Okan University GCRIS Standard Database
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MXenes for CRISPR-Based Diagnostics: Innovations and Advancements
No full textThe incorporation of MXenes into CRISPR-based diagnostics marks a transformative advancement in molecular testing across environmental monitoring, biomedical diagnostics, and food safety. MXenes, a class of twodimensional materials characterized by their exceptional electrical conductivity, hydrophilicity, and customizable surface properties, significantly enhance the sensitivity and specificity of CRISPR assays. Recent developments demonstrate that MXene composites improve the stability and performance of CRISPR systems, facilitating rapid and accurate detection of pathogens and genetic markers. These capabilities support applications such as analyzing environmental DNA (eDNA), point-of-care testing for infectious diseases, and identifying contaminants in food products. Despite these advancements, challenges such as sample processing, stability, the necessity for nucleic acid amplification, and regulatory barriers complicate practical implementations. This review explores the recent advancements of MXene-assisted CRISPR diagnostics, examines the challenges hindering their broader application, and discusses future perspectives for improving detection capabilities and integrating innovative technologies to enhance diagnostic efficacy.Science Citation Index Expande
Mitochondrial Dysfunction in Hepatocellular Carcinoma: From Metabolism to Targeted Therapies
No full textGlobally, liver cancer is reported to be the third leading cause of cancer-related mortality. The most common type of these cancers is hepatocellular carcinoma (HCC). Current preventive strategies, including lifestyle modifications, antiviral therapies, and surveillance, are limited in their effectiveness. Mitochondria play critical roles in regulating cellular metabolism, oxidative stress, and apoptosis. Mitochondrial dysfunction can accelerate HCC progression, particularly in patients with liver diseases such as metabolic-associated fatty liver disease (MAFLD) and metabolic dysfunction-associated steatohepatitis (MASH). In this review, we discuss the mechanisms of mitochondrial dysfunction in HCC from a molecular point of view, including oxidative stress, mitophagy dysregulation, mitochondrial dynamics dysregulation, and mitochondrial DNA (mtDNA)-mediated dysregulation of innate immune responses. Additionally, we explore molecular-targeted therapies aimed at restoring mitochondrial function. Critical approaches include targeting reactive oxygen species pathways through agents such as iridium (III) complexes and Mito Rh S, which induce cancer cell death through apoptosis and ferroptosis. Other compounds, including dehydrocrenatidine, enhance oxidative phosphorylation and promote apoptosis. Inhibitors of dynamin-related protein 1 (Drp1) target mitochondrial fission to reduce tumor growth. Furthermore, mitophagy modulators, such as SIRT1 activators, improve mitochondrial quality control, minimize the negative effects of oxidative stress, and reduce cancer development. Clinical trials are ongoing for the mitochondrial enzyme-targeting agents CPI-613 and Gamitrinib, a heat shock protein-targeting agent, which have hence shown great promise for these therapies. With further investigation, mitochondrial-targeted interventions could be promising for preventing or reducing HCC incidence and recurrence, increasing long-term survival, and improving the quality of life of patients with advanced-stage disease.Science Citation Index Expande
Search for High-Mass Resonances in a Final State Comprising a Gluon and Two Hadronically Decaying W Bosons in Proton-Proton Collisions at S = 13 TeV
No full textA search for high-mass resonances decaying into a gluon, g, and two W bosons is presented. A Kaluza-Klein gluon, gKK, decaying in cascade via a scalar radion R, gKK → gR → gWW, is considered. The final state studied consists of three large-radius jets, two of which contain the products of hadronically decaying W bosons, and the third one the hadronization products of the gluon. The analysis is performed using proton-proton collision data at s = 13 TeV collected by the CMS experiment at the CERN LHC during 2016–2018, corresponding to an integrated luminosity of 138 fb−1. The masses of the gKK and R candidates are reconstructed as trijet and dijet masses, respectively. These are used for event categorization and signal extraction. No excess of data events above the standard model background expectation is observed. Upper limits are set on the product of the gKK production cross section and its branching fraction via a radion R to gWW. This is the first analysis examining the resonant WW+jet signature and setting limits on the two resonance masses in an extended warped extra-dimensional model. © 2025 Elsevier B.V., All rights reserved.Science Citation Index Expande
Sınıf V Kompozit Restorasyonlarda Hassasiyet Giderici Olarak Kullanılan Gümüş Diyamin Florür ve Diyot Lazerin Mikrosızıntı ve Renk Değişmesi Üzerindeki Etkisi
No full textAmaç: Bu çalışmanın amacı, hassasiyet giderici amaçlı kullanılan gümüş diamin florür ve diyot lazer uygulamalarının sınıf V kavitelerin restorasyonlarında, mikrosızıntıya ve renk değişimine olan etkilerini değerlendirmektir. Gereç ve Yöntemler: Bu çalışmada yirmi adet insan molar dişi kullanıldı. Her bir dişin bukkal ve lingual yüzeylerinde standart Sınıf V kaviteler (4x3x3mm) hazırlandı. Dişler tedavi yöntemlerine göre rastgele 4 gruba (n=10) ayrıldı. Grup 1(gümüş diamin florür), Grup 2 (940 nm diyot lazer), Grup 3 (gümüş diamin florür + 940 nm diyot lazer), Grup 4’teki örneklere hiçbir tedavi protokolü uygulanmadı. Tüm kaviteler, nano-hibrid kompozit rezin ile restore edildi. Restorasyonlar diskler ile cilalandı. Örneklerin renk ölçümü spektrometre cihazı ile 1, 7, 14, ve 28. günlerde yapıldı. Renk değişimi, CIEDE 2000 formülüyle hesaplandı. Örnekler %0.2 Rhodamine B boyası ile boyandı ve bukko-lingual yönde kesildi. Boya penetrasyonu bir stereomikroskop altında skorlandı. Veriler Shapiro-Wilks ve Tukey HSD testi kullanılarak %5 anlamlılık düzeyinde istatistiksel olarak analiz edildi. Bulgular: Renk değişimi açısından değerlendirildiğinde, Grup 1 ve Grup 3 arasında istatistiksel olarak anlamlı bir fark bulundu. Grup 2’de, 1-7. gün ile 1-14. Gün, 1-7. gün ile 1-28. Gün zaman aralıklarında, renk değişimi farkı istatistiksel olarak anlamlı bulundu. En yüksek mikrosızıntı skorları, lazer kullanılan gruplarda elde edilmiştir. Sonuç: Potasyum içeren solüsyonun kullanılmasına rağmen gümüş diamine florür uygulanan gruplarda renk değişimi eşik değerin üzerinde görüldü. Ayrıca, lazer kullanılan gruplarda da kabul edilemez renk değişimleri gözlendi
Pressure Ulcers, Risk Factors and Psychosocial Effects in Surgical Operations
No full textBasınç ülserleri, cerrahi operasyon geçiren hastalarda uzun süreli immobilizasyon, ameliyat süresi ve pozisyonlandırmaya bağlı olarak gelişerek hastanın hem klinik hem de psikososyal sağlığını olumsuz yönde etkilemektedir. Bu çalışma, cerrahi operasyon geçiren hastalarda basınç ülseri gelişimine katkı sağlayan risk faktörlerini belirleyerek psikososyal etkilerini değerlendirmeyi amaçlamaktadır. Klinik çalışmalar, İstanbul Kartal Dr. Lütfi Kırdar Şehir Hastanesi cerrahi birimlerinde operasyon geçiren ve ameliyat sonrası servislerde yatan 208 hasta üzerinde gerçekleştirilmiştir. Veri toplama sürecinde; 3S Ameliyathane Basınç Yarası Risk Tanılama Ölçeği, NPUAP Basınç Yarası Evrelendirme Kriterleri ile hastaların basınç ülserine bağlı psikolojik durumlarını ve kaygılarını ölçmek amacıyla geliştirilmiş Yarı Yapılandırılmış Görüşme Formu kullanılmıştır. Analizler sonucunda, hastaların büyük çoğunluğunun (%85,6) düşük risk grubunda yer aldığı, %14'ünün ise yüksek risk grubunda olduğu belirlenmiştir. Klinik muayene bulgularına göre, %10,1'inde farklı evrelerde basınç yarası tespit edilmiş ve bu yaraların en sık %52,4 oranında Evre I düzeyinde olduğu saptanmıştır. İstatistiksel analizler, basınç ülseri riskinin cinsiyet, yaş, ameliyat kliniği, ameliyat öncesi aktivite durumu, boy/kilo oranı, tüm vücuttaki cilt durumu, cildin stres durumu, ameliyattaki kanama miktarı, ameliyat süresi, ameliyattaki stres, vücut ısısı ve ameliyat pozisyonu gibi çok sayıda değişkene bağlı olarak anlamlı farklılıklar gösterdiğini ortaya koymuştur. Çalışma, cerrahi basınç ülserlerinin sadece fiziksel risk faktörleriyle değil, aynı zamanda hastaların psikososyal durumlarıyla da yakından ilişkili olduğunu göstermektedir. Basınç ülseri gelişen hastalarda kaygı, depresyon ve sosyal izolasyon gibi psikososyal etkiler belirgin olup, bu durumların yara iyileşme süreçlerini olumsuz etkilediği tespit edilmiştir.Pressure ulcers develop in patients undergoing surgical operations due to prolonged immobilization, operation duration, and positioning, adversely affecting both the clinical and psychosocial health of the patient. This study aims to identify the risk factors contributing to the development of pressure ulcers in surgical patients and to evaluate their psychosocial effects. Clinical research was conducted on 208 patients who underwent surgery in the surgical units and were hospitalized postoperatively at İstanbul Kartal Dr. Lütfi Kırdar City Hospital. Data collection tools included the 3S Operating Room Pressure Ulcer Risk Assessment Scale, the NPUAP Pressure Ulcer Staging Criteria, and a Semi-Structured Interview Form developed to assess patients' psychological conditions and anxieties related to pressure ulcers. Analysis revealed that the majority of patients (85.6%) were classified in the low-risk group, while 14% were in the high-risk group. Clinical examination found pressure ulcers at various stages in 10.1% of patients, with Stage I ulcers being the most common at 52.4%. Statistical analyses demonstrated significant differences in pressure ulcer risk based on multiple variables, including gender, age, surgical clinic, preoperative activity status, height/weight ratio, overall skin condition, skin stress status, amount of intraoperative bleeding, operation duration, intraoperative stress, body temperature during surgery, and surgical positioning. The study highlights that surgical pressure ulcers are closely related not only to physical risk factors but also to the psychosocial status of patients. Psychosocial effects such as anxiety, depression, and social isolation were notably observed in patients who developed pressure ulcers, and these factors were found to negatively impact the wound healing process
The Influence of Clinician Experience on the Primary Stability of Tri-Oval Versus Standard Parallel-Walled Implants Placed Using Different Surgical Protocols: An Ex Vivo Study
No full textPurpose: To investigate the effect that clinical experience has on implant primary stability using insertion torque (IT) and resonance frequency analysis (RFA) from two different drilling protocols: (1) implant-specific osteotomy protocol and (2) conventional drilling. Materials and Methods: A total of 60 tri-oval and 60 parallel-walled implants were placed in fresh bovine ribs by three clinicians (B.K., M.& Ccedil;., and M.A.D), who were classified according to the total number of implants they had previously placed. Tri-oval implants were placed with an implant-specific osteotomy protocol, and parallel implants were placed with conventional drilling. The ITs of the implants were measured by the same clinician who performed the operation. An independent examiner (O.G.) measured the RFA of all implants after placement via a resonance frequency analyzer. Results: In the IT evaluation, no statistical significance was observed between the clinicians and both tri-oval implants and parallel implants (P = .293 and P = .98, respectively); in all experience levels, the ITs were significantly lower in parallel implants. Additionally, across all experience levels, tri-oval implants demonstrated greater RFA values than parallel implants (P = .001). Within-group comparisons of RFA by experience level for the tri-oval implants did not show a statistically significant difference (P = .950). However, in parallel implants, there was a significant difference between the moderately experienced and inexperienced groups (P = .019). Conclusions: The implant-specific osteotomy procedure with tri-oval implants offers greater primary stability compared to conventional osteotomy with parallel-walled implants, regardless of the clinician's experience.Science Citation Index Expande
Intuitive Eating, Maternal Attachment, and Weight Status in Postpartum Women: A Cross-Sectional Study
No full textBackground The postpartum period is characterized by significant changes in eating behaviors, emotional regulation and body weight. Intuitive eating and maternal attachment may play a key role in regulating women's weight status during early postpartum. Methods This cross-sectional study was conducted between February and May 2022 in Turkey, involving 264 healthy postpartum women (1-4 months) aged 18-40 years. Sociodemographic information, dietary habits, and anthropometric measurements were collected. Intuitive Eating Scale-2 (IES-2) and Maternal Attachment Scale (MAS) was administered. We classified BMI levels below 25 as "lower BMI"" and above 25 as "higher BMI". Results Of the participants, 45.8% reported eating intuitively. Body mass index (BMI) was significantly higher in those with low levels of intuitive eating behaviour (p = < 0.001). A positive correlation was found between maternal attachment and intuitive eating (r = 0.129, p = 0.037). Higher intuitive eating was associated with lower BMI (beta = -0.269, p = < 0.001). Skipping meals and night eating were associated with lower intuitive eating (p = 0.023). In logistic regression analysis, low intuitive eating (< 3.4 points) was associated with a high BMI during the early postpartum (OR = 2.63; 95% CI 1.57-4.40, p = < 0.001). Conclusions Intuitive eating behaviour is positively associated with maternal attachment. However, higher intuitive eating is associated with lower BMI levels, night eating, and skipping meals. The results suggest that public health counselling promoting intuitive eating may be beneficial for early postpartum women who are at risk of excessive weight gain.Science Citation Index Expande
Search for a cH Signal in the Associated Production of at Least One Charm Quark with a Higgs Boson in the Diphoton Decay Channel in pp Collisions at TeV
No full textThis paper presents the first search for a cH signal sensitive to the coupling of the charm quark (c) to the Higgs boson (H) in the associated production of at least one charm quark with a Higgs boson decaying to two photons. The results are based on a data set of proton-proton collisions at a center-of-mass energy of 13 TeV collected with the CMS experiment at the LHC, corresponding to an integrated luminosity of 138 fb−1. Assuming the standard model (SM) rates for all other Higgs boson production processes, the observed (expected) upper limit at 95% confidence level on the cH signal strength is 243 (355) times the SM prediction. Under the same assumption, the observed (expected) allowed interval on the Higgs boson to charm quark coupling modifier, κc, is |κc| c| < 72.5) at 95% confidence level. © The Author(s) 2025
Beta-Voltaic Nuclear Batteries - Review of Recent Developments, Challenges and Future Research Directions
No full textWith its high energy density, extended service life, robust anti-interference capability, compact size, low weight, and ease of integration, beta-voltaic batteries which transform decay energy from radioisotope sources into electrical energy have gained interest from researchers over the years. However, there is currently no study that provides a comprehensive overview of studies on the topic using the systematic and bibliometric review approach. This study thus provides a comprehensive bibliometric and systematic review of beta-voltaic technology from 2000 to 2024, revealing an annual growth rate of 8.76 % in research publications. Key research themes include nuclear batteries, gallium nitride, silicon carbide, and nanotechnology, with emerging themes including radiation remediation and micro nuclear batteries for medical implants. Despite their high energy density and long-term reliability, beta-voltaic batteries face technical, environmental, and social challenges, including low power output, inefficiencies, radioactive decay management, limited availability of isotopes, high production costs, and public mistrust in nuclear technology.Ministry of Science and Higher Education of the Russian Federation [N 975.42, FEUZ-2022-0031]The research funding was from the Ministry of Science and Higher Education of the Russian Federation (Ural Federal University Program of Development within the Priority-2030 Program) and (Tolerant Efficient Energy Based on Renewable Energy Sources) grant number: N 975.42. Young Scientist laboratory 347/23. Grant Number FEUZ-2022-0031.Science Citation Index Expande
Progress of Hydrogen Production From Food Waste-A Systematic, Content, and Bibliometric Review
No full textFood waste (FW) presents difficulties for waste management which is a significant worldwide issue. However, there is a growing energy crisis globally, and there is not enough fossil fuel available to support the growing demand. This can however be overcome using environmentally acceptable and sustainable energy such as biohydrogen. This study thus employed a systematic, content-based, and bibliometric review approach to analyze the literature on hydrogen production from FW resources within the last two decades. The study used the bibliometric analysis tools (i.e., Biblioshiny in R and the VOSviewer) to analyze and visualize a total of 2022 pertinent documents on the subject matter obtained from the Scopus database. According to the analyzed data, biohydrogen, a biofuel produced through biological processes, has the potential to reduce greenhouse gas emissions, but its widespread adoption requires addressing production rate, yield, and process scaling. China turned out to be the nation with the most papers on the subject, totaling 2610. The USA (829), India (501), Italy (471), South Korea (419), Brazil (374), Japan (285), Germany (257), Spain (256), Canada (187), and the UK (187) were the other top-performing nations. The study ended with future research directions that researchers can work on in the future. The findings of this study could guide future research on the conversion of food waste to hydrogen energy based on the research gaps identified in the study.Emerging Sources Citation Inde