OHSU Digital Collections (Oregon Health and Science University)
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Structural characterization of δβγ epithelial sodium channels provide insight into channel assembly
No full textWhen thinking of sodium channels in the nervous system the most notable are voltage gated sodium channels, but a multitude of non-voltage gated channels also contribute to sodium homeostasis in the brain. One of these lesser studied sodium channels in the nervous system is the Epithelial Sodium Channel (ENaC)
Development of chemical biology tools to follow signal transduction in cells
No full textThe goal of my PhD has been to develop and adapt optical chemical biology approaches to study signal transduction in cells. I developed genetically encoded FRET sensors to monitor with high temporal resolution PARP1-dependent ADP-ribosylation in live cells. I explored CB1 location-dependent functionality by adapting genetic code expansion to generate novel tagging strategies in live cells. Finally, I characterized chemically engineered lipid probes designed to follow lipid transport, metabolism and protein-interactions
Temporomandibular disorders and Anatomic-Psychologic Score
No full textCurrently, it is not possible to accurately predict the prognosis of temporomandibular disorders (TMDs). The objective of this study was to test two hypotheses concerning predicting longitudinal changes in the temporomandibular joint (TMJ) of human subjects. Hypothesis 1: To test if Anatomic-Psychologic Score (APS), an instrument which utilizes easily measured variables, predicted longitudinal changes in TMJ tissue integrity. Hypothesis 2: To test if Machine Learning Models accurately rank ordered anatomic and psychosocial variables that were associated with longitudinal changes in TMJ tissue integrity
