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Enhancing homology-directed repair for treatment of murine phenylketonuria
No full textThe goal of this dissertation is to improve our understanding of the factors governing genetic repair to facilitate whole gene insertion into the genome of mature organisms. While this work mainly focuses on developing a sustained cure for phenylketonuria (PKU) using combined small molecule and CRISPR/Cas9-mediated gene editing, the ultimate goal of this research is to invent a framework from which many genetic diseases could be treated, if not cured
Examining delays in follow-up care in adult patients with type 2 diabetes mellitus at a primary care clinic
No full textTimely follow-up care is necessary to ensure proper management and reduce adverse events in patients with type 2 diabetes mellitus (T2DM). Though the American Diabetes Association (ADA) has guidelines to direct care, patients do not always attend follow-up visits. The clinic where the QI project occurred has no data showing why patients do or do not come for regular follow-up care specifically for T2DM. This project aims to assess facilitators and barriers to timely ADA-guided follow-up care in adult patients with T2DM at a primary care clinic in a suburban county of Washington (WA)
Impact of accessing real-time glucose concentrations via a continuous glucose monitoring device on dietary quality among pregnant persons with gestational diabetes mellitus
No full textA secondary analysis of data, derived from a single-center, open-label, randomized-controlled trial comparing the management of gestational diabetes mellitus (GDM) using real-time continuous glucose monitoring (CGM) vs conventional self-capillary blood glucose monitoring (SCBG), was conducted to explore differences in dietary quality. Dietary quality was assessed with a single Automated Self-Administered 24-hour Recall and mean nutrient values were calculated into Healthy Eating Index (HEI-2020) scores. Among a subgroup of participants with complete glucose and dietary intake data (n=66), secondary analysis aims were to determine 1) if having access to continuous glucose monitoring (CGM) data influenced maternal dietary quality among pregnant individuals with gestational diabetes mellitus (GDM) randomized to CGM (Dexcom© G6) or SCBG (Contour® Next Blood), 2) if glucose time-in-range (GTIR;63-140mg/dL) was different for those who achieved HEI ≥ 64, and 3) if dietary changes made to address GDM persisted into the postpartum period. Though no statistically significant differences in dietary quality and glucose homeostasis were observed between participants with and without access to CGM data, participants during pregnancy had higher HEI sub-scores for seafood and plant proteins, and refined grains compared to the postpartum period. These data will be useful to plan appropriately powered studies to optimize maternal, fetal, and infant health outcomes in pregnancies affected by GDM
Evaluating the pharmacogenomic impact of PDGFRA alterations in Glioma
No full textThis dissertation investigates the functional significance and therapeutic implications of novel extracellular domain (ECD) alterations in PDGFRA found in glioma. Specifically, this work presents a comprehensive assessment of the oncogenic potential and pharmacogenomic profiles of PDGFRA K385I/L, the defining alteration in myxoid glioneuronal tumor, and establishes a scalable framework for evaluating additional ECD mutations across diverse glioma subtypes. The dissertation further extends this approach to characterize twenty PDGFRA ECD variants identified in both pediatric and adult gliomas, revealing shared oncogenic properties and differential sensitivity to type II tyrosine kinase inhibitors. Finally, this work presents the discovery and real-time functional assessment of a novel MDM2::PDGFRA fusion in recurrent glioblastoma, highlighting translational strategies for integrating molecular characterization into patient care
History and Annual Report of the Portland Free Dispensary
No full text"A Brief History of the Portland Free Dispensary - A Department of the Peoples' Institute in Affiliation with the Medical School of the University of Oregon; Rendered with the Annual Report June 1920"
The People's Institute, in partnership with the University of Oregon Medical School (now OHSU), established a free dispensary in Portland in 1908, which focused on providing medical care for women and children. As the demand for services grew between 1908 and 1917, both staffing and care offerings expanded significantly. The increasing needs of the community eventually necessitated a move to larger facilities within the Portland metropolitan area.The organization's annual report documented its founding story, historical development, and financial status as of 1919.</p
