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EVALUATING BARRIERS OF CHANGE IN SUSTAINABLE SUPPLY CHAIN PERFORMANCE USING ISM-MICMAC METHODOLOGY
No full textVarious industries around the world have faced many changes, the most important of which are the globalisation of markets, technological changes, shorter life of products, and the diversification of customer demands and needs. Due to the changes, there has recently been a significant focus on the development of supply chains (SCs) within the industries and the improvement of various executive systems in such chains. One of the mentioned systems that has received a lot of attention in recent years is the performance evaluation system.The main objective of this research is to investigate the barriers of change to achieve sustainable performance with the interpretive structural modelling (ISM)/MicMac approach. The current research is applied in terms of the research objective; and descriptive survey research, in terms of the topic and research questions. The data collection tool was an expert questionnaire. The statistical population studied in this research were experts in the field of SC in the food industry. The snowball sampling method was used to select 20 people. Excel and MicMac software were used for data analysis. Based on ISM, the criteria were categorised into 4 levels. The results obtained from the MicMac analysis revealed that legal barriers were the most effective barriers, with a score of 300. Economic barriers ranked second with a score of 220, while human barriers ranked third with a score of 200. Also, environmental barriers were placed in the first priority of effectiveness, with a score of 280. Social barriers ranked second with a score of 240, and economic barriers ranked third with a score of 200. The map of the direct effects of legal barriers was placed as the most important in the independent matrix. Economic, technological and human barriers were placed in the interface matrix. The dependent matrix encompassed social and environmental barriers as well. It was found that these barriers exhibit a robust interdependence and limited guidance. Essentially, these variables wield significant influence but possess limited effectiveness within the system
Developments in the field of respiratory nursing in Türkiye
Full text linkNursing plays a critical role in delivering healthcare services. It is a health discipline encompassing both science and art, designed to support people from birth to the end of life, in health and illness. Nurses are required to identify the physical and psychological needs of individuals, families and society with a comprehensive, human-oriented approach and to meet these needs. Nursing provides essential services at every stage of healthcare, from health protection and improvement to disease treatment and rehabilitation. In T & uuml;rkiye, nursing education is offered at high school, associate and undergraduate levels. Specialisation in a specific branch is possible through Master's and doctoral studies. However, there is no specialised branch or recognised certificate programme in respiratory nursing. Nurses specialising in respiratory diseases typically work in respiratory or intensive care units. Respiratory nurses play a crucial role in care and treatment management within the multidisciplinary team. This viewpoint provides information about the historical development of nursing, nursing education, and the status and development of respiratory nursing in T & uuml;rkiye, as well as the efforts by the International Coalition for Respiratory Nursing to recognise respiratory nursing as a specialty worldwide
Ensemble-based classification algorithm to enhance stability of energy management in IoT-based smart grid networks
No full textThe exponential increase in electricity consumption makes renewable energy management a necessity within the global warming context. Internet of things (IoT) has a key role in effective data transmission for better managing of energy dissipation in smart grids. Since smart grid network deployment involves huge complexities due to the large data volume being generated, applying artificial intelligent methods is essential to better manage the process. Moreover, reducing energy consumption in a stable smart grid system and fault detection are important in managing electricity congestions, power failure and grid stability problems. This paper aims to present a novel prediction architecture involving ensemble bagging trees and analysis of variance (ANOVA) as a feature selection strategy to improve stability of energy consumption and maximise prediction factors such as accuracy, precision, recall and F1-score in IoT-based smart grids. Experimental and simulation results show that the proposed architecture can decrease training time and improve accuracy of prediction with 99.999% on validation (training) data and 100% on test data than other state-of-the-are machine learning mechanisms
The relationship between oxLDL, sLOX-1, PCSK9 and carotid intima-media thickness in patients with prediabetes and type 2 diabetes
Full text linkAffection of vascular structures is a known complication in diabetes and prediabetes. Subclinical atherosclerosis begins to develop years before both cardiovascular and cerebrovascular diseases become symptomatic. The aim of this study was to evaluate the relationship between circulating oxidized LDL (oxLDL), soluble lectin-like oxidized LDL (sLOX)-1 and proprotein convertase subtilisin/kexin type 9 (PCSK9) levels and carotid intima-media thickness (CIMT) in patients with prediabetes and T2DM. We recruited 50 T2DM patients with macrovascular complications, 50 T2DM patients with uncomplicated, 50 prediabetes patients, and 50 healthy participants. The common carotid arteries were visualized by high-resolution B-mode carotid artery ultrasonography. Measurement of serum oxLDL, sLOX-1 and PCSK9 levels were assessed by using a commercially available human enzyme-linked immunosorbent assay (ELISA) method. Homeostasis model assessment for insulin resistance (HOMA-IR) was also calculated. Circulating LDL-C, oxLDL, sLOX-1 and PCSK9 levels were significantly higher in T2DM patients with macrovascular complications compared to control group, prediabetes and uncomplicated diabetes. There was significant difference, especially between the controls and the T2DM patients with macrovascular complications. The CIMT increased progressively from control through to T2DM. Both right and left CIMT also showed significant differences between the groups of prediabetes versus uncomplicated diabetes at p < 0.001 showing progressive increase in vascular involvement with progression of disease. There was a positive correlation between PCSK9 levels with LDL-C, oxLDL, sLOX-1, and CIMT. ROC curve analyses showed that PCSK9, as well as oxLDL and LOX-1, was a strong predictor of T2DM with high sensitivity and specificity. In this study, we found that oxLDL, sLOX-1 and PCSK9 levels were significantly associated with carotid intima-media thickness. Our findings suggest that these biomarkers may be used as potential markers for the assessment of cardiovascular risk in patients with prediabetes and type 2 diabetes
B-Cell and T-Cell Populations in Peripheral Blood Linked to Ocrelizumab Treatment Efficacy in Multiple Sclerosis
Full text linkBackground/Aim: Ocrelizumab, a CD20-targeting monoclonal antibody, is used for treatment of multiple sclerosis. The aim of this study was to explore the utility of peripheral blood cell subsets in prediction of treatment response to ocrelizumab in relapsing remitting multiple sclerosis (RRMS). Patients and Methods: Thirty-one patients with RRMS resistant to first-line immunomodulating agents were enrolled and followed-up for 12 months under ocrelizumab treatment. Disease activity was monitored by 6-monthly assessments of Expanded Disability Status Scale and cranial-spinal magnetic resonance imaging. No evidence of disease activity (NEDA-3) status was determined, and peripheral blood mononuclear cells were immunophenotyped by flow cytometry. Results: Peripheral blood populations of CD19+ B-cells, plasma cells and CD3'CD20' T-cells decreased under ocrelizumab therapy, whereas populations of switched memory B-cells, CD4' T-cells, na & iuml;ve T-cells and regulatory B-1a and CD49d' T-cells were increased. NEDA-3 status was achieved by 19 patients, who exhibited elevated baseline populations of regulatory CD49d' T- and B-1a-cells, reduced post-treatment (month 6 or 12) populations of switched memory B-cells, and increased post-treatment populations of na & iuml;ve T-cells. Month 12 Expanded Disability Status Scale scores correlated positively with plasmablast and na & iuml;ve T-cell populations. Conclusion: Response to ocrelizumab is linked to baseline regulatory and post-treatment effector B- and T-cell subset populations. Memory B-cells appear to be a marker of treatment efficacy for ocrelizumab
Fabrication and characterization of silver nanowire-coated porous alginate wet-laid webs for wound dressing applications (vol 296, 139770, 2025)
No full textWound care presents an imposed financial burden for healthcare organizations, prompting the need for novel and cost-efficient dressings. In this study, we address this challenge by introducing a novel approach to fabricate antibacterial alginate-based fibrous materials using a combination of wet spinning and the wet-laying method, which offer advantages including structural and functional properties such as breathability, nontoxicity, biocompatibility, and cost-effectiveness.
The wet spinning method was employed to develop porous and non-porous Ca-alginate fibers with diameters of 100 ± 4.3 nm and 132 ± 1.2 nm, respectively. Porous Ca-alginate fibers were fabricated with the utilization of polyvinyl alcohol (PVA) as a pore-forming polymer. Obtained fibers were cut into 1–2 cm lengths to fabricate wet-laid webs. Finally, silver nanowires (AgNWs) were synthesized and then coated on the wet-laid webs at concentrations of 1 % and 3 % to impart antibacterial properties. FTIR analyses confirmed the successful removal of PVA, and swelling tests demonstrated that both porous and non-porous samples exhibit high swelling ability. The porous wet-laid materials swelled 12 times their initial weight, while this amount was 5 times their initial weight in non-porous wet-laid materials at a 60-min timepiece. SEM analysis verified fiber integrity, and MTT assays showed excellent cytocompatibility. Additionally, in vitro tests highlighted the scaffold's potential to support cell attachment and proliferation. The results demonstrate that wet-laid alginate-based fibrous dressings have low cytotoxicity, superior swelling capacity, antibacterial activity, and biocompatibility. This study underscores the potential of the silver nanowires-coated wet-laid webs as a novel and effective approach for producing multifunctional wound care materials
Approximation by Bicomplex Favard-Szász-Mirakjan Operators
Full text linkThe aim of this paper is to consider bicomplex Favard-Sz & aacute;sz-Mirakjan operators and study some approximation properties on a compact C2 disk. We provide quantitative estimates of the convergence. Moreover, the Voronovskaja-type results for analytic functions and the simultaneous approximation by bicomplex Favard-Sz & aacute;sz-Mirakjan operators are investigated
Turkish validity and reliability study of the kidney transplant understanding tool (K-TUT) in Kidney transplant recipients
No full textAim: The study was conducted methodologically to evaluate the validity and reliability of the KTUT scale in kidney transplant recipients. Material and Method: The population of the study consisted of kidney transplant patients at a private hospital group in Istanbul, while the sample comprised patients who met the inclusion criteria and volunteered for the study. Based on ten times the number of scale items, 220 individuals were included in the sample to prevent data loss and to ensure high representativeness. In the study, data collection tools such as the "Patient Information Form" and the "KTUT" scale were employed. The test-retest study was repeated two weeks later with 50 participants. The participants in the retest were not included in other tests of the scale. Findings: The overall content validity index of the scale (S-CVI/Ave) was found to be 0.93. According to the experts' opinions, the content validity of the scale is high, and the majority of the items have been deemed appropriate for the measurement purpose. The internal consistency reliability coefficient of the scale (Cronbach's Alpha) was calculated as 0.789. This threshold indicates that the scale possesses an acceptable level of reliability for use at the group level. In addition, the results of the study reveal that the scores of the K-TUT scale show a significant difference in the 27 % lower and 27 % upper groups. Conclusion: As a result of the study, the K-TUT scale has been shown to reliably distinguish knowledge levels and to be an effective measurement tool in the field of kidney transplant. It is thought that using the Turkish version of the K-TUT to evaluate the knowledge levels of kidney transplant recipients will contribute to evaluation of developed programs and the improvement of patients' treatment processes
Development and validation of the Breast Cancer Myths Scale for women
Full text linkOBJECTIVE: The aim of this study was to develop and validate the Breast Cancer Myths Scale for women. METHODS: Confirmatory and exploratory factor analyses were used in this methodological study. The internal consistency was evaluated using the RESULTS: The root mean square error of approximation was calculated as 0.072. The final scale version demonstrated excellent internal consistency CONCLUSION: The Breast Cancer Myths Scale (single factor, 16 items) is a reliable and valid measure that can be used to evaluate breast cancer myths
Evaluation of total sulfhydryl levels and dietary habits in pemphigus vulgaris
Full text linkIntroduction: Pemphigus vulgaris (PV) is a rare autoimmune bullous dermatitis caused by autoantibodies against desmoglein-1 and desmoglein-3. Sulfhydryl group/total thiols play a key role in numerous cellular activities, such as antioxidant protection, detoxification, cell growth, and apoptosis. Acantholysis may develop due to chemical reasons. Aim: The aim of this study was to investigate the relationship between PV and serum total sulfhydryl levels. Material and methods: The study was conducted with a total of 177 individuals, comprising 86 PV patients and 91 controls. Age, gender, smoking status, alcohol consumption, and pemphigus-triggering food intake were recorded. Diagnosis of PV was established based on the clinical and histopathologic examinations followed by a direct immunofluorescence and indirect immunofluorescence test. Serum total sulfhydryl level (TSH) was measured by spectrophotometric method. Results: Mean age was 41.94 +/- 11.41 years in the patient group and 39.86 +/- 11.72 years in the control group. In the PV group, smoking was noted in 62.8% (n = 54) and alcohol consumption was noted in 32.6% (n = 28) of the patients. There was a significant difference in total sulfhydryl levels between the groups. Conclusions: Our findings suggest that foods and drugs containing sulfhydryl groups may induce pemphigus vulgaris or aggravate the disease