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Data associated with the publication: Cholinergic reinforcement signaling is impaired by amyloidosis prior to its synaptic loss.
No full textAlzheimer's Disease (AD) is associated with amyloidosis and dysfunction of the cholinergic system which is crucial for learning and memory. However, the nature of acetylcholine signaling within regions of cholinergic-dependent plasticity and how it changes with experience is poorly understood, much less the impact of amyloidosis on this signaling. Therefore, we optically measure the release profile of acetylcholine to unexpected, predicted, and predictive events in visual cortex (VC)—a site of known cholinergic-dependent plasticity—in a preclinical mouse model of AD that develops amyloidosis. We find that acetylcholine exhibits reinforcement signaling qualities, reporting behaviorally-relevant outcomes and displaying release profiles to predictive and predicted events that change as a consequence of experience. We identify three stages of amyloidosis occurring prior to the degeneration of cholinergic synapses within VC and observe that cholinergic responses in amyloid-bearing mice become impaired over these stages, diverging progressively from age- and sex-matched littermate controls. In particular, amyloidosis degrades signaling of unexpected rewards and punishments, and attenuates the experience-dependent 1) increase of cholinergic responses to outcome predictive visual cues, and 2) decrease of cholinergic responses to predicted outcomes. Hyperactive spontaneous acetylcholine release occurring transiently at the onset of impaired cholinergic signaling is also observed, further implicating disrupted cholinergic activity as an early functional biomarker in AD. Our findings suggest that acetylcholine acts as a reinforcement signal that is impaired by amyloidosis prior to pathological degeneration of the cholinergic system, providing a deeper understanding of the effects of amyloidosis on acetylcholine signaling and informing future interventions for AD
Data associated with the publication: 2019–2020 H1N1 clade A5a.1 viruses have better in vitro fitness compared with the co circulating A5a.2 clade
No full textThis dataset includes the raw data and analyses of glycan array binding assays, plaque assays, infectious virus growth curves, and serum neutralization assays from the above publication. These are in the format of Excel sheets, GraphPad Prism files, and for plaque assays pictures of the plaque wells. The data are organized according to the assays performed
Data associated with the publication: Optical properties of organic hazes in water-rich exoplanet atmospheres: Implications for observations with JWST
No full textWe report the optical properties of two haze analogous to those produced in temperate water-rich exoplanet atmospheres. Their optical constants (the real refractive indices, n, and the extinction coefficients, k) are derived from 0.4 to 28.6 μm, covering optical wavelengths accessible with Hubble and ground-based facilities and the entire JWST wavelength range. The optical constants of our water-rich derived exoplanet hazes differ from those of the Titan-like hazes, therefore affecting transmission, thermal emission, and reflected light spectra of exoplanets to different extents. The two sets of optical constants reported here are applicable for temperate water-rich exoplanet atmospheres and can be used for current and future observational and modeling efforts of such atmospheres
Data associated with the publication: NO2 exposure effect on mixed conductivity and Seebeck coefficient in thiophene polymers
No full textDevice current-voltage data and plots leading to Seebeck coefficients, in the form of spreadsheets and graphs
Data associated with the publication: Human scent guides mosquito thermotaxis and host selection under naturalistic conditions
No full textThis archive contains raw videos of mosquito behavior in .h624 format, mosquito trajectories extracted from those videos in .txt or .csv format, weather data in .csv, as well as raw GC/MS files in .mzml format used in the publication
Data associated with the publication: A quantitative acoustic analysis of the vocal repertoire of the common marmoset (Callithrix jacchus).
No full textVocal recordings from marmoset colony, categorized by call types and subjects
Data associated with the publication: Synthetic data accelerates the development of generalizable learning-based algorithms for X-ray image analysis
No full textThis dataset contains training and testing data files associated with the SyntheX benchmark experiments. It corresponds to three SyntheX applications, namely hip imaging, surgical tool detection and covid. The usage of the dataset is documented in https://github.com/arcadelab/SyntheX
Data associated with: Chagas cardiomyopathy cohort in Bolivia
No full textThis includes general recruitment data (age,sex, dates of interviews and tests), medical history answers, medications, ekg results and echo results for patients in the chagas cardiomyopathy cohor
Estadística Agrícola de la República, 1899-1900/ Agricultural Statistics from Mexico, 1899-1900
No full textIn 1898, the Mexican Agricultural Society proposed a comprehensive survey of Mexico's agricultural properties to be presented at the Paris Exposition in 1900. In collaboration with the national Department of Fomento, or Development, they proposed and revised a table requesting information on agricultural activity across the country by property. Asserting that the Statistical Office already had much information to hand, Fomento officials removed numerous columns from the proposed table. They then circulated the resultant survey to every municipal president in Mexico in summer 1899.
This dataset is built on transcriptions of the tables returned by municipal and state officials. It represents about 1,400 municipalities from 18 states and territories. The EstadisticaAgricola1899_AllData file includes all the transcribed data at the property level. The EstadisticaAgricola1899_SummaryStatistics file includes data summarized at the municipal level. The tables were transcribed as directly as possible, with the Annotation column containing any writing from outside the table itself. Transcriber notes regarding decisions made, illegible content, etc., is included in the Summary Statistics table, as is information on who signed the table and when they signed it. If information was written vertically across an entire column for a town, that information has been copied into the appropriate cell for each property within that town. Transcribers used their best judgment with regards to ditto marks versus indications that there was no information to include in a particular cell, as enumerators’ use of symbols to denote the two distinct options often looked similar. The codebook for each table contains additional information about how names, units of measure, and other information was standardized.
It is important to note that enumerators responded to the table in very different ways. The data in this dataset is not commensurate and care must be taken in drawing comparisons beyond the municipal level. Lacking clear instructions, officials made different decisions about what kind of properties to include, how to note yield, whether to include information at the municipal or property level, and so on. For more analysis and detail about overall patterns in the dataset, see Casey Marina Lurtz, “A Confounded Statistic: Understanding Incommensurability in Turn of the Century Mexico,” The Americas, 80:2 (2023).
Original transcriptions of the dataset are available by request from Casey Marina Lurtz ([email protected]). They were completed by Lurtz, Oriol Regue Sendros, and Lauren MacDonald. Students in Johns Hopkins University’s Making Maps of Mexico class in Spring 2021 and Fall 2022 contributed to decision making around how to standardize information in the columns. At the MSE Library at Johns Hopkins, Marley Kalt helped with data management, and Lena Denis and Reina Chano Murray provided advice and instruction on mapping the data. Visualizations of the data can be found at https://caseylurtz.com/agricultural-statistics. A shapefile for mapping data from Mexico in the late nineteenth century based on municipalities listed in the 1900 Census will be published there and to the ArcGIS Living Atlas soon.
Photographs of the original manuscript tables are available by contacting Casey Marina Lurtz ([email protected]) or can be located at the Mexican Archivo General de la Nación, Fomento y Obras Publicas: Exposiciones Extranjeras y del País, cajas 51-53
Data associated with the publication: T cell immune deficiency rather than chromosome instability predisposes patients with short telomere syndromes to squamous cancers
No full textSingle nucleotide variants that passed quality control criteria and generated by Muteck2 from 8 tumors sequenced by whole genome sequencing at mean 72x coverage