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Comment on: "Man Plus Machine: A Randomized Control Trial of Artificial Intelligence Including the Impact of Adjunctive Polyp Detection Techniques"
No full textCorrigendum to “Food neophobia correlates with motor cortex excitability in response to disgust-related stimuli” [Appetite 217 (2026) 108334]
No full textSelective and sustainable recovery of lithium from black mass via microwave and green leaching techniques
No full textI programmi decorativi degli edifici e delle vasche battesimali fra centro e periferia: ricezione dei modelli ed elaborazioni regionali
No full textIntegrating FPGA-Based Acceleration in Industrial Motion Control System
No full textManufacturing processes increasingly depend on advanced production machinery that must deliver high quality and large volumes. This applies to die-bonding machines as well that, especially at the time being after the years of shortage, need to meet very high standards of speed and accuracy. To achieve this, these devices are exploring the use of computer vision algorithms for automatic recognition of wafer positioning and die size. Nevertheless, these systems are typically managed by software-only solutions, which may fall short under stringent execution time requirements. A promising solution is the use of heterogeneous platforms, combining general-purpose processors with reconfigurable hardware. Such platforms offer the flexibility to handle both software tasks, which benefit from operating system support, and critical functions requiring hardware acceleration. This article presents a closed-loop implementation of a vision-based multisensor control system for an industrial application. The implementation exploits the capabilities of system on module technologies to provide flexible input/output and software execution coupled with computing acceleration for the vision algorithm on the reconfigurable field-programmable gate array (FPGA) fabric. The FPGA coprocessor has been designed leveraging the high-level synthesis technology and optimized on a dataset of 10 k realistic images to meet the industrial use case's performance, communication, and accuracy requirements. Moreover, the resulting accelerator performance and resource utilization demonstrate the possibility of reaching state-of-the-art metrics of handwritten hardware designs while allowing for higher abstraction and productivity of the design process
Cities and Commercial Activities at the Service of Tourism. Three Sicilian Case Studies Compared
No full textAs a complex space-time construct of knowledge and capital, the city narrates itself by incorporating the diverse experiences of its inhabitants. Within this premise, the process of touristification takes shape, grounded in an awareness of the tourism sector’s contribution to national gross domestic product. Cities often find themselves adapting their various components to the logic of destinations and tourist consumption. As a result, tourism is frequently associated with critical issues such as gentrification and the erosion of local identity.
Accommodating tourist flows necessitates the reorganization of the urban context in both structural and communicative terms. This lays the foundation for research on factors such as the arrangement of streets and squares, the delineation of public and private spaces, and the concept of ‘foodification’, which is often linked to the touristification of historic centres.
In alignment with the interests of commercial geography and an urban-economic perspective focused on the impact of commercial activities on urban space reconfiguration (Cirelli et al., 2021), this study investigates the phenomenon within a broader framework, examining its effects on commercial activities. Specifically, three case studies from metropolitan cities in Sicily– Palermo, Catania, and Messina – will be analyzed to identify similarities and differences. These analyses will be based on the image of the destination/city, territorial characteristics, and the stakeholders involved
Brain dynamics and personality: a preliminary study
No full textPersonality can be considered a system characterized by complex dynamics that are extremely adaptive depending on continuous interactions with the environment and situations. The present preliminary study explores the dynamic interplay between brain flexibility and personality by taking the dynamic approach to personality into account, thereby drawing from Cloninger's psychobiological model. 46 healthy individuals were recruited, and their brain dynamics were assessed using magnetoencephalography (MEG) during the resting state. We identified brain activation patterns and measured brain flexibility by employing the theory of neuronal avalanches. Subsequent correlation analyses revealed a significant positive association between brain flexibility and cooperativeness, thus highlighting the role of brain reconfiguration tendencies in fostering openness, tolerance, and empathy towards others. Additionally, this preliminary finding suggests a neurobiological basis for adaptive social behaviors. Although the results are preliminary, this study provides initial insights into the intricate relationship between brain dynamics and personality, thus laying the groundwork for further research in this emerging field using a dynamic network analysis of the functional activity of the brain
Tumour microenvironment heterogeneity in primary and metastatic paired melanoma samples and its correlation with genetic features and prognosis
No full textBackground: The prognostic impact of tumour microenvironment (TME) heterogeneity in primary cutaneous melanomas (CM) and paired distant metastases is unclear. Few studies have explored the impact of genetic features on TME immune cell distribution. This study assessed the prognostic impact of TME heterogeneity and investigated the correlation between genetic features and TME cell composition.
Methods: Demographics, treatments and outcome of melanoma patients - with paired samples - from five Italian Melanoma Intergroup (IMI) centers were collected. TME immune phenotypes and cell distribution in FFPE whole tumour sections were analyzed using 9 biomarkers (CD3, CD4, CD8, CD20, CD68, CD163, PD-1, PD-L1, FOXP3), classifying samples as desert (D), excluded (E), or inflamed (I). Additionally, genomic pathways were assessed by next-generation sequencing in both primary and paired samples.
Results: TME was evaluated in 221 samples from 91 patients.The distribution of immune phenotype (I vs E/D) of CD8+cells (p<0.0001), CD163+cells (p<0.0001), CD20+cells (p=0.0008), CD3+cells (p<0.0001), CD4+cells (p<0.0001), CD68+cells (p<0.0001), PD1+cells (p=0.00015) significantly differed between metastatic and primary melanomas. In primary tumors, BRAFV600 status did not correlate with immune phenotypes. However, in paired metastases, it was inversely associated with infiltration of CD8+, CD3+, CD68+, and CD20+cells. Patients in the CD8 + D/E TME group had significantly shorter median survival (21 months) compared to those with at least one inflamed (I) TME sample [(58 months); HR 2.35, 95 % CI 1.28–4.32].
Conclusions: Metastatic and primary melanomas show distinct immune phenotypes. Longitudinal TME assess- ment predicts overall survival
Improving Outcomes in Immediate Prepectoral Reconstruction of Large and Ptotic Breast: The Reliability of Fifth Anterior Intercostal Artery Perforator Flap
No full textBackground and objective: Conservative mastectomy is burdened by possible necrosis of the breast skin and nipple-areola complex, particularly among patients with macromastia and severe ptosis undergoing heterologous reconstruction. It is well known that anterior fifth intercostal artery perforator plays a critical role in nipple-areola complex blood supply. Our study investigates outcomes of large or ptotic breasts, undergoing immediate prepectoral direct-to-implant breast reconstruction covered by dermoadipose flap based on the fifth anterior intercostal artery perforator. Methods: We conducted a retrospective study on 70 consecutive patients who underwent skin-reducing mastectomy, with or without nipple preservation, using an inverted T-pattern. Setup of a dermo-adipose flap with an inferior pedicle, based on the anterior intercostal artery perforator of the fifth intercostal space was performed, according to preoperative Doppler ultrasound. Immediate breast reconstruction was performed using Microthane implants. We assessed rate of mastectomy flap necrosis (Mayo Clinic Classification), at 12 months follow up, pre- and postmastectomy satisfaction with breast, physical well-being of the chest with BREAST-Q questionnaire, and spinal pain using the McGill Pain Questionnaire. Results: No complications such as hematoma, seroma, or implant infections occurred. Ischemic complications were observed in 11 cases (13.9%), however, only in one case was implant removal necessary. Satisfaction with breast appearance, chest physical well-being, and the pain rating index all significantly improved postoperatively. Conclusions: Direct to implant reconstruction using the inferiorly pedicled flap based on the AICAP is a reliable and reproducible technique that offers favorable results with low complication rates in large or ptotic skin reducing mastectomies
Therapeutic management of traumatic facial palsy: a systematic review
No full textPurpose: Trauma is a common cause of facial nerve palsy, accounting for 3% of all cases. While many facial palsies resolve with medical treatment, some require surgical intervention. This systematic review aimed to determine the best therapeutic strategy for traumatic facial palsy. Methods: We reviewed eligible articles for patient demographics, pre-treatment assessment, parameters of selected treatment, type of treatment, outcomes, and post-treatment assessment. Results: Among 135 unique citations, 32 studies were considered eligible, reporting treatment data for 2079 patients. Most studies (n = 30) were case series. The main proposed therapeutic strategies were medical, surgical, or a combination of both. For almost all the selected studies, the House-Brackmann (HB) scale was used to estimate the severity of facial palsy. Conclusion: Based on the existing literature, a standardized guideline for the treatment of traumatic facial palsy is not well delineated, due to the extreme heterogeneity of available therapeutic choices and the lack of standardized patient stratification