH research grants K 131991, K 133046, K 138136, K 143460, K 143477, K 146913, K 146914, K 147048, 2020-2.2.1-ED-2021-00181, TKP2021-NKTA-64, and 2021-4.1.2-NEMZ_KI (Hungary); the Council of Science and Industrial Research, India; ICSC - National Research Centre for High Performance Computing, Big Data and Quantum Computing and FAIR - Future Artificial Intelligence Research, funded by the NextGenerationEU program (Italy); the Latvian Council of Science; the Ministry of Education and Science, project no. 2022/WK/14, and the National Science Center, contracts Opus 2021/41/B/ST2/01369 and 2021/43/B/ST2/01552 (Poland); the Fundacao para a Ciencia e a Tecnologia, grant CEECIND/01334/2018 (Portugal); the National Priorities Research Program by Qatar National Research Fund; MCIN/AEI/10.13039/501100011033, ERDF "a way of making Europe'', and the Programa Estatal de Fomento de la Investigacion Cientifica y Tecnica de Excelencia Maria de Maeztu, grant MDM-2017-0765 and Programa Severo Ochoa del Principado de Asturias (Spain); the Chulalongkorn Academic into Its 2nd Century Project Advancement Project, and the National Science, Research and Innovation Fund via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation, grant B39G670016 (Thailand); the Kavli Foundation; the Nvidia Corporation; the SuperMicro Corporation; the Welch Foundation, contract C-1845; and the Weston Havens Foundation (USA).Science Citation Index Expande
rs17576 Polymorphism of Matrix Metalloproteinase-9 in Predicting Coronary Artery Disease Severity and Its Adverse Outcome
No full textBACKGROUND: The role of matrix metalloproteinases in developing ischemic heart disease has been suggested. We investigated the effect of the MMP-9 gene polymorphism rs17576 on the severity of coronary artery disease and outcomes in affected individuals. METHODS: A total of 654 patients suspected of having coronary artery disease were assessed. Real-time PCR was performed for MMP-9 (rs17576) genotyping, and ELISA was used to assess MMP-9 plasma levels. The patients were followed up for one year. RESULTS: Coronary angiography showed coronary artery involvement in 28% of patients. The frequencies of AA, AG, and GG genotypes of rs17576 in the group without coronary artery involvement were 5.5%, 31.4%, and 63.1%, respectively, while in those with coronary artery disease, the frequencies were 55.2%, 29.5%, and 15.3%, respectively, showing a significant difference (p < 0.001). The frequency of the major allele (G allele) in the normal group and the groups with single-, two-, and three-coronary involvement was 21.1%, 65.4%, 61.8%, and 85.0%, respectively, indicating a significant difference (p < 0.001). The mean serum level of MMP-9 was 2,963 ± 1,077 pg/ml in the group with coronary artery disease and 2,145 ± 926 pg/ml in the group without coronary involvement, with a significant difference between the two groups (p = 0.008). The presence of the A allele of rs17576 was associated with an increased hazard of one-year mortality in the coronary artery disease group (HR = 5.764, p < 0.001). CONCLUSION: Tracking the rs17576 polymorphism of the MMP-9 gene can predict coronary artery disease severity and its long-term poorer outcome. © 2025 Elsevier B.V., All rights reserved.Emerging Sources Citation Inde
Kanun Sazında Sürütme ve Arpej Tekniklerinin İncelenmesi ile Bu Tekniklere Yönelik Geliştirici Etüt ve Eser Örnekleri
No full textTürk müziğinde önemli bir yere sahip olan kanun sazının günümüzdeki icralarında farklı farklı teknikler kullanıldığı bilinmektedir. Bu tekniklerin gerek bestecilere gerekse icracılara bir tür zenginlik sağladığı açıktır. Yazılı, görsel ve görsel-işitsel verilerden faydalanılmış olan bu çalışmada literatür tarama yöntemi kullanılmış olup kanun sazında sürütme ve arpej tekniklerinin örnek etüt ve eserlerden de yararlanılarak incelenmesi amaçlanmıştır. İlgili literatür ve çalışmalar incelendiğinde bu tekniklerin yeterince ele alınmadığı tespit edilmiş olup bu konunun daha derin ve etkili bir şekilde ortaya koyulması amacı ile gerek diğer bestecilere gerekse tarafımıza ait olan müzikal örnekler aracılığla söz konusu tekniklerin nasıl uygulanabileceği üzerinde durulmuştur. Bu çalışmada öncelikle kanun sazının tarihsel ve yapısal özellikleri genel olarak ele alınmış yaygın olarak kullanılan diğer tekniklere de kısaca değinilmiştir. Ardından, bağımsız bölüm başlıkları altında sürütme ve arpej tekniklerine odaklanılmıştır. Bu tekniklerin daha anlaşılır bir şekilde sunulabilmesi amacıyla, örnek eser ve etütler üzerinden açıklamalar yapılmıştır. Sürütme tekniği için 4 eser 3 etüt olmak üzere toplam 7; arpej tekniği için ise 3 eser 4 etüt olmak üzere toplam 7 müzikal örnek kullanılmıştır. Üzerinde, sürütme ve arpej tekniklerine dair gerekli görülen yerlerde eklemeler/vurgular yapılmış, özel semboller kullanılmış ve parmak numaraları belirtilmiş olan bu müzikal örneklerin çalışmanın bulguları niteliğinde olduğu düşünülebilir. Sonuç olarak toplam 14 müzikal örnek ile gerçekleştirilen bu çalışma, gerek icracılara gerekse bestecilere yeni bir bakış açısı kazandırmayı da hedeflemektedir. Çalışmanın, kanun sazının icrası ve teknik çeşitliliğine de önemli bir katkı sağlayacağı düşünülebilir. Anahtar kelimeler: Türk Müziği, Kanun, Arpej Tekniği, Sürütme TekniğiIt is known that different techniques are used in today's performances of the kanun instrument, which has an important place in Turkish music. It is clear that these techniques provide a kind of richness to both composers and performers. In this study, which uses written,visual and audiovisual data, the literature review method has been used and it has been aimed to examine the sürütme (skidding) and arpeggio techniques in the kanun instrument by using sample etudes and works. When the relevant literature and studies were examined , it was determined that these techniques were not handled sufficiently , and in order to reveal this subject in a deeper and more effective way, it was emphasized how the mentioned techniques can be applied through musical examples belonging to both other composers and us. In this study, first of all, the historical and structural features of the kanun instrument were generally discussed and other commonly used techniques were briefly mentioned. Then the focus was on sürütme and arpeggio techniques under independent section headings. In order to present these techniques in a more understandable way, explanations were made through sample works and etudes. A total of seven(7) musical examples were used, four (4) pieces and three (3) etudes for the sürütme technique; and a total of seven (7) musical examples were used, three (3) pieces and four (4) etudes for the arpeggio technique. These musical examples , on which additions/emphasis were made where necessary regarding sürütme and arpeggio techniques , special symbols were used and finger numbers were specified , can be considered as the findings of the study. In conclusion, this study, which was carried out with a total of 14 musical examples, also aims to provide a new perspective to both performers and composers. It can also be considered that the study will also make a significant contribution to the performance and technical diversity of the kanun instrument. Keywords: Turkish Music , Kanun, Arpeggio Technique, Sürütme Techniqu
Advancing Ovarian Cancer Care: Recent Innovations and Challenges in the Use of MXenes and Their Composites for Diagnostic and Therapeutic Applications
No full textOvarian cancer remains the deadliest form of gynecologic malignancy, largely owing to the absence of reliable early diagnostic tools and the limited effectiveness of current therapeutic strategies. Recent advances in nanotechnology-particularly the emergence of two-dimensional materials known as MXenes-offer promising avenues to address these challenges. This review highlights the emerging role of MXenes and their composites in the management of ovarian cancer, focusing on their potential in biomarker detection and targeted treatment strategies. We provide a comprehensive analysis of the latest studies examining the physicochemical features of MXenes, their synthesis and surface functionalization approaches, and their application in ovarian cancer, including biosensing, drug delivery, and combinatorial therapeutic systems. MXene-based biosensors have shown remarkable detection limits in detecting ovarian cancer biomarkers, such as cancer antigen 125 (CA125), human epididymis protein 4 (HE4), lipolysis-stimulated lipoprotein receptor (LSR), and carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5). However, several challenges remain, including issues of biocompatibility, structural stability, and clinical scalability. Continued interdisciplinary research is essential to address these limitations, optimize MXene functionalization, and translate their laboratory success into clinical settings. With appropriate advancements, MXenes hold significant promise for enabling more precise, efficient, and patient-specific approaches to ovarian cancer diagnosis and therapy.Emerging Sources Citation Inde
The Effect of Atlantoaxial Stabilization on Juvenile Idiopathic Scoliosis Involving Chiari Malformation and Syrinx
No full textIdiopathic scoliosis (IS) is frequently asSociated with Chiari malformation (CM) and syringomyelia, conditions thought to share a common underlying cause: Atlantoaxial instability. Atlantoaxial stabilization has recently emerged as a novel treatment option. A 4-year-old girl presented with progressive scoliosis (Cobb angle of 28.6 degrees), neck pain, CM, and syringomyelia. The patient was diagnosed with central or axial atlantoaxial instability and underwent C1-C2 fixation. Postoperatively, she experienced significant relief from neck pain. Follow-ups demonstrated progressive syrinx reduction, while X-rays revealed a Cobb angle decrease to 21 degrees in 18 months. This case highlights the potential of atlantoaxial stabilization to halt scoliosis progression in IS patients with CM and syringomyelia. Unlike traditional multisegmental stabilization, C1-C2 fixation offers a minimally invasive approach and preserves spinal mobility in growth-age patients. Atlantoaxial instability should be considered in IS cases with CM and syringomyelia. Atlantoaxial stabilization alone may provide effective treatment with favorable clinical and radiological outcomes.Emerging Sources Citation Inde
An Investigation into the Effects of Various Phase Change Materials on Industrial Electronic Systems' Cooling Rates Through Experimentation Based on a Specific Dimensionless Number
No full textThe development of electronic equipment depends on the performance of their processors, which themselves require operating at low temperatures. So, solutions that can keep their temperatures low are significant for the advancement of this valuable industry. This study attempts to find an effective solution to this problem in a practical case, which is the ASUS GT 730 silent graphics card. The working condition of this processor's heatsink is simulated by a heat source with 1.7-and 2.1-W heat flow rates. To cool down the system, a new experimental setup is proposed, in which the heatsink is placed inside an aluminum box where water flows through a copper pipe. In addition, two phase change materials (PCM), including Lauric Acid and Paraffin wax, with different volume percentages, are separately injected into the box to examine the influence of the properties of these materials on energy storage. Hence, 18 modes are obtained based on heat flux, PCM type, and their volume percentages. To compare the effectiveness, a dimensionless number is introduced as a special measure based on the time duration recorded for each mode, named dimensionless melting time efficiency (DMTE). This number, which adapts to the physics of the process, is defined as the ratio of the total heat input to the total heat capacity of PCM (sensible and latent). This new setup, together with the definition of the dimensionless number, provides an appropriate tool for achieving the best arrangement selection for higher thermal energy absorption. The results show that the presence of phase change materials, regardless of their type, will increase the efficiency of the system. Furthermore, using the maximum volume percentage of the phase change material will maximize the cooling efficiency of the system, where DMTE can be reduced by around 64 % for both PCMS and both input heat flow rates from 25 % volume percentage to full. Also, it is concluded that the choice of Lauric acid as phase material change for this case can enhance the performance of the system, where DMTE of Lauric acid decreases by 6.25 % for an input heat flow rate of 1.7 W and 9.68 % for 2.1 W than paraffin wax when the volume percentage of PCMs is maximum.Science Citation Index Expande
Leniniana ve Yugonostalji: Post-Sosyalist Kimlik ve Kültürel Bellek Üzerine Görsel Bir İnceleme
No full textBu çalışma, Leniniana ve Yugonostalji üzerinden post-sosyalist kimlik inşası ile kültürel bellek arasındaki ilişkiyi disiplinler arası görsel analiz yöntemi temelinde incelemeyi amaçlamaktadır. Post-Sovyet ve post-Yugoslav dönemlerde Lenin ve Tito figürleri, görsel temsiller aracılığıyla yeniden şekillendirilmiş ve kolektif bellekte farklı anlamlar kazanmıştır. Çalışma, kolektif bellek ve hafıza mekânları kuramları ışığında teorik bir zemine oturmaktadır. Leniniana, Sovyet ideolojisinin en önemli görsel temsil geleneklerinden biri olarak Sovyet halkının kültürel belleğinde kalıcı bir yer edinmiştir. Ancak Sovyetler Birliği’nin dağılmasıyla Lenin’in kamusal alandaki temsili farklılaşmış ve yeni anlamlar kazanmıştır. Benzer şekilde, Yugonostalji, Tito liderliğinde inşa edilen kolektif belleğin, Yugoslavya’nın çöküşü sonrasında nostaljik bir unsur olarak yeniden şekillenişini temsil etmektedir. Çalışma, posterleri, duvar resimleri, çağdaş sanat işleri ve dijital imgeler gibi çeşitli görsel materyaller üzerinden yapılan nitel bir örnek olay analizine dayanmaktadır. Seçilen imgeler, post-sosyalist nostaljinin temsili, ideolojik boşluğun sembolik telafisi ve toplumsal kimlik arayışlarının kültürel izleri açısından değerlendirilmiştir. Görsel imgelerin nostalji, ideoloji ve kültürel bellekle etkileşimi ele alınarak, bu figürlerin post-sosyalist dönemdeki yeni anlatılara nasıl eklemlendiği incelenmektedir. Özellikle propaganda ve popüler kültür aracılığıyla bu imgelerin nasıl dönüşüm geçirdiği de tartışılmıştır. Çalışmanın temel bulguları, Lenin ve Tito görsellerinin, geçmiş rejimlerin ideolojik mirasının kolektif bellekten tamamen silinmediğini; aksine güncel kimlik müzakerelerinde yeniden üretildiğini göstermektedir. Sonuç olarak, Leniniana ve Yugonostalji’nin görselleri, post-sosyalist kimliklerin temsili ve kültürel hafızanın evrimini anlamada kritik bir rol oynamakta; post-sosyalist toplumların geçmişle kurdukları ilişkiye dair önemli ipuçları sunmaktadır
A Comprehensive Review of Data Analytics and Storage Methods in Geothermal Energy Operations
No full textGeothermal energy storage (GES) systems are thoroughly examined in this research, with a focus on methods like borehole thermal energy storage (BTES), underground thermal energy storage (UTES), and aquifer thermal energy storage (ATES). It highlights the importance of thermal energy storage (TES) systems in addressing global energy challenges. The feasibility of UTES for large-scale energy storage and its integration with geothermal power plants is investigated. The ATES, with the advantage of large storage capacity and low operating costs has could be employed in regions with suitable aquifers. The adaptability of BTES to different ground conditions and its small land footprint made it a spotlight for the researchers. The study emphasizes the role of TES technologies in meeting the growing demand for renewable energy, reducing the impact of climate change, and providing efficient energy solutions for heating, ventilating, and air conditioning. HVAC systems. Also, the application of geothermal power plants and TES systems in decreasing the dependence on nonrenewable energy sources and increasing energy efficiency increase investigated. The development of reliable and affordable sensors, together with improvements in processing power, has made data-intensive algorithms and real-time operational decision-making applications in the field of geothermal energy. The study also delves into the potential of machine learning to optimize geothermal design, monitor performance, improve performance, find errors, and more. It was shown that artificial neural networks were the most common kind of trained model, while several other models were often used as benchmarks for performance. Picture selection, systematic time series feature engineering and model evaluation were all areas that showed a lot of promise in the systematic review for future research and practical applications.Emerging Sources Citation Inde
A Case Series of Diamine Oxidase Deficiency Misdiagnosed as Anxiety or Panic Attacks in Patients with Tachycardia
No full textBackground:Diamine oxidase (DAO) deficiency, a key marker of histamine intolerance (HIT), often mimics anxiety or panic disorders, leading to a misdiagnoses and delayed treatment.Cases:We present five female patients (aged 25-54) with chronic, non-specific symptoms, including palpitations, nasal congestion, and gastrointestinal disturbances, initially attributed to the anxiety. Serum DAO levels below 10 IU/mL confirmed HIT in all cases. Treatment with a low-histamine diet and DAO supplementation significantly improved symptoms, highlighting the importance of considering HIT in such cases. One patient experienced recurrence after discontinuing treatment, emphasizing the need for long-term management. Genetic testing in one case revealed variants linked to reduced DAO activity, suggesting a potential genetic predisposition.Conclusion:These findings underscore the importance of DAO level assessment in patients with unexplained symptoms and the role of multidisciplinary care in accurate diagnosis and management. Further studies are needed to refine diagnostic criteria and explore long-term strategies for HIT.Science Citation Index Expanded - Social Science Citation Inde