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Multifunctional peptide amphiphiles for anticancer delivery
No full textThis dissertation describes the use of a library of novel peptide amphiphile conjugates for investigating the effects of hydrophilicity, lipophilicity and amphiphilicity on structure, plasma-based delivery, and antitumor efficacy. These results describe guidelines for hitchhiking nanomaterials which can be utilized to treat cancer with a ubiquitous targeting mechanism
Advanced accelerated transepithelial corneal crosslinking
No full textThis dissertation presents a novel transepithelial corneal crosslinking technique, termed Casey crosslinking, evaluated through ex vivo experiments. The findings suggest that Casey crosslinking may be more effective than existing transepithelial crosslinking approaches and can achieve corneal stiffening comparable to the standard epithelium-off Dresden protocol, while potentially minimizing postoperative complications
Curing marasmus: evaluating famine’s persistence as a method of structural oppression
No full textThis Capstone Research Synthesis examines famine as a persistent social problem and its relationship with oppressive, unjust societal frameworks. Three constitutive research questions evaluate
separate facets of this question: the role of oppression in creating famine, the commensurability
of responses in relation to cause, and the incorporation of social justice in responses. This synthesis contributes a
framework for evaluating the emergence of and responses to famines within diverse systems and establishes structural injustice as a primary target for famine prevention
Learning protein ubiquitination from 3D structures: patterns of cancer somatic mutations and deep learning models for prediction
No full textThis dissertation presents a structure-informed deep learning framework for predicting protein ubiquitination sites using AlphaFold2-derived 3D structural features and graph neural networks. It integrates spatial modeling with cancer genomics data to analyze the enrichment and functional impact of somatic mutations near ubiquitination sites. By combining structural bioinformatics, machine learning, and cancer mutation analysis, the work advances both predictive performance and biological interpretability. The findings highlight new mechanistic insights into ubiquitin signaling and its dysregulation in cancer
Revealing the metastatic blueprint of neoplastic-immune hybrid cells
No full textThe work presented herein advances our understanding of neoplastic-immune hybrid cells as drivers of cancer progression and metastasis. My dissertation studies reveal shared hybrid metastatic phenotypes across cancer types, including enhanced migration, immune evasion, and altered metabolism, and identify RUNX1 as a key regulator of hybrid cell invasive biology in colorectal cancer. Together, this work provides a foundation for understanding the molecular basis of hybrid cell heterogeneity and its role in cancer dissemination
Astrocyte syncytium regulation of neuronal excitability and neurovascular coupling
No full textAstrocytes are glial cells in the central nervous system that form a vast electrical network connected via gap junctions, called astrocyte syncytium. My thesis focused on the role of astrocyte syncytium in regulating neuronal excitability and neurovascular coupling in the brain.
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Interview with Steve Stadum, J.D.
No full textIn this oral history interview, Steve Stadum reflects on his personal background, legal career, and extensive leadership roles at OHSU. He discusses his early life in Portland, education at Stanford and Lewis & Clark, and transition from law practice to serving as OHSU’s general counsel. Stadum recounts his pivotal role in the development of the South Waterfront campus and the Portland Aerial Tram, detailing the legal, political, and logistical challenges involved. He also shares insights into establishing OHSU’s first regulatory compliance program and his tenure at both the Knight Cancer Institute and Fred Hutchinson Cancer Center. Returning as Interim President of OHSU in 2024, Stadum addresses institutional morale, financial pressures, and federal policy challenges, emphasizing transparency and authenticity in leadership
Developing bioprinting techniques and ultrasound-responsive materials for cellular genetic manipulation in 3D tumor constructs
No full textModeling early cellular interactions in the 3D tumor microenvironment is critical to understanding and intercepting early-stage disease, including HER2+ breast cancer. However, it is a challenge to create architecturally relevant in vitro tissue models that allow for noninvasive, spatiotemporally controlled genetic manipulation to simulate early-stage disease. To address this challenge, this work leverages focused ultrasound as a noninvasive stimulus for remote genetic manipulation. This dissertation establishes multiple platforms for 3D bioprinting of complex ultrasound-responsive tissue constructs to enable ultrasound-mediated site-specific delivery of genetic payloads
Pten regulates the development of the stereotyped dendritic arbors of the starburst amacrine cell
No full textNeurons develop stereotyped morphologies in order to perform circuit-specific computations and functions. However, the developmental mechanisms which govern how these neurons acquire their form is not fully understood. In this dissertation, I show the phosphatase PTEN is required for normal dendritic branching in the starburst amacrine cell