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Mentorship matters: enhancing newly graduated CRNA onboarding through implementation of formal mentor training
No full textNewly graduated Certified Registered Nurse Anesthetists (CRNAs) encounter significant challenges without formal mentor support and guidance. While mentoring is crucial for professional development, mentors often struggle to provide effective support without formal training. This presentation explores the impact of mentor training modules on enhancing mentor confidence
Pacific NW advanced practice registered nurse (APRN) health policy and legislative advocacy participation
No full textAPRNs are not significantly involved in health policy or legislative advocacy, despite this opportunity to improve population health. The purpose was to measure APRN participation in health policy and legislative advocacy in the Pacific NW and explore associations between APRN participation and 2024 federal election impact on policy engagement
A multidimensional approach to understanding prenatal cardiometabolic health, nutrition, and psychosocial factors in relation to the maternal inflammatory milieu and offspring neurodevelopment
No full textDissertation examining preconceptional/prenatal/pregnancy factors with the potential to influence maternal inflammation during pregnancy and offspring neurobehavioral development in toddlerhood, using multivariate approaches
Streamlined prior auth for peds GI
Get PDFThe following project focused on improving the prior authorization (PA) process for pediatric gastroenterology patients at Doernbecher Children’s Hospital, where delays in obtaining medications like PPIs and acid blockers often disrupt care. Through stakeholder interviews, workflow mapping, and literature review, major barriers were identified such as inconsistent communication, fragmented systems, and administrative inefficiencies. To address these, three key recommendations were proposed including implementing electronic PA (ePA) tools within the electronic health record, revising the existing in-basket triage system, and creating a centralized resource guide. The project emphasizes how inefficiencies cause disruptions in flow without a streamlined process and highlights the importance of tracking key performance indicators to ensure ongoing improvement and patient-centered care
Digestible carbohydrate intake and growth and body composition outcomes among infants born at term: a systematic review
No full textThe goal of this systematic review was to identify, summarize, and synthesize available peer-reviewed research and data to provide a comprehensive assessment of the relationship between digestible carbohydrate intake from all nutritional sources and growth outcomes among healthy term infants (born after 37 weeks of gestation) between birth and 12 months of age
Using in vitro models to predict TKI sensitivities of PDGFRA-mutant gastrointestinal stromal tumor
No full textThe majority of PDGFRA-mutant gastrointestinal stromal tumors (GIST) harbor exon 18 mutations, most commonly D842V, which is treated with avapritinib (a new type I TKI) but is resistant to imatinib and other type II TKIs used to treat GIST. As other complex exon 18 non-D842V, 842-position mutations have been observed, it was previously assumed that these would also be type II TKI resistant, and while much remained unknown and not well-documented, there was clinical evidence of successful imatinib treatment in some cases. Unfortunately, avapritinib is either unavailable or inaccessible to many exon 18 PDGFRA-mutant GIST patients worldwide, therefore I investigated whether imatinib could be used instead as first-line therapy, as it is more accessible and cost-effective. My dissertation describes a novel and comprehensive study of the use of in vitro models to predict TKI sensitivities of exon 18 mutations based on the 842-position amino acid and how structural changes at this position modulate TKI type-specific sensitivities. These findings provide paradigm-shifting evidence that can be integrated into clinical decisions to further individualize the treatment of PDGFRA-mutant GIST and improve clinical outcomes
Touched with fire: how MYC drives life and oncogenesis
No full textMYC is an enigmatic master regulator implicated in nearly every facet of cellular biology. Throughout my PhD research and deep engagement with the literature, my singular goal has been to uncover MYC’s fundamental roles in normal cell function and to understand how these roles become corrupted during oncogenesis
