Johns Hopkins Research Data Repository
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Data associated with the publication: The influenza B virus Victoria and Yamagata lineages display distinct cell tropism and infection induced host gene expression in human nasal epithelial cell cultures
No full textUnderstanding Influenza B virus infections is of critical importance in our efforts to control severe influenza and influenza-related disease. Until 2020, two genetic lineages of influenza B virus – Yamagata and Victoria – circulated in the population. These lineages are antigenically distinct but differences in virus replication or the induction of host cell responses after infection have not been carefully studied. Recent IBV clinical isolates of both lineages were obtained from influenza surveillance efforts of the Johns Hopkins Center of Excellence in Influenza Research and Response and characterized in vitro. B/Victoria and B/Yamagata clinical isolates were recognized less efficiently by serum from influenza-vaccinated individuals in comparison to the vaccine strains. B/Victoria lineages formed smaller plaques on MDCK cells compared to B/Yamagata, but infectious virus production in primary human nasal epithelial cell (hNEC) cultures showed no differences. While ciliated epithelial cells were the dominant cell type infected by both lineages, B/Victoria lineages had a slight preference for MUC5AC-positive cells, while B/Yamagata lineages infected more basal cells. Finally, while both lineages induced a strong interferon response 48 hours after infection of hNEC cultures, the B/Victoria lineages showed a much stronger induction of interferon related signaling pathways compared to B/Yamagata. This demonstrates that the two influenza B virus lineages differ not only in their antigenic structure but in their ability to induce host innate immune responses
Data associated with the publication: Sensitive organic electrochemical transistor biosensors: Comparing single and dual gate configuration and different COOH-functionalized bioreceptor layers
No full textElectronic response data for devices functionalized with different receptor polymers and exposed to different concentrations of biomolecules. Data are organized by figure number in the manuscript. Data are in the form of spreadsheets and comma separated files (csv). The files can be opened with Microsoft Excel (csv) and Origin (opj. Or opju). The transfer curves were drawn for VG-ID values
Data associated with the publication: Bilateral widefield calcium imaging reveals circuit asymmetries and lateralized functional activation of mouse auditory cortex.
No full textThe deposited data includes MATLAB scripts (.m files) and the corresponding data (.mat files) required to reproduce the figures in the publication. Additional calcium dynamic traces for each animal are also included. Data are stored in either .mat files or .tif files. Some text files (.txt) are included for instruction on using the MATLAB scripts (.m files) for generating figures
Data and code associated with the publication: Mode switching in organisms for solving explore-vs-exploit problems.
No full textThis project includes datasets and codes pertinent to the study of how organisms solve the explore–exploit conflict while performing tasks where the same category of movement is used for both gathering information (“explore”) and achieving task goals (“exploit”). The datasets contain (1) an experimental dataset from a novel study on weakly electric fish Eigenmannia virescens while tracking a stationary refuge, and (2) published experimental datasets from ten phylogenetically diverse organisms from amoebae to humans, used for reanalysis. The experimental dataset from the stationary shuttle tracking of weakly electric fish was collected in the LIMBS laboratory at JHU in 2021
Data associated with the publication: Effect of organic electroactive crystallites in a dielectric matrix on the electrical properties of a polymer dielectric.
No full textThis file contains original instrument data for material conductivities, effects of static charging on transistor current-voltage relationships, confocal microscopy of quaterthiophene crystallites in polystyrene, data showing dielectric breakdown behavior for polystyrene-based capacitors with quaterthiophene crystallites present, device structures, scanning electron microscopy, atomic force microscopy, laser optical microscopy thickness measurements,kelvin probe force microscopy showing static charge trapped on crystallites, and x-ray diffraction
Data associated with the publication: Perceptual specializations for processing species-specific vocalizations in the common marmoset (Callithrix jacchus)
No full textHow humans and animals segregate sensory information into discrete, behaviorally meaningful categories is one of the hallmark questions in neuroscience. Much of the research around this topic in the auditory system has centered around human speech perception, in which categorical processes result in an enhanced sensitivity for acoustically meaningful differences and a reduced sensitivity for nonmeaningful distinctions. Much less is known about whether non-human primates process their species-specific vocalizations in a similar manner. We address this question in the common marmoset, a small arboreal New World primate with a rich vocal repertoire produced across a range of behavioral contexts. We first show that marmosets perceptually categorize their vocalizations in ways that correspond to previously defined call types for this species. Next, we show that marmosets are differentially sensitive to changes in particular acoustic features of their most common call types, and that these sensitivity differences are matched to the population statistics of their vocalizations in ways that likely maximize category formation. Finally, we show that marmosets are less sensitive to changes in these acoustic features when within the natural range of variability of their calls, which possibly reflects perceptual specializations which maintain existing call categories. These findings suggest specializations for categorical vocal perception in a New World primate species and pave the way for future studies examining their underlying neural mechanisms
Data associated with the publication: Shared satisfaction among residents living in multiracial neighborhoods
No full textThe repository contains data and files necessary to replicate the analyses in "Shared Satisfaction among Residents Living in Multiracial Neighborhoods" that is published in the journal Social Problems
Data associated with publication: Polycystin-2 dependent transcriptome reveals potential initiators of autosomal dominant polycystic kidney disease
No full textThe reposited data contain transcriptome profiles generated from RNA-Seq analysis in a newly developed kidney ADPKD cell line and bioinformatic profiles of cellular processes. The transcriptome data set includes transcript abundance of genes identified in transcriptomic profiling and Pkd2-dependent transcriptomic changes. The bioinformatic profile data sets include comprehensive maps of the Pkd2-dependent genes on the curated gene sets and gene sets of Gene Ontology database
Data associated with the publication: Binocular 3D otolith-ocular reflexes: responses of chinchillas to natural and prosthetic stimulation after ototoxic injury and vestibular implantation.
No full textThe otolith end organs inform the brain about gravitational and linear accelerations, driving the otolith-ocular reflex (OOR) to stabilize the eyes during translational motion (e.g., moving forward without rotating) and head tilt with respect to gravity. We previously characterized OOR responses of normal chinchillas to whole-body tilt and translation and to prosthetic electrical stimulation targeting the utricle and saccule via electrodes implanted in otherwise normal ears. Here we extend that work to examine OOR responses to tilt and translation stimuli after unilateral intratympanic gentamicin injection and to natural/mechanical and prosthetic/electrical stimulation delivered separately or in combination to animals with bilateral vestibular hypofunction after right ear intratympanic gentamicin injection followed by surgical disruption of the left labyrinth at the time of electrode implantation. Unilateral intratympanic gentamicin injection decreased natural OOR response magnitude to about half of normal, without markedly changing OOR response direction or symmetry. Subsequent surgical disruption of the contralateral labyrinth at the time of electrode implantation surgery further decreased OOR magnitude during natural stimulation, consistent with bimodal-bilateral otolith end organ hypofunction (ototoxic on the right ear, surgical on the left ear). Delivery of pulse-frequency- or pulse-amplitude-modulated prosthetic/electrical stimulation targeting the left utricle and saccule in phase with whole-body tilt and translation motion stimuli yielded responses closer to normal than the deficient OOR responses of those same animals in response to head tilt and translation alone
Data associated with: Toward accurate cerebral blood flow estimation in mice after accounting for anesthesia
No full textThe deposited data contains the dataset of an MRI study focusing at correcting the anesthetic effects of isoflurane on CBF measurements in mice. Major data are the original MRI data generated by the Bruker Biospec 11.7T MRI system with other data generated from the processing of the original data using the MATLAB