IEU GCRIS Database (İzmir Ekonomi Üniversitesi)
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Incorporating Ethics Into Infectious Disease Clinical Practice Guidelines
No full textRodriguez-Bano, Jesus/0000-0001-6732-9001; Scudeller, Luigia/0000-0001-7240-9567Background: Incorporating ethics into clinical practice guidelines (CPGs) can be challenging. This is particularly evident for infectious diseases (ID) CPGs because of the complexity of ID ethics (IDE) and the multiplicity of populations at risk for infections. Objectives: The OPENING project (IncOrPorating Ethics iN ClINical Guidelines: Practical Indications) was initiated by the European Society of Clinical Microbiology and Infectious Diseases Ethics Advisory Committee in collaboration with the European Society of Clinical Microbiology and Infectious Diseases Guidelines Subcommittee to generate guidelines for the systematic inclusion of ethics principles into ID CPGs. Sources: The first part of the project, presented here, aimed at: (a) performing a scoping review of articles published in PubMed and Google Scholar between 1990 and 2024 discussing ethics inclusion in CPGs; (b) reviewing guidance documents for ethics incorporation in documents from international societies; (c) outlining how the main ethics principles could be included in ID CPGs according to the results retrieved. Content: We retrieved 21 articles written between 1994 and 2024. None of these specifically focused on IDE. The main topic discussed in articles and societies' guidance was the inclusion of equity principles at different stages of CPGs development. Multiple authors also addressed how specific subgroups and disadvantaged populations should be considered in the preparation of CPGs. Involvement of patients and their representatives in CPGs was also advocated. A structured framework for the systematic inclusion of IDE principles in CPGs was suggested to summarize these points
Scaling the Impact of the Energy Transition Through Inclusivity and Diversity Across Living Labs
No full textThe energy transition has not benefited all segments of society equally, raising critical questions about the design of just energy policies and projects. This inequity highlights the need for inclusive approaches, especially within living labs piloting sustainable energy solutions. A key challenge for living labs is achieving broad societal impact, which is fundamentally tied to inclusivity. Living lab research must prioritize diversifying participants and stakeholders to effectively scale solutions across diverse communities. Individual characteristics, such as gender, ethnic identity, level of education, wealth, and income, strongly influence the ability to participate in energy projects. As spaces for co-production and transformation, living labs should fully embrace diversity as a key principle, fostering deliberative exchange connecting actors from different backgrounds. The European Green Deal prioritizes a "just transition," signaling the political demand to develop transdisciplinary research projects that address issues such as energy poverty, the gender pay gap, and social segregation. To investigate this disparity, we designed and implemented four citizen action labs in Germany, Norway, Switzerland, and T ; uuml;rkiye, experimenting with different notions of inclusivity and diversity. Based on our findings, we explore the concept of inclusivity at the sociopolitical context (scaling up), stakeholder, and population locality (scaling deep and scaling out). In particular, we focus on the role of recruitment as a bottleneck for diverse public engagement. Leveraging the knowledge gained from the research process, this article provides evidence for setting up living labs in the energy transition, targeting distinctive social groups to create a meaningful impact across society.DIALOGUES Project - European Union [101022585]This work was part of the DIALOGUES project funded by the European Union's Horizon 2020 Research and Innovation Programme under [grant number 101022585]
Avelumab Maintenance in Patients With Metastatic Urothelial Carcinoma in a Real-Life Expanded-Access Program (Eap)
No full textHeritage at Play: Designing Roleplaying Games To Enhance Museum Experience
No full textThis research explores the transformative potential of role-playing games (RPGs) to enhance museum experiences by embedding cultural heritage into gameplay. Focusing on the Izmir Archaeology and Ethnography Museum, the study examines how RPGs can cultivate meaningful museum experiences. By integrating tangible artifacts with intangible narratives, the research aims to craft play experiences that resonate with diverse audiences, fostering a deeper understanding of cultural heritage and museums. The study employs a research through design methodology, emphasizing an iterative design process and playtesting to explore the design of a computer role-playing game (CRPG) encompassing the museum experience. Design challenges include ensuring meaningful gameplay experiences informed by instructional museum content, designing complex gameplay elements for audiences with varying game familiarity, and elevating informal learning in a cultural heritage context. By investigating game design and game-based learning methodologies, the research leverages design practices to explore a multidisciplinary design space. The research leverages design practices to explore a multidisciplinary design space, treating RPG design for museums as a design situation to generate applicable knowledge through design activity. The findings reveal both theoretical and practical implications for the use of RPGs in museum settings. The study demonstrates how RPGs can contextualize museum artefacts, foster curiosity and engagement with heritage narratives, and provide a meaningful learning experience. The research contributes to the growing field of game-based learning in cultural heritage, offering insights into the design process and evaluation of serious games for museums.Bu araştırma, rol yapma oyunlarının (RPG'ler), kültürel mirası oyun deneyimine entegre ederek müze deneyimlerini geliştirme potansiyelini incelemektedir. İzmir Arkeoloji ve Etnografya Müzesi'ni odak noktası olarak alan çalışma, RPG'lerin anlamlı ve etkileyici müze deneyimleri oluşturmadaki rolünü araştırmaktadır. Somut eserleri soyut anlatılarla birleştirerek, araştırma, çeşitli müze ziyaretçileri için anlamlı bir oyun deneyimi tasarlamayı, kültürel mirasın daha derin bir şekilde anlaşılmasını ve farkındalığını artırmayı, ayrıca müze kurumuna olan ilgiyi güçlendirmeyi amaçlamaktadır. Araştırmada tasarım yoluyla araştırma metodolojisi benimsenmiş, iteratif bir tasarım süreci ve oyun testi odaklı bir yaklaşım kullanılmıştır. Bu bağlamda, müze deneyimini kapsayan bir bilgisayar rol yapma oyununun (CRPG) tasarımı ele alınmıştır. Çalışma sırasında bir dizi tasarım zorluğu ortaya çıkarılmıştır; bunlar arasında, müze içerikleriyle zenginleştirilmiş anlamlı ve amaçlı bir oyun deneyimi sunma, farklı seviyelerde video oyunu ve RPG bilgisine sahip bir kitle için karmaşık oyun unsurları tasarlama ve kültürel miras bağlamında gayriresmî öğrenmeyi artırma gibi unsurlar yer almaktadır. Oyun tasarımı ve oyun tabanlı öğrenme metodolojilerini inceleyen araştırma, disiplinler arası bir tasarım alanını keşfetmek için tasarım pratiğinden yararlanmıştır. Çalışma, RPG'lerin müze bağlamında tasarımını bir sorun olarak değil, bir tasarım durumu olarak ele alarak, tasarım eylemi yoluyla uygulanabilir tasarım bilgisi üretme zihniyetini benimsemektedir. Araştırma bulguları, müze ortamlarında RPG kullanımına ilişkin hem teorik hem de pratik çıkarımlar sunmaktadır. Çalışma, RPG'lerin müze eserlerini bağlama oturtma, kültürel miras anlatılarına merak ve katılımı artırma, ayrıca anlamlı bir öğrenme deneyimi sağlama potansiyelini ortaya koymaktadır. Araştırma, kültürel miras bağlamında oyun tabanlı öğrenme alanına katkıda bulunarak, müzeler için ciddi oyunların tasarım süreci ve değerlendirilmesi üzerine önemli bilgiler sunmaktadır
Diabetic Foot Care Behavior and Self-Efficacy Levels in Individuals With Diabetic Foot Ulcers in Turkey
No full textObjective: This study aimed to explore the connection between demographic characteristics, diabetes-related knowledge, foot self-care behaviors, and self-efficacy levels in individuals with diabetic foot ulcers. Additionally, it investigated whether there is a correlation between foot care behaviors and self-efficacy levels among these individuals. Methods: This descriptive and cross-sectional study was conducted with individuals who applied to a training and research hospital with a diabetic foot ulcer and received treatment between October 2019 and October 2020. Data were collected through the Patient Identification Characteristics Form, the Diabetes Management Self- Efficacy Scale, and the Foot Self-Care Behavior Scale. Percentage, mean, Mann-Whitney U test, Kruskal-Wallis test, and Spearman correlation analysis were used to analyze the data. Results: The mean self-efficacy score among individuals with diabetic foot ulcers was 68.39 +/- 14.03, while the mean foot self-care behavior score was 59.10 +/- 10.13. Previous diabetes education, regular exercise, and educational status significantly influenced scores on both scales. Furthermore, a positive linear relationship was observed between foot self-care behaviors and self-efficacy levels in individuals with diabetic foot. Conclusions: To enhance self-efficacy levels and promote foot self-care behaviors in individuals with diabetic foot ulcers, continuous education, and regular follow-up examinations are essential. Providing tailored care based on demographic characteristics and evolving health conditions related to diabetes is expected to reduce complications effectively
The Multivariate Local Dependence Function
No full textThe local dependence function is important in many applications of probability and statistics. We extend the bivariate local dependence function (Bairamov and Kotz 2000; Bairamov, Kotz, and Kozubowski 2003) to three-variate and multivariate local dependence function characterizing the dependency between three and more random variables in a given specific point. The definition and properties of the three-variate local dependence function are discussed. An example of a three-variate local dependence function for underlying three-variate normal distribution is presented. The graphs and tables with numerical values are provided. The multivariate extension of the local dependence function that can characterize the dependency between multiple random variables at a specific point is also discussed. © 2025 Taylor ; Francis Group, LLC
Understanding Sensorial Properties of Olive Oil
No full textUpon completion of the case, the participants will be able to: assess perceptions of the olive oil culture knowledge; classify the types of olive oil; identify the impact of production and harvesting on the organoleptic properties of the olive oil; examine the positive and negative attributes of different olive oil types; discuss the sensory qualities of locally produced or artisanal olive oils; and develop tasting abilities to be able to effectively inform customers or tourists about the qualities of olive oil. © 2025 selection and editorial matter, Aise Kim, Gürhan Aktaş and Metin Kozak
De-Escalation of Nodal Surgery in Clinically Node-Positive Breast Cancer
No full textImportance: Increasing evidence supports the oncologic safety of de-escalating axillary surgery for patients with breast cancer after neoadjuvant chemotherapy (NAC). Objective: To evaluate the oncologic outcomes of de-escalating axillary surgery among patients with clinically node (cN)-positive breast cancer and patients whose disease became cN negative after NAC (ycN negative). Design, Setting, and Participants: In the NEOSENTITURK MF-1803 prospective cohort registry trial, patients from 37 centers with cT1-4N1-3M0 disease treated with sentinel lymph node biopsy (SLNB) or targeted axillary dissection (TAD) alone or with ypN-negative or ypN-positive disease after NAC were recruited between February 15, 2019, and January 1, 2023, and evaluated. Exposure: Treatment with SLNB or TAD after NAC. Main Outcomes and Measures: The primary aim of the study was axillary, locoregional, or distant recurrence rates; disease-free survival; and disease-specific survival. Number of axillary lymph nodes removed was also evaluated. Results: A total of 976 patients (median age, 46 years [range, 21-80 years]) with cT1-4N1-3M0 disease underwent SLNB (n = 620) or TAD alone (n = 356). Most of the cohort had a mapping procedure with blue dye alone (645 [66.1%]) with (n = 177) or without (n = 468) TAD. Overall, no difference was found between patients treated with TAD and patients treated with SLNB in the median number of total lymph nodes removed (TAD, 4 [3-6] vs SLNB, 4 [3-6]; P =.09). Among patients with ypN-positive disease, those who underwent TAD were more likely to have a lower median lymph node ratio (TAD, 0.28 [IQR, 0.20-0.40] vs SLNB, 0.33 [IQR, 0.20-0.50]; P =.03). At a median follow-up of 39 months (IQR, 29-48 months), no significant difference was found in the rates of ipsilateral axillary recurrence (0.3% [1 of 356] vs 0.3% [2 of 620]; P ≥.99) or locoregional recurrence (0.6% [2 of 356] vs 1.1% [7 of 620]; P =.50) between the TAD and SLNB groups, with an overall locoregional recurrence rate of 0.9% (9 of 976). The initial clinical tumor stage, pathologic complete response, and use of blue dye alone as a mapping procedure were not associated with the outcome. Even though patients with TAD demonstrated an increased disease-free survival rate compared with the SLNB group, this difference did not reach statistical significance (94.9% vs 92.6%; P =.07). Factors associated with decreased 5-year disease-specific survival were cN2-3 axillary stage (cN1, 98.7% vs cN2-3, 96.8%; P =.03) and nonluminal type tumor pathologic characteristics (luminal, 98.9% vs nonluminal, 96.9%; P =.007). Conclusions and Relevance: The short-term results suggest very low rates of axillary and locoregional recurrence in a select group of patients with cN-negative disease after NAC treated with TAD alone or SLNB alone followed by regional nodal irradiation regardless of the SLNB technique or nodal pathology. Whether TAD might provide a clear survival advantage compared with SLNB remains to be proven in studies with longer follow-up. © 2025 American Medical Association. All rights reserved
Circular Materials—a Multiscale Approach To Circularity at a Building, Components and Materials Level
No full textSustainable practices and strategies to enhance resource efficiency while minimising waste in buildings and their constituent elements are key towards circularity at the urban built environment. In this chapter three implementation scales, under the paradigm of the circular economy (CE), are measured—i.e., buildings, components and materials—, considering both new and existing buildings’ implementations. Aspects such as design for adaptability and flexibility, modular and flexible spaces and concepts, energy and water efficiency are discussed. By implementing CE strategies at the component-level using a multipronged approach would extend the lifespan and contribute to environmental and economic sustainability. This includes the refurbishment and upgrading of components and the adoption of modular construction techniques, among other techniques and solutions. The last part of the chapter presents the concept of circular materials and its circularity potential at promote extended product lifecycles and transforming waste into valuable resources. Integrating sustainable and circular design principles within construction practices is proposed towards more sustainable and resource-efficient industries’ transformations. © The Author(s) 2025
Investigation of Glass Ceiling Syndrome Among Radiation Professionals: a Comparative Analysis
No full textPurpose: This study investigates the perception of the glass ceiling syndrome among technicians working in radiology, nuclear medicine, and radiation oncology in healthcare institutions in Turkey. Material and Methods: Adopting a comparative approach, this research examines the prevalence and impact of the glass ceiling phenomenon on female workers in these specific fields. The theoretical framework is based on a comprehensive review of the relevant literature, while empirical data was collected via questionnaires administered to 311 participants in Turkey. The collected data was analyzed using descriptive statistics, chi-square analysis, and independent sample tests. Results: The results reveal that the majority of this group of professionals were women (78.1%). It was also found that the majority were medical imaging technicians, with 64%, and most were working in private institutions (65.3%). The only significant difference detected in the total score and subscale scores of the glass ceiling scale (except mentoring) was for gender (p0.05). A significant difference was found in the professional discrimination subscale score among various position groups, one of the other variables regarding composition of the survey participants (p0.05). Conclusion: This study enhances understanding of gender dynamics among radiation workers and highlights the need for targeted interventions to address the glass ceiling syndrome. The findings provide key insights for promoting workforce equity and organizational development in healthcare institutions