Yamagata University Academic Repository
Not a member yet
6724 research outputs found
Sort by
Do 2-cm pancreatic tumors localize in the pancreas? Analysis of the greatest and smallest diameter of the autopsied pancreas
Get PDF論文(Article)Background: Local tumor growth and tumor size are key factors that determine the prognosis of patients with pancreatic cancers. In the present study, we measured the the greatest and smallest diameters of the pancreas to clarify the largest pancreatic ductal adenocarcinomas that can be confined to the pancreas.
Materials and Methods: Pancreatic tissues obtained from 10 autopsied patients were cut into 5-mm sections vertical to the main pancreatic duct. Each slice was processed for microscopic examination and was captured using a virtual slide scanner. We measured the greatest diameter of the pancreas in each slide.
Results: The average greatest diameters of the pancreatic body and tail were less than 2 cm in 2 cases for the pancreatic body and 5 cases for the pancreatic tail. All cases contained slides for which the greatest pancreatic diameter measured less than 2 cm, with 5 cases for the pancreatic head and body and 9 cases for the pancreatic tail. The average smallest diameters of the pancreatic head, body, and tail were less than 2 cm for all cases, and there were 3 cases in which they were less than 1 cm.
Conclusion: Our study, which evaluated the entire pancreatic parenchyma from autopsy tissues, revealed that the pancreas has many areas where diameters are less than 2 cm, suggesting that most 2 cm tumors cannot be limited to the pancreas
Genotoxicity of occupational exposure of anesthesiologists to sevoflurane : The relationship between DNA damage and the work environment
Get PDF論文(Article)Background: Inhalation anesthetics are often used for general anesthesia. However, several studies have reported that occupational exposure to inhalation anesthetics induces DNA damage and that sevoflurane anesthesia causes reversible genotoxic effects in patients. Our aim was to investigate the genotoxic effects in anesthesiologists of occupational exposure to sevoflurane, and to reveal the relevance of DNA damage and the work environment of anesthesiologists.
Methods: Alkaline comet assay of the peripheral blood lymphocytes of 53 anesthesiologists (exposed group) and 37 office workers (control group) was performed, following which 100 cells were classified into 5 classes: 0: no migration, to 4: very high migration, the distance of migration being dependent on the degree of DNA damage. The total comet score (TCS) was calculated as n1+2×n2+3×n3+4×n4. Anesthesiologists were asked about their work environment.
Results and Conclusions: TCSs were no different between the exposed and control groups (7.16±7.88 vs. 7.63±6.73, p=0.82) (95%CI 3.91-10.41 vs. 4.97-10.29). There was no significant association between TCS and the frequency of usage of sevoflurane. In conclusion, our study did not reveal DNA damage with chronic occupational exposure to sevoflurane
