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Thermal Conversion of Acetylene‐Containing Cyclotriphosphazene to Graphitic Materials: Controlling Solid‐State Morphology through Heating Rates
No full textCarbon‐rich materials have growing potential for applications ranging from electronics to drug delivery. Traditional methods for preparing these materials often require high temperatures and yield mixtures of products with poor control over structure and properties. To address this, researchers are increasingly using molecular precursors with specific reactive sites that allow for a tunable and well‐defined synthesis. This work presents alkyne‐terminated cyclotriphosphazenes as promising precursors for synthesizing nitrogen and phosphorus rich graphitic materials with tunable solid‐state properties. By applying thermal annealing below 400 °C, it was demonstrated by our groups that precise heating can selectively control ring‐opening polymerization of the phosphazene core and crosslinking of terminal acetylenes. Spectroscopic and thermal analysis revealed that slow thermal heating (below 32 °C/min) promotes simultaneous ring‐opening polymerization, acetylene crosslinking and graphitization to yield a brittle thin film. In contrast, rapid heating (above 32 °C/min) exclusively induces acetylene crosslinking and graphitization, preserving the cyclotriphosphazene ring and producing a soluble, amorphous black powder. Characterization by electron microscopy and gas absorption analysis confirmed that the fast‐heated material has a surface area of 261.03 m 2 /g, a nitrogen uptake of 822.50 cm 3 /g, and a significant increase in pore volume. These findings present a new versatile approach for generating carbon‐rich, porous graphitic materials for various applications.Natural Sciences and Engineering Research Council of Canada (Award: RGPIN‐2022‐04428, RGPIN‐2019‐07271)University of Windso
A high-throughput screening approach to discover potential colorectal cancer chemotherapeutics: repurposing drugs to identify novel disruptors of 14-3-3 proteins
No full textIn silico genomic insights into bacteriophages infecting ESBL-producing Escherichia coli from human, animal, and environmental sources
No full textBackground: The emergence of antimicrobial resistance (AMR) in Escherichia coli, particularly extended-spectrum beta-lactamase-producing E. coli (ESBL-EC), is a global public health concern. Bacteriophages (phages) play a significant role in bacterial evolution and the spread of antibiotic resistance genes (ARGs). This study investigates prophages integrated within ESBL-EC genomes to assess their diversity, gene content, and potential contributions to ESBL-EC persistence across human, animal, and environmental reservoirs. Between May and December 2020, a cross-sectional study was conducted in Abuja and Lagos, collecting 448 stool, cecal, and environmental samples from abattoir workers, slaughtered cattle, and the abattoir environment. ESBL-EC genomes from these samples, obtained in an earlier study, were analyzed for phage regions using PHASTER. Intact prophages were analyzed in silico using computational tools to detect ARGs, ESBL genes, virulence factors, and heavy metal resistance. Their genomic relationships were examined with statistical significance of p < 0.05. Results: Out of 448 samples, ESBL-EC prevalence was 21.7% (97/448). Among 97 ESBL-EC isolates, 646 prophage regions were detected, with 30% (194/646) classified as intact phages. Among the 158 phages with genus assignments, Punavirus was the most prevalent (60.1%). Escherichia was the most frequent predicted host (308/646), particularly in cattle (n = 143) and human (n = 124) sources. Among ESBL-EC genomes, 83.5% (81/97) with intact phages carried phage-associated ARGs, 76.3% (74/97) carried phage-associated ESBL genes, 18.6% (18/97) harbored phage-associated virulence factors, 15.5% (15/97) contained phage-associated plasmids, and 10.3% (10/97) had heavy metal resistance. The most prevalent phage-associated ARGs detected were qnrS1 (73/81) and blaCTX-M-15 (72/81). Two isolates recovered from abattoir workers carried two phage-like plasmids, each harboring either tet(A) or blaCTX-M-55 gene. The predominant phage lifestyles were temperate (n = 182), mainly in the Peduoviridae family, and lytic (n = 12) in the Punavirus genus. Conclusion: This is the first study in Nigeria to characterize phages in ESBL-EC isolates at the One Health interface. The presence of intact phages in humans, animals, and the environment underscores the complex interactions shaping phage ecology. The discovery of ARGs, virulence genes, and heavy metal resistance within prophages suggests a potential role in AMR dissemination. Future research should focus on elucidating mechanisms of ARG transfer mediated by phages in One Health settings
Theory and Method in Cross-Cultural and Intercultural Psychology
No full textThe field of cross-cultural psychology examines the relationships between the cultural contexts in which individuals develop and now live, and the psychological characteristics they display. The field of intercultural psychology examines how individuals with different cultural backgrounds and psychological characteristics engage each other and adapt to each other when living in culturally diverse societies. In both fields, the theoretical position of universalism is helpful. This approach considers that all human beings share the same fundamental psychological processes (such as perceiving, thinking). Cultural experiences shape these processes during the course of development into variable competencies (such as abilities, attitudes, and values). Cultural situations then promote (or constrain) the expression of these competencies as performances in appropriate settings. Without these basic similarities, there can be no possibility of comparing behaviors across cultures (a methodological issue); nor could there be any mutual understanding or mutual acceptance across cultural boundaries when persons of different backgrounds interact. These theoretical and methodological issues will be elaborated using findings from a large international study of immigrant youth. The application of such findings to promote immigrant well-being can only be ensured when they are based in sound theoretical and methodological foundations
The Lance: School Year 1987-1988: Summer Lance 1988
No full textSummer Lance 1988 Vol. 1: no. 1 (1988: June 9) 8p.Vol. 2: no. 2 (1988: June 23) 12p.Vol. 3: no. 3 (1988: July 7) 8p.Vol. 4: no. 4 (1988: July 21) 8p.Vol. 5: no. 5 (1988: Aug. 4) 8p
Experience of how to build an MRI machine from scratch
No full textEuropean Research CouncilNgee Ann KongsiERC (Award: 834940
Oxidative addition chemistry of bis(4,5-dimethoxybenzo)-1,2,5,6-tetrathiocin with cyclopentadienyl metal carbonyl complexes and the mechanochemical transformation of CpCo(dmobdt) to [CpCo(dmobdt)] 2
No full textMicrowave-promoted oxidative addition of tetrathiocin 1 to CpCo(CO) 2 affords CpCo(dmobdt) which undergoes a mechanochemical transformation to [CpCo(dmobdt)] 2 .Natural Sciences and Engineering Research Council of Canada (Award: 2020-04627, DG-2018-0425, 2024-04043, 2024-04186, RTI-2022-00005, RTI-2020-00310, DG-2020-04627, DG-2024-04043, DG-2024-04186)Canada Foundation for Innovation (Award: LOF-212442)H2020 Marie Skłodowska-Curie Actions (Award: #101151188
The Lance: School Years 2017-2019
No full textDuring School Years 2017-2019, the Lance was published as a blog: http://uwindsorlance.com. The attached files were created on May 27, 2019 by Rick Santarossa, the Editor-in-Chief. Some of the content is not rendered accurately or completely
On Separating Path and Tree Systems in Graphs
No full textWe explore the concept of separating systems of vertex sets of graphs. A separating system of a set X is a collection of subsets of X such that for any pair of distinct elements in X, there exists a set in the separating system that contains exactly one of the two elements. A separating system of the vertex set of a graph G is called a vertex-separating path (tree) system of G if the elements of the separating system are paths (trees) in the graph G. In this paper, we focus on the size of the smallest vertex-separating path (tree) system for different types of graphs, including trees, grids, and maximal outerplanar graphs
