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40 yaş üstü sağlıklı bireylerde verbal fragmantasyonların gramatik karmaşıklıkla ilişkisi The relationship between verbal fragmentation and grammatical complexity in healthy individuals over 40
No full textDil becerilerinin yetişkinlik döneminde nasıl şekillendiği ve dilsel üretim süreçlerindeki
değişimler, geleneksel dil edinimi yaklaşımlarında sabit bir olgu olarak ele alınmıştır. Ancak,
dilsel üretim süreçlerinde verbal fragmantasyonun gramatik karmaşıklıkla olan ilişkisinin daha
ayrıntılı bir şekilde incelenmesi gerekmektedir. Bu çalışma, 40 yaş üstü sağlıklı bireylerden
toplanan anlatı örneklerini analiz ederek, bu iki dilsel bileşenin etkileşimlerini anlamayı
amaçlamaktadır.
Çalışmada, "Kurbağa Neredesin?" Hikayesi, "Kurabiye Hırsızlığı Resmi" ve "Kaza
Kompozisyon Resmi" anlatı araçlarıyla katılımcılardan dil örnekleri toplanmıştır. Toplanan
veriler SALT-TK 18 Research yazılımı kullanılarak analiz edilmiştir. Verbal fragmantasyon
ölçütleri arasında sözce içi duraksama, sözcük ve morfem düzeyinde omisyon, hatalar ve
tekrarlar yer almıştır. Gramatik karmaşıklık ise ortalama sözce uzunluğu (OSU-M), karmaşık
cümle oranları ve eylemsi sayısı gibi parametreler kullanılarak değerlendirilmiştir. Analizlerde,
değişkenler arasındaki ilişkiler regresyon ve korelasyon yöntemleriyle incelenmiştir. Bu
incelemelerin sonucunda GK’nın bağımsız, VF’nin ise bağımlı değişken olarak
değerlendirildiği regresyon analizlerinde, morfolojik omisyonlar (R2=0,59), tek sözcük
düzeyinde boşluk doldurma (R2=0,53), sözcüksel omisyon (R2=0,55) ve ifade düzeyinde
düzenleme (R2=0,65) gibi VF türlerinin GK’dan etkilendiği görülmüştür. Özellikle OSU-M ile
tümcesel yoğunluk (p: 0.854) arasında pozitif yönlü güçlü korelasyon bulunması, OSU-M’nin
Türkçe konuşan yetişkinlerin anlatı örneklerinde bir GK parametresi olarak
değerlendirilebileceği varsayımını güçlendirmektedir. Bu bulgular, dilbilgisel karmaşıklığın
artmasının VF türlerini etkilediğini ve Türkçe söylemlerde morfosentaktik işlemlemleme
yükünü artırabileceğini ortaya koymaktadır
Kidney Disease: Improving Global Outcomes (KDIGO) Workshop on the Nurse's Role in Managing the Symptoms of People Receiving Dialysis
Full text linkAdults with kidney failure receiving dialysis frequently report high symptom burden that can limit life participation and decrease the quality of life. Fatigue, itch, pain, anxiety, depressive symptoms, sleep problems, nausea, vomiting, muscle cramps, breathlessness, and decreased cognition can negatively impact important daily activities. Nurses are the majority health professional group that provides care for people receiving dialysis and have a major role in managing these symptoms. However, routine symptom management by nurses is not universal or standardized in dialysis care. In December of 2023, Kidney Disease: Improving Global Outcomes (KDIGO) held a workshop on the Nurse's Role in Managing the Symptoms of People Receiving Dialysis. The discussions focused on the current barriers nurses face when identifying and assessing symptoms, strategies for identifying symptoms, and the ongoing monitoring and management of symptoms. Nephrology nurses are pivotal in supporting the person with kidney failure receiving dialysis to minimize symptoms, optimize symptom management, decrease dialysis treatment burden, and improve life participation and quality of life
Exploring habenular structural connectivity in Parkinson's disease: insights from 7 T MRI study
No full textBackgroundPD is marked by both motor and non-motor symptoms, with its pathophysiology involving many neural pathways and brain regions beyond the dopaminergic system. While mainly gray matter changes have been noted, white matter changes also exist in PD. Habenula, known for its role in reward processing, mood regulation, motor functions, and cognition, is of interest due to its connection to mood disorders in PD. This study aims to explore diffusion metrics and structural connectivity changes in the habenula of newly diagnosed PD patients using 7 T MRI.Methods84 PDs and 38 HCs were recruited from Maastricht University Medical Centre. Clinical, demographic, and total Beck Depression Inventory (BDI) scores were recorded. A 7 T brain MRI was conducted. Diffusion metrics and structural connectivity were evaluated.ResultsThe mean diffusion metrics of Hb were not significantly different between the groups. However, in PD patients, there was an increase in mean structural connectivity from the right Hb to the right hippocampus (p = 0.006) and the right fusiform gyrus (p = 0.007). On the left side, enhanced connectivity was observed with the left pallidum (p = 0.040) and left accumbens (p = 0.009). In the PD group, a significant correlation was found between the BDI total score and increased structural connectivity from the right Hb to the left cingulate isthmus (R2 = 0.090, p = 0.003).ConclusionThis pioneering study examines diffusion metrics and structural connectivity of Hb in PD patients using high-resolution 7 T MRI. Our findings highlight the habenula's potential role in PD pathophysiology, with altered connectivity suggesting early neurodegenerative or compensatory processes. These results underscore the importance of the habenula as a biomarker for PD and its potential as a therapeutic target
Fonksiyonel Besinlerin Oksidatif Stres Üzerine Etkileri
Full text linkFonksiyonel besinler, içerdikleri biyoaktif bileşenler sayesinde sağlık üzerinde olumlu etkiler yaratabilen ve geleneksel besinlerden farklı olarak belirli sağlık hedeflerine
yönelik geliştirilen gıdalar olarak tanımlanır. Bu kavram, ilk kez 1980’lerde Japonya’da ortaya çıkmış ve o zamandan bu yana dünya genelinde hızla yaygınlaşarak gıda ve sağlık
endüstrilerinde önemli bir yere sahip olmuştur. Fonksiyonel besinler, yalnızca temel besin öğelerini sağlamanın ötesinde, düzenli ve yeterli düzeyde tüketildiklerinde vücutta
çeşitli sağlık yararları sunabilirler. Bu besinler, hastalıkların önlenmesine yardımcı olma, bağışıklık sistemini güçlendirme ve genel refahı artırma gibi potansiyellere sahiptir.
Fonksiyonel besinlerin içeriğinde bulunan antioksidanlar, özellikle oksidatif stresle mücadelede kilit bir rol oynar. Oksidatif stres, organizmada reaktif oksijen ve nitrojen türlerinin üretiminin artması ve vücudun doğal antioksidan savunma mekanizmalarının bu duruma karşı yetersiz kalması sonucu meydana gelir. Bu durum, hücre hasarına neden
olabilir ve kardiyovasküler hastalıklar, kanser, diyabet gibi birçok kronik hastalığın gelişiminde rol oynar. Fonksiyonel besinlerin içerdiği biyoaktif bileşenler, bu tür süreçlere
karşı vücudu koruyarak hastalık riskini azaltabilir ve sağlığı optimize edebilir. Böylece, fonksiyonel besinler hem koruyucu bir etki sunar hem de bireylerin günlük yaşam
kalitesini artırma potansiyeline sahiptir.
Fonksiyonel besinler, oksidatif stresle mücadelede ve vücuttaki biyokimyasal dengenin korunmasında önemli bir rol oynayabilir. Bu tür besinler, içerdikleri biyoaktif bileşenler
sayesinde vücudun savunma mekanizmalarını destekleyerek oksidatif stresin neden olduğu hücre hasarını azaltabilir. Örneğin, yeşil çay, polifenol adı verilen güçlü antioksidan
bileşenler bakımından zengindir. Bu polifenoller, vücutta serbest radikallerin etkisini azaltarak hücreleri korur ve oksidatif stresi minimize eder. Benzer şekilde, kahve de
biyoaktif bileşenler içerir ve nükleer faktör eritroid 2 yolaklarını aktive ederek hücresel koruyucu proteinlerin üretimini teşvik edebilir. Ancak bu etkiler, kanser hücrelerinde
istenmeyen sonuçlara yol açabilir. Akdeniz diyetinin vazgeçilmez bir öğesi olan zeytinyağının içerdiği bileşikler ile reaktif oksijen türlerinin oluşumunu azalttığı bilinmektedir.
EPA, antioksidan enzimlerin ifadesini artırırken, DHA mitokondriyal sağlığı destekleyip inflamasyonu azaltabilir. Kırmızı üzüm içeriğindeki resveratrol, antioksidan özellik göstererek çeşitli hastalıkların önlenmesine yardımcı olmaktadır. Yapılan klinik çalışmalarda, fonksiyonel ve besleyici özellikleri içeriğindeki ß-glukana atfedilen yulafın oksidatif stres
üzerine olumlu etkileri görülmüştür. Sonuç olarak, fonksiyonel besinlerin sağlıklı bireylerde oksidatif stresin azaltılmasında ve genel sağlık durumunun iyileştirilmesinde önemli
bir rol oynayabileceği görülmektedir.Functional foods are defined as foods that have positive effects on health due to the bioactive components they contain and that are developed for specific health goals,
unlike traditional foods. This concept first emerged in Japan in the 1980s and has since spread rapidly around the world, taking on an important place in the food and health
industries. Functional foods, beyond just providing basic nutrients, can offer various health benefits to the body when consumed regularly and adequately. These foods have
the potential to help prevent diseases, strengthen the immune system and increase general well-being.
Antioxidants found in functional foods play a key role, especially in combating oxidative stress. Oxidative stress occurs when the production of reactive oxygen and nitrogen
species in the body increases and the body’s natural antioxidant defense mechanisms become inadequate against this condition. This can cause cell damage and play a role
in the development of many chronic diseases such as cardiovascular diseases, cancer, and diabetes. The bioactive components contained in functional foods can protect the
body against such processes, reduce the risk of disease, and optimize health. Thus, functional foods offer both a protective effect and have the potential to increase the daily
quality of life of individuals.
Functional foods can play an important role in combating oxidative stress and maintaining biochemical balance in the body. Such foods can reduce cell damage caused by
oxidative stress by supporting the body’s defense mechanisms thanks to the bioactive components they contain. For example, green tea is rich in powerful antioxidant components called polyphenols. These polyphenols protect cells by reducing the effects of free radicals in the body and minimize oxidative stress. Similarly, coffee also contains
bioactive components and can activate nuclear factor erythroid 2 pathways and stimulate the production of cellular protective proteins. However, these effects can lead to
undesirable results in cancer cells. It is known that olive oil, an indispensable element of the Mediterranean diet, reduces the formation of reactive oxygen species with the
compounds it contains. EPA increases the expression of antioxidant enzymes, while DHA supports mitochondrial health and can reduce inflammation. Resveratrol in red grapes
helps prevent various diseases by showing antioxidant properties. In clinical studies, the positive effects of oats, whose functional and nutritional properties are attributed to
the ß-glucan in its content, on oxidative stress have been observed. In conclusion, it seems that functional foods can play an important role in reducing oxidative stress and
improving general health status in healthy individuals
The Triglyceride-Glucose Index, a Marker of Insulin Resistance, Is Associated with the Myocardial Performance Index in Asymptomatic Subjects
Full text linkBackground and Objectives: The myocardial performance index (MPI) is a diagnostic tool that assesses both the systolic and diastolic function of ventricles. The MPI provides a comprehensive view of the overall efficiency of the heart's pumping ability, making it a valuable tool for detecting early signs of heart dysfunction, even in the absence of overt symptoms. In this regard, we aimed to explore the relationship between the triglyceride-glucose (TyG) index and subclinical heart failure (HF), as well as its correlation with the MPI, in asymptomatic patients visiting a routine cardiology outpatient clinic. The study specifically excluded individuals with known diabetes, hypertension, and HF, focusing instead on those who had undergone 12 h fasting blood glucose (FBG) and triglyceride (TG) tests. Materials and Methods: The study included 125 patients with FBG, TG, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) data after the exclusion criteria were applied. Results: When asymptomatic patients were categorized as MPI normal or MPI (+) subjects, significant differences were found between the groups in terms of body mass index (BMI), metabolic syndrome (MetS) components, and serum TG values. Pearson correlation analysis revealed a significant and positive correlation between the MPI and TyG index (r = 0.358, p < 0.001). Regression analysis was used to determine the effective parameters in subclinical left ventricular dysfunction (SCLVD). In univariate regression analysis, obesity, the presence of MetS, serum TG, and the TyG index were identified as risk factors. In multivariate regression analysis, the TyG index was found to be the independent risk factor. Conclusions: The positive association found between the MPI and TyG index suggests a link with metabolic disorders and myocardial performance. Obesity, the presence of MetS, serum TG, and the TyG index were identified as risk factors for SCLVD in asymptomatic patients. Notably, the TyG index was identified as an independent risk factor for SCLVD, highlighting its potential role in the early identification and risk stratification of individuals at risk for cardiac dysfunction. These findings suggest that monitoring the TyG index could provide valuable insights into subclinical heart dysfunction, particularly in patients with metabolic abnormalities
The Association Between Depression and Antidiabetic Treatments in Type 2 Diabetes Patients with Both Good and Poor Glycemic Control
Full text linkBackground: Much research has demonstrated that there is a relation between depression and chronic diseases. Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases, and it is an expanding global health problem. This study aims to explore the relationship between glycemic control (GC), antidiabetic agents, and depression in T2DM, focusing on how depression affects treatment adherence and GC. Methods: This prospective study included 250 patients with T2DM. Demographic information and laboratory results were obtained from the patients as well as from the hospital's laboratory system. Beck's Depression Inventory (BDI) scores, GC indicator HbA1c levels, and antidiabetic agents used by the patients were compared. Results: Upon analyzing the findings, we found a statistically significant positive correlation between the severity of depression and HbA1c levels (p < 0.001). Additionally, no significant relationship was observed between depression and the use of oral antidiabetic medications, except for metformin. However, a significant association between depression and insulin use was found even in patients with good GC (p < 0.001), regardless of whether HbA1c was high. Conclusions: Regardless of the type of antidiabetic treatment, diabetic patients receiving intensive insulin therapy, whether they have good or poor GC, should be carefully evaluated for depressive symptoms. Appropriate psychiatric support should be provided to help achieve GC and enhance their quality of life. Our study is the first to emphasize the importance of close monitoring for diabetic patients using insulin, even those with good GC. Understanding these interactions may improve disease management, patient outcomes, and quality of life
Türkçe konuşan sağlıklı yetişkinlerde alternan (tekrarlı) ve sıralı konuşma diadokokinezisi: Normatif verilerin belirlenmesi / Normative data of alternating (repetitive) and sequential speech diadochokinesis in Turkish-speaking healthy adults
No full textBu araştırmanın amacı, Türkçe konuşan sağlıklı yetişkin bireylerde diadokinetik (DDK)
üretim hızlarının yaş ve cinsiyete göre farklılık gösterip göstermediğini incelemek ve
normatif veriler elde etmektir. Çalışmaya, 18–75 yaş aralığında herhangi bir nörolojik,
gelişimsel veya iletişimsel bozukluğu olmayan toplam 300 sağlıklı birey katılmıştır.
Katılımcılar yaşlarına göre üç gruba ayrılmıştır. 18–35 yaş (n =131), 36–55 yaş (n = 112)
ve 56–75 yaş (n=57). Örneklemin 168’i kadın, 132’si erkektir.
Araştırma öncesinde tüm katılımcılardan bilgilendirilmiş onam alınmış ve demografik
bilgiler toplanmıştır. Katılımcıların dil yeterlilikleri, Yetişkinlerde ve Yaşlılarda Dil
Bozuklukları Taraması (DTLA); oral-motor becerileri ise Oral-Konuşma Mekanizması
Tarama Testi (OSMSE-3) ile değerlendirilmiştir. Ölçütleri karşılayan bireylerden, /pa/, /ta/,
/ka/ (alternan/tekrarlı motor hız -AMR) ve /pataka/ (sıralı motor hız-SMR) hecelerini içeren
DDK görevlerini 5 saniye boyunca olabildiğince hızlı ve doğru şekilde tekrar etmeleri
istenmiştir. Alınan ses kayıtları, Audacity yazılımı ile analiz edilerek, tekrar sayılarına göre
saniyedeki hece üretim sayısı (HBS: hece/saniye) hesaplanmıştır.
Elde edilen bulgular, SMR görevlerinde AMR’ye göre daha yüksek üretim hızları olduğunu
göstermiştir. Yaş arttıkça her iki görevde de üretim hızları anlamlı düzeyde azalmıştır.
Görev sırasının genel performans üzerinde anlamlı etkisi bulunmamıştır. Cinsiyet değişkeni
üretim hızları üzerinde anlamlı fark göstermemiştir. Reaksiyon süresi ile üretim hızı
arasındaki ilişki zayıf ve anlamsız bulunmuştur. Ölçümler iki bağımsız değerlendirici
tarafından yapılmış ve yüksek tutarlılık sağlanmıştır
Addressing barriers to and strategies for herpes zoster vaccination in immunocompromised patients in Türkiye: an expert consensus
Full text linkObjectivesImmunocompromised (IC) patients are at increased risk of herpes zoster (HZ; i.e. shingles) and subsequent complications which can significantly impact quality of life. While current evidence indicates a strong disease presence of HZ in T & uuml;rkiye, literature on the management of HZ in this population is lacking.MethodsWe conducted a survey with 6 disease experts from various medical specialties in T & uuml;rkiye to understand their opinions on the burden of HZ and the challenges faced by IC patients, in order to establish a comprehensive and evidence-based expert consensus.ResultsExperts agreed that the burden of HZ is significant among IC patients in T & uuml;rkiye. However, they identified a need for increased local epidemiological data to better understand the health impact of HZ in T & uuml;rkiye. Improved dissemination of information regarding HZ to physicians was also highlighted to increase awareness of HZ.ConclusionsStrategies to enhance current practices and increase vaccine coverage should include incorporation of HZ vaccination into official guidelines and recommendations, with full or partial reimbursement for HZ vaccination in IC patients. Setting up official or society-initiated online platforms could also support ongoing collaboration and provide continuously updated guidelines reflecting the latest advances in HZ vaccination and disease management
Validity and Reliability of the Turkish Version of the Dynamic Evaluation of Motor Speech Skill (DEMSS-TR) Test for Children With Speech Sound Disorders
No full textBackgroundChildhood apraxia of speech (CAS) is a complex motor speech disorder that requires careful differential diagnosis, particularly in languages where validated diagnostic tools are lacking. The Dynamic Evaluation of Motor Speech Skill (DEMSS) is a widely used tool for identifying CAS, but a Turkish version had not yet been developed.AimsThis study aimed to adapt DEMSS into Turkish (DEMSS-TR) and evaluate its psychometric properties for use with Turkish-speaking children with speech sound disorders (SSD).MethodsEighty-two monolingual Turkish-speaking children aged 3;0 to 6;11 with SSDs participated. Participants were assessed for speech-motor skills, oral-motor function, articulation, and language development. Following translation and pilot testing, DEMSS-TR was evaluated for internal consistency, test-retest reliability and intra- and inter-rater reliability. Validity was assessed through expert-based content validation, cluster analysis and receiver operating characteristic (ROC) analysis.ResultsDEMSS-TR demonstrated strong reliability and validity. Cronbach's alpha exceeded 0.90 for all subtests and the total score. Test-retest coefficients ranged from 0.823 to 0.991, with inter- and intra-rater reliability consistently above 0.90. Content validity was supported by expert ratings, with all items exceeding a content validity ratio of 0.80. Cluster analysis revealed three distinct participant groupings consistent with CAS, mild CAS and non-CAS diagnoses. ROC analysis showed high sensitivity and specificity across subtests and total score, confirming the tool's diagnostic accuracy.ConclusionsDEMSS-TR is a reliable and valid assessment for identifying CAS in Turkish-speaking children with SSDs. Its dynamic, structured format allows clinicians to observe motor speech behaviours under cued and spontaneous conditions, supporting accurate diagnosis and treatment planning. This adaptation addresses a significant gap in Turkish clinical practice and contributes to the international literature on cross-linguistic assessment of motor speech disorders.WHAT THIS PAPER ADDSWhat is already known on the subject It is performed with the Dynamic Evaluation of Motor Speech Skills (DEMSS) (Strand et al. 2013; Strand and McCauley 2019), which performs the dynamic evaluation of childhood apraxia of speech (CAS), one of the subtypes of speech sound disorders. Although the original language of the test is English, there are validity and reliability studies in Swedish and Brazilian Portuguese. What this paper adds to existing knowledge This study represents the first international research on CAS in Turkish, presenting reliability and validity data for the first Turkish CAS assessment tool. Uniquely, the study adhered strictly to the original English DEMSS during its adaptation. Unlike other language studies, this research employed Cluster Analysis, a less common validation method in speech and language impairment scales, providing a valuable guide for future test development or adaptation. Additionally, it highlights the importance of dynamic evaluation in the field of motor speech disorders, demonstrating its practical application. What are the potential or actual clinical implications of this work? This study holds significant clinical implications, particularly in improving the accuracy and standardisation of motor speech assessments for Turkish-speaking children.
By validating this tool, clinicians can more precisely diagnose and tailor treatment plans for individuals with motor speech disorders, especially CAS, ensuring that interventions are both culturally and linguistically appropriate. This advancement not only enhances the consistency of assessments across different clinical settings but also contributes to more effective and individualised speech therapy, ultimately leading to better patient outcomes.WHAT THIS PAPER ADDSWhat is already known on the subject It is performed with the Dynamic Evaluation of Motor Speech Skills (DEMSS) (Strand et al. 2013; Strand and McCauley 2019), which performs the dynamic evaluation of childhood apraxia of speech (CAS), one of the subtypes of speech sound disorders. Although the original language of the test is English, there are validity and reliability studies in Swedish and Brazilian Portuguese. What this paper adds to existing knowledge This study represents the first international research on CAS in Turkish, presenting reliability and validity data for the first Turkish CAS assessment tool. Uniquely, the study adhered strictly to the original English DEMSS during its adaptation. Unlike other language studies, this research employed Cluster Analysis, a less common validation method in speech and language impairment scales, providing a valuable guide for future test development or adaptation. Additionally, it highlights the importance of dynamic evaluation in the field of motor speech disorders, demonstrating its practical application. What are the potential or actual clinical implications of this work? This study holds significant clinical implications, particularly in improving the accuracy and standardisation of motor speech assessments for Turkish-speaking children. By validating this tool, clinicians can more precisely diagnose and tailor treatment plans for individuals with motor speech disorders, especially CAS, ensuring that interventions are both culturally and linguistically appropriate. This advancement not only enhances the consistency of assessments across different clinical settings but also contributes to more effective and individualised speech therapy, ultimately leading to better patient outcomes.WHAT THIS PAPER ADDSWhat is already known on the subject It is performed with the Dynamic Evaluation of Motor Speech Skills (DEMSS) (Strand et al. 2013; Strand and McCauley 2019), which performs the dynamic evaluation of childhood apraxia of speech (CAS), one of the subtypes of speech sound disorders. Although the original language of the test is English, there are validity and reliability studies in Swedish and Brazilian Portuguese. What this paper adds to existing knowledge This study represents the first international research on CAS in Turkish, presenting reliability and validity data for the first Turkish CAS assessment tool. Uniquely, the study adhered strictly to the original English DEMSS during its adaptation. Unlike other language studies, this research employed Cluster Analysis, a less common validation method in speech and language impairment scales, providing a valuable guide for future test development or adaptation. Additionally, it highlights the importance of dynamic evaluation in the field of motor speech disorders, demonstrating its practical application. What are the potential or actual clinical implications of this work? This study holds significant clinical implications, particularly in improving the accuracy and standardisation of motor speech assessments for Turkish-speaking children.
By validating this tool, clinicians can more precisely diagnose and tailor treatment plans for individuals with motor speech disorders, especially CAS, ensuring that interventions are both culturally and linguistically appropriate. This advancement not only enhances the consistency of assessments across different clinical settings but also contributes to more effective and individualised speech therapy, ultimately leading to better patient outcomes
Alzheimer demansı ve ileri yaş depresyonunu ayırt edecek kısa nörobilişsel test bataryasının geliştirilmesi
Full text linkErken evre Alzheimer demansı ile ileri yaş depresyonunun ayırıcı tanısında kapsamlı ve zaman alan nöropsikolojik değerlendirmelerin gerekmesi, hem yaşlı bireyler hem de uygulayıcılar için önemli bir güçlük oluşturmaktadır. Bu araştırma, pilot çalışma niteliğinde olup literatür doğrultusunda Alzheimer demansının ve ileri yaş depresyonunun ayrımını yapabildiği bulgulanan testlerden nispeten daha kısa bir nörobilişsel değerlendirme protokolü oluşturarak hızlı bir tarama sağlamayı amaçlamaktadır. Bu amaç doğrultusunda, İstanbul'da yaşayan ve 60-79 yaş aralığında Alzheimer demansı tanılı (n=15), sağlıklı kontrol grubu (n=15) ve geç başlangıçlı ileri yaş depresyonu tanılı (n=2) katılımcılardan veriler toplanmıştır. İlk aşamada, katılımcılara Geriatrik Depresyon Ölçeği, Mini Mental Durum Testi, Wechsler Bilgi ve Yönelim Alt Testi, Sayı Menzili testleri uygulanmıştır. İkinci aşamada Mantıksal Bellek Testi, Rey Karmaşık Şekil Testi, Öktem Sözel Bellek Süreçleri Testi Kısa Formu, Boston Adlandırma Testi Kısa Formu, Sözel Akıcılık Testleri, Benzerlikler Testi Kısa Formu'nu içeren İstanbul Kısa Nörobilişsel Test Bataryası uygulanmıştır. Verilerin istatistiksel analizleri SPSS 29.0 programı kullanılarak gerçekleştirilmiştir. Normal dağılımın Shapiro-Wilk Testi ile değerlendirilmesinin ardından Bağımsız Örneklem T-Testi ve Mann-Whitney U Testi ile gruplar arasında karşılaştırmalar yapılmış, yaş ve eğitimin kontrol edilmesi amacıyla ANCOVA ve Quade Testi uygulanmıştır. Sonuçlara bakıldığında, İstanbul Kısa Nörobilişsel Test Bataryası'nın tüm alt bileşenlerinde anlamlı farklılıklar görülmekte olup (p<0.05) bu farklılıkların büyük - çok büyük etki büyüklüğü gösterdiği ortaya konmuştur. Ayrıca, depresyon tanılı katılımcılar, z puanları üzerinden bireysel olarak değerlendirilmiştir. Dahası, literatüre bakıldığında benzer bir patern ileri yaş depresyonu için de sağlanmakta olup İstanbul Kısa Nörobilişsel Test Bataryası'nın, erken evre Alzheimer demansı ve ileri yaş depresyonunu ayırt etme konusunda önemli bir potansiyel taşıdığı görülmektedir. Klinik uygulamalarda hızlı, ekonomik ve güvenilir bir tarama yöntemi olarak kullanılabileceğine işaret eden bulgular, geliştirilen kısa protokolün yalnızca ayırıcı tanıda değil, hastalığın takibinde de genel bilişsel durumu değerlendirmede işlevsel olabileceğini göstermektedir. Bu yönüyle çalışma, hem ayırıcı tanı hem de bireyselleştirilmiş tedavi planlarının oluşturulmasına katkı sağlayarak ileri araştırma ve uygulamalara temel oluşturabilir.The need for comprehensive and time-consuming neuropsychological assessments in the differential diagnosis of early-stage Alzheimer's dementia and late-life depression poses a significant challenge for both elderly individuals and practitioners. This study is a pilot study and aims to provide a rapid screening by creating a relatively shorter neurocognitive assessment protocol than the tests that have been found to differentiate Alzheimer's dementia and late-life depression in the literature. For this purpose, data were collected from participants aged 60-79 years with Alzheimer's dementia (n=15), healthy control group (n=15) and participants diagnosed with late onset late life depression (n=2) living in Istanbul. In the first stage, Geriatric Depression Scale, Mini Mental State Examination, Wechsler Knowledge and Orientation Subtest, Digit Span Forward tests were administered to the participants. In the second stage, the Istanbul Short Neurocognitive Test Battery, which includes Logical Memory Test, Rey Complex Figure Test, Öktem Verbal Memory Processes Test Short Form, Boston Naming Test Short Form, Verbal Fluency Tests, Similarities Test Short Form, was administered. Statistical analysis of the data was performed using SPSS 29.0 program. After evaluating the normal distribution with the Shapiro-Wilk Test, comparisons were made between groups with the Independent Sample T-Test and Mann-Whitney U Test, and ANCOVA and Quade Test were applied to control for age and education. The results showed that there were significant differences in all subcomponents of the Istanbul Brief Neurocognitive Test Battery (p<0.05), and that these differences showed large to very large effect sizes. In addition, participants diagnosed with depression were evaluated individually on their z scores. Moreover, a similar pattern is found in the literature for depression in advanced age, indicating that the Istanbul Brief Neurocognitive Test Battery has a significant potential to differentiate between early-stage Alzheimer's dementia and late-life depression. The findings indicating that it can be used as a rapid, economical and reliable screening method in clinical applications suggest that the developed short protocol may be functional not only in differential diagnosis but also in evaluating the general cognitive status in the follow-up of the disease. In this respect, the study may provide a basis for further research and applications by contributing to both differential diagnosis and individualized treatment plans