Portail HAL EHESS (École des hautes études en sciences sociales)
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La fragmentation des unités phraséologiques dans le Dictionnaire des expressions et locutions
No full textInternational audienceThe article examines the treatment of phraseological units (PUs)in the Dictionnaire des expressions et locutions, focusing on their macro- andmicrostructural fragmentation. PUs, which are fixed sequences with meaningsbeyond those of individual words, are often fragmented, making them difficultto access. The study focuses on fruit-related PUs, which form a corpus rich inmetaphors and cultural symbolism.L’article examine le traitement des unités phraséologiques (UP) dansl e Dictionnaire des expressions et locutions, en se concentrant sur leurfragmentation macro- et microstructurale. Les UP, qui sont des séquencesfigées avec un sens dépassant celui des mots individuels, sont souventfragmentées, rendant leur accès difficile. L’étude se focalise sur les UP liées auxfruits, un corpus riche en métaphores et en symbolismes culturels
Filling the gaps: Original chronologies of silver fir (Abies alba Mill.) and European beech (Fagus sylvatica L.) living trees in the French Pyrenees
No full textInternational audienceBetween 2016 and 2024, as part of several research projects on forest history in the mountain belt of the central French Pyrenees, we cored 360 living trees at breast height, including 309 silver fir (Abies alba Mill. 1768) and 51 European beech (Fagus sylvatica L. 1753), using an increment drill. In addition, 64 cross-sections of beech stems were harvested with a chainsaw during a forest cut by the forest manager. The trees are located in 14 stands (13 fir-dominated forests with some beech, 1 beech-dominated forest, in 3 stands we sampled both species) spread over the French Central Pyrenees and subject to different levels of harvesting pressure: regularly harvested, harvested 30-40 years ago, not harvested for a long time (>100 years). In each stand, we established three to five circular plots of 1 ha each. Depending on the main objective of the research projects, trees were selected from the largest, dominant or co-dominant individuals according to a pre-established protocol, as for the BENDYS project [1] (full description in Py-Saragaglia et al., 2020), or to represent the full range of diameter at breast height (DBH) available in the 1 ha circular plots. All samples were processed using standard dendrochronological techniques at the GEODE laboratory in Toulouse (PANGEME analysis platform). Tree-ring measurements were made with a resolution of 0.001 mm using either a LINTAB sliding table connected to TsapWin software (RINNTECH, Heidelberg, Germany) or CooRecorder [2] software applied to a high-resolution scan of the samples. All samples were cross-dated using CDendro [2] software. The robustness of the chronologies was assessed using reference curves available for both species in the Pyrenees for beech and in southern France for fir.The present dataset provides two reference chronologies for fir and beech in this part of the Pyrenees and 17 master stand chronologies, 13 from fir and 4 from beech. The reference chronologies were constructed from 324 of the 424 individual ring series sampled, 253 from fir (309 sampled) and 71 from beech (115 sampled). All reference chronologies are suitable for dendroarchaeological studies (dating, dendroprovenance, reconstruction of ancient practices, etc.), dendroecological studies (resilience of species, effect of management on growth, etc.) and dendroclimatological studies (climate reconstruction, climate sensitivity of the two species, etc.)
Allogeneic umbilical cord-derived mesenchymal stromal cells as treatment for systemic lupus erythematosus: a single-centre, open-label, dose-escalation, phase 1 study
No full textInternational audienceBackground: Patients with systemic lupus erythematosus (SLE) with inadequate responses to standard therapies have unmet therapeutic needs. The immunomodulatory, proangiogenic, and antifibrotic properties of mesenchymal stromal cells support their use in treating patients with SLE. We aimed to assess the safety of a single intravenous infusion of allogeneic umbilical cord-derived mesenchymal stromal cells in patients with severe SLE.Methods: This prospective, single-centre, open-label, dose-escalation, Bayesian phase 1 study was done at the Saint-Louis University Hospital (Paris, France). Eligible patients were aged 18-70 years, were diagnosed with SLE according to American College of Rheumatology criteria with positive antinuclear antibodies, had a baseline Safety of Estrogens in Lupus Erythematosus National Assessment-SLE Disease Activity Index (SELENA-SLEDAI) score of 6 or more, and had disease that was refractory to first and second line SLE therapies. Patients were to receive a single intravenous infusion of 1 × 106, 2 × 106, or 4 × 106 umbilical cord-derived mesenchymal stromal cells per kg (manufactured from a single umbilical cord) in cohorts of five patients per dose, starting at 2 × 106 cells per kg. The primary endpoint was the rate of treatment-related severe adverse events (grade ≥3) in the first 10 days after infusion of umbilical cord-derived mesenchymal stromal cells. People with lived experience were involved in study design, patient enrolment, and dissemination of the study findings. This study is registered with ClinicalTrials.gov, NCT03562065, and the EU Clinical Trials Register, EudraCT2017-001400-29.Findings: From May 14, 2019, to March 6, 2023, 29 patients were screened for eligibility, eight of whom were enrolled in the study. Enrolment was terminated early after inclusion of eight patients and no patients received the 1 × 106 dose of umbilical cord-derived mesenchymal stromal cells. Seven (88%) of eight participants were cisgender women and one (13%) was a cisgender man. The median age was 35 years (range 26-57) and the median SLE disease duration was 12 years (5-19). All patients received at least 2 × 106 cells per kg (range 2 × 106 to 4 × 106). No severe adverse events and three infusion-related adverse events (two grade 1 and one grade 2) occurred in two patients in the first 10 days after infusion. After 12·4 months (range 12-13) of follow-up, no treatment-related severe adverse events and three non-treatment-related severe adverse events occurred in one patient after relapse.Interpretation: Our results suggest that a single infusion of 2 × 106 cells per kg or 4 × 106 cells per kg of allogeneic umbilical cord-derived mesenchymal stromal cells was safe in patients with severe SLE. Placebo-controlled trials are needed to confirm clinical efficacy and the role of B-cell modifications in clinical benefit.ClinicalTrials.gov/NCT03562065 https://clinicaltrials.gov/study/NCT0356206
Rapport sur la création d'une page "ANR Projets" concernant le portail HAL-EHESS
No full textThis report details the process and findings related to the creation of a page dedicated to ANR projects on the HAL-EHESS portal. The main objective is to centralize, visualize, and promote ANR projects conceived and managed by EHESS members. It examines existing tools (HAL API, ANR-HAL, and AuréHAL) and identifies shortcomings: lack of project structuring on ANR-HAL, missing metadata (project managers, partner structures), and data extraction issues. The report outlines the necessary information for the new page and emphasizes the need to better identify the affiliations of EHESS members.Ce rapport détaille la création d'une page dédiée aux projets ANR sur le portail HAL-EHESS, visant à centraliser et valoriser ces projets. Il examine les outils existants (API HAL, portails ANR-HAL et AuréHAL) et constate des lacunes : manque de structuration des projets sur ANR-HAL, métadonnées manquantes (responsables, structures partenaires) et problèmes d'extraction de données. Le rapport identifie les informations nécessaires pour la nouvelle page et souligne le besoin de mieux identifier les affiliations des membres de l'EHESS
A hypothesis test for comparing two partitions obtained from the same dataset
No full textInternational audienceWe propose a non parametric hypothesis test to compare two partitions of a same data set. The partitions may result from two different clustering approaches. The test may be done using any comparison index but we focus in particular on the Matching Error (ME) that is related to the misclassification error in supervised learning. Some properties of the ME and, especially, its distribution function for the case of two different partitions are analyzed. Extensive simulations and experiments show the efficiency of the test
The CHIPS Database: A Repository for Reference Data on Chemical Analysis in Archaeometallurgy of Iron
No full textThis preprint presents the core concepts of the CHIPS database, the project of a global repository of reference chemical data related to the archaeometallurgy of iron. Archaeometallurgists interested in iron do not currently have access to extensive chemical reference data repositories. Yet chemical data is of crucial importance both for reconstructing ancient technical systems and economic structures, by determining the operating conditions and the exchange networks. We are seeking to meet this need with the CHIPS database, developed on PostgreSQL. The goal is to provide the scientific community with global reference data in a standardised format. Chemical data can be selected using spatial, chronological or typological queries, thanks to the documentation of archaeological contexts and samples. Particular care has been taken to assess the quality of the chemical data, based on analytical metadata (types of analysis and technical characteristics of the analysers). In order to guarantee the interoperability of the database, the main tables are referenced by libraries, gazetteers and thesauri that are considered as standards by the archaeological community. The data can currently be consulted using a cartographic interface, and the development of a more advanced interface is envisaged, based on the implementation of graphic display tools for chemical data
Information disclosure in preemption races:Blessing or (winner's) curse?
No full textNational audienceFirms receiving independent signals on a common-value risky project compete to be the first to invest. When firms are symmetric and competition is winner-take-all, rents are fully dissipated in equilibrium and the extent to which signals are publicly disclosed is irrelevant for welfare. When disclosure of signals is asymmetric, welfare is highest when firms are most asymmetric, and policies that uniformly promote disclosure may backfire, especially when competition is severe. When firms strategically select their disclosure policies, a moderate subsidy for disclosure induces a low correlation between firms’ policies, and thus maximizes welfare
Regional trade policy uncertainty
No full textInternational audienceHigher trade policy uncertainty has recessionary effects on U.S. states. To demonstrate this, we first build a novel empirical measure of regional trade policy uncertainty based on the volatility of national import tariffs at the sectoral level and on the sectoral composition of imports in U.S. states. We find that a state that is more exposed to an unanticipated increase in tariff volatility suffers from a larger drop in real GDP and employment than the average U.S. state. We then build a two-region open-economy model and find that the precautionary saving behavior is the main driver of the recession, although this effect is reinforced by high exposure to import tariffs. The feedback effect resulting from trade connections with the Foreign country primarily influences the persistence of these dynamics. ✩ The National Bureau of Economic Research has provided financial sponsorship to make this article open access and had no influence or involvement over the review or approval of any content. ✩✩ This article is part of a special issue entitled: ISOM 2024 published in Journal of International Economics. ★ We are grateful to the organizers of the 2024 NBER International Seminar on Macroeconomics (ISoM), Jordi Galí and Kenneth West as well as our discussants, Andrea Raffo and Joseph Steinberg, the Editor Linda Tesar and the participants for their insightful comments. The comments and remarks provided</div