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The use of digital applications in chronic lung diseases in Turkey
No full textMeeting Abstract
Meeting: European-Respiratory-Society Congress (ERS
Synthesis and Anticancer Activity of Novel Indole Derivatives as Dual EGFR/SRC Kinase Inhibitors
No full textBackground Recent studies showed that the cooperation between c-SRC and EGFR is responsible for more aggressive phenotype in diverse tumors, including glioblastomas and carcinomas of the colon, breast, and lung. Studies show that combination of SRC and EGFR inhibitors can induce apoptosis and delay the acquired resistance to chemotherapy. Therefore, such combination may lead to a new therapeutic strategy for the treatment of EGFR-mutant lung cancer. Osimertinib was developed as a third-generation EGFR-TKI to combat the toxicity of EGFR mutant inhibitors. Due to the resistance and adverse reaction of osimertinib and other kinase inhibitors, 12 novel compounds structurally similar to osimertinib were designed and synthesized.Methods Compounds were synthesized by developing novel original synthesis methods and receptor interactions were evaluated through a molecular docking study. To evaluate their inhibitory activities against EGFR and SRC kinase, in vitro enzyme assays were used. Anticancer potencies were determined using lung, breast, prostate (A549, MCF6, PC3) cancer cell lines. Compounds were also tested against normal (HEK293) cell line to evaluate their cyctotoxic effects.Results Although, none of compounds showed stronger inhibition compared to osimertinib in the EGFR enzyme inhibition studies, compound 16 showed the highest efficacy with an IC50 of 1.026 mu M. It also presented potent activity against SRC kinase with an IC50 of 0.002 mu M. Among the tested compounds, the urea containing derivatives 6-11 exhibited a strong inhibition profile (80.12-89.68%) against SRC kinase in comparison to the reference compound dasatinib (93.26%). Most of the compounds caused more than 50% of cell death in breast, lung and prostate cancer cell lines and weak toxicity for normal cells in comparison to reference compounds osimertinib, dasatinib and cisplatin. Compound 16 showed strong cytotoxicity on lung and prostate cancer cells. Treatment of prostate cancer cell lines with the most active compound, 16, significantly increased the caspase-3 (8-fold), caspase-8 (6-fold) and Bax (5.7-fold) levels and decreased the Bcl-2 level (2.3-fold) compared to the control group. These findings revealed that the compound 16 strongly induces apoptosis in the prostate cancer cell lines.Conclusion Overall kinase inhibition, cytotoxicity and apoptosis assays presented that compound 16 has dual inhibitory activity against SRC and EGFR kinases while maintaining low toxicity against normal cells. Other compounds also showed considerable activity profiles in kinase and cell culture assays
Masabaşı çalışanlarda beslenme bilgi düzeyinin ve beslenme durumunun sağlık algısı üzerine etkisinin değerlendirilmesi = Evaluation of the effect of nutrition knowledge level and nutritional status on health perception of desk workers
No full textSağlıklı yaşamın temel bileşenleri doğru beslenme ve fiziksel aktivite olarak bilinmektedir. Günlük çalışma rutinlerinin çoğunu oturarak geçiren masabaşı çalışanlarının fiziksel, fizyolojik, sosyal ve psikolojik açıdan sağlığı olumsuz yönde etkilemektedir. Bu çalışmada masabaşı çalışan bireylerin, beslenme bilgi düzeyi ve beslenme durumlarının sağlık algısı üzerine etkilerinin araştırılması amaçlanmıştır. Bu çalışma, 01.01.2023 – 01.02.2024 tarihleri arasında Afyonkarahisar'da masabaşı çalışan 94 gönüllü ile yapılmıştır. Katılımcıların anket formu ile sosyodemografik özellikleri, besin tüketim kayıtları, beslenme bilgi düzeyi ve sağlık algısı düzeyi sorgulanmıştır. Bireylerin beslenme durumları 24 saatlik besin tüketim kaydı ile belirlenmiştir. Bireylerin beslenme bilgilerini sorgulamak amacıyla Yetişkinler için Beslenme Bilgi Düzeyi Ölçeği (YETBİD); sağlık algısı durumlarını saptamak amacıyla ise Sağlık Algısı Ölçeği (SAÖ) kullanılmıştır. Katılımcıların %80.90'u erkek ve %19.10'i kadındır. Yaş ortalaması 36.80±9.02'yıldır. Katılımcıların %59.60'sının eğitim durumu yüksel okul ve lisanstır. BKİ ortalamaları 26.66±3.81 kg/m²'dir. En çok atlanılan ana öğün%25.50 sıklıkla kahvaltıdır. Katılımcıların %36.20'sinin en çok öğün atlama nedeni unuttuğu/fırsat bulamadığı içindir. YETBİD ölçeğinin temel beslenme kısmında katılımcıların %57.4'ü orta temel beslenme bilgi düzeyine sahipken; besin tercihi kısmında tüm katılımcıların %100'ü kötü bilgi düzeyine sahiptir. Katılımcıların aldıkları enerjinin %14.54±3.81'i proteinden, %41.38±11.61'i yağdan ve %40.21±10.75'i karbonhidrattan gelmektedir. Katılımcılarda günlük A vitamini, tiamin, B6 vitamini, folat ve B12 vitamini, kalsiyum, magnezyum, çinko ve selenyum alımı yetersizdir. Çalışmaya katılan kadınların beslenme bilgi düzeyi, erkeklerden daha yüksektir (p=.048<0.05). Eğitim seviyesi arttıkça sağlık algısı da yükselmektedir (p=.019<0.05). SAÖ ile YETBİD ölçeği arasında pozitif yönlü ve güçlü bir ilişki vardır (r=.239; p=.020). Masabaşı çalışanların sağlık algısını artırmak için beslenme konusunda bilinçlendirilmesi gerekmektedir. Bunu sağlamak için sağlıklı beslenmenin anlatılacağı eğitim programları düzenleyerek çalışanların bilgilendirilmeleri sağlanmalıdır. Bu konuda daha büyük örneklem grupları ile çalışmalar yapılması önerilmektedir. Anahtar kelimeler: beslenme, masabaşı çalışan, sağlık algısıThe basic components of a healthy life are known as proper nutrition and physical activity. It negatively affects the physical, physiological, social and psychological health of desk workers who spend most of their daily work routine sitting. This study aimed to investigate the effects of nutritional knowledge and nutritional status on the health perception of individuals working at a desk. This study was conducted with 94 volunteers working at a desk in Afyonkarahisar between 01.01.2023 and 01.02.2024. The participants' sociodemographic characteristics, food consumption records, nutritional knowledge level and health perception level were questioned with the survey form. Nutritional status of individuals was determined by a 24-hour food consumption record. Nutrition Knowledge Level Scale for Adults (YETBİD) to question individuals' nutritional knowledge; Health Perception Scale (HAS) was used to determine health perception status. 80.90% of the participants are men and 19.10% are women. The average age is 36.80±9.02 years. The education level of 59.60% of the participants is high school or undergraduate. The average BMI is 26.66±3.81 kg/m². The most commonly skipped main meal is breakfast, 25.50% of the time. The most common reason for 36.20% of the participants to skip meals is because they forgot or did not have the opportunity. While 57.4% of the participants had a medium basic nutrition knowledge level in the basic nutrition section of the YETBİD scale; In the food preference section, 100% of all participants have poor knowledge. 14.54±3.81% of the energy consumed by the participants comes from protein, 41.38±11.61% from fat and 40.21±10.75% from carbohydrates. Participants had insufficient daily intake of vitamin A, thiamine, vitamin B6, folate and vitamin B12, calcium, magnesium, zinc and selenium. The nutrition knowledge level of women participating in the study is higher than men (p=.048<0.05). As the education level increases, the perception of health also increases (p=.019<0.05). There is a positive and strong relationship between SAS and YETBİD scale (r=.239; p=.020). Desk workers need to be made aware of nutrition to increase their health perception. To ensure this, employees should be informed by organizing training programs to explain healthy nutrition. It is recommended to conduct studies with larger sample groups on this subject. Keywords: healthperception, nutrition, deskworke
TURKEY BONE MARROW TRANSPLANT NURSING PROFILE: RESEARCH RELATED FEATURES AND BARRIERS TO RESEARCH UTILIZATION
No full textMeeting50th Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT
Koroner Arter Hastalığında Doğru Antiplatelet Seçimi
Get PDFKoroner arter hastalığı yaygın bir kardiyovasküler hastalıktır. Antiplatelet tedavi, koroner arter hastalığının tüm formlarında, özellikle de perkütan koroner
girişim uygulanan hastalarda tedavinin temel taşıdır. Güncel antiplatelet tedavi, aterotrombotik komplikasyonların önlenmesinde yüksek düzeyde etkilidir.
Kanama riskini artırmadan aterotrombotik olayları daha iyi önleyici özelliklere sahip hem oral hem iv yeni antiplatelet ilaçlar klinik kullanıma girmiştir. Bu
makalenin amacı, soru-cevap tarzında oral ve intravenöz antiplatelet ajanların kullanımı hakkında güncel bilgiler sunmaktır.Coronary artery disease is a common cardiovascular disease. Antiplatelet therapy is the cornerstone of treatment in all forms of coronary artery disease,
especially those undergoing percutaneous coronary intervention. Contemporary antiplatelet therapy is maximumly influental in prohibiting atherothrombotic complications. Novel antiplatelet drugs, both oral and iv, with better preventive properties of atherothrombotic events without increasing the risk of
bleeding have entered clinical use. The aim of this article is to provide up-to-date information on the use of oral and intravenous antiplatelet agents in a
question and answer style
Evaluation of Nurses' Competency, Motivation, and Stress Levels in Disaster Management
No full textObjectives: This study was conducted to determine the relationships between nurses’ competency, motivation, and stress levels in disaster management, as well as to shed light on the
establishment of effective disaster management programs.
Methods: In our research we used a correlational, descriptive, cross-sectional design. The sample
of the study was composed of 498 nurses working in Turkey. The “Descriptive and Professional
Characteristics and Disaster Experiences of Nurses” form, the “Competencies for Disaster
Nursing Management Questionnaire,” the “Perceived Stress Scale,” and the “Nurses Job Motivation Scale” were used in data collection.
Results: Nurses’ disaster management competency and motivation levels were found to be
adequate, and their stress levels were found to be moderate. A weak positive correlation was
found between disaster management competency and motivation, but a weak negative correlation was found between stress levels. Age, education level, experience level, training in disaster
nursing, and knowledge of duties and responsibilities in disasters were associated with significant differences in terms of disaster competency and its dimensions, motivation, and stress
levels.
Conclusions: The study found that nurses’ disaster experiences impacted their competency,
feeling of preparedness, and stress and motivation levels, and motivation was found to be a
predictor of increasing competency
The effect of cerebellar lesıons on language in Turkısh speakıng indıvıduals
Get PDFBackgroundThe cerebellum is approximately 10% of the brain volume and is responsible for attention, language, emotion and cognitive functions. Linguistic processing difficulties and cognitive impairments may be observed in individuals with cerebellar lesions depending on the location and severity of the damage. There is no study evaluating language in Turkish-speaking individuals with cerebellar lesions.ObjectiveTo determine the differences in linguistic and visuospatial skills of Turkish speaking individuals with cerebellar lesions compared to control groups, including a right hemisphere lesion group and a healthy control group.MethodFifteen patients with cerebellar lesion (without hemispatial neglect and dysarthria), 15 patients with right hemisphere lesion due to right arter cerebri media (without hemispatial neglect) and 15 healthy control were included. To clarify the language impairment specific to cerebellar lesions, we also included individuals with right hemisphere lesions, which are typically assumed not to present with aphasia. The Language Assessment Test for Aphasia (ADD), Benton Judgment of Line Orientation Test, Benton Facial Recognition Test, Single Letter Deletion Test were used. The "Accident Scene" picture was used for collecting narrative speech samples. After a three group comparison a post-hoc pairwise analysis was performed.ResultsAmong the microstructural parameters in the narrative language analysis, the effort ratio was significantly higher in the cerebellar lesion group compared to the healthy control group. Among the non-verbal cognitive tests, the Benton Facial Recognition Test score was significantly lower in the cerebellar and right hemisphere lesion group compared to the healthy control group. Total score, naming and grammar scores in the ADD test were significantly lower in the cerebellar lesion group compared with the healthy control group. There was no difference between cerebellar and right hemisphere lesions in terms of ADD score, ADD subtests and narrative parameters.ConclusionIn Turkish-speaking individuals with cerebellar lesions, verbal productivity may be interrupted by effort behaviours, and standard aphasia assessment tests may reveal impaired grammar and naming performance without a diagnosis of aphasia. In addition to reduced efficiency in verbal production, facial recognition may be impaired. We found no difference between individuals with lesions in the cerebellum and right hemisphere. This suggests that ischemic damage may affect different components of language independently of the diagnosis of aphasia
The Effects of L-Ascorbic Acid on Isoniazid-Induced Protein Oxidation and Hepatotoxicity in Rats
Get PDFIsoniazid (INH) is hepatotoxic drug. Oxidative stress has been reported as one of the mechanisms of INH induced hepatotoxicity. In the current study, our
aim was to evaluate the redox status of plasma and liver proteins as well as the protective role and dose of ascorbic acid (AA) in INH-induced hepatotoxicity in rats. Protein oxidation parameters such as protein carbonyl (PCO), total thiol (T-SH) levels and paraoxonase-1 (PON-1) activity was determined in the
liver and the plasma of rats. Rats under study were randomly divided into four groups: (1) control; (2) INH (50mg/kg/day); (3) INH (50mg/kg/day) + AA (100
mg/kg/day); and (4) INH + AA (1000 mg/kg/day). INH administration resulted in abnormal elevation of plasma and hepatic PCO levels. On the other hand,
the levels of the plasma and hepatic T-SH and PON1 activity significantly decreased. Supplementation of AA (100 mg/kg/day) dose partially reverted these
abnormalities in the redox status of the proteins and activities of PON1 after the administration of INH. Changes in oxidative stress are likely involved in the
pathogenesis of INH-induced hepatoxicity in rats.İzoniazid (INH) hepatotoksik bir ilaçtır. Oksidatif stres, INH kaynaklı hepatotoksisitenin mekanizmalarından biri olarak rapor edilmiştir. Çalışmada amacımız,
sıçanlarda INH kaynaklı hepatotoksisitede askorbik asid (AA)’in koruyucu rolü ve dozunun yanı sıra plazma ve karaciğer proteinlerinin redoks durumunu
değerlendirmekti. Sıçanların karaciğer ve plazmalarında protein karbonil (PCO), total tiol (T-SH) seviyeleri ve paraoksonaz-1 (PON-1) aktivitesi gibi protein
oksidasyon parametreleri belirlendi. Sıçanlar rastgele dört gruba ayrıldı: (1) kontrol; (2) INH (50mg/kg/gün); (3) INH (50mg/kg/gün) + AA (100 mg/kg/gün);
ve (4) INH + AA (1000 mg/kg/gün). INH uygulaması, plazma ve hepatik PCO düzeylerinde anormal yükselme ile sonuçlanmıştır. Aynı zamanda, plazma ve
hepatik T-SH seviyeleri ve PON1 aktivitesi önemli ölçüde azaldı. AA (100 mg/kg/gün) dozu takviyesi, proteinlerin redoks durumundaki ve INH uygulamasından
sonra PON1 aktivitelerindeki bu anormallikleri kısmen geri döndürdü. Oksidatif stresteki değişiklikler muhtemelen sıçanlarda INH kaynaklı hepatoksisitenin
patogenezinde yer almaktadır
Idiopathic Pulmonary Fibrosis (IPF) and Hypersensitivity Pneumonitis (HP): Comparison of GAP, ILD-GAP, CPI Models
No full textMeeting Abstract
Meeting: European-Respiratory-Society Congress (ERS
Is There a Change in Occupational Balance and Quality of Life of University Staff With or Without COVID-19?
Get PDFAmaç: COVID-19 pandemisi sürecinde birçok meslek grubunun okupasyonel denge ve yaşam kalitesi etkilenmiş, üniversite çalışanları pandemi nedeniyle
değişen yaşam koşulları ile karşı karşıya kalmıştır. Çalışmanın amacı, bu yeni durumların COVID-19 olan ve olmayan üniversite personelinde okupasyonel
denge ve yaşam kalitesinde değişikliklere neden olup olmadığını araştırmaktır.
Gereç ve Yöntem: Üniversite personelinde okupasyonel dengeyi değerlendirmek için Türkiye Okupasyonel Denge Anketi 11 (OBQ11-T), yaşam kalitesini
değerlendirmek için Çalışanlar için Yaşam Kalitesi Ölçeği (ÇYKÖ) kullanıldı. COVID-19 olan katılımcılar çalışma grubu olarak kabul edildi ve COVID-19 olmayan
katılımcılar kontrol grubuna dahil edildi. Verilerin istatistiksel analizinde bağımsız t-testi ve Kruskal-Wallis testleri kullanıldı.
Sonuçlar ve Tartışma: COVID-19 olan üniversite personelinin ÇYKÖ puanlarının merhamet memnuniyeti alt ölçeği kontrol grubuna göre anlamlı olarak düşük
bulundu (p=0,038). COVID-19 pozitif olan akademik personelin tükenmişlik düzeyi, idari personele göre anlamlı olarak yüksekti (p=0,028). OBQ11-T puanları
COVID-19’lu erkeklerde COVID-19’lu kadınlara göre anlamlı olarak düşük bulundu (p=0,043). COVID-19 geçiren üniversite personelinde okupasyonel denge ve
yaşam kalitesi puanları etkilendi.Purpose: During the COVID-19 pandemic, occupational balance, and quality of life (QoL) were affected by many professions, and university staff were faced
with changing living conditions experienced due to the pandemic. This study aims to investigate whether these new situations cause changes in occupational balance and QoL in university personnel with and without COVID-19.
Material and Methods: The Turkish Occupational Balance Questionnaire 11 (OBQ11-T) was used to evaluate occupational balance in university staff, and the
Professional Quality of Life Scale (ProQoL) was used to evaluate the QoL. Participants who had COVID-19 were accepted as the study group and participants
who hadn’t COVID-19 were included in the control group. Independent t-test and Kruskal-Wallis tests were used in the statistical analysis of the data.
Results and Conclusions: The compassion satisfaction subscale of ProQoL scores of university staff who had COVID-19 were found to be significantly lower
than those of the control group (p=0.038). The burnout level of the COVID-19-positive academic staff was significantly higher than the administrative staff
(p=0.028). OBQ11-T scores were found to be significantly lower in males with COVID-19 compared to females with COVID-19 (p=0.043). Occupational balance
and QoL scores were affected in university staff who had COVID-19