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Benefits of behavioral health intervention for glycemic control in pediatric and young adult patients with type 1 diabetes
No full textThis dissertation utilized medical record data from 2008 to 2023 from the Harold Schnitzer Diabetes Health Center at Oregon Health & Science University to evaluate the unique effects of behavioral health intervention on HbA1c trajectory in pediatric and young adult patients with type 1 diabetes. Results of this research confirm the importance of integrated behavioral treatment models in a specialized medical clinic
Modulation of P2X receptors
No full textP2X receptors are ATP-gated ion channels that play critical roles in physiological and pathophysiological conditions throughout the body. This dissertation elucidates mechanisms of high-affinity agonism and allosteric antagonism for the P2X7 receptor, providing a framework to develop small-molecules with significant therapeutical potential to treat inflammatory diseases
Biallelic CEBPA mutations alter chromatin accessibility and STAT activation
No full textThe overall aim of this work is to understand how biallelic CEBPA mutations block differentiation and contributed to the development of acute myeloid leukemia (AML). This work shows that biallelic mutant Cebpa cells exhibit downregulation of gene expression programs involved in myeloid differentiation as well as altered chromatin accessibility and subsequent loss of CEBPA binding to its canonical regulatory gene elements. Additionally, it shows that CEBPA cooperates with STAT3 to regulate expression of differentiation associated genes, and that genes with overlapping CEBPA and STAT3 peaks are protected in biallelic mutant Cebpa cells with a cooperating CSF3R mutation Together, these data implicate a dependence on activated STAT signaling for oncogenesis in biallelic Cepba mutant AML
Optical control of cannabinoid receptor signaling: a membrane-tethered photopharmacological approach
No full textA barrier in designing safer CB1R drugs is our lack of understanding the circuit and tissue-specific involvement of AEA and THC in different CB1R-mediated pathologies, which is compounded by their physiochemical properties as cannabinoids. Here we develop two photopharmacological tools with THC and AEA to overcome current limitations in the application of cannabinoid ligands and advance our ability to optically control CB1R on select cells
Adverse outcomes following new benzodiazepine and Z-drug prescriptions among adult Oregon Medicaid beneficiaries: 2016 - 2019
No full textBenzodiazepine receptor agonists (BZRA), which include brand names such as Valium, Xanax and Ambien, have been prescribed in clinical practice for decades. Despite their widespread use, these medications carry FDA black box warnings. Risks from long-term use of BZRA have been extensively studied. However, little is known about the adverse outcomes following new BZRA use. This dissertation used claims from adult Medicaid beneficiaries with new BZRA use to investigate 1) factors associated with first long-term BZRA prescription, 2) factors associated with 90-day discontinuation, and 3) rates of first ED visits
Antenatal breastfeeding education through routine prenatal care at a community hospital: a quality improvement initiative
No full textA community hospital identified barriers to breastfeeding support, including inconsistent lactation education and provider knowledge. A ten-week quality improvement project using the Plan-Do-Study-Act framework integrated evidence-based lactation education into routine prenatal care, with 79% of patients receiving education. The initiative improved provider adherence and documentation, with future recommendations to expand education efforts and address workflow issues for better breastfeeding outcomes
